Anticoagulation and vascular anomalies
Res Pract Thromb Haemost. 2024 Apr 3;8(3):102402. doi: 10.1016/j.rpth.2024.102402. eCollection 2024 Mar.ABSTRACTA State of the Art lecture titled "Anticoagulation and Vascular Anomalies" was presented at the International Society on Thrombosis and Haemostasis (ISTH) Congress in 2023. Vascular anomalies have