Implicating Cellular Senescence in the Fibrosis and Inflammation of NASH
Nonalcoholic steatohepatitis, NASH, is a condition characterized by chronic inflammation and fibrosis in the liver. Fibrosis is a malfunction of tissue maintenance, the deposition of excessive, scar-like collagen that disrupts tissue structure and function. Like all fibrotic diseases, means of effectively reversing the progression of NASH are presently lacking. NASH is a lifestyle condition, a consequence of fatty liver and obesity, but losing weight and otherwise changing lifestyle will not significantly reverse established fibrosis and loss of liver function. Where fibrosis and inflammation characterize a condition, we m...
Source: Fight Aging! - October 26, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Mark Cuban CostPlus Drug Company Is Distributing Roche Accu-Chek Testing Supplies
Taking a bit of a break from my recent podcast recommendations, but kind of an extension of the previous one about theMark Cuban CostPlus Drug Company, on October 11, 2022, Mark Cuban ' s startup known as the Mark Cuban CostPlus Drug Company ( " MCCPDC " , in different notices shared on Twitter, LinkedIn, Facebook, etc.) announced a partnership with Roche Diabetes Care to bring CostPlus Drugs patients to buy Accu-Chek testing supplies through them at a lower price. Thecost of buying Accu-Chek test strips from CostPlus is $16.79 for a quantity of 50 test strips. That works out to a cost of $0.34 per strip. Price-...
Source: Scott's Web Log - October 23, 2022 Category: Endocrinology Tags: 2022 Accu-Chek cash price costplus drug company mark cuban Roche Source Type: blogs
Podcast Recommendation: Global Healthy Living Foundation " How I Built This Lab With Guy Raz "
So, next up on my podcast recommendation (and incidentally, I should note that my recommendations are for specific podcast episodes, not necessarily all episodes within a given podcast, although you may also like subscribing to certain podcasts as the content tends to e similar to an episode I ' m recommending) is one I only occasionally listen to if the topic sounds interesting. The podcast episode I am recommending today is one created by NPR called the " How I Built This Lab With Guy Raz " podcast (Guy Raz is the name of the host) in which he interviewed billionaire Mark Cuban. Mr. Cuban was on this particular podc...
Source: Scott's Web Log - October 22, 2022 Category: Endocrinology Tags: costplus drug company how i built this lab mark cuban NPR podcast Source Type: blogs
Podcast Recommendation: " How I Built This Lab With Guy Raz "
So, next up on my podcast recommendation (and incidentally, I should note that my recommendations are for specific podcast episodes, not necessarily all episodes within a given podcast, although you may also like subscribing to certain podcasts as the content tends to be similar to an episode I ' m recommending) is one I only occasionally listen to if the topic sounds interesting. The podcast episode I am recommending today is one created by NPR called the " How I Built This Lab With Guy Raz " podcast (Guy Raz is the name of the host) in which he interviewed billionaire Mark Cuban. Mr. Cuban was on this particular pod...
Source: Scott's Web Log - October 22, 2022 Category: Endocrinology Tags: costplus drug company how i built this lab mark cuban NPR podcast Source Type: blogs
Podcast Recommendation: " How I Built This Lab With Guy Raz " Episode With Mark Cuban on His CostPlus Drug Co.
So, next up on my podcast recommendation (and incidentally, I should note that my recommendations are for specific podcast episodes, not necessarily all episodes within a given podcast, although you may also like subscribing to certain podcasts as the content tends to be similar to an episode I ' m recommending) is one I only occasionally listen to if the topic sounds interesting. The podcast episode I am recommending today is one created by NPR called the " How I Built This Lab With Guy Raz " podcast (Guy Raz is the name of the host) in which he interviewed billionaire Mark Cuban. Mr. Cuban was on this particular pod...
Source: Scott's Web Log - October 22, 2022 Category: Endocrinology Tags: costplus drug company how i built this lab mark cuban NPR podcast Source Type: blogs
Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Interventions Testing Program Results for Rapamycin and Arcabose in Combination
The Interventions Testing Program (ITP) at the National Institute on Aging (NIA) performs rigorous, expensive assessments of the ability of various (usually pharmaceutical) interventions to slow aging in mice. Conducting a study with rigor in this context means the use of large numbers of mice spread across multiple facilities, with careful control of the environment in order to minimize both known and unknown confounding factors in life span studies. Most of the interventions tested over the past twenty years of the ITP, on the basis of earlier studies suggesting that they may slow aging, in fact fail to extend life in mi...
