Therapeutic management of fibrosis in systemic sclerosis patients - an analysis from the Swiss EUSTAR cohort
CONCLUSION: Overall, in Switzerland, a wide range of medications is prescribed for systemic sclerosis patients. This includes modern, targeted treatments for which randomised controlled clinical trial have been recently reported.PMID:38579324 | DOI:10.57187/s.3630 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Kevin Windirsch Suzana Jordan Mike Oliver Becker Cosimo Bruni Rucsandra Dobrota Muriel Elhai Ion-Alexandru Garaiman Carmen-Marina Mihai Michele Iudici Paul Hasler Camillo Ribi Britta Maurer Armando Gabrielli Anna-Maria Hoffmann-Vold Oliver Distler Source Type: research

A crossover study to evaluate the pharmacokinetics and bioequivalence of hydroxychloroquine tablets in healthy Chinese subjects
CONCLUSION: The investigation demonstrated that the test and reference preparations are bioequivalent and well tolerated under both fasting and fed conditions in healthy Chinese subjects.PMID:38577751 | DOI:10.5414/CP204406 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 5, 2024 Category: Drugs & Pharmacology Authors: Jie Feng Shuang-Yu Kuang Jun-Han Wan Rong Li Yi-Jie Zhu Bei-Lei Cai Lei Guan Zheng Zhang Source Type: research

A crossover study to evaluate the pharmacokinetics and bioequivalence of hydroxychloroquine tablets in healthy Chinese subjects
CONCLUSION: The investigation demonstrated that the test and reference preparations are bioequivalent and well tolerated under both fasting and fed conditions in healthy Chinese subjects.PMID:38577751 | DOI:10.5414/CP204406 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 5, 2024 Category: Drugs & Pharmacology Authors: Jie Feng Shuang-Yu Kuang Jun-Han Wan Rong Li Yi-Jie Zhu Bei-Lei Cai Lei Guan Zheng Zhang Source Type: research

A crossover study to evaluate the pharmacokinetics and bioequivalence of hydroxychloroquine tablets in healthy Chinese subjects
CONCLUSION: The investigation demonstrated that the test and reference preparations are bioequivalent and well tolerated under both fasting and fed conditions in healthy Chinese subjects.PMID:38577751 | DOI:10.5414/CP204406 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 5, 2024 Category: Drugs & Pharmacology Authors: Jie Feng Shuang-Yu Kuang Jun-Han Wan Rong Li Yi-Jie Zhu Bei-Lei Cai Lei Guan Zheng Zhang Source Type: research

Therapeutic management of fibrosis in systemic sclerosis patients - an analysis from the Swiss EUSTAR cohort
CONCLUSION: Overall, in Switzerland, a wide range of medications is prescribed for systemic sclerosis patients. This includes modern, targeted treatments for which randomised controlled clinical trial have been recently reported.PMID:38579324 | DOI:10.57187/s.3630 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Kevin Windirsch Suzana Jordan Mike Oliver Becker Cosimo Bruni Rucsandra Dobrota Muriel Elhai Ion-Alexandru Garaiman Carmen-Marina Mihai Michele Iudici Paul Hasler Camillo Ribi Britta Maurer Armando Gabrielli Anna-Maria Hoffmann-Vold Oliver Distler Source Type: research

A crossover study to evaluate the pharmacokinetics and bioequivalence of hydroxychloroquine tablets in healthy Chinese subjects
CONCLUSION: The investigation demonstrated that the test and reference preparations are bioequivalent and well tolerated under both fasting and fed conditions in healthy Chinese subjects.PMID:38577751 | DOI:10.5414/CP204406 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 5, 2024 Category: Drugs & Pharmacology Authors: Jie Feng Shuang-Yu Kuang Jun-Han Wan Rong Li Yi-Jie Zhu Bei-Lei Cai Lei Guan Zheng Zhang Source Type: research

Accelerated hydroxychloroquine toxic retinopathy (response to letter)
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 5, 2024 Category: Opthalmology Source Type: research

