Comparison of normocalcemic versus hypercalcemic primary hyperparathyroidism in a hypercalciuric renal stone population
CONCLUSION: Our data show the relevance of dynamic tests to unmask NHPT in hypercalciuric renal stone patients.PMID:38497124 | DOI:10.1210/clinem/dgae162 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 18, 2024 Category: Endocrinology Authors: Halimi Caroline Bor Clemence Chieze Remi Saint-Jacques Camille P érié Sophie Wagner Isabelle Talbot Jean-Noel Montravers Fran çoise Letavernier Emmanuel Buob David Daudon Michel Frochot Vincent Haymann Jean-Philippe Source Type: research
Severe secondary hyperparathyroidism: an increasing problem in CKD but the best management option is still unknown
J Bras Nefrol. 2024 Apr-Jun;46(2):e2024E004. doi: 10.1590/2175-8239-JBN-2024-E004en.NO ABSTRACTPMID:38498844 | DOI:10.1590/2175-8239-JBN-2024-E004en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - March 18, 2024 Category: Urology & Nephrology Authors: Mark Kung Dah Tiong Nigel David Toussaint Source Type: research
Diagnostic Performance of 99mTc-Sestamibi SPECT/CT and
18F-Choline PET/CT in Locating Hyperfunctioning Parathyroid
Glands in Patients with Primary Hyperparathyroidism
Conclusion The results of our study showed the significant usefulness of
18F-choline PET/CT in patients with negative or inconclusive
results of 99mTc-sestamibi SPECT/CT in accurately locating
hyperfunctioning parathyroid glands in PHPT patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 18, 2024 Category: Endocrinology Authors: Mandic, Ante Kraljevic, Ivana Skoric Polovina, Tanja Zibar Tomsic, Karin Dusek, Tina Balasko, Annemarie Solak, Mirsala Kastelan, Darko Tags: Article Source Type: research
ASO Author Reflections: A Call for Updated Recommendations for Germline Mutation Testing in Patients with Primary Hyperparathyroidism
Ann Surg Oncol. 2024 Mar 15. doi: 10.1245/s10434-024-15192-1. Online ahead of print.NO ABSTRACTPMID:38488894 | DOI:10.1245/s10434-024-15192-1 (Source: Ann Oncol)
Source: Ann Oncol - March 15, 2024 Category: Cancer & Oncology Authors: Sophie Dream Patrick T Hangge Tracy S Wang Source Type: research
Identification of suitable reference genes for RT-qPCR studies in human parathyroid tissue glandular cells
This study aims to determine and compare the most stable to least stable genes for parathyroid tissue cells. 43 human parathyroid tissue obtained from primary and secondary hyperparathyroidism patients and glandular cells isolated enzymatically by removal of extracellular matrix components. After extraction of the total RNA, cDNA synthesis was performed, then qRT-PCR evaluated 14 candidate reference genes. Stability was determined by RefFinder software (Delta ct, BestKeeper, Genorm, and NormFinder algorithms), and the outcome was evaluated for five groups. Even if assessed with different groups, the most stable genes were ...
Source: Gene - March 15, 2024 Category: Genetics & Stem Cells Authors: Beyza Goncu Source Type: research
ASO Author Reflections: A Call for Updated Recommendations for Germline Mutation Testing in Patients with Primary Hyperparathyroidism
Ann Surg Oncol. 2024 Mar 15. doi: 10.1245/s10434-024-15192-1. Online ahead of print.NO ABSTRACTPMID:38488894 | DOI:10.1245/s10434-024-15192-1 (Source: Ann Oncol)
Source: Ann Oncol - March 15, 2024 Category: Cancer & Oncology Authors: Sophie Dream Patrick T Hangge Tracy S Wang Source Type: research
Identification of suitable reference genes for RT-qPCR studies in human parathyroid tissue glandular cells
This study aims to determine and compare the most stable to least stable genes for parathyroid tissue cells. 43 human parathyroid tissue obtained from primary and secondary hyperparathyroidism patients and glandular cells isolated enzymatically by removal of extracellular matrix components. After extraction of the total RNA, cDNA synthesis was performed, then qRT-PCR evaluated 14 candidate reference genes. Stability was determined by RefFinder software (Delta ct, BestKeeper, Genorm, and NormFinder algorithms), and the outcome was evaluated for five groups. Even if assessed with different groups, the most stable genes were ...
