Inequity of Access: Scoping the Barriers to Assisted Reproductive Technologies
Pharmacy (Basel). 2023 Jan 16;11(1):17. doi: 10.3390/pharmacy11010017.ABSTRACTInfertility impacts millions of people of reproductive age worldwide, with approximately 10-15% of couples affected. When infertility is present, there are many potential barriers to treatment, leading to inequity of access. Assisted reproductive technologies (ART) are the mainstay of medical treatment for infertility and include procedures such as in vitro fertilisation. This scoping review aims to explore the barriers to accessing assisted reproductive technologies to highlight a potential role for the pharmacist in addressing these barriers. F...
Source: Rural Remote Health - January 17, 2023 Category: Rural Health Authors: Amanda Mackay Selina Taylor Beverley Glass Source Type: research

Inequity of Access: Scoping the Barriers to Assisted Reproductive Technologies
Pharmacy (Basel). 2023 Jan 16;11(1):17. doi: 10.3390/pharmacy11010017.ABSTRACTInfertility impacts millions of people of reproductive age worldwide, with approximately 10-15% of couples affected. When infertility is present, there are many potential barriers to treatment, leading to inequity of access. Assisted reproductive technologies (ART) are the mainstay of medical treatment for infertility and include procedures such as in vitro fertilisation. This scoping review aims to explore the barriers to accessing assisted reproductive technologies to highlight a potential role for the pharmacist in addressing these barriers. F...
Source: Rural Remote Health - January 17, 2023 Category: Rural Health Authors: Amanda Mackay Selina Taylor Beverley Glass Source Type: research

Analysis of euploidy rates in preimplantation genetic testing for aneuploidy cycles with progestin-primed versus GnRH agonist/antagonist protocol
ConclusionsThe PPOS protocol had no negative effect on euploid blastocyst formation, and the pregnancy outcomes in FET cycles using the PPOS protocol were similar to those of the GnRH agonist and antagonist protocols.Trial registration This trial was retrospectively registered (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 16, 2023 Category: Research Source Type: research

Alternatives to in vitro fertilisation
We summarised the latest evidence on the (cost)-effectiveness and safety of different alternatives to IVF, including expectant management, IUI, tubal flushing, IVM and IVC. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 12, 2023 Category: Reproduction Medicine Authors: Jennifer A. Wessel, Sarah Hunt, Madelon van Wely, Femke Mol, Rui Wang Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
Reprod Fertil Dev. 2022 Dec;35(2):1-18. doi: 10.1071/RD22204.ABSTRACTMetabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In...
Source: Reproduction, Fertility, and Development - January 2, 2023 Category: Reproduction Medicine Authors: J L M R Leroy B Meulders K Moorkens I Xhonneux J Slootmans L De Keersmaeker A Smits O Bogado Pascottini W F A Marei Source Type: research