Modulating the antibacterial effect of the existing antibiotics along with repurposing drug metformin
This study suggest Metformin and other experimented drugs can be used as adjuvants boost up antibiosis but further study is needed to find out the safety and efficacy of this non-antibiotic drug as potent antibiotic adjuvant.PMID:38519821 | DOI:10.1007/s00203-024-03917-5 (Source: Archives of Microbiology)
Source: Archives of Microbiology - March 23, 2024 Category: Microbiology Authors: Md Omar Faruqe Source Type: research
Look after the COVID ‐19 pandemic: Mortality rates among patients with rheumatic diseases
ConclusionCOVID-19 is a serious infection and the current study emphasized that patients with rheumatic diseases had increased mortality rates, particularly in patients who were old, male, and on immunosuppressive treatments. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 22, 2024 Category: Rheumatology Authors: Ezgi Çimen Güneş,
Seda Çolak,
Zeynep B. Şenlik,
Emre Tekgöz,
Kerime Altunay,
Tuğba Özdemirkan,
Baran C. Aytaç,
Asiye Ç. Şimşek,
Muhammet Çınar,
Sedat Yılmaz Tags: ORIGINAL ARTICLE Source Type: research
Initiation of belimumab with higher daily prednisolone is effective for rapid glucocorticoid reduction: A 96-week retrospective study
CONCLUSIONS: Our study showed that a delay in belimumab initiation led to higher SLEDAI-2K score and difficulty in achieving a 50% GC reduction at 96 weeks. Since GC-related adverse events increase with long-term administration of GC though with small daily doses, we proposed here that belimumab should be started in combination with higher daily prednisolone.PMID:38509864 | DOI:10.1177/09612033241240859 (Source: Lupus)
Source: Lupus - March 21, 2024 Category: Rheumatology Authors: Takashi Yamane Akira Hashiramoto Source Type: research
Hydroxychloroquine interaction with phosphoinositide 3-kinase modulates prostate cancer growth in bone microenvironment: In vitro and molecular dynamics based approach
Int J Biol Macromol. 2024 Mar 19:130912. doi: 10.1016/j.ijbiomac.2024.130912. Online ahead of print.ABSTRACTPatients with advanced prostate cancer (PCa) are more likely to develop bone metastases. Tumor cells thrive in the bone microenvironment, interacting with osteoblasts and osteoclasts. Given the PI3K/AKT pathway's metastatic potential and signal integration's ability to modulate cell fates in PCa development, drugs targeting this system have great therapeutic promise. Hydroxychloroquine (HCQ) is an anti-malarial medication commonly used to treat clinical conditions such as rheumatology and infectious disorders. We exp...
Source: International Journal of Biological Macromolecules - March 21, 2024 Category: Biochemistry Authors: K M Abdullah Gunjan Sharma Faizan Abul Qais Imran Khan Simran Takkar Jyoti B Kaushal Ranjana Kanchan Tarique Sarwar Bandana Chakravarti Jawed A Siddiqui Source Type: research
Retraction Note: Do Zinc Supplements Enhance the Clinical Efficacy of Hydroxychloroquine?: A Randomized, Multicenter Trial
Biol Trace Elem Res. 2024 Mar 21. doi: 10.1007/s12011-024-04150-3. Online ahead of print.NO ABSTRACTPMID:38512453 | DOI:10.1007/s12011-024-04150-3 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - March 21, 2024 Category: Biology Authors: Sherief Abd-Elsalam Shaimaa Soliman Eslam Saber Esmail Mai Khalaf Ehab F Mostafa Mohammed A Medhat Ossama Ashraf Ahmed Mohamed Samir Abd El Ghafar Mohamed Alboraie Sahar M Hassany Source Type: research
Hydroxychloroquine interaction with phosphoinositide 3-kinase modulates prostate cancer growth in bone microenvironment: In vitro and molecular dynamics based approach
Int J Biol Macromol. 2024 Mar 19:130912. doi: 10.1016/j.ijbiomac.2024.130912. Online ahead of print.ABSTRACTPatients with advanced prostate cancer (PCa) are more likely to develop bone metastases. Tumor cells thrive in the bone microenvironment, interacting with osteoblasts and osteoclasts. Given the PI3K/AKT pathway's metastatic potential and signal integration's ability to modulate cell fates in PCa development, drugs targeting this system have great therapeutic promise. Hydroxychloroquine (HCQ) is an anti-malarial medication commonly used to treat clinical conditions such as rheumatology and infectious disorders. We exp...
Source: Mol Biol Cell - March 21, 2024 Category: Molecular Biology Authors: K M Abdullah Gunjan Sharma Faizan Abul Qais Imran Khan Simran Takkar Jyoti B Kaushal Ranjana Kanchan Tarique Sarwar Bandana Chakravarti Jawed A Siddiqui Source Type: research
Initiation of belimumab with higher daily prednisolone is effective for rapid glucocorticoid reduction: A 96-week retrospective study
CONCLUSIONS: Our study showed that a delay in belimumab initiation led to higher SLEDAI-2K score and difficulty in achieving a 50% GC reduction at 96 weeks. Since GC-related adverse events increase with long-term administration of GC though with small daily doses, we proposed here that belimumab should be started in combination with higher daily prednisolone.PMID:38509864 | DOI:10.1177/09612033241240859 (Source: Lupus)
Source: Lupus - March 21, 2024 Category: Rheumatology Authors: Takashi Yamane Akira Hashiramoto Source Type: research
UCOMB-real life data: treatment strategies for chronic urticaria patients with comorbidities
CONCLUSIONS: Combining treatment modalities for chronic urticaria and comorbidities are available and feasible with a good safety profile.PMID:38508226 | DOI:10.1080/09546634.2024.2329784 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 20, 2024 Category: Dermatology Authors: Petra Staubach Benedikt Bilo Joachim W Fluhr Karoline Krause Kanokvalai Kulthanan Andac Salman Connie Katelaris Jonathan A Bernstein Marcus Maurer Caroline Mann Source Type: research
COVID ‐19 in patients with Down syndrome: A systematic review
ConclusionMore studies are needed to better understand COVID-19 infections among persons with DS. In addition, the study was limited by a lack of statistical analyses and a specific comparison group. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 20, 2024 Category: Allergy & Immunology Authors: Praveen N. K. Pitchan Velammal,
Suryakumar Balasubramanian,
Fathima Shehnaz Ayoobkhan,
Gautham V. K. Mohan,
Pearl Aggarwal,
Ali A. Rabaan,
Syed A. Khan,
Farah Yasmin,
Thoyaja Koritala,
Salim R. Surani Tags: REVIEW ARTICLE Source Type: research
Case report: A case of resistant anti ‐SAE1 dermatomyositis with severe periorbital edema after hydroxychloroquine that responded to adalimumab
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 20, 2024 Category: Rheumatology Authors: Maria Farhat,
Boutros Soutou Tags: LETTER TO THE EDITOR Source Type: research
Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research
Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research
Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research
Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research
