Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Forms of Lowered Calorie Intake Treat Even Late Stage Type 2 Diabetes
Type 2 diabetes is a lifestyle disease for near all patients. It results from excess visceral fat tissue, with some evidence suggesting that the specific issue is excess fat in the pancreas. Low calorie diets produce a reversal of symptoms, perhaps in large part due to loss of visceral fat. Here researchers show that intermittent fasting, another approach to reducing calorie intake, also helps to reduce the symptoms suffered by patients and the dependency on medication.
One might conclude that most type 2 diabetics are choosing to remain type 2 diabetics by refraining from lowered calorie intake and consequent weigh...
Source: Fight Aging! - December 20, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Role of SIRT6 in Aging
While much the history of work on sirtuins is one of disappointing results, the majority of that work involved SIRT1. Both SIRT3 and SIRT6 may be more interesting, based on animal studies conducted since the SIRT1 era. SIRT3 localizes to the mitochondria, and mitochondrial function is important in the context of aging. Researchers have shown that SIRT3 upregulation in mice improves hematopoietic stem cell function. SIRT6 upregulation, however, has been shown to modestly extend life in mice, there is a larger body of work surrounding its effects on metabolism than is the case for SIRT3, and at least one group is attempting ...
Source: Fight Aging! - December 12, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Lack of innovation is leading to disparities in diabetes care
Having spent over 30 years of my career in diabetes, first as a practicing diabetologist and later as a diabetes researcher, I’ve met many people with diabetes. And while diabetes care has evolved significantly over my career, I’m amazed to see that daily insulin management is just as complex and manual for many people, particularly
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Lack of innovation is leading to disparities in diabetes care originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 8, 2022 Category: General Medicine Authors: James Malone, MD Tags: Conditions Diabetes Endocrinology Source Type: blogs
My Trial of the New Abbott Freestyle Libre 3
There are many compelling features on the new Abbott Freestyle Libre 3 and I may decide to switch; but I may wish to first try the new Dexcom G7 once it ' s FDA-approved. But I won ' t wait forever...In my 15 years of writing this blog, one thing I have never done is something I occasionally see some younger, less-discerning members of the blogging community do: which is to pimp their blogs (and themselves) out to receive free so-called " blog-ola " . I ' ve been blogging since 2005, and I have never endorsed a product in order to get free things, nor have I ever used my blog to even solicit free stuff from companies which...
Source: Scott's Web Log - December 7, 2022 Category: Endocrinology Tags: 2022 Abbott Abbott Freestyle Libre 3 CGM CGMS Dexcom Source Type: blogs
Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Don ’ t blame Big Pharma for insulin ’ s problems
For diabetics, insulin matters as much as H2O. Unfortunately, insulin’s a hell of a lot more expensive than bottled water. High insulin prices force approximately nine million Americans to balance their wallet and well-being. The American Action Forum reported that a type-one diabetic’s average yearly expense for insulin was $~6000 (i.e., $500/month). It’s easy to
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Don’t blame Big Pharma for insulin’s problems originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 4, 2022 Category: General Medicine Authors: Rushi Nagalla Tags: Policy Diabetes Endocrinology Source Type: blogs
Calorie Restriction as a Treatment to Slow Parkinson's Disease
Calorie restriction is known to suppress inflammation to some degree, alongside many other benefits to health that result from the reaction of cells and biological systems to a reduced calorie intake. Since chronic inflammation in brain tissue is implicated in the onset and development of neurodegenerative conditions, this makes calorie restriction a topic of interest in this part of the field. With a few exceptions, that interest largely manifests as research aimed at reproducing some of the metabolic alterations of calorie restriction with small molecule drugs, however, rather than more more rigorously testing calorie re...
Source: Fight Aging! - December 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Diabetes Management Tech for Type II patients: Interview with Jeffrey Brewer, CEO of Bigfoot Biomedical
Bigfoot Biomedical, a medtech company based in California, has developed the Bigfoot Unity System, a diabetes management technology for patients on multiple daily injection therapy. The system uses continuous glucose monitoring data and doctor recommendations to provide insulin dose recommendations, helping patients to avoid uncertainty.
The company argues that type 2 diabetes patients have been historically underserved by the medtech industry, in part because such patients typically tend to be older at diagnosis, and perhaps less inclined to adopt new technologies. This contrasts with type 1 “power users” w...
Source: Medgadget - December 2, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Telemedicine bigfootbiomed diabetes type 2 Source Type: blogs
Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Gene Pathway Analysis In Action – 3 × 4 DNA Test Review
In the past couple of years, I have taken at least 10 genetic tests, including this latest DNA test from 3×4 Genetics. This may seem excessive, but I have my reasons. I graduated from medical school as a genetic specialist and completed my PhD as a clinical genomics researcher, and although I turned to medical futurism, my original field never ceases to fascinate me. I’m very curious about how these tests advance and hope I might be able to provide insights for patients worldwide about what they can expect to learn from such tests and what those tests can really deliver.
Thus, I didn’t hesitate for a second to ...
Source: The Medical Futurist - November 24, 2022 Category: Information Technology Authors: Andrea Koncz Tags: Genomics Personalized Medicine dna testing genetic test Genetic testing review dna test review 3x4 Genetics pathway analysis Source Type: blogs
IGF1 Gene Therapy as a Neuroprotective Treatment, Slowing Female Reproductive Aging
Researchers here describe an interesting approach to slowing aspects of neurodegeneration that contribute to, among other things, female reproductive aging. That is the focus of this paper, but numerous other aspects of the aging brain are also involved. IGF1 is well studied in the context of aging, and manipulation of the signaling pathways linking insulin, IGF1, and growth hormone has been shown to extend life span in a number of species. Where we can make direct comparisons between mice and humans, such as between growth hormone receptor knockout mice and humans with Laron syndrome, the effects are nowhere near as large...
Source: Fight Aging! - November 23, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Where Does Diabetes Technology Stand In 2022?
Diabetes management went through a radical transformation in the last years due to technology: the diabetes patient community found a strong voice online, continuous glucose monitors are taking the place of finger pricks, digital patches and insulin pumps make the dosage of insulin more predictable, and connected devices promise the era of artificial pancreas real soon. We looked around where diabetes technology stands today and what could we expect in the next 5-10 years.
The diabetes community and digital health tech companies pushing for change
Diabetes continues to affect the lives of millions around the globe. A...
Source: The Medical Futurist - November 22, 2022 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine community diabetes digital digital health patient technology artificial pancreas blood diabetes management insulin diabetic health management blood sugar Source Type: blogs
