Efficacy and safety of hydroxychloroquine for treatment of mild SARS ‐CoV‐2 infection and prevention of COVID‐19 severity in pregnant and postpartum women: A randomized, double‐blind, placebo‐controlled trial
ConclusionsHCQ was found to be safe in pregnant and postpartum women with asymptomatic or mild SARS-CoV-2 infection. Although the prevalence of infection was decreased in the HCQ group, the statistical power was insufficient to confirm the potential beneficial effect of HCQ for COVID-19 treatment. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 15, 2024 Category: OBGYN Authors: Raquel Gonz ález, Anna Goncé, Mª. del Mar Gil, Edurne Mazarico, Elena Ferriols‐Pérez, Paloma Toro, Elisa Llurba, Elisa Saéz, Miguel Ángel Rodríguez‐Zambrano, Laura García‐Otero, Marta López, Belén Santacruz, Mª. Ángeles Romá Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Highly sensitive detection of multiple antiviral drugs using graphitized hydroxylated multi-walled carbon nanotubes/ionic liquids-based electrochemical sensors
In this study, we developed a highly sensitive electrochemical sensor comprising a glassy carbon electrode (GCE) modified with graphitized hydroxylated multi-walled carbon nanotubes (G-MWCNT-OH) and 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6, IL) for the detection of six ATVs including famciclovir (FCV), remdesivir (REM), favipiravir (FAV), hydroxychloroquine sulfate (HCQ), cepharanthine (CEP) and molnupiravir (MOL). The morphology and structure of the G-MWCNT-OH/IL nanocomposites were characterized comprehensively, and the electroactive surface area and electron conductivity of G-MWCNT-OH/IL/GCE were determi...
Source: Environmental Research - February 14, 2024 Category: Environmental Health Authors: Zhipeng Zhang Huizi Zheng Ying Liu Shuang Ma Qi Feng Jiao Qu Xiaolin Zhu Source Type: research

Immune recovery uveitis in Whipple ’s disease: an unusual ocular presentation
ConclusionsThis case underlines the possibility of IRU complicating WD. Ophthalmologists, rheumatologists, and internists should be aware of this rare complication, particularly in the context of previous immunosuppressive therapy. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - February 13, 2024 Category: Opthalmology Source Type: research

Nivolumab-induced lichenoid penile ulceration and re-emergent mucocutaneous eruption treated with hydroxychloroquine
Australas J Dermatol. 2024 Feb 9. doi: 10.1111/ajd.14223. Online ahead of print.NO ABSTRACTPMID:38337182 | DOI:10.1111/ajd.14223 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - February 10, 2024 Category: Dermatology Authors: Virginia A Headd August Mathien Susan Pei Drew Kuraitis Source Type: research

Case report: Additional use of hydroxychloroquine in treatment ‐resistant recurrent cerebral infarctions with antiphospholipid antibody syndrome
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 9, 2024 Category: Rheumatology Authors: Shuntaro Isogai, Masayuki Mizuno, Koji Uehara, Kenji Okita, Taio Naniwa Tags: LETTER TO THE EDITOR Source Type: research

Automated analysis of choroidal thickness in patients with systemic lupus erithematosus treated with hydroxychloroquine
ConclusionsIn SLE patients, HCQ is correlated to decreased CT, especially in the inferior and temporal areas. The choroid shows different responses to SLE activity and HCQ, and some sectors may be more sensitive than others. (Source: International Ophthalmology)
Source: International Ophthalmology - February 9, 2024 Category: Opthalmology Source Type: research

Factors affecting different COVID-19 outcomes in patients with systemic lupus erythematosus during the second pandemic wave of COVID-19 in China
CONCLUSION: Different COVID-19 outcomes in people with SLE are mostly driven by COVID-19 vaccination, medications, and activity SLE. More importantly, three doses of COVID-19 vaccination may be associated with better outcomes.PMID:38314781 | DOI:10.1177/09612033241230736 (Source: Lupus)
Source: Lupus - February 5, 2024 Category: Rheumatology Authors: Peng-Cheng Liu Min Zhang Jian-Bin Li Yi-Lin Peng Shu-Jiao Yu Rui Wu Source Type: research

Characteristics and prevalence of clinical remission of rheumatoid arthritis in a nationwide study from Indonesia
ConclusionThe remission rate of Indonesian RA patients is 24.5%, and low disease activity is 18.5%. Methotrexate and leflunomide are the most frequent conventional DMARDs used. Delayed diagnosis, delayed treatment, and DMARD monotherapy contributed to the current low remission rate in Indonesia. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 5, 2024 Category: Rheumatology Authors: Bagus Putu Putra Suryana, Rudy Hidayat, Sumariyono Sarmidi, Suryo Anggoro Kusumo Wibowo, Laniyati Hamijoyo, Andri Reza Rahmadi, Blondina Marpaung, Andi Raga Ginting, Gede Kambayana, Pande Ketut Kurniari, Mahriani Sylvawani, Najirman, Nyoman S Tags: ORIGINAL ARTICLE Source Type: research

Deciphering the immunological interactions: targeting preeclampsia with Hydroxychloroquine ’s biological mechanisms
Preeclampsia (PE) is a complex pregnancy-related disorder characterized by hypertension, followed by organ dysfunction and uteroplacental abnormalities. It remains a major cause of maternal and neonatal morbidity and mortality worldwide. Although the pathophysiology of PE has not been fully elucidated, a two-stage model has been proposed. In this model, a poorly perfused placenta releases various factors into the maternal circulation during the first stage, including pro-inflammatory cytokines, anti-angiogenic factors, and damage-associated molecular patterns into the maternal circulation. In the second stage, these factor...
Source: Frontiers in Pharmacology - February 5, 2024 Category: Drugs & Pharmacology Source Type: research

Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
Toxicol Lett. 2024 Feb 2;393:84-95. doi: 10.1016/j.toxlet.2024.01.012. Online ahead of print.ABSTRACTHydroxychloroquine (HCQ), a derivative of chloroquine (CQ), is an antimalarial and antirheumatic drug. Since there is limited data available on the genotoxicity of HCQ, in the current study, we used a battery of in vitro assays to systematically examine the genotoxicity of HCQ in human lymphoblastoid TK6 cells. We first showed that HCQ is not mutagenic in TK6 cells up to 80 μM with or without exogenous metabolic activation. Subsequently, we found that short-term (3-4 h) HCQ treatment did not cause DNA strand breakage as me...
Source: Toxicology Letters - February 4, 2024 Category: Toxicology Authors: Xilin Li Yuan Le Yuxi Li Si Chen Lei Guo Xin Fu Mugimane G Manjanatha Nan Mei Source Type: research