Membranous lupus nephritis secondary to secukinumab therapy: A case report and literature review
We report the case of a 57-year-old man who developed membranous lupus nephritis after secukinumab treatment for psoriasis. Anti-SSA and PM-Scl antibodies were positive. dsDNA, anti-Smith, and anti-histone antibodies were negative, and serum complement was low. Secukinumab was discontinued, while tacrolimus was initiated, subsequently switched to cyclosporin, belimumab, glucocorticosteroid, and hydroxychloroquine with a good response. The relationship between lupus erythematosus and IL-17 inhibition requires further research.PMID:38569663 | DOI:10.1177/09612033241242698 (Source: Lupus)
Source: Lupus - April 3, 2024 Category: Rheumatology Authors: Yi Zhou Zhangxue Hu Source Type: research

From Prescription to Predicament: Hydroxychloroquine (HCQ)-Induced Cardiogenic Shock (CS)
We present a case of biopsy-proven HCQ-induced CS successfully managed with tMCS as a bridge to recovery. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Al-Busaidi, R. Gilead, D.H. Brahmbhatt, Y. Xie, N. Aleksova, A. Luk, J. Duero Posada, Y. Moayedi, M.A. Seidman, M. Laflamme, R.J. Cusimano, J. Alvarez, E. Fan, H. Faghfoury, F. Billia Source Type: research

End-Stage Heart Failure After Hydroxychloroquine Exposure in a Teenager
We present the first report of HCQ-induced heart failure (HF) in a paediatric patient. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Power, D.M. Levy, A. Nagy, C. Haller, L.R. Brandao, O. Zaulan, B. Langanecha, A. Maurich, K. George, L. Fazari, A. Jeewa Source Type: research

Exome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathy
Eye, Published online: 28 March 2024; doi:10.1038/s41433-024-03044-xExome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathy (Source: Eye)
Source: Eye - March 28, 2024 Category: Opthalmology Authors: Hsun-I Chiu Hui-Chen Cheng Chih-Chiau Wu Shih-Jen Chen De-Kuang Hwang Yi-Ming Huang Yu-Bai Chou Po-Kang Lin Tai-Chi Lin Ko-Hua Chen Pei-Yu Lin Yu-Fan Chang An-Guor Wang Source Type: research

Necrotizing Parasagittal Meningioma in Patient with Systemic Lupus Erythematosus after Treatments with Methotrexate and Hydroxychloroquine
Discussions Necrotizing of small and benign meningioma is rarely found but otherwise interesting. The cause of this phenomenon is not yet understood thoroughly. In this case, we suspected various possible causes such as vasculitis interrupting blood supply, use of immunosuppressive drugs such as hydroxychloroquine or methotrexate, or, less likely, latent infections in the immunocompromised patient. Despite the lack of more evidence supports, this finding encourages further study of nonsurgical or salvage treatment of inoperable meningioma, so sequalae after refractory recurrences of meningioma can be prevented, and patie...
Source: Journal of Neurological Surgery Reports - March 28, 2024 Category: Neurosurgery Authors: Wangapakul, Thitikan Moguel, Ambar Elizabeth Riley Kayssi, Abdel Raouf Tags: Case Report Source Type: research

Case report: Systemic lupus erythematosus combined with myocardial hypertrophy
CONCLUSION: Myocardial hypertrophy may be an important sign of active and prognostic assessment in SLE diagnosis and management. Similarly, when encountering cases of myocardial hypertrophy, the possibility of autoimmune disease should be considered in addition to common causes.PMID:38533913 | DOI:10.1002/iid3.1214 (Source: Atherosclerosis)
Source: Atherosclerosis - March 27, 2024 Category: Cardiology Authors: Shanshan Wang Xinfeng Wei Wenqing Yang Dan Zhang Source Type: research

Case report: Systemic lupus erythematosus combined with myocardial hypertrophy
ConclusionMyocardial hypertrophy may be an important sign of active and prognostic assessment in SLE diagnosis and management. Similarly, when encountering cases of myocardial hypertrophy, the possibility of autoimmune disease should be considered in addition to common causes. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 27, 2024 Category: Allergy & Immunology Authors: Shanshan Wang, Xinfeng Wei, Wenqing Yang, Dan Zhang Tags: SHORT REPORT Source Type: research