Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Effects of Gly-Low Supplementation on Long Term Health in Mice
The gly-low combination of common supplements is sold as GLYLO by Juvify Health, another of the supplement-focused spinout companies from the Buck Institute, an organization that should consider starting spinning out companies that are doing something more ambitious to treat aging as a medical condition. The scientifically interesting part of the underlying research is that inhibiting glycation to reduce methylglyoxal based advanced glycation endproducts (AGEs) appears, for reasons yet to be determined, to reduce appetite in mice. This leads to modest calorie restriction, and calorie restriction is well known to produce a ...
Source: Fight Aging! - November 14, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Morderate Calorie Restriction Improves Late Life Health in Mice
Up to a point, greater calorie restriction in mice produces greater benefits to health and longevity. Most animal studies do not examine moderate calorie restriction, however, so it is interesting to see one that does. The results reported in this study are much as expected; it is by now well established that calorie restriction is beneficial, shifting metabolism into a state more conducive to lasting good health.
Chronic calorie restriction (CR) results in lengthened lifespan and reduced disease risk. Many previous studies have implemented 30-40% calorie restriction to investigate these benefits. The goal of our ...
Source: Fight Aging! - November 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Moderate Calorie Restriction Improves Late Life Health in Mice
Up to a point, greater calorie restriction in mice produces greater benefits to health and longevity. Most animal studies do not examine moderate calorie restriction, however, so it is interesting to see one that does. The results reported in this study are much as expected; it is by now well established that calorie restriction is beneficial, shifting metabolism into a state more conducive to lasting good health.
Chronic calorie restriction (CR) results in lengthened lifespan and reduced disease risk. Many previous studies have implemented 30-40% calorie restriction to investigate these benefits. The goal of our ...
Source: Fight Aging! - November 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Is Ketosis Anyway?
The carb craze may be responsible for thrusting the term ketosis into the mainstream vernacular. Before that, it was a word you rarely heard outside of medicine. Before Dr. Atikins and the low carb evangelists came along, you could relegate ketosis to a power point slide in an occasional diabetes lecture and be done with it.
Now it seems like ketosis is the in-word with soccer moms and zone dieters alike. And, while its conceptual popularity has grown, there’s still a lot of misunderstanding floating around about what ketosis is and what it means for your body. Much like belly button ...
Source: The EMT Spot - November 9, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Connecting IGF1 Signaling and Cellular Senescence
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Link: https://doi.org/10.3390/cells11203260 ...
Source: Fight Aging! - November 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Basic Functions of Abdominal Organs
Most EMT level providers are square on the primary function of the stomach. We can name several things our liver is doing for us and we get the whole kidney concept as well. But when we start drifting beyond the basics, the conversation can turn fuzzy.
OK … It’s been a little while since I studied this. What was the spleen doing again? Something about the immune system right? Oh, the Pancreas that produces Insulin doesn’t it? Or was that the gallbladder?
Fear not. I put together a handy reference for you. Here’s a list of all those abdominal organs for your review. Now you can sort your large...
Source: The EMT Spot - November 7, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamm...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Podcast Episode Recommendation: This Week Health: Conference " Mark Cuban's Cost Plus Drugs Is Solving the Equity Problem in Prescription Medicine "
My next podcast episode recommendation is another one on Mark Cuban ' s CostPlus Drug Company. Recall that myprevious blog post was an interview with the CEO of that company, Alex Oshmyansky. In that episode, Dr. Oshmyansky not only revealed he was an insulin-dependent person with diabetes himself, but he also told the podcaster that Mark Cuban is surprisingly involved in seemingly miniscule details which he said was not only interesting and helpful, but also demonstrates just how involved Mr. Cuban himself is in the Cost Plus Drug Company startup itself. Also, Mr. Cuban likes to talk to the press about his new venture.Thi...
Source: Scott's Web Log - November 4, 2022 Category: Endocrinology Tags: 2022 cost plus drug company costplus drug company mark cuban podcast Source Type: blogs
Growth Hormone Receptor Knockout in Adipose Tissue Extends Life in Mice
The record for mouse life span is held by growth hormone receptor knockout lineages, approaching a 70% gain, but a lot of that increase is due to early life effects. These animals are very small in comparison to their peers. In comparison, growth hormone receptor knockout in adulthood has a greater impact on female mice than on male mice, and the gain in life span is much reduced. In today's open access paper, researchers demonstrate another approach, generating a lineage of mice in which growth hormone receptor is only disabled in fat tissue. Again, the outcomes are different in male and female mice, and smaller than thos...
Source: Fight Aging! - November 2, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 31st 2022
This study used mice to evaluate how their lifestyles - eating fatty foods vs. healthy and exercising vs. not - affected the metabolites of their offspring. Metabolites are substances made or used when the body breaks down food, drugs or chemicals, or its own fat or muscle tissue. "We have previously shown that maternal and paternal exercise improve health of offspring. Tissue and serum metabolites play a fundamental role in the health of an organism, but how parental exercise affects offspring tissue and serum metabolites has not yet been investigated."
Researchers used targeted metabolomics - the study of metaboli...
Source: Fight Aging! - October 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Podcast Episde Recommendation: TWiST Solving Prescription Drug Pricing in the U.S. with Cost Plus Drugs and Capital Rx CEOs
So next up on my recommendation for informative podcast episodes is an episode of the podcast called " This Week in Startups " (TWiST) With Jason Calacanis& Molly Wood, spoecifically an episode which interviewsMark Cuban Cost Plus Drug Company CEO and Founder Alex Oshmyansky AND the CEO of another startup aiming to disrupt the Pharmacy Benefit Manager (PBM) industry, Capital Rx CEO AJ Loiacono. Incidentally, the PBM startup offers a coupon-generating website and app of its own called CapitalRx Advantage Savings (or CRxAdvantage)https://capitalrxadvantage.com/ which is one worth saving on your smartphone.During the inte...
Source: Scott's Web Log - October 29, 2022 Category: Endocrinology Tags: 2022 capitalrx mark cuban podcast startups Source Type: blogs
Podcast Episode Recommendation: TWiST Solving Prescription Drug Pricing in the U.S. with Cost Plus Drugs and Capital Rx CEOs
So next up on my recommendation for informative podcast episodes is an episode of the podcast called " This Week in Startups " (TWiST) With Jason Calacanis& Molly Wood, spoecifically an episode which interviewsMark Cuban Cost Plus Drug Company CEO and Founder Alex Oshmyansky AND the CEO of another startup aiming to disrupt the Pharmacy Benefit Manager (PBM) industry, Capital Rx CEO AJ Loiacono. Incidentally, the PBM startup offers a coupon-generating website and app of its own called CapitalRx Advantage Savings (or CRxAdvantage)https://capitalrxadvantage.com/ which is one worth saving on your smartphone.During the inte...
Source: Scott's Web Log - October 29, 2022 Category: Endocrinology Tags: 2022 capitalrx mark cuban podcast startups Source Type: blogs
Recommended Podcast: NPR's the " An Arm and a Leg " Show
With most of my recent podcast shares, I was pretty specific to note that I was recommending a particular podcast episode, but stopped short of recommending you subscribe to the entire podcast.However, there are at least are a few podcasts which I actuallyrecommend you subscribe to: one specifically is today ' s recommendation: a podcast known as the " Arm and a Leg " showhttps://armandalegshow.com/, which was started by an enterprising NPR reporter from an NPR station in Chicago by the name of Dan Weissman, who is also the podcast ' s creator& host, although his podcast is now produced with support from NPR and others...
Source: Scott's Web Log - October 28, 2022 Category: Endocrinology Tags: 2022 NPR podcast Source Type: blogs
