How Can the Immune System Go Awry?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed.
The immune system is designed to closely monitor the body for signs of intruders that may cause infection. But what happens if it malfunctions? Overactive and underactive immune systems can both have negative effects on your health.
Autoimmune Disorders
To effectively monitor the body for pathogens, the adaptive immune system has to learn what a pathogen “looks like” on a molecular level. During their development, white blood cells go through training to learn how to differe...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Injury and Illness Diseases Immunology Miniseries Infectious Diseases Microbes Sepsis Source Type: blogs
Deconstructing diabetes stigma: A panel discussion
In conclusion, the discussion was an enriching and eye-opening event, bringing together passionate individuals dedicated to challenging the stigma around diabetes. By amplifying our voices and working together, we can make a lasting impact on the lives of those touched by diabetes.Visit enddiabetesstigma.org and become a part of the movement for change. If you’d like to get involved in spreading more awareness about this, reach out to Dennis and/or leave a comment here.
Full transcript and show notes
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Source: Scott's Diabetes Blog - January 4, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Taurine is a semi-essential amino acid. Dietary taurine supplementation has been shown to modestly slow aging in mice, though as for all such interventions there is always the question of whether it will prove to be less useful in humans, and also whether these results in mice will be disproved by the much more rigorous Interventions Testing Program (ITP), once that group gets around to assessing taurine supplementation. Few of the numerous interventions thought to modestly slow aging in mice on the basis of earlier research actually held up once subjected to the ITP degree of experimental rigor.
Speculatively, taur...
Source: Fight Aging! - December 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fibroblast Senescence in the Aging Dermis
A growing body of evidence points to a significant role for senescent cells in the aging of skin, including the work of some researchers who believe that changes that occur in skin over early adult life may be influenced by the presence of senescent cells. Skin is a large organ and its state of inflammation does influence the rest of the body. It remains to be seen as to whether presently available senolytic therapies can produce a meaningful effect on the burden of senescent cells in skin, and to what degree that will affect manifestations of skin aging in humans.
Skin aging is characterized by changes in its str...
Source: Fight Aging! - December 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Existing Geroprotective Drugs May Not Interact Well with Exercise
The big disadvantage of the geroprotective approach to aging, which is essentially to undertake the long-term use of supplements and small molecule drugs to alter metabolism in ways that slow aging over years and decades, is that distinct supplements and small molecules and adjustments tend to combine in unexpected ways. Short of testing every combination in laboratory species, something that Brian Kennedy's team has been working on, one can never know the outcome of combining a treatment. Based on presentations and interviews given by Kennedy in the last few years, the result of combining two geroprotectors that individua...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Ginger Vieira – Exercise with Type 1 Diabetes
In conclusion, Ginger Vieira’s book, Exercise with Type 1 Diabetes (affiliate link), is a must-read for anyone with diabetes who wants to incorporate exercise into their daily routine.
Ginger’s expertise and personal experiences make this book a valuable resource for understanding the impact of exercise on blood sugar levels and managing diabetes effectively.
With practical tips and a supportive approach, Ginger empowers readers to take control of their health and enjoy the benefits of exercise. Don’t miss out on this concise and informative guide! ...
Source: Scott's Diabetes Blog - December 20, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Age-Related Dysbiosis as a Contributing Cause of Delerium
Delerium is not an often discussed topic in the context of aging research, but it is an age-related occurrence, usually presenting in the old, particularly those suffering neurodegenerative conditions. Researchers here argue that the aged gut microbiome contributes meaningfully to risk of episodes of delerium. The balance of populations in the gut microbiome changes with age in detrimental ways, such as an increase in pro-inflammatory microbial species and a loss of those microbes that generate beneficial metabolites. It is now known that Alzheimer's and Parkinson's patients exhibit a distinctly different gut microbiome fr...
Source: Fight Aging! - December 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Abbott Gets Real About " Formulary Exclusions " Bankrolled by Rival Dexcom in the U.S.
My followers may recall that I ' ve written not-so-kind blog posts about how Dexcom paying legally-exempted rebate kickbacks (seehttps://blog.sstrumello.com/2023/06/dexcom-pays-pbms-kickbacks-to-exclude.html for one such blog post) to major Pharmacy Benefit Managers (PBMs) contingent upon " formulary exclusions of less costly rival continuous glucose monitoring (CGM) systems such as Abbott Freestyle Libre. The retail prices for both CGM sensor brands are remarkably close (ranging from $57.33/sensor to $61.28/sensor). However, the cost computation is not based on the cost per sensor, but must be computed on a cost per ...
Source: Scott's Web Log - December 14, 2023 Category: Endocrinology Tags: 2023 Abbott Freestyle Libre 3 coupons Dexcom PBM PBMs Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
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Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mari Ruddy and Extreme Healing
Today, I have the pleasure of sharing an incredibly inspiring conversation with one of my heroes, Mari Ruddy. If you are not familiar with Mari, buckle up – her story is one of profound resilience, strength, and healing. Like me, Mari lives with type 1 diabetes. She was diagnosed in 1981, and in addition to dealing with diabetes, Mari has also courageously overcome several other life challenges.
Mari discovered her love for distance cycling at the age of 39. TeamWILD, one of the organizations she created, played a crucial role in my journey, and it...
Source: Scott's Diabetes Blog - December 10, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
A Twin Study to Assess Short Term Cardiometabolic Health Benefits of a Vegan Diet
If you're familiar with discussion of veganism as a lifestyle choice, nothing in this material will all that surprising. Vegans tend towards lower calorie intake and the benefits resulting from that, and that may be the dominant effect when looking at commonly measured health metrics in vegan study participants. It would be interesting to see more comparison studies in which the vegans were held to the same calorie intake as the omnivore control participants, but, alas, that is logistically harder and thus not the approach chosen by most study organizers.
Although it's well-known that eating less meat improves car...
Source: Fight Aging! - December 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Longevity Industry Feature in Biopharma Dealmakers: Repair Biotechnologies, Deciduous Therapeutics, and More
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. (Source: Fight Aging!)
Source: Fight Aging! - December 4, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