Source: Fight Aging! - October 6, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Robotic Capsule Drills Intestinal Mucus to Deliver Protein Drugs
Engineers at MIT have collaborated to develop a robotic drug delivery capsule that is specially designed to administer delicate protein drugs, such as insulin, through the wall of the intestine. Proteins are not suited for oral delivery, as they are typically destroyed by the low pH in the intestine and they can’t pass through the mucus layer that lines the gastrointestinal tract.
Protecting protein drugs from the acidic environment and providing a way to traverse this mucus layer is the goal behind this latest technology. The capsule can be loaded with the protein and then once swallowed it becomes activated by ...
Source: Medgadget - October 5, 2022 Category: Medical Devices Authors: Conn Hastings Tags: GI Materials Medicine mit MITnews Source Type: blogs
Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging.
A Popular Science Article on the State of Epigenetic Clocks
https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/
This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rapamycin in Early Life Delays Development and Modestly Extends Life Span in Mice
As a general rule, 10% life extension in mice via metabolic alteration is uninteresting. It depends on the fine details, of course, but most age-slowing interventions so far discovered are in some way upregulating cellular stress response mechanisms, or adjusting growth hormone signaling. Neither of these approaches works anywhere near as well in long-lived mammals, such as our own species, as it does in short-lived mammals, such as mice, and in lower animal species. Short-lived species have life spans that are very plastic in response to environmental cues, such as the lack of nutrients that provoke greater stress respons...
Source: Fight Aging! - September 30, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Novo Nordisk Will Sell An Unbranded Version of Tresiba in the U.S.
Sometimes communicating the right message to the right party at the right time may result in a pleasantly unexpected thing happening!During this year ' s EASD which took place in Stockholm, Sweden (a beautiful city I ' ve visited more than a few times over the years), at the end of a Live Tweet event with Novo Nordisk Live@NovoNordiskLive, I shared a few thoughts which had been bothering me about Novo Nordisk ' s commitment to its U.S. unbranded insulin strategy (I described its commitment as " half-hearted " ), and I did so by sharing several slide images which I got directly from Novo Nordisk ' s quarterly investor prese...
Source: Scott's Web Log - September 29, 2022 Category: Endocrinology Tags: authorized generic insulin analogs 2022 authorized generics Inc. Novo Nordisk Pharma unbranded insulin Source Type: blogs
Oocyte Mitophagy in Reproductive Aging
We examined the requirements for mitochondrial fusion and fission in oocytes of both wild-type worms and the long-lived, long-reproducing insulin-like receptor mutant daf-2. We find that normal reproduction requires both fusion and fission, but that daf-2 mutants utilize a shift towards fission, but not fusion, to extend their reproductive span and oocyte health.
daf-2 mutant oocytes' mitochondria are punctate (fissioned) and this morphology is primed for mitophagy, as loss of the mitophagy regulator PINK-1 shortens daf-2's reproductive span. daf-2 mutants maintain oocyte mitochondria quality with age at least in pa...
Source: Fight Aging! - September 29, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - September 27, 2022.
Conclusions:This study revealed strong and consistent patterns of association between digital health literacy and the use of a web-based PHR. The results indicate potential actions for promoting PHR uptake, including improving digital technology and skill experiences that may improve digital health literacy and willingness to engage in web-based PHR. Uptake may also be improved through more responsive digital services, strengthened health care, and better social support. A holistic approach, including targeted solutions, is needed to ensure that web-based PHR can realize its full potential to help reduce health inequities....
Source: Australian Health Information Technology - September 27, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, September 26th 2022
This study examined the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. This was a UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78,430 of 103,684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021.
We found no minimal threshold for the beneficial association of step counts with incident dementia. Our findings suggest that approxima...
Source: Fight Aging! - September 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - September 20, 2022.
-----This weekly blog is to explore the news around the larger issues around Digital Health, data security, data privacy, AI / ML. technology, social media and any related matters.I will also try to highlightADHA Propagandawhen I come upon it.Just so we keep count, the latest Notes from the ADHA Board were dated 6 December, 2018 and we have seen none since! It ’s pretty sad!Note: Appearance here is not to suggest I see any credibility or value in what follows. I will leave it to the reader to decide what is worthwhile and what is not! The point is to let people know what is being said / published that I have come upon, a...
Source: Australian Health Information Technology - September 20, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
