A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
Cost-Effectiveness and Clinical Outcomes of Secondary Hyperparathyroidism Treatments in Patients with Chronic Kidney Disease
AbstractThe study addresses the challenge of treating secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients, focusing on the cost-effectiveness of surgical versus pharmacological interventions. Conducting a retrospective analysis on 152 CKD patients with SHPT at the Third People's Hospital of Chengdu, the study matched 80 patients into two groups: 40 undergoing parathyroidectomy with autotransplantation (PTX + AT) and 40 treated with calcimimetics. PTX + AT was more effective in alleviating symptoms, particularly bodily pain, and demonstrated greater cost-effectiveness over a long-term peri...
Source: Calcified Tissue International - February 20, 2024 Category: Orthopaedics Source Type: research
Multiple endocrine neoplasia type 2 - solving the puzzle
J Family Med Prim Care. 2023 Dec;12(12):3402-3405. doi: 10.4103/jfmpc.jfmpc_328_23. Epub 2023 Dec 21.ABSTRACTMultiple endocrine neoplasia (MEN) are tumors that involve two or more endocrine glands. It can also involve other organs and tissues as well. Out of the four types of MEN type 2 is the most common. In MEN type 2 or type 3, paraganglioma is rare, but in our case, medullary thyroid carcinoma (MTC), hyperparathyroidism, and pheochromocytoma were associated with the paraganglioma.PMID:38361883 | PMC:PMC10866221 | DOI:10.4103/jfmpc.jfmpc_328_23 (Source: Primary Care)
Source: Primary Care - February 16, 2024 Category: Primary Care Authors: Ajay K Jha Ashok Sunder Sridhar Pradhan Source Type: research
Multiple endocrine neoplasia type 2 - solving the puzzle
J Family Med Prim Care. 2023 Dec;12(12):3402-3405. doi: 10.4103/jfmpc.jfmpc_328_23. Epub 2023 Dec 21.ABSTRACTMultiple endocrine neoplasia (MEN) are tumors that involve two or more endocrine glands. It can also involve other organs and tissues as well. Out of the four types of MEN type 2 is the most common. In MEN type 2 or type 3, paraganglioma is rare, but in our case, medullary thyroid carcinoma (MTC), hyperparathyroidism, and pheochromocytoma were associated with the paraganglioma.PMID:38361883 | PMC:PMC10866221 | DOI:10.4103/jfmpc.jfmpc_328_23 (Source: Primary Care)
Source: Primary Care - February 16, 2024 Category: Primary Care Authors: Ajay K Jha Ashok Sunder Sridhar Pradhan Source Type: research
Carotid intima-media thickness in surgically or conservatively managed patients with primary hyperparathyroidism
CONCLUSION: Our results suggest that in postmenopausal PHPT patients subclinical atherosclerosis could be halted by PTx, whereas it worsens over time in not operated patients with milder disease.PMID:38345411 | DOI:10.1210/clinem/dgae053 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 12, 2024 Category: Endocrinology Authors: Vincenzo Carnevale Flavia Pugliese Cristina Eller-Vainicher Antonio S Salcuni Luciano Nieddu Iacopo Chiodini Alfredo Scillitani Source Type: research
Improvement of mood and sleep quality in patients with primary hyperparathyroidism after parathyroidectomy: A prospective case-control study
This study aims to assess the negative effects of mood and sleep on patients with primary hyperparathyroidism compared to healthy controls and analyze their improvement after surgery. (Source: Surgery)
Source: Surgery - February 12, 2024 Category: Surgery Authors: Beatriz Febrero, Juan Jos é Ruiz-Manzanera, Inmaculada Ros-Madrid, Adrián Vergara, José M. Rodríguez Source Type: research
Real ‐world data of Brazilian adults with X‐linked hypophosphatemia (XLH) treated with burosumab and comparison with other worldwide cohorts
ConclusionsThis study confirms the efficacy and safety of burosumab on XLH adult patients observed in clinical trials. Additionally, we observed a decrease in iPTH levels in patients with moderate to severe HPT at the baseline. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - February 10, 2024 Category: Genetics & Stem Cells Authors: Maria Helena Vaisbich,
Ant ônio César Paulillo de Cillo,
Bárbara Campolina C. Silva,
Catarina Brasil DÁlva,
Érico Higino de Carvalho,
Juliana M. C. M. de Almeida,
Larissa L. M. Marques,
Marcia Ribeiro,
Mauro Borghi M. da Silva,
Paula Frassin Tags: ORIGINAL ARTICLE Source Type: research
Some thoughts on surgery for primary hyperparathyroidism
Parathyroid surgery is an endless exercise of intelligence, enjoyment and … frustration. Even well-trained endocrine surgeons acknowledge that although straightforward parathyroidectomy (PTX) is the rule in, let's say, 90% of the cases, the remaining 10% can be a real challenge, not only from a technical point of view but also from the diagnostic, localization, genetics and postoperative aspects. I am pleased and honored to have been invited to write this introduction editorial and provide the reader with personal insights regarding some of the issues addressed in this comprehensive volume of the AJS on controversies and...
