IVF (in vitro fertilisation) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Peri-implantation glucocorticoid administration for assisted reproductive technology cycles
CONCLUSIONS: Overall, there was insufficient evidence that administration of peri-implantation glucocorticoids in IVF/ICSI cycles influenced clinical outcomes. These findings were limited to the routine use of glucocorticoids in subfertile women undergoing IVF or ICSI.PMID:35771604 | PMC:PMC9245898 | DOI:10.1002/14651858.CD005996.pub4 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - June 30, 2022 Category: General Medicine Authors: Carolien M Boomsma Mohan S Kamath Stephen D Keay Nick S Macklon Source Type: research

Methylome-wide analysis of IVF neonates that underwent embryo culture in different media revealed no significant differences
NPJ Genom Med. 2022 Jun 29;7(1):39. doi: 10.1038/s41525-022-00310-3.ABSTRACTA growing number of children born are conceived through in vitro fertilisation (IVF), which has been linked to an increased risk of adverse perinatal outcomes, as well as altered growth profiles and cardiometabolic differences in the resultant individuals. Some of these outcomes have also been shown to be influenced by the use of different IVF culture media and this effect is hypothesised to be mediated epigenetically, e.g. through the methylome. As such, we profiled the umbilical cord blood methylome of IVF neonates that underwent preimplantation ...
Source: Molecular Medicine - June 29, 2022 Category: Molecular Biology Authors: Rebekka M Koeck Florence Busato Jorg Tost Dimitri Consten Jannie van Echten-Arends Sebastiaan Mastenbroek Yvonne Wurth Sylvie Remy Sabine Langie Tim S Nawrot Michelle Plusquin Rossella Alfano Esm ée M Bijnens Marij Gielen Ron van Golde John C M Dumoulin Source Type: research

The effectiveness of Paraffin oil and Mineral oil for day-5 embryo culture in couples undergoing in vitro fertilisation
CONCLUSION: In day-5 embryo culture, Paraffin and Mineral oil resulted in a comparable live birth rate.PMID:35749967 | DOI:10.1016/j.ejogrb.2022.06.014 (Source: Reproductive Biology)
Source: Reproductive Biology - June 24, 2022 Category: Reproduction Medicine Authors: Huy H Pham Quyen T Dang Hue N Nguyen Cam T Tran Quan T Pham Ben W Mol Vinh Q Dang Source Type: research

Commentary on Romanis Assisted Gestative Technologies
In ‘Assisted Gestative Technologies,’ Romanis argues for the conceptual creation of a new genus of assisted reproductive technologies (ARTs), in recognition of the unique ethical, legal and social implications assistive gestative technologies (AGTs) raise.1 She argues this taxonomic classification might allow for ethicolegal determinations regarding one AGT to be generalised to other instances of this technology. Romanis correctly identifies a lack of appropriate regulations for dealing with the rapidly developing field of assisted and artificial gestation, noting the current discussion of surrogacy law reform ...
Source: Journal of Medical Ethics - June 23, 2022 Category: Medical Ethics Authors: Kendal, E. Tags: Commentary Source Type: research

The inconsistency argument: why apparent pro-life inconsistency undermines opposition to induced abortion
Most opposition to induced abortion turns on the belief that human fetuses are persons from conception. On this view, the moral status of the fetus alone requires those in a position to provide aid—gestational mothers—to make tremendous sacrifices to benefit the fetus. Recently, critics have argued that this pro-life position requires more than opposition to induced abortion. Pro-life theorists are relatively silent on the issues of spontaneous abortion, surplus in vitro fertilisation human embryos, and the suffering and death of born persons due to lack of access to food, shelter and medical care. Colgrove et ...
Source: Journal of Medical Ethics - June 23, 2022 Category: Medical Ethics Authors: Simkulet, W. Tags: Original research Source Type: research

Expression of membrane fusion proteins in spermatozoa and total fertilisation failure during in vitro fertilisation
ConclusionOur results indicate that acrosomal exocytosis, IZUMO1 and SPESP1 expression in spermatozoa could play a crucial role in achieving fertilisation during IVF. However, the size of our cohort was quite small, and our results need to be validated with quantitative methods in larger cohorts.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - June 21, 2022 Category: Urology & Nephrology Authors: Simona Ioana Enoiu, Marie Berg Nygaard, Mona Bungum, S øren Ziebe, Morten R. Petersen, Kristian Almstrup Tags: ORIGINAL ARTICLE Source Type: research

