Anabolic Resistance in Sarcopenia
Anabolic resistance is a description of a state, not a starting point for a therapy. Anabolism is the metabolism of growth and repair, and in a state of anabolic resistance cells become less responsive to the signaling environment that normally encourages growth and repair. If the goal is therapies, then why this anabolic resistance occurs becomes the question. Muscles lose mass and strength with age, leading to the condition called sarcopenia. This, obviously, must involve anabolic resistance, and here researchers discuss what is known of this view of the sarcopenia of old age.
The development of sarcopenia in th...
Source: Fight Aging! - November 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Role of Insulin in Aging
The relationship between insulin metabolism and aging is one of the most studied areas of the field, with decades of researchers putting in time to deepen the understanding of the web of interactions surrounding insulin. Yet this has failed to lead to any practical outcome when it comes to slowing or reversing aging. Researchers now have an incrementally better idea as to why obesity, metabolic syndrome, and type 2 diabetes shorten life and worsen health, but that was well understood to be the case well prior to the advent of modern biotechnology.
Experimental studies in animal models of aging such as nematodes, f...
Source: Fight Aging! - October 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The hypoglycemia fear syndrome
In this episode of BDI Briefs, we dive into causes, symptoms, and strategies for managing fear of hypoglycemia for people with type 1 and type 2 diabetes.Learn about the Be Safe and Feel Safe strategies, the importance of diabetes technology, and how to regain confidence in blood sugar management.Polonsky, W. H., Guzman, S. J., & Fisher, L. (2023). The Hypoglycemic Fear Syndrome: Understanding and Addressing This Common Clinical Problem in Adults With Diabetes. Clinical diabetes : a publication of the American Diabetes Association, 41(4), 502–509. https://doi.org/10.2337/cd22-0131
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Source: Scott's Diabetes Blog - October 30, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microfluidic System Incorporates Eight Organ Tissues for Drug Testing
Researchers at Northwestern University have developed a sophisticated microfluidic system that incorporates tissue from up to eight different organ systems. The technology is unprecedented in allowing researchers to study complex interactions between different organs during disease. Moreover, it also allows for more comprehensive drug testing that investigates the effects of drug candidates on multiple organ systems at once. Called Lattice, the system is a significant advancement over pre-existing in vitro systems, which typically only allow researchers to study two organ tissues at once. The entire system fits into a spac...
Source: Medgadget - October 26, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine northwestern Source Type: blogs
Klotho Improves Cell Defenses in Brain Cells
This study offers new insights into the roles of Klotho in regulating energy metabolism and the redox state in the brain.
Link: https://doi.org/10.1038/s41598-023-41166-6 (Source: Fight Aging!)
Source: Fight Aging! - October 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Calorie Restriction Improves Pancreatic Function in Aging Mammals
Beta cells in the pancreas produce insulin and are essential to the regulation of glucose metabolism. Dysfunction in this cell population causes diabetes, whether the origin is autoimmune destruction of beta cells (type 1 diabetes) or senescence of beta cells brought on by obesity (type 2 diabetes). Aging also impairs beta cell function through some of the same mechanisms, such as cellular senescence and constant, unresolved inflammatory signaling. The practice of calorie restriction slows aging, albeit to a greater degree in short-lived species than in long-lived species, and so it is not surprising to see that calorie re...
Source: Fight Aging! - October 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Your Insulin of the Future Could Be " Made in China " if Big PBMs Have a Say in the Matter
Back on June 16, 2022, I published an article on LinkedIn entitled "How the Civica Insulin Announcement May Be Disruptive to the PBM Kickback Scheme" (see the article athttps://www.linkedin.com/pulse/how-civica-insulin-announcement-may-disruptive-pbm-scheme-strumello/ if you wish to read it) which predicted that a growing number of insulin biosimilars whose active pharmaceutical ingredients (API ' s) are cultured in offshore laboratories are forecast to hit the U.S. market in the next few years. According to the FDA and the individual companies whom I also follow on LinkedIn, the U.S. Food and Drug Administration (FDA) typ...
