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Hypovitaminosis D and hyperparathyroidism: a 5-year postoperative follow-up of 30,458 gastric bypass and sleeve gastrectomy patients
CONCLUSIONS: Previous studies alongside these results suggest that RYGB, more so than SG, may cause hypovitaminosis D and thereby hyperparathyroidism, which could lead to osteopenia. The threshold for 25-OH-D should be >75 nmol/L, and despite higher levels, current vitamin D supplementation may not be sufficient. Follow-up should include screening for hyperparathyroidism and hypovitaminosis D.PMID:38614927 | DOI:10.1016/j.soard.2024.02.004 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 13, 2024 Category: Surgery Authors: Katharina Stevens Hella Hultin Magnus Sundbom Source Type: research

Multiple and hereditary renal tumors: a review for radiologists
Radiologia (Engl Ed). 2024 Mar-Apr;66(2):132-154. doi: 10.1016/j.rxeng.2024.03.001. Epub 2024 Mar 23.ABSTRACT80% of renal carcinomas (RC) are diagnosed incidentally by imaging. 2-4% of "sporadic" multifocality and 5-8% of hereditary syndromes are accepted, probably with underestimation. Multifocality, young age, familiar history, syndromic data, and certain histologies lead to suspicion of hereditary syndrome. Each tumor must be studied individually, with a multidisciplinary evaluation of the patient. Nephron-sparing therapeutic strategies and a radioprotective diagnostic approach are recommended. Relevant data for the rad...
Source: Radiologia - April 13, 2024 Category: Radiology Authors: M Á Corral de la Calle J Encinas de la Iglesia G C Fern ández Pérez A Fraino M Repoll és Cobaleda Source Type: research

Tertiary hyperparathyroidism masking an atypical parathyroid tumor
Key Clinical MessageAtypical parathyroid tumors represent a group of parathyroid neoplasms of uncertain malignant potential. In view of preoperative diagnostic difficulties, suspicious features for malignancy may guide the surgeon to perform a radical surgical approach. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 13, 2024 Category: General Medicine Authors: Styliani Laskou, Ismini Kountouri, Eleni Paschou, Christos Topalidis, Paraskevi Axi, Georgios Petrakis, Christoforos Kosmidis, Konstantinos Sapalidis Tags: CASE REPORT Source Type: research

Pitfalls in the interpretation of parathyroid pathology
This article briefly describes the pathology of the parathyroid gland seen commonly in routine practice and the application of recent WHO terminologies in practice. The commonest clinical presentation is hypercalcaemia due to hyperparathyroidism. Diagnosis of parathyroid lesions requires the integration of clinical, biochemical, surgical and histopathological features. MDT discussion and optimized clinical information support the pathological features. Often, histological specimens require a detailed workup including processing the entire gland, further levels and sectioning, and ancillary testing. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 13, 2024 Category: Pathology Authors: Shonali Natu Tags: Mini-symposium: endocrine pathology Source Type: research

Evaluation of the thiazide challenge test to differentiate primary from hypercalciuria-related hyperparathyroidism
CONCLUSION: the TCT aids in discriminating patients with PHPT from those with SHPT-IH based on a rise in serum calcium. Other parameters are not different between both groups. Larger prospective trials are necessary to further define the diagnostic potential of the TCT, its most appropriate biochemical outcome variables, and decision cut-offs.PMID:38605120 | DOI:10.1210/clinem/dgae239 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2024 Category: Endocrinology Authors: Ewout Verly Bruno Lapauw Dr Charlotte Verroken Source Type: research

Disparities in the Treatment of Primary Hyperparathyroidism: A Scoping Review and Conceptual Model
We present a review of the current literature on disparities in the treatment of hyperparathyroidism, with a focus on gaps in knowledge and paths forward. (Source: American Journal of Surgery)
Source: American Journal of Surgery - April 11, 2024 Category: Surgery Authors: Alexander S. Chiu, Markayle Schears, Mary Hitchcock, Rebecca Sippel, Amy Kind Source Type: research

Analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory biomarkers in chronic kidney disease: impact of parathyroidectomy
CONCLUSION: N/L and P/L ratios are not reliable biomarkers of inflammation in SHPT patients undergoing PTX. Uremia, which induces a state of chronic inflammation in dialysis patients, and the use of immunosuppression in kidney transplant recipients are some of the confounding factors that prevent the use of this tool in clinical practice.PMID:38591824 | DOI:10.1590/2175-8239-JBN-2023-0175en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Andre Kakinoki Teng Eduardo Jorge Duque Shirley Ferraz Crispilho Wagner Domingues Vanda Jorgetti Luciene M Dos Reis Rosilene M Elias Rosa Maria Affonso Moys és Source Type: research

Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis
This study aims to evaluate the effects and mechanisms of capsiates in the treatment of secondary hyperparathyroidism. To achieve our research objectives, we conducted a study on patients' serum and examined changes in metabolic markers using serum metabolomics. We induced secondary hyperparathyroidism in rat through dietary intervention and divided them into four groups. The first group, referred to as the Parathyroid Hormone (PTH) group, received a low-calcium and high-phosphate diet (0.2% calcium, 1.2% phosphorus). The second group served as the control group, receiving a standard phosphate and calcium diet (0.6% calciu...
Source: J Cell Mol Med - April 9, 2024 Category: Molecular Biology Authors: Peiting Li Jianda Zhou Tianyin Wang Jun Li Wei Wu Source Type: research

Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis
This study aims to evaluate the effects and mechanisms of capsiates in the treatment of secondary hyperparathyroidism. To achieve our research objectives, we conducted a study on patients' serum and examined changes in metabolic markers using serum metabolomics. We induced secondary hyperparathyroidism in rat through dietary intervention and divided them into four groups. The first group, referred to as the Parathyroid Hormone (PTH) group, received a low-calcium and high-phosphate diet (0.2% calcium, 1.2% phosphorus). The second group served as the control group, receiving a standard phosphate and calcium diet (0.6% calciu...
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Peiting Li Jianda Zhou Tianyin Wang Jun Li Wei Wu Source Type: research