PDZ-Binding Kinase, a Novel Regulator of Vascular Remodeling in Pulmonary Arterial Hypertension
CONCLUSIONS: PBK is a newly described target for PAH that is upregulated in proliferating PA smooth muscle cells, where it contributes to proliferation through changes in cytokinesis and cell cycle dynamics to promote medial thickening, fibrosis, increased PA resistance, elevated right ventricular systolic pressure, right ventricular remodeling, and PH.PMID:38682326 | DOI:10.1161/CIRCULATIONAHA.123.067095 (Source: Circulation)
Source: Circulation - April 29, 2024 Category: Cardiology Authors: Zsuzsanna Bordan Robert Batori Stephen Haigh Xueyi Li Mary Louise Meadows Zach L Brown Madison A West Kunzhe Dong Weihong Han Yunchao Su Qian Ma Yuqing Huo Jiliang Zhou Mahmoud Abdelbary Jennifer Sullivan Neal L Weintraub David W Stepp Feng Chen Scott A B Source Type: research
Rapid examination of lung tissues by nonlinear microscopy
CONCLUSIONS: This study demonstrated that nonlinear microscopy readily replicates traditional H&E staining for both lung tumors and nonneoplastic pulmonary structures. Nonlinear microscopy provides many advantages over frozen section analysis and is an optical imaging platform that has the potential to augment rapid pathologic evaluation of resected tissues in the age of digital pathology.PMID:38682548 | DOI:10.1093/ajcp/aqae046 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Yue Sun Timothy D Weber James G Fujimoto Seymour Rosen Paul A VanderLaan Source Type: research
The Information Technology (IT) Infrastructure of the Multicenter Archipelago of Ovarian Cancer Research Biobank: A Potential Blueprint for Other Biobanks
Conclusion: The IT infrastructure of the AOCR biobank represents a new standard for biobanks, offering flexibility to handle diverse diseases and types of biomaterials. This infrastructure bypasses the need for disease-specific, custom-built software, thereby being cost- and time-effective while ensuring data quality and legislative compliance. The adaptability of this infrastructure highlights its potential to serve as a blueprint for the development of IT infrastructures in both new and existing biobanks.PMID:38682281 | DOI:10.1089/bio.2023.0118 (Source: Biopreservation and Biobanking)
Source: Biopreservation and Biobanking - April 29, 2024 Category: Biomedical Science Authors: Hein S Zelisse Sander de Ridder Mignon D J M van Gent Constantijne H Mom G Bea A Wisman Eva-Maria Roes Anna K L Reyners Jurgen M Piek Gatske M Nieuwenhuyzen-de Boer Christianne A R Lok Cornelis D de Kroon Loes F S Kooreman Marc-Jan Janssen Maurice Phm Jan Source Type: research
"It has to be better, otherwise we will get stuck." A Review of Novel Directions for Mental Health Reform and Introducing Pilot Work in the Netherlands
CONCLUSION: By embracing a social trial and leveraging digital platforms, the Dutch mental health care system can overcome challenges and provide more equitable, accessible, and high-quality care to individuals.PMID:38680529 | PMC:PMC11046893 | DOI:10.2174/0117450179271206231114064736 (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - April 29, 2024 Category: Psychiatry Authors: Jim van Os Floortje Scheepers Michael Milo Gijs Ockeloen Sinan Guloksuz Philippe Delespaul Source Type: research
Personalization above anonymization? A role for considering the humanity and spirituality of the dead in anatomical education
This article argues that considering the relevance of spirituality, and wha t endures of a donor's humanity after death, would enhance contemporary anatomy education and the ethical treatment of human body donors (and derivatives). In developing this argument, we (the authors) address the historical connection between spirituality and anatomy, including the anatomical locat ions of the soul. This serves as a basis for examining the role of the mimetic—or imitative—potential of deceased human donors as representations of the living. We deliberate on the ways in which the depersonalization and anonymization of those dona...
Source: Anatomical Sciences Education - April 29, 2024 Category: Anatomy Authors: Michelle D. Lazarus,
Peter Douglas,
Georgina C. Stephens Tags: DISCURSIVE ARTICLE Source Type: research
Client and staff perceptions of acceptability of MyCheck: a direct-to-pathology telehealth and e-testing service for comprehensive bloodborne virus and sexually transmissible infection screening
Lise Lafferty, Clinton Rautenbach, Anna McNulty, Nathan Ryder, Carolyn Slattery, Rebecca Houghton, Aurelie Kenigsberg, Carolyn Murray, Nigel Carrington, Prital Patel - Volume 21(3) Sydney Sexual Health Centre (SSHC) piloted MyCheck, a direct-to-pathology pathway that facilitated bloodborne virus/sexually transmissible infection testing at participating pathology collection centres located across New South Wales. This qualitative study sought to understand perspectives of acceptability of the MyCheck intervention among SSHC clients and providers’. The MyCheck intervention was perceived by both SSHC clients an...
