Reversine Increases Cell Plasticity, and Appears to Allow Some Cell Types to Escape Senescence
If I'm understanding the results presented here correctly, the reversine small molecule enables senescent cells to return to a more normal state of function, including replication, at least in muscle cells examined in cell culture. The researchers believe it is triggering some of the same reprogramming pathways as the Yamanaka factors, perhaps by inducing expression of Oct4, but are not yet certain as to what is going on under the hood. Is it a good idea to take senescent cells in the body and return them to normal function? That is a good question, and has been raised for other approaches to senescence reversal. At least ...
Source: Fight Aging! - January 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Investigating the Comparative Biology of Variations in Rockfish Species Life Spans
The comparative biology of aging, the study of aging in species with widely divergent life spans, is hoped to improve the catalog and understanding of important mechanisms of aging. It may or may not turn out to be the case that the biochemistry of long-lived species can give rise to practical therapies that slow aspects of human aging, at least in the near future of the next few decades. Engineering a human that ages more slowly seems a far more daunting task than the production of rejuvenation therapies that repair the known forms of cell and tissue damage that drive aging.
An alternative to comparing other specie...
Source: Fight Aging! - January 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Clearing Senescent Cells as a Treatment for Type 2 Diabetes
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes.
Link: https://doi.org/10.18632/aging.204483 (Source: Fight Aging!)
Source: Fight Aging! - January 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What's new in midwifery - mostly COVID related
The last collection of things you may want to know about. Firstly, COVID related:Asystematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy, published in Pediatric Research.Another,of the effectiveness and safety of COVID-19 vaccine in pregnant women, published in BJOG.Then, apopulation based matched cohort study of major congenital anomalies following COVID-19 vaccination and SARS-CoV-2 infection - two separate groups, using health records from Scotland, published in Nature Communications.Anda sequential prospective meta-analysis of clinical risk factors of adverse outcomes a...
Source: Browsing - January 26, 2023 Category: Databases & Libraries Tags: midwifery Source Type: blogs
Considering Autophagy in Long-Lived Species
To what degree is autophagy important in the sizable differences in life span between mammalian species? That is an interesting question. It appears that long-lived species exhibit more effective autophagy, and it also appears that many of the methods of altering metabolism in order to modestly slow aging that were discovered over the past thirty years involve upregulation of autophagy. The effects of calorie restriction on longevity depend upon the correct function of autophagy, and vanish if autophagy is disabled.
It is worth noting that autophagy is difficult to measure, however. It involves many distinct process...
Source: Fight Aging! - January 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An Example of Senolytics Impoving Metabolic Function in Old Mice
The first senolytic therapy to be tested in mice and humans was the combination of dasatinib and quercetin. This continues to be tested in human trials by the Mayo Clinic, and has been shown to reduce the burden of senescent cells in humans to much the same degree as it does in mice. It remains to be seen as to whether any of the many forms of senolytic treatment under development are very much better at clearing senescent cells from aged tissues than dasatinib and quercetin. Either way, it is likely that the use of multiple different senolytics will be better than one alone, due to tissue by tissue differences in biodistr...
Source: Fight Aging! - January 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Medicare Advantage UpCoding Has Been Eliminated by CMS Effective 2022
By GEORGE HALVORSON
Medicare Advantage now enrolls almost exactly half the people enrolled in Medicare — and has both significant fans and hardline opponents in the health care policy circles who disagree about its performance.
The biggest attack point that comes from the critics deals with the issues of coding accuracy by the plans. The payment model for the program is capitation — and that capitation is based on the average cost of fee-for-service Medicare in every county. The people who designed the model believed that the country should use the average cost of fee-for-service Medicare in every county as the b...
Source: The Health Care Blog - January 23, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy CMS George Halvorson Medicare Advantage Source Type: blogs
Costco Wholesale: What Is Its Pharmacy Strategy? It's Complicated.
Conclusion: Costco Pharmacy Manages Hybrid Cash/Insurance Payments for Rx Drugs Better Than Most Other Big Pharmacy Chains. Still, Costco Won ' tALWAYS Be the Low-Price Leader Because of How the U.S. Prescription Drug Market Functions.Costco Pharmacy ' s cash prices for many prescriptions may be low enough for people to simply bypass their insurance and pay out-of-pocket, which Costco welcomes, similar to how Mark Cuban Cost Plus Drug Co. or a number of other rapidly-growing, cash-only pharmacies which are popping up nationwide operate because their cash prices may be potentially even cheaper than by using insurance. Howev...
Source: Scott's Web Log - January 21, 2023 Category: Endocrinology Tags: 2023 Big pharma bypass insurance cash pharmacy cash-only pharmacy Costco Costco Wholesale Corp. PBM ' Source Type: blogs
Drug Diversion – Can AI Monitoring Solve This Growing Issue?