Source: American Journal of Surgery - February 10, 2024 Category: Surgery Authors: Antonio Sitges-Serra Tags: My Thoughts / My Surgical Practice Source Type: research
The clinical significance of calcium/magnesium ratio in primary hyperparathyroidism: unveiling a clinical association
CONCLUSION: Ca/Mg and cCa/Mg ratios in particular seem more valuable in determining the presence of nephrolithiasis than the currently used 24-h urine Ca measurement. Compared to urinary Ca measurements, they are cheaper, more practical, and more accessible.PMID:38332247 | DOI:10.1007/s42000-024-00530-5 (Source: Hormones)
Source: Hormones - February 9, 2024 Category: Endocrinology Authors: Ekin Yi ğit Köroğlu Abbas Ali Tam Sevg ül Fakı Belma Tural Balsak Fatma Ay ça Edis Özdemir Didem Özdemir Oya Topalo ğlu Reyhan Ersoy Bekir Çakır Source Type: research
Potential Role of Bone Metabolism Markers in Kidney Transplant Recipients
CONCLUSION: Kidney transplantation significantly improves mineral and bone disorders associated with end-stage kidney disease by modulating MBD markers and reducing bone metabolism markers, such as Dickkopf-related protein 1, osteoprotegerin, osteocalcin, osteopontin, and sclerostin. Moreover, the panel of bone biomarkers effectively predicted hypercalcemia and dyslipidemia in transplant recipients.PMID:38332694 | DOI:10.2174/0109298673250291231121052433 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Fl ávia Maria Borges Vigil Pedro Alves Soares Vaz de Castro Ursula Gramiscelli Hasparyk Vict ória Soares Bartolomei Ana Cristina Sim ões E Silva Source Type: research
Bilateral exploration in primary hyperparathyroidism: Double adenoma distribution and biochemical patterns over two decades
We investigated if anatomic patterns of abnormal parathyroid glands have ch anged for primary hyperparathyroidism (pHPT) as atypical biochemical presentation (normohormonal and normocalcemic) has increased. (Source: American Journal of Surgery)
Source: American Journal of Surgery - February 9, 2024 Category: Surgery Authors: Tim Beck, Gustavo Romero-Velez, Salem I. Noureldine, Gilman Plitt, Sarah Wang, Judy Jin Tags: Original Research Article Source Type: research
Which Localizing Strategy is the Most Cost-Effective in Reoperative Primary Hyperparathyroidism?
2%-10% of patients with primary hyperparathyroidism (PHPT) who undergo parathyroidectomy develop persistent/recurrent disease. The aim of this study was to determine which preoperative localization method is most cost-effective in reoperative PHPT. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - February 9, 2024 Category: Surgery Authors: Victor Gazivoda, Katherine M. Prioli, Albert C. Li, Laura Pizzi, Amanda M. Laird, Toni Beninato Tags: Endocrine Surgery Source Type: research
Four-Dimensional Computed Tomography for Parathyroid Adenoma Localization: A Pre-Operative Imaging Protocol
CONCLUSIONS: A 4D CT has impressive rates of accurate localization of parathyroid adenomas; however due to the radiation exposure involved, it should remain a second line imaging modality. PHPT patients should first be evaluated with USG, with 4D CT used if this is unsuccessful and patients are greater than 40 years old, have a high BMI, or are having revision surgery.PMID:38321924 | DOI:10.1177/00034894241230353 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - February 7, 2024 Category: ENT & OMF Authors: Nikhil Bellamkonda Julie Highland Hilary C McCrary Lauren Slattery Brody King Charles Teames Kaylee LeBaron Richard H Wiggins Dev Abraham Jason P Hunt Source Type: research