Source: Sexual Health - April 29, 2024 Category: Sexual Medicine Authors: Lise Lafferty Clinton Rautenbach Anna McNulty Nathan Ryder Carolyn Slattery Rebecca Houghton Aurelie Kenigsberg Carolyn Murray Nigel Carrington Prital Patel Source Type: research
Childhood internalizing, externalizing and attention symptoms predict changes in social and nonsocial screen time
ConclusionChildren with psychiatric symptoms have different subsequent media use patterns, including higher rates of subsequent nonsocial engagement. Ensuring that ongoing data collection and analysis efforts attend to temporality and transitions in the relation between media use and psychiatric symptoms will accelerate progress in the field. (Source: Social Psychiatry and Psychiatric Epidemiology)
Source: Social Psychiatry and Psychiatric Epidemiology - April 29, 2024 Category: Psychiatry Source Type: research
Secondary analyses of sex differences in attention improvements across three clinical trials of a digital therapeutic in children, adolescents, and adults with ADHD
Attention-deficit/hyperactivity disorder (ADHD) remains underdiagnosed and undertreated in girls. Inattentive symptoms, often predominant in girls with ADHD, represent a key driver of impairment and often pers... (Source: BMC Public Health)
Source: BMC Public Health - April 29, 2024 Category: Consumer Health News Authors: Jessica E. Flannery, Stephen P. Hinshaw, Scott H. Kollins and Caitlin A. Stamatis Tags: Research Source Type: research
Clinical Decision Support for Surgery: A Mixed Methods Study on Design and Implementation Perspectives from Urologists
To assess urologist attitudes toward clinical decision support embedded into the electronic health record and define design needs to facilitate implementation and impact. With recent advances in big data and artificial intelligence, enthusiasm for personalized, data-driven tools to improve surgical decision-making has grown, but the impact of current tools remains limited. (Source: Urology)
Source: Urology - April 29, 2024 Category: Urology & Nephrology Authors: Hung-Jui Tan, Brooke N. Spratte, Allison M. Deal, Hillary M. Heiling, Elizabeth M. Nazzal, William Meeks, Raymond Fang, Randall Teal, B. Vu Maihan, Antonia V. Bennett, Susan Blalock, Arlene Chung, David Gotz, Matthew Nielsen, Daniel S. Reuland, Alex HS Ha Source Type: research
External correlates of adult digital problem-solving process: An empirical analysis of PIAAC PSTRE action sequences.
This study explores the utility of action sequence features in understanding how problem-solving behavior relates to cognitive proficiencies and demographic characteristics. This is empirically illustrated with the process data from the 2012 PIAAC PSTRE digital assessment. Regularized regression results showed that action sequence features are more predictive of examinees’ demographic and cognitive characteristics compared to final outcomes. Partial least squares analysis further aided the identification of behavioral patterns systematically associated with demographic/cognitive characteristics. (PsycInfo Database Record...
Source: Zeitschrift fur Psychologie - April 29, 2024 Category: Psychiatry & Psychology Source Type: research
How pregnant women with diabetes experience telemonitoring of the fetal heart rate – An interview study
In complicated pregnancies, the rising focus on telehealth has made foetal monitoring at home an alternative to hospitalization or frequent outpatient clinic visits [1]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 29, 2024 Category: OBGYN Authors: Ingrid Jepsen, Jane H. Nielsen, Stine A. Eriksen, Rikke D. Maimburg Tags: Full length article Source Type: research
How do coffee farmers engage with digital technologies? A capabilities perspective
This study points out the relevant role of situated ideas of development in positioning technologies in or out of the farm, and broader digitalization agendas in or out of farmers’ life projects. At the same time, it presents a critique of notions of universality that drive unquestioned quests for technification. In contrast, building on a relational perspective, this study calls for embracing a perspective of multiplicity within notions of development and innovation. (Source: Agriculture and Human Values)
Source: Agriculture and Human Values - April 29, 2024 Category: Food Science Source Type: research
Regional variations and sex-related differences of stiffness in human tracheal ligaments
ConclusionThese results reveal that there are regional and sex-related differences in the stiffness of human tracheal ligaments. (Source: Surgical and Radiologic Anatomy)
Source: Surgical and Radiologic Anatomy - April 29, 2024 Category: Anatomy Source Type: research
Clinical evaluation of droplet digital pcr for suspected ascites infection in patients with liver cirrhosis
ConclusionsddPCR, with appropriate panel design, has advantages in pathogen detection and clinical management of ascites infection, especially for patients with fungal and polymicrobial infections. Patients with atypical spontaneous bacterial peritonitis benefited more from ddPCR. (Source: Hepatology International)
Source: Hepatology International - April 29, 2024 Category: Infectious Diseases Source Type: research
Spinal Cord Injuries in Iraq: A Teleassessment Survey of the Survivors from 2017 to 2018 Islamic State of Iraq and Syria War
Telemedicine and e-Health, Ahead of Print. (Source: Telemedicine and e-Health)
Source: Telemedicine and e-Health - April 29, 2024 Category: Information Technology Authors: Munib Abdullah Fathe Faical Farhat Saad K. Karim Wassim Moalla Source Type: research
