A Discussion of Mitochondrially Derived Peptide MOTS-c
A number of mitochondrially derived peptides are thought to have positive effects on cell function, though as for most of the approaches of this nature, it is unclear that it is any better than a structured exercise program. One of the better studied of these peptides is MOTS-c, which is itself upregulated by exercise - arguably one of a number of known exercise mimetics. Delivering signal molecules that are normally upregulated by exercise should in principle recapture some of the beneficial effects of exercise, but so far this line of development has yet to much improve on exercise itself.
Mitochondria are organ...
Source: Fight Aging! - February 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Alzheimer's Disease as a Consequence of Maladaptive Fructose Metabolism
Researchers here discuss the proposal that Alzheimer's disease results from high sugar and glycemic carbohydrate intake. It is certainly possible that this mechanism contributes, but one has to ask why, if this was a dominant mechanism, is lifestyle much less correlated with Alzheimer's incidence than is the case for common metabolic diseases such as type 2 diabetes? One of the challenges all along with Alzheimer's is that it doesn't have a strong enough correlation with metabolic dysfunction and lifestyle choice to believe that it can be wholly, or even largely, a metabolic condition.
An important aspect of survi...
Source: Fight Aging! - February 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Business of Diabetes: Dexcom Spends Big on Super Bowl Ad to Hype New G7 Claiming " Feels Like Magic " ; But the Ad Isn't Magic
This month was the U.S. NFL ' s Super Bowl #57; the two teams which played one another were the Philadelphia Eagles and the Kansas City (Missouri) Chiefs, and the Kansas City Chiefs were the winners in a close game throughout. For a moment, let ' s just overlook that Kansas City ' s team name is rooted in the same racism against indigenous native Americans (after all, the team ' s logo is an arrowhead, which was created by native Americans) the same view ultimately forced the old Washington Redskins to change the team name to the Washington Commanders), and let ' s instead focus on this year ' s game advertising. But Misso...
Source: Scott's Web Log - February 18, 2023 Category: Endocrinology Tags: Business of Diabetes 2023 Abbott Advertising business strategy CGM CGMS Dexcom Freestyle Libre Super Bowl Source Type: blogs
Dexcom Spends Big on Super Bowl Ad to Hype New G7 Claiming " Feels Like Magic " ; But Formulary Exclusions Aren't Magic
This month was the U.S. NFL ' s Super Bowl #57; the two teams which played one another were the Philadelphia Eagles and the Kansas City (Missouri) Chiefs, and the Kansas City Chiefs were the winners in a close game throughout. For a moment, let ' s just overlook that Kansas City ' s team name is rooted in the same racism against indigenous native Americans (after all, the team ' s logo is an arrowhead, which was created by native Americans) the same view ultimately forced the old Washington Redskins to change the team name to the Washington Commanders), and let ' s instead focus on this year ' s game advertising. Whil...
Source: Scott's Web Log - February 18, 2023 Category: Endocrinology Tags: Business of Diabetes 2023 Abbott Advertising business strategy CGM CGMS Dexcom Freestyle Libre Super Bowl Source Type: blogs
Empowering Type 2 diabetes patients with innovative insulin management tools [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Our guest today is James Malone, an endocrinologist and health care executive with over 30 years of experience in the field of diabetes. James has seen firsthand the challenges that many people with type 2 diabetes (T2D) face when it comes to daily insulin
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Empowering Type 2 diabetes patients with innovative insulin management tools [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 16, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Diabetes Source Type: blogs
Two More Podcast Episode Recommendations
Today, I ' m recommending TWO seperate podcast episodes which you might find informative.They come from Dr. Zubin Damania, MD who ' s an internist who describes himself as a UCSF/Stanford-trained physician and he calls his weekly podcast as ZDoggMD. The other one is an interview with Dr. Marion Mass, MD who is a Pediatrician working in Chalfont, PA whom I ' ve come to respect for her efforts to expose systematic wrongdoing in the business of healthcare.I ' ll start with ZDoggMD ' s recent podcast episode. I ' m posting the YouTube version of his February 14, 2022 podcast entitled " The Ugly Truth Behind Soaring Drug Prices...
Source: Scott's Web Log - February 15, 2023 Category: Endocrinology Tags: 2023 Marion E. Mass Mark Cuban Cost Plus Drug Company podcast Source Type: blogs
Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed.
The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How Will IoT and AI Transform the Patient-Doctor Relationship?
The following is a guest article by Thomas Serval, CEO and Founder of Baracoda.
