The efficacy and safety of hydroxychloroquine versus leflunomide in patients with IgA nephropathy: a single-center experience
CONCLUSION: Both hydroxychloroquine combined with a renin-angiotensin system inhibitor and leflunomide combined with a renin-angiotensin system inhibitor were more effective than a renin-angiotensin system inhibitor alone in improving proteinuria in IgAN patients. Hydroxychloroquine was more effective in reducing proteinuria, and leflunomide showed superiority in reducing hematuria. Our results need to be verified in large-scale randomized controlled trials.PMID:38225440 | DOI:10.1007/s40620-023-01839-x (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 15, 2024 Category: Urology & Nephrology Authors: Wei-Jie He Juan Wang Nan Liu Gu-Yue Li Xin-Wang Zhu Li Yao Lin-Lin Liu Source Type: research
Zinc complexes of chloroquine and hydroxychloroquine versus the mixtures of their components: Structures, solution equilibria/speciation and cellular zinc uptake
J Inorg Biochem. 2024 Mar;252:112478. doi: 10.1016/j.jinorgbio.2024.112478. Epub 2024 Jan 3.ABSTRACTThe zinc complexes of chloroquine (CQ; [Zn(CQH+)Cl3]) and hydroxychloroquine (HO-CQ; [Zn(HO-CQH+)Cl3]) were synthesized and characterized by X-Ray structure analysis, FT-IR, NMR, UV-Vis spectroscopy, and cryo-spray mass spectrometry in solid state as well as in aqueous and organic solvent solutions, respectively. In acetonitrile, up to two Zn2+ ions bind to CQ and HO-CQ through the tertiary amine and aromatic nitrogen atoms (KN-aminCQ = (3.8 ± 0.5) x 104 M-1 and KN-aromCQ = (9.0 ± 0.7) x 103 M-1 for CQ, and KN-aminHO-CQ = ...
Source: Journal of Inorganic Biochemistry - January 13, 2024 Category: Biochemistry Authors: Andrea Squarcina Alicja Franke Laura Senft Constantin Onderka Jens Langer Thibaut Vignane Milos R Filipovic Peter Grill Bernhard Michalke Ivana Ivanovi ć-Burmazović Source Type: research
Effectiveness of Drug Repurposing and Natural Products Against SARS-CoV-2: A Comprehensive Review
Clin Pharmacol. 2024 Jan 4;16:1-25. doi: 10.2147/CPAA.S429064. eCollection 2024.ABSTRACTThe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a betacoronavirus responsible for the COVID-19 pandemic, causing respiratory disorders, and even death in some individuals, if not appropriately treated in time. To face the pandemic, preventive measures have been taken against contagions and the application of vaccines to prevent severe disease and death cases. For the COVID-19 treatment, antiviral, antiparasitic, anticoagulant and other drugs have been reused due to limited specific medicaments for the disease. Drug r...
Source: Clinical Pharmacology: Advances and Applications - January 10, 2024 Category: Allergy & Immunology Authors: Paula Andrea Vel ásquez Juan C Hernandez Elkin Galeano Jaime Hincapi é-García Mar ía Teresa Rugeles Wildeman Zapata-Builes Source Type: research
A temporary regulation to manage an impending shortage due to extraordinary prescribing patterns of chloroquines observed during early phase of COVID-19 epidemic
CONCLUSION: After an observed increase in prescriptions of C/HC, a temporary regulation was introduced on 2nd April 2020 to reduce prescriptions from specialists not usually prescribing C/HC to avoid shortages for patients within approved indications. Subsequently, dispensed prescriptions decreased from April and remained at pre-COVID-19 levels thereafter.PMID:38188250 | PMC:PMC10770639 | DOI:10.48101/ujms.v128.10033 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - January 8, 2024 Category: General Medicine Authors: Karl-Mikael K älkner Anders Sundstr öm Maria Juhasz Haverinen Kenneth Nordback Veronica Arthurson Bj örn Zethelius Rickard Ljung Source Type: research
A temporary regulation to manage an impending shortage due to extraordinary prescribing patterns of chloroquines observed during early phase of COVID-19 epidemic
CONCLUSION: After an observed increase in prescriptions of C/HC, a temporary regulation was introduced on 2nd April 2020 to reduce prescriptions from specialists not usually prescribing C/HC to avoid shortages for patients within approved indications. Subsequently, dispensed prescriptions decreased from April and remained at pre-COVID-19 levels thereafter.PMID:38188250 | PMC:PMC10770639 | DOI:10.48101/ujms.v128.10033 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - January 8, 2024 Category: General Medicine Authors: Karl-Mikael K älkner Anders Sundstr öm Maria Juhasz Haverinen Kenneth Nordback Veronica Arthurson Bj örn Zethelius Rickard Ljung Source Type: research
Enteritis: a window to the diagnosis of systemic lupus erythematosus in an adolescent girl: case report
CONCLUSION: This case emphasises the need for healthcare providers to be alert to the possibility of lupus enteritis. It also highlights the importance of close follow-up of cases who have non-specific gastro-intestinal symptoms. Lupus enteritis should be considered in the differential diagnosis of recurrent non-specific gastro-intestinal symptoms in children, especially adolescents, to ensure timely diagnosis and treatment.Abbreviations: ACR American College of Rheumatology; ANA anti-nuclear antibody; CRP: C-reactive protein; CT: computerised tomography; CECT: contrast-enhanced computerised tomography; EULAR: European Lea...