The effectiveness of Paraffin oil and Mineral oil for day-5 embryo culture in couples undergoing in vitro fertilisation
Culture system plays a vital role in assisted reproductive technology (ART) programs, influencing the developmental and implantation capacity of embryos. Oil has been widely used as an overlay in microdrop culture systems to prevent medium evaporation, maintain appropriate pH, temperature, osmotic conditions and protect embryos from microbial contamination [1 –3]. Therefore, it can limit the adverse effects on the metabolism of embryos as well as the variation in DNA and protein. However, it has been shown that oil could also cause some detrimental effects on embryos due to the peroxidation process [4,5]. (Source: Europe...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - June 18, 2022 Category: OBGYN Authors: Huy H. Pham, Quyen T Dang, Hue N Nguyen, Cam T Tran, Quan T. Pham, Ben W Mol, Vinh Q Dang Source Type: research

Protecting the brain of the micropreemie
Advances in perinatal care have seen substantial improvements in survival without disability for extremely preterm infants. Protecting the developing brain and reducing neurodevelopmental sequelae of extremely preterm birth are strategic priorities for both research and clinical care. A number of evidence-based interventions exist for neuroprotection in micropreemies, inclusive of prevention of preterm birth and multiple births with implantation of only one embryo during in vitro fertilisation, as well as antenatal care to optimize fetal wellbeing, strategies for supporting neonatal transition, and neuroprotective developm...
Source: Seminars in Fetal and Neonatal Medicine - June 17, 2022 Category: Perinatology & Neonatology Authors: S.M. Boyd, S.J. Tapawan, N. Badawi, H. Popat Source Type: research

Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial
This study is a multicentre, prospective, randomised, double-blind, placebo-controlled trial to study the efficacy of GnRH antagonist pretreatment for women with endometriosis who are undergoing IVF. A total of 814 patients with endometriosis undergoing fertility treatment will be enrolled and randomised 1:1 into two groups: elagolix 200 mg two times per day or placebo for 8 weeks, prior to undergoing IVF. All participants will then undergo IVF treatment per local protocols. The primary outcome is live birth. Secondary outcomes include oocyte number, fertilisation rate, embryo morphology and implantation rates, as well as ...
Source: BMJ Open - June 17, 2022 Category: General Medicine Authors: Taylor, H., Li, H. J., Carson, S., Flores, V., Pal, L., Robbins, J., Santoro, N. F., Segars, J. H., Seifer, D., Huang, H., Young, S., Zhang, H. Tags: Open access Obstetrics and gynaecology Source Type: research

Factors affecting clinical pregnancy in controlled ovarian hyperstimulation with GnRH-a long protocol: a retrospective cross-sectional study
In conclusion, endometrial thickness (>14.69 mm) on the day of transfer, two cleavage embryos transferred, and female age (≤33.5 years) are independent factors affecting clinical pregnancy outcomes in controlled ovarian hyperstimulation with GnRH-a long protocol for assisted conception. IMPACT STATEMENTWhat is already known on this subject? Fresh embryo transfer cycle with GnRH-a long protocol will result in a higher pregnancy rate in controlled ovarian hyperstimulation cycles.What do the results of this study add? Endometrial thickness on the day of transfer, number of embryos transferred, and female age were indepen...
Source: Journal of Obstetrics and Gynaecology - June 9, 2022 Category: OBGYN Authors: Yanli Fan Yi-Fei Sun Yue-Ming Xu Zi-Yu Cao Zhuo-Ye Luo Yong Sun Zhi-Ming Zhao Gui-Min Hao Bu-Lang Gao Source Type: research

Neurodevelopment at 5 years of age for preterm-born children according to mode of conception: a cohort study
Preterm delivery is a risk factor for sub-optimal neurodevelopment. Pregnancies conceived after medically-assisted reproduction – which includes in vitro fertilisation, with or without intracytoplasmic insemination, as well as induction of ovulation followed by intra-uterine insemination or timed intercourse – have a higher risk of preterm delivery. Few studies have evaluated the outcome at more than 2 years of age of su ch preterm-born children. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - June 4, 2022 Category: OBGYN Authors: Caroline Verhaeghe, Laetitia Marchand-martin, Monique Kaminski, G éraldine Gascoin, Laurence Foix l’hélias, Pierre-Yves Ancel, Pierre-Emmanuel Bouet, Andrei S. Morgan Tags: Original Research: Gynecology Source Type: research