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Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Correlation of IVF outcomes and number of oocytes retrieved: a UK retrospective longitudinal observational study of 172 341 non-donor cycles
Conclusion There was only limited benefit in LBR beyond the 6–15 oocyte group going to the 16–25 oocytes group, after which there was significant decline in LBR. The MGP risk was lower in 1–5 group. (Source: BMJ Open)
Source: BMJ Open - January 2, 2023 Category: General Medicine Authors: Bahadur, G., Homburg, R., Jayaprakasan, K., Raperport, C. J., Huirne, J. A. F., Acharya, S., Racich, P., Ahmed, A., Gudi, A., Govind, A., Jauniaux, E. Tags: Open access, Reproductive medicine Source Type: research

Differences between sperm sharing and egg sharing are morally relevant
Sperm sharing arrangements involve a man (‘the sharer’) allowing his sperm to be used by people seeking donor sperm (‘the recipients’) in exchange for reduced price in vitro fertilisation. Clinics in the UK have offered egg sharing since the 1990s and the arrangement has been subjected to regulatory oversight and significant ethical analysis. By contrast, until now no published ethical or empirical research has analysed sperm sharing. Moreover the Human Fertilisation and Embryology Authority (HFEA) does not record the number of sperm sharing arrangements taking place. This paper describes the sperm ...
Source: Journal of Medical Ethics - December 19, 2022 Category: Medical Ethics Authors: Hodson, N. Tags: Original research Source Type: research

Ovarian Hyperstimulation Syndrome (OHSS) requiring Intensive Care Unit (ICU) admission between 1996-2020 in England, Wales, and Northern Ireland
This study aimed to quantify rates of Ovarian Hyperstimulation Syndrome (OHSS) requiring intensive care unit (ICU) admission and assess whether trends have changed between 1996-2020 commensurate with the introduction of safer IVF practices.MethodsData regarding Intensive Care Unit (ICU) admission across England, Wales and Northern Ireland was gathered retrospectively from the Intensive Care National Audit and Research Centre (ICNARC) database. 38,957 female patients aged between 18-55 years were admitted to ICU for OHSS or related conditions between 1996-2020. The primary outcome was the rate of OHSS requiring ICU admissio...
Source: Frontiers in Endocrinology - December 15, 2022 Category: Endocrinology Source Type: research

Effects of air pollution on clinical pregnancy rates after in vitro fertilisation (IVF): a retrospective cohort study
Conclusion Air pollution could have a negative effect on assisted reproductive technology results and therefore precautions should be taken to minimise the impact of outdoor air on embryo culture. (Source: BMJ Open)
Source: BMJ Open - November 29, 2022 Category: General Medicine Authors: Tartaglia, M., Chansel-Debordeaux, L., Rondeau, V., Hulin, A., Levy, A., Jimenez, C., Bourquin, P., Delva, F., Papaxanthos-Roche, A. Tags: Open access, Epidemiology Source Type: research

Nomogram models to predict low fertilisation rate and total fertilisation failure in patients undergoing conventional IVF cycles
Conclusion The novel nomogram models provided effective methods for clinicians to predict LFR and TFF in traditional IVF cycles. (Source: BMJ Open)
Source: BMJ Open - November 25, 2022 Category: General Medicine Authors: Wang, Q., Wan, Q., Bu, X., Feng, Q., Li, T., Lv, X., Meng, X., Chen, M., Qian, Y., Yang, Y., Geng, L., Zhong, Z., Tang, X., Ding, Y. Tags: Open access, Epidemiology Source Type: research

Day 5 versus day 3 embryo biopsy for preimplantation genetic testing for monogenic/single gene defects
CONCLUSIONS: We are uncertain if there is a difference in live births and miscarriages, viable intrauterine pregnancies, ectopic pregnancies, stillbirths or termination of pregnancies between day 5 and day 3 embryo biopsy for PGT-M. There was insufficient evidence to draw any conclusions regarding other adverse outcomes. The results should be interpreted with caution, as the evidence was of very low certainty due to limited studies, high risk of bias in the included study, and an overall low level of precision.PMID:36423200 | DOI:10.1002/14651858.CD013233.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 24, 2022 Category: General Medicine Authors: Tijana Vlajkovic Mihaela Grigore Rik van Eekelen Lucian Puscasiu Source Type: research

Day 5 versus day 3 embryo biopsy for preimplantation genetic testing for monogenic/single gene defects
CONCLUSIONS: We are uncertain if there is a difference in live births and miscarriages, viable intrauterine pregnancies, ectopic pregnancies, stillbirths or termination of pregnancies between day 5 and day 3 embryo biopsy for PGT-M. There was insufficient evidence to draw any conclusions regarding other adverse outcomes. The results should be interpreted with caution, as the evidence was of very low certainty due to limited studies, high risk of bias in the included study, and an overall low level of precision.PMID:36423200 | DOI:10.1002/14651858.CD013233.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 24, 2022 Category: General Medicine Authors: Tijana Vlajkovic Mihaela Grigore Rik van Eekelen Lucian Puscasiu Source Type: research

Novel therapeutic avenues for kisspeptin
Curr Opin Pharmacol. 2022 Nov 19;67:102319. doi: 10.1016/j.coph.2022.102319. Online ahead of print.ABSTRACTKisspeptin is a hypothalamic neuropeptide that acts via the hypothalamus to stimulate hypothalamic gonadotrophin-releasing hormone secretion and downstream gonadotrophin release. In health, kisspeptin induces normal puberty and modulates ovulation in healthy women. Hypothalamic kisspeptin expression is reduced in several functional reproductive disorders; thus, treating such conditions with kisspeptin is conceptually attractive. Recent studies have demonstrated that kisspeptin can induce a more physiological degree of...
Source: Current Opinion in Pharmacology - November 22, 2022 Category: Drugs & Pharmacology Authors: Jovanna Tsoutsouki Ali Abbara Waljit Dhillo Source Type: research