Healthcare has never been an easy topic to discuss. Whether you’re at the doctor’s office or in the comfort of your home, talking about your health can be overwhelming. Most of us don’t enjoy going to the doctor. The anxiety of a doctor finding something wrong or being embarrassed to ask questions are some of the reasons why people prefer to get in and out at appointments. Coupled with primary care physicians spending a little more than 15 minutes with their patients, there isn’t enough time to discuss concerns or take a deep look at a...
Source: EMR and HIPAA - February 10, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data Healthcare IT Telemedicine and Remote Monitoring AliveCor Analyzing Data Artificial Intelligence Baracoda ECG EndoBRAIN EndoBRAIN-EYE Health Data Internet of Things IoT Patient-Doctor Rela Source Type: blogs
Reviewing the Development of Senotherapeutics
Today's open access paper is a very readable tour of the present state of research and development of therapies targeting senescent cells, whether to destroy them or alter their function in favorable ways. In both cases the primary goal is to reduce the senescence-associated secretory phenotype (SASP), the pro-growth, pro-inflammatory signaling that contributes to degenerative aging as the number of senescent cells rises over the course of later life. It is hoped that clearance of senescent cells will produce a sizable positive impact for late life health, reducing chronic inflammation, slowing the onset of near all age-re...
Source: Fight Aging! - February 7, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Mark Cuban Cost Plus Drug Company ( " MCCPDC " ) PBC May Be Able to Say " Mission Accomplished " Even if Sales Stop Growing
On January 19, 2022, a startup called theMark Cuban Cost Plus Drug Company ( " MCCPDC " )opened its doors to the American public as a new online pharmacy and generic manufacturing startup. Initially, MCCPDC was also planning to launch its own Pharmacy Benefit Manager, but it later scrapped those plans, instead announcing several PBM partnerships with some PBM startups which do not engage in " spread pricing " , including on generic, biosimilar and " authorized generic " drugs. The company bears the name of its famous principal investor, multibillionaire Mark Cuban, who is perhaps best known as both owner of the NBA te...
Source: Scott's Web Log - February 7, 2023 Category: Endocrinology Tags: authorized generic 2023 Alex Oshmyansky authorized generics Biosimilar biosimilars Cost Plus costplus drug company drug prices drug pricing generic drugs mark cuban Mark Cuban Cost Plus Drug Company Source Type: blogs
Podcast Episode Recommendation: The Huddle Conversations with the ADCES Diabetes Care Team
First of all, I need to acknowledge that ADCES is a trade organization for the Association of Diabetes Care& Education Specialists, which is the most recent name for one of the associations for diabetes educators. Frankly, I am only recommending this particular podcast episode, but honestly, I cannot really recommend a subscription to its podcast; in fact, I don ' t even remember what the organization ' s old name was because it seems to have changed its name so many times over the years. Beyond that, ADCES tends to focus far more extensively on subjects related to Type 2 diabetes since that group constitute...
Source: Scott's Web Log - February 1, 2023 Category: Endocrinology Tags: 2023 Aaron Kowalski ADCES Association of Diabetes Care & Education Specialists Civica Civica Rx CivicaRx CivicaScript JDRF podcast Source Type: blogs
Transforming diabetes education with “ AH-HA! ” moments
"AH-HA!" moments in diabetes education
Welcome to episode 2 of BDI Briefs! Our aim with BDI Briefs is to take a brief look at important issues about the emotional side of diabetes.In this short discussion, Scott, Bill, and Susan discuss innovative ways to transform diabetes education by creating “AH-HA!” moments in group education sessions. I also encourage you to look at more research from the Behavioral Diabetes Institute. Enjoy! And please let us know what you think and what you’d like to hear more about from BDI.And remember to s...
Source: Scott's Diabetes Blog - January 30, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes.
Communication Between Blood and Brain in Aging and Rejuvenation
https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/
As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inte...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reversine Increases Cell Plasticity, and Appears to Allow Some Cell Types to Escape Senescence
If I'm understanding the results presented here correctly, the reversine small molecule enables senescent cells to return to a more normal state of function, including replication, at least in muscle cells examined in cell culture. The researchers believe it is triggering some of the same reprogramming pathways as the Yamanaka factors, perhaps by inducing expression of Oct4, but are not yet certain as to what is going on under the hood. Is it a good idea to take senescent cells in the body and return them to normal function? That is a good question, and has been raised for other approaches to senescence reversal. At least ...
Source: Fight Aging! - January 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