Source: Paediatrics and international child health - January 7, 2024 Category: Pediatrics Authors: Ashray Patel Shilpa Krishnapura Lakshminarayana Dhanalakshmi Kumble Mallesh Kariyappa Gautham Ramkumar H Anilkumar Sagar Bhattad Source Type: research
Aerosol Delivery and Spatiotemporal Tissue Distribution of Hydroxychloroquine in Rat Lung
Eur J Pharm Sci. 2024 Jan 4:106693. doi: 10.1016/j.ejps.2024.106693. Online ahead of print.ABSTRACTInhalation enables the delivery of drugs directly to the lung, increasing the retention for prolonged exposure and maximizing the therapeutic index. However, the differential regional lung exposure kinetics and systemic pharmacokinetics are not fully known, and their estimation is critical for pulmonary drug delivery. The study evaluates the pharmacokinetics of hydroxychloroquine in different regions of the respiratory tract for multiple routes of administration. We also evaluated the influence of different inhaled formulatio...
Source: European Journal of Pharmaceutical Sciences - January 6, 2024 Category: Drugs & Pharmacology Authors: Wenhao Xia Aditya R Kolli Arkadiusz K Kuczaj Justyna Szostak Sharon Lam Wei Wen Toh Asef Purwanti Wei Teck Tan Raymond Ng Blaine Phillips Manuel C Peitsch Julia Hoeng Source Type: research
Adverse cutaneous reaction to hydroxychloroquine in a patient with anti-SAE-1-positive dermatomyositis and a history of diffuse large B-cell lymphoma
This report highlights the utility of the myositis-specific antibody panel to guide diagnosis and management, as well as the potential for developing dermatomyositis years after a lymphoma diagnosis.PMID:38174019 | PMC:PMC10761009 | DOI:10.1080/08998280.2023.2274231 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - January 4, 2024 Category: Universities & Medical Training Authors: Corley Pruneda Soumya A Reddy Hannah Buckingham Michelle Tarbox Source Type: research
Retraction for Angelakis et al., "Abnormal Weight Gain and Gut Microbiota Modifications Are Side Effects of Long-Term Doxycycline and Hydroxychloroquine Treatment"
Antimicrob Agents Chemother. 2024 Jan 4:e0150923. doi: 10.1128/aac.01509-23. Online ahead of print.NO ABSTRACTPMID:38174939 | DOI:10.1128/aac.01509-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - January 4, 2024 Category: Microbiology Authors: American Society for Microbiology Source Type: research
Retinal Vasculitis in a Patient with Rhupus
Ocul Immunol Inflamm. 2024 Jan 4:1-3. doi: 10.1080/09273948.2023.2295533. Online ahead of print.ABSTRACTThis case report describes a case of retinal vasculitis in a patient with Rhupus, which has not been reported earlier in the literature. A 39-year-old female patient with a history of Rhupus presented with sudden vision loss in her left eye. The patient was treated earlier, for her polyarthritis, with oral corticosteroids, hydroxychloroquine, and oral methotrexate, which were discontinued after 1 year of treatment. At presentation, fundus examination of the left eye revealed mild vitritis, perivenous sheathing, and hemor...
Source: Ocular Immunology and Inflammation - January 4, 2024 Category: Allergy & Immunology Authors: Harshali Kamat Ashad Sivaraman Mithun C B Parthopratim Dutta Majumder Source Type: research
Adverse cutaneous reaction to hydroxychloroquine in a patient with anti-SAE-1-positive dermatomyositis and a history of diffuse large B-cell lymphoma
This report highlights the utility of the myositis-specific antibody panel to guide diagnosis and management, as well as the potential for developing dermatomyositis years after a lymphoma diagnosis.PMID:38174019 | PMC:PMC10761009 | DOI:10.1080/08998280.2023.2274231 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - January 4, 2024 Category: Universities & Medical Training Authors: Corley Pruneda Soumya A Reddy Hannah Buckingham Michelle Tarbox Source Type: research
Retraction for Angelakis et al., "Abnormal Weight Gain and Gut Microbiota Modifications Are Side Effects of Long-Term Doxycycline and Hydroxychloroquine Treatment"
Antimicrob Agents Chemother. 2024 Jan 4:e0150923. doi: 10.1128/aac.01509-23. Online ahead of print.NO ABSTRACTPMID:38174939 | DOI:10.1128/aac.01509-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - January 4, 2024 Category: Microbiology Authors: American Society for Microbiology Source Type: research
Adverse cutaneous reaction to hydroxychloroquine in a patient with anti-SAE-1-positive dermatomyositis and a history of diffuse large B-cell lymphoma
This report highlights the utility of the myositis-specific antibody panel to guide diagnosis and management, as well as the potential for developing dermatomyositis years after a lymphoma diagnosis.PMID:38174019 | PMC:PMC10761009 | DOI:10.1080/08998280.2023.2274231 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - January 4, 2024 Category: Universities & Medical Training Authors: Corley Pruneda Soumya A Reddy Hannah Buckingham Michelle Tarbox Source Type: research