Source: Gene - March 15, 2024 Category: Genetics & Stem Cells Authors: Beyza Goncu Source Type: research
Biochemical characteristics and clinical manifestation of normocalcemic primary hyperparathyroidism
ConclusionThe patients with nPHPT show a more favorable biochemical profile compared to those with hPHPT. Nevertheless, clinical manifestations and complications are similar, without a significant difference in the frequency of osteoporosis, nephrolithiasis, gastrointestinal disorders and low-energy fractures. (Source: Endocrine)
Source: Endocrine - March 15, 2024 Category: Endocrinology Source Type: research
Abnormalities of serum magnesium levels in dialysis patients undergoing parathyroidectomy
In conclusion, magnesium abnormalities play a minor role in hungry bone syndrome after parathyroidectomy for secondary hyperparathyroidism. Patients with higher serum magnesium levels had greater severity of pruritus. (Source: Updates in Surgery)
Source: Updates in Surgery - March 13, 2024 Category: Surgery Source Type: research
Metastatic Calcification from Secondary Hyperparathyroidism
Am J Med Sci. 2024 Mar 7:S0002-9629(24)01115-7. doi: 10.1016/j.amjms.2024.03.007. Online ahead of print.NO ABSTRACTPMID:38460923 | DOI:10.1016/j.amjms.2024.03.007 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 9, 2024 Category: General Medicine Authors: Kai Cheng Jun Li Xiaoming Liu Source Type: research
Metastatic Calcification from Secondary Hyperparathyroidism
Am J Med Sci. 2024 Mar 7:S0002-9629(24)01115-7. doi: 10.1016/j.amjms.2024.03.007. Online ahead of print.NO ABSTRACTPMID:38460923 | DOI:10.1016/j.amjms.2024.03.007 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 9, 2024 Category: General Medicine Authors: Kai Cheng Jun Li Xiaoming Liu Source Type: research
The Role of Demographic and Clinical Factors in Germline Mutation Testing for Patients with Primary Hyperparathyroidism
CONCLUSIONS: Most patients with onset of hypercalcemia age ≤ 40 years, positive FHx, or other clinical concerns underwent genetic counseling, while most with MGD did not. As no germline mutations were identified in patients with MGD alone, further investigation of MGD as a sole indication for genetic counseling may be warranted.PMID:38459417 | DOI:10.1245/s10434-024-15104-3 (Source: Ann Oncol)
Source: Ann Oncol - March 8, 2024 Category: Cancer & Oncology Authors: Patrick T Hangge Sophie Dream Tina W F Yen Kara Doffek Samantha M Stachowiak Joseph Shaker Douglas B Evans Tracy S Wang Source Type: research
Unveiling the Hidden Stroke Threat in Patients with Atrial Fibrillation and Primary Hyperparathyroidism
In conclusion, this study highlights a marked association between PHPT and ischemic stroke in AF patients independent of the conventional CHA2DS2-VASc score. The potential mechanisms implicated include vascular changes, cardiac dysfunction, and coagulation cascade alterations. The presence of primary hyperparathyroidism should be taken into consideration when deciding the assessment of thromboembolic risk.PMID:38452840 | DOI:10.1016/j.amjcard.2024.03.003 (Source: Atherosclerosis)
Source: Atherosclerosis - March 7, 2024 Category: Cardiology Authors: Georges Khattar Samer Asmar Elie Bou Sanayeh Praneeth Keesari Wissam Rahi Fouad Sakr Michel Khoury Michael Cinelli Samantha Lee Mitchell Weinberg Marcin Kowalski Valay Parikh Source Type: research
Numerous osteoclasts and osteoblasts in the bone marrow due to hyperparathyroidism
Int J Hematol. 2024 Mar 6. doi: 10.1007/s12185-024-03742-y. Online ahead of print.NO ABSTRACTPMID:38446380 | DOI:10.1007/s12185-024-03742-y (Source: International Journal of Hematology)
Source: International Journal of Hematology - March 6, 2024 Category: Hematology Authors: Yi Feng Tao Wang Source Type: research