Source: Scott's Web Log - October 15, 2023 Category: Endocrinology Tags: 2023 Congress insulin insulin prices lawmakers PBM Pharmacy Benefit Managers Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The High Cost of Type 2 Diabetes as a Lifestyle Condition
Type 2 diabetes is near entirely a lifestyle condition, and can be reversed even in later stages via suitably aggressive dietary and weight loss interventions. Obesity in early adult life is sufficient to cause type 2 diabetes via some combination of mechanisms involving excess fat in the pancreas and increased stress put upon insulin-generating beta cells resident in the pancreas, leading to greater cellular senescence and altered cell behavior. Excess visceral fat is in general harmful to the body via its metabolic activity. There are a range of ways beyond an increased burden of senescent cells by which it can produce c...
Source: Fight Aging! - October 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Another Three Biosimilar Insulins Planned from Meitheal Pharmaceuticals, Inc.
On September 21, 2023, Chicago-basedMeitheal Pharmaceuticals, Inc. (which is a subsidiary of a Chinese parent company named Nanjing King-Friend Biochemical Pharmaceutical Co., Ltd.) announced an exclusive commercial licensing agreement with a different Chinese company known asTonghua Dongbao Pharmaceutical Co. Ltd. with intent to sell three insulin biosimilars in the U.S. market. The company press release can be seen athttps://www.meithealpharma.com/news/61 while the pharmaceutical industry trade press covered the story athttps://www.thepharmaletter.com/article/licensing-deal-to-bring-three-new...
Source: Scott's Web Log - September 30, 2023 Category: Endocrinology Tags: 2023 Biosimilar insulin Meitheal Pharmaceuticals Source Type: blogs
How Could Digital Technology Make An Impact On Primary Care?
I truly hope that very soon I do not have to make an appointment at the GP when I suspect signs of a disease, but my GP will send me a message that she spotted something irregular in my latest test results and my digital health data, so I’d better visit. Let me show you in detail how primary care should be carried out in the future!
Digital health should become an organic part of primary care in the future
I live a fairly healthy life. I use data to improve my lifestyle and to make better decisions by optimising my sleep pattern, my physical, my cognitive or my emotional abilities; and I had several genetic tests....
Source: The Medical Futurist - September 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research Healthcare Innovation technology wearables GP primary care general practitioner Source Type: blogs
Abbott Acquires Bigfoot Biomedical. Unity has a new home. Some Bigfoot employees might not like it.
In mid-September 2023, the medical technology startup known as Bigfoot Biomedical, reached a definitive agreement to be acquired by Abbott Laboratories (see the official press release athttps://www.prnewswire.com/news-releases/abbott-to-acquire-bigfoot-biomedical-furthering-efforts-to-develop-personalized-connected-solutions-for-people-with-diabetes-301918254.html for details). Financial terms of the deal were not disclosed. Bigfoot ' s CEO Was Fired from JDRFSome people with diabetes might recall that Bigfoot Biomedical was co-founded by Jeffrey Brewer, whose previous job was as CEO of the JDRF. But Mr. Brewer was sh...
Source: Scott's Web Log - September 20, 2023 Category: Endocrinology Tags: 2023 Abbott Bigfoot Biomedical Bigfoot Unity Dexcom FTC Source Type: blogs
Growth Factor-Loaded Microparticles Enhance 3D Bioprinted Muscle
Researchers at the Terasaki Institute in Los Angeles have developed a new method to create 3D printed muscle constructs with enhanced muscle cell alignment and maturation. The technique involves creating microparticles loaded with insulin-like growth factor (IGF) using a microfluidic platform. Then, these particles are included in a bioink that also incorporates myoblast cells and a gelatin-based hydrogel. Once 3D printed, the resulting constructs show enhanced cell growth, elongation, and alignment, and in some cases even began to spontaneously contract after a ten day incubation. The Terasaki researchers hope that their ...
Source: Medgadget - September 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Rehab Surgery artificial muscle TerasakiInst Source Type: blogs
Cells Release Insulin in Response to Music
Researchers at ETH Zurich have developed an insulin delivery system that relies on music as a trigger. The unusual technology is based on calcium ion channels that typically reside in the cell membrane. Such channels are sensitive to mechanical deformation and these researchers discovered that sound waves will activate the channels. When insulin-producing cells are genetically modified to express this channel, they will experience an influx in calcium ions when music is played close by, prompting them to release insulin. The concept could be useful as a treatment for diabetes, whereby such cells, housed in a specialized ca...
Source: Medgadget - September 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine diabetes ETH Zurich Source Type: blogs