The following is a guest article by Claire Reilly, Director of Clinical Operations at Imprivata and former Emergency Room Charge Nurse.
Although often overshadowed by major news and events, drug diversion – the rerouting of medications intended for patients by healthcare staff and is actually theft – has been a persistent problem in all healthcare settings. Pharmacies, doctors’ offices, hospitals, and care homes are all places drug diversion can occur if prescribing is not carefully monitored and managed.
In recent years, multiple factors have combined to create a perfect storm for drug diversion. Healthcar...
Source: EMR and HIPAA - January 19, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data Clinical Healthcare IT Regulations Adderall Alcohol Abuse Artificial Intelligence Big Data Technologies Claire Reilly COVID-19 Drug Abuse Drug Diversion Drug Overdoses EHR Electronic Hea Source Type: blogs
Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A High Level View of Efforts to Modulate Inflammaging and Immunosenescence of the Aged Immune System
Change and disruption in the immune system is an important component of degenerative aging. Broadly, the immune system becomes ever more inflammatory (inflammaging) while also becoming ever less effective (immunosenescence). The immune system is not only responsible for defending against invasive pathogens and destroying errant cells, but it is also tightly integrated into the normal processes of tissue maintenance and operation. When immune cells become inflammatory, they abandon the range of tasks needed to keep tissues functional. Short-term inflammation is necessary in response to injury and infection, but unresolved, ...
Source: Fight Aging! - January 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Podcast Episode Recommendation: Politico Pulse Check - Can Mark Cuban disrupt prescription drugs?
Next up on my podcast episode recommendations. Today ' s recommended podcast comes fromPolitico, which is a media outlet that has a podcast called "Pulse Check" . Politico describes its Pulse Check podcast this way: " Politico Pulse Check delivers the latest news in healthcare with sharp policy analysis and a dose of real-world perspective " . In other words, the " Pulse Check " podcast is about healthcare and health care policy emanating from Washington, DC.On December 20, 2022, Politico Plus Check interviewed Mark Cuban about his cash-payCost Plus Drug Company. Before I get to the episode itself, I must acknowledge that ...
Source: Scott's Web Log - January 10, 2023 Category: Endocrinology Tags: 2023 Costco mark cuban politico pulse check podcast Source Type: blogs
Podcast Recommendation: Selected Episides of Diabetes Connections with Stacey Simms
So, my next podcast recommendation is for two specific episodes ofDiabetes Connections with Stacey Simms, and more specifically two in which she discusses the Civica insulin announcement which was first announced on March 3, 2022 (see the original Civica press release athttps://www.businesswire.com/news/home/20220303005321/en/Civica-to-Manufacture-and-Distribute-Affordable-Insulin/ or the concurrent JDRF press release athttps://www.prnewswire.com/news-releases/jdrf-announces-support-of-civica-to-manufacture-and-distribute-low-cost-insulin-301495050.html). Many people subscribe to Diabetes Connections, although I ' m s...
Source: Scott's Web Log - January 9, 2023 Category: Endocrinology Tags: 2023 Aaron Kowalski Civica Civica Rx CivicaRx GeneSys Biologics Ned McCoy Stacey Simms Source Type: blogs
If SAMHSA Seriously Wants to Destigmatize People with Substance Use Disorder, It Can Start by Destigmatizing How They Receive Treatment
Jeffrey A. SingerIn 2001, the Food and Drug Administration transferred regulation of methadone treatment programs for opioid use disorder (nowadays called Opioid Treatment Programs or OTPs) to the Drug Enforcement Administration and the Substance Abuse and Mental Health Services Administration. DEA and SAMHSA work together to establish and enforce criteria for treating people with substance use disorder and the regulations that govern how health care practitioners prescribe and administer opioids as medication assisted treatment (MAT) for opioid use disorder. The rules govern the dose and number of drugs clinicians prescri...
Source: Cato-at-liberty - January 3, 2023 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Empathy and longevity in diabetes with BDI Briefs
Introducing BDI Briefs
I’m very excited to share the first episode of BDI Briefs! Together with Dr. Bill Polonsky and Dr. Susan Guzman from the Behavioral Diabetes Institute, our aim with BDI Briefs is to take a brief look at important issues about the emotional side of diabetes.In this short discussion, Scott, Bill, and Susan talk about an interesting study from 2019 that found an association between primary care practitioner empathy and longevity in people with newly diagnosed type 2 diabetes. There is a lot to unpack, and we only scratch the s...
Source: Scott's Diabetes Blog - December 29, 2022 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
