Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes

Conclusions HCQ exacerbates psoriasis-like skin inflammation by increasing the expression of IL-6, stimulating DC infiltration, and promoting Th17 expression in the microenvironment of the skin.Key messages This study provided possible mechanisms for inducing psoriasis during HCQ treatment through an animal model.PMID:38059657 | DOI:10.1080/08923973.2023.2281283

Source: Immunopharmacology and Immunotoxicology - December 7, 2023 Category: Allergy & Immunology Authors: Ling-Jung Yen Ying-Chin Chen Kai-Chun Wang Meng-Chieh Shih Chia-Ling Li Sheng-Jie Yu Ling-Ying Lu Source Type: research