Methotrexate-Induced Accelerated Nodulosis in a Patient with Systemic Lupus Erythematosus
Ann Dermatol. 2023 Nov;35(Suppl 2):S272-S274. doi: 10.5021/ad.21.312.ABSTRACTMethotrexate (MTX)-induced accelerated nodulosis (MIAN) reportedly occurs in patients with rheumatic arthritis receiving MTX therapy. However, it has also been reported in patients with other autoinflammatory conditions, such as systemic lupus erythematosus (SLE). A 38-year-old woman diagnosed with SLE presented with multiple movable, firm, flesh-colored nodules on both hands that had developed 3 years ago. She was taking oral medications, specifically hydroxychloroquine, azathioprine, and MTX. Histopathological examination revealed palisaded gran...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Hyeong Mok Kwon Eun Hye Jeong Jung Eun Yim Hye Ri Kim Dong Hoon Shin Jong Soo Choi Young Kyung Bae Source Type: research
Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes
Conclusions HCQ exacerbates psoriasis-like skin inflammation by increasing the expression of IL-6, stimulating DC infiltration, and promoting Th17 expression in the microenvironment of the skin.Key messages This study provided possible mechanisms for inducing psoriasis during HCQ treatment through an animal model.PMID:38059657 | DOI:10.1080/08923973.2023.2281283 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 7, 2023 Category: Allergy & Immunology Authors: Ling-Jung Yen Ying-Chin Chen Kai-Chun Wang Meng-Chieh Shih Chia-Ling Li Sheng-Jie Yu Ling-Ying Lu Source Type: research
Methotrexate-Induced Accelerated Nodulosis in a Patient with Systemic Lupus Erythematosus
Ann Dermatol. 2023 Nov;35(Suppl 2):S272-S274. doi: 10.5021/ad.21.312.ABSTRACTMethotrexate (MTX)-induced accelerated nodulosis (MIAN) reportedly occurs in patients with rheumatic arthritis receiving MTX therapy. However, it has also been reported in patients with other autoinflammatory conditions, such as systemic lupus erythematosus (SLE). A 38-year-old woman diagnosed with SLE presented with multiple movable, firm, flesh-colored nodules on both hands that had developed 3 years ago. She was taking oral medications, specifically hydroxychloroquine, azathioprine, and MTX. Histopathological examination revealed palisaded gran...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Hyeong Mok Kwon Eun Hye Jeong Jung Eun Yim Hye Ri Kim Dong Hoon Shin Jong Soo Choi Young Kyung Bae Source Type: research
Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes
Conclusions HCQ exacerbates psoriasis-like skin inflammation by increasing the expression of IL-6, stimulating DC infiltration, and promoting Th17 expression in the microenvironment of the skin.Key messages This study provided possible mechanisms for inducing psoriasis during HCQ treatment through an animal model.PMID:38059657 | DOI:10.1080/08923973.2023.2281283 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 7, 2023 Category: Allergy & Immunology Authors: Ling-Jung Yen Ying-Chin Chen Kai-Chun Wang Meng-Chieh Shih Chia-Ling Li Sheng-Jie Yu Ling-Ying Lu Source Type: research
Methotrexate-Induced Accelerated Nodulosis in a Patient with Systemic Lupus Erythematosus
Ann Dermatol. 2023 Nov;35(Suppl 2):S272-S274. doi: 10.5021/ad.21.312.ABSTRACTMethotrexate (MTX)-induced accelerated nodulosis (MIAN) reportedly occurs in patients with rheumatic arthritis receiving MTX therapy. However, it has also been reported in patients with other autoinflammatory conditions, such as systemic lupus erythematosus (SLE). A 38-year-old woman diagnosed with SLE presented with multiple movable, firm, flesh-colored nodules on both hands that had developed 3 years ago. She was taking oral medications, specifically hydroxychloroquine, azathioprine, and MTX. Histopathological examination revealed palisaded gran...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Hyeong Mok Kwon Eun Hye Jeong Jung Eun Yim Hye Ri Kim Dong Hoon Shin Jong Soo Choi Young Kyung Bae Source Type: research
Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes
Conclusions HCQ exacerbates psoriasis-like skin inflammation by increasing the expression of IL-6, stimulating DC infiltration, and promoting Th17 expression in the microenvironment of the skin.Key messages This study provided possible mechanisms for inducing psoriasis during HCQ treatment through an animal model.PMID:38059657 | DOI:10.1080/08923973.2023.2281283 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 7, 2023 Category: Allergy & Immunology Authors: Ling-Jung Yen Ying-Chin Chen Kai-Chun Wang Meng-Chieh Shih Chia-Ling Li Sheng-Jie Yu Ling-Ying Lu Source Type: research
Methotrexate-Induced Accelerated Nodulosis in a Patient with Systemic Lupus Erythematosus
Ann Dermatol. 2023 Nov;35(Suppl 2):S272-S274. doi: 10.5021/ad.21.312.ABSTRACTMethotrexate (MTX)-induced accelerated nodulosis (MIAN) reportedly occurs in patients with rheumatic arthritis receiving MTX therapy. However, it has also been reported in patients with other autoinflammatory conditions, such as systemic lupus erythematosus (SLE). A 38-year-old woman diagnosed with SLE presented with multiple movable, firm, flesh-colored nodules on both hands that had developed 3 years ago. She was taking oral medications, specifically hydroxychloroquine, azathioprine, and MTX. Histopathological examination revealed palisaded gran...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Hyeong Mok Kwon Eun Hye Jeong Jung Eun Yim Hye Ri Kim Dong Hoon Shin Jong Soo Choi Young Kyung Bae Source Type: research
Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes
Conclusions HCQ exacerbates psoriasis-like skin inflammation by increasing the expression of IL-6, stimulating DC infiltration, and promoting Th17 expression in the microenvironment of the skin.Key messages This study provided possible mechanisms for inducing psoriasis during HCQ treatment through an animal model.PMID:38059657 | DOI:10.1080/08923973.2023.2281283 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 7, 2023 Category: Allergy & Immunology Authors: Ling-Jung Yen Ying-Chin Chen Kai-Chun Wang Meng-Chieh Shih Chia-Ling Li Sheng-Jie Yu Ling-Ying Lu Source Type: research
Methotrexate-Induced Accelerated Nodulosis in a Patient with Systemic Lupus Erythematosus
Ann Dermatol. 2023 Nov;35(Suppl 2):S272-S274. doi: 10.5021/ad.21.312.ABSTRACTMethotrexate (MTX)-induced accelerated nodulosis (MIAN) reportedly occurs in patients with rheumatic arthritis receiving MTX therapy. However, it has also been reported in patients with other autoinflammatory conditions, such as systemic lupus erythematosus (SLE). A 38-year-old woman diagnosed with SLE presented with multiple movable, firm, flesh-colored nodules on both hands that had developed 3 years ago. She was taking oral medications, specifically hydroxychloroquine, azathioprine, and MTX. Histopathological examination revealed palisaded gran...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Hyeong Mok Kwon Eun Hye Jeong Jung Eun Yim Hye Ri Kim Dong Hoon Shin Jong Soo Choi Young Kyung Bae Source Type: research
Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes
Conclusions HCQ exacerbates psoriasis-like skin inflammation by increasing the expression of IL-6, stimulating DC infiltration, and promoting Th17 expression in the microenvironment of the skin.Key messages This study provided possible mechanisms for inducing psoriasis during HCQ treatment through an animal model.PMID:38059657 | DOI:10.1080/08923973.2023.2281283 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 7, 2023 Category: Allergy & Immunology Authors: Ling-Jung Yen Ying-Chin Chen Kai-Chun Wang Meng-Chieh Shih Chia-Ling Li Sheng-Jie Yu Ling-Ying Lu Source Type: research
