Mapping a prevention strategy to reduce medically indicated preterm births: a trio of low-risk modifiable factors for the triad of the mother, fetus, and placenta
See corresponding article onpage 813. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 26, 2021 Category: Nutrition Source Type: research

Healthy diet during pregnancy —navigating the double-edged sword
See corresponding article onpage 540. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 26, 2021 Category: Nutrition Source Type: research

Insects on the menu: characterization of protein quality to evaluate potential as an alternative protein source for human consumption
See corresponding article onpage 934. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 24, 2021 Category: Nutrition Source Type: research

Increasing the availability and utilization of reliable data on population micronutrient (MN) status globally: the MN Data Generation Initiative
This report describes the current situation with regard to data availability, the reasons for the lack of relevant information, and the steps needed to correct this situation, including implementation of a multi-component MN Data Generation Initiative to advocate for critical data collection and provide related technical assistance, laboratory services, professional training, and financial support. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 24, 2021 Category: Nutrition Source Type: research

Mediterranean diet and prudent diet are both associated with low circulating esterified 3-hydroxy fatty acids, a proxy of LPS burden, among older adults
ConclusionsBased on 2 complementary approaches, the identified plant-based dietary patterns were associated with lower 3-OH FA concentrations, and thus a lower LPS burden, which is considered a potent trigger of inflammatory response. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 24, 2021 Category: Nutrition Source Type: research

Using naso- and oro-intestinal catheters in physiological research for intestinal delivery and sampling in vivo: practical and technical aspects to be considered.
ABSTRACTIntestinal catheters have been used for decades in human nutrition, physiology, pharmacokinetics, and gut microbiome research, facilitating the delivery of compounds directly into the intestinal lumen or the aspiration of intestinal fluids in human subjects. Such research provides insights about (local) dynamic metabolic and other intestinal luminal processes, but working with catheters might pose challenges to biomedical researchers and clinicians. Here, we provide an overview of practical and technical aspects of applying naso- and oro-intestinal catheters for delivery of compounds and sampling luminal fluids fro...
Source: American Journal of Clinical Nutrition - May 24, 2021 Category: Nutrition Source Type: research

Investigating the performance of 24-h urinary sucrose and fructose as a biomarker of total sugars intake in US participants – a controlled feeding study
ConclusionsIn this controlled feeding study, total sugars intake was the main determinant of 24uSF confirming its utility as a biomarker of total sugars in this population. Next steps will include validation of stability assumptions of the biomarker calibration equation proposed here, which will allow its use as an instrument for dietary validation and measurement error correction in diet-disease association studies. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 24, 2021 Category: Nutrition Source Type: research

Association between maternal plasma ferritin concentration, iron supplement use, and the risk of gestational diabetes: a prospective cohort study
ConclusionsBoth elevated plasma ferritin concentrations in the early second trimester and use of ≥60 mg/d of supplemental iron during pregnancy are independently associated with increased risk of GDM. Further clinical trials with precision nutrition approaches considering both baseline iron status and supplement use are needed to evaluate the benefits and risks of iron supplementation during pregnancy. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 21, 2021 Category: Nutrition Source Type: research

Different associations between HDL cholesterol and cardiovascular diseases in people with diabetes mellitus and people without diabetes mellitus: a prospective community-based study
ConclusionsHigh HDL-cholesterol concentrations were paradoxically associated with high risk of composite CVD outcomes in individuals with or without DM. However, low HDL-cholesterol concentrations failed to predict future CVD risk in individuals with DM. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 21, 2021 Category: Nutrition Source Type: research

Associations of circulating choline and its related metabolites with cardiometabolic biomarkers: an international pooled analysis
ConclusionsCirculating choline, carnitine, and DMG were associated with unfavorable cardiometabolic risk profiles, whereas circulating betaine was associated with a favorable cardiometabolic risk profile. Future prospective studies are needed to examine the associations of these metabolites with incident cardiovascular events. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 21, 2021 Category: Nutrition Source Type: research

Nutrient intakes of Canadian adults: results from the Canadian Community Health Survey (CCHS) –2015 Public Use Microdata File
ConclusionsA significant number of Canadian adults may not be meeting recommendations for several essential nutrients, contributing to nutrient inadequacies. These results highlight the nutrients of concern by specific age-sex groups that may be important for public health interventions aimed at improving diet quality and nutrient adequacy for Canadian adults. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 21, 2021 Category: Nutrition Source Type: research

Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study
ConclusionsWeight loss induced by an energy-restricted MedDiet and physical activity induce changes in gut microbiota. The role of MedDiet-induced changes on the host might be via short-chain fatty acid producing bacteria, whereas with energy restriction, these changes might be modulated with other mechanisms, which need to be explored in future studies. This trial was registered athttp://www.isrctn.com/ISRCTN89898870 as ISRCT 89898870. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 21, 2021 Category: Nutrition Source Type: research

Effectiveness and cost-effectiveness of 4 supplementary foods for treating moderate acute malnutrition: results from a cluster-randomized intervention trial in Sierra Leone
ConclusionsThe 4 supplements performed similarly across recovery (but not sustained recovery) and costed measures. Analyses of posttreatment outcomes are necessary to estimate the full cost of MAM treatment. This trial was registered atclinicaltrials.gov as NCT03146897. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 21, 2021 Category: Nutrition Source Type: research

Trends in junk food consumption among US children and adults, 2001 –2018
ConclusionsFrom 2001 to 2018, %E from junk food represented nearly 1 in 5 calories among children, without change, and nearly 1 in 7 calories, with modest decrease, among adults, with disparities in subgroups. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 21, 2021 Category: Nutrition Source Type: research

Insects are a viable protein source for human consumption: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial
ConclusionsIngestion of a meal-like amount of lesser mealworm –derived protein is followed by rapid protein digestion and amino acid absorption and increases muscle protein synthesis rates both at rest and during recovery from exercise. The postprandial protein handling of lesser mealworm does not differ from ingesting an equivalent amount of milk protein co ncentrate in vivo in humans.This trial was registered atwww.trialregister.nl as NL6897. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - May 21, 2021 Category: Nutrition Source Type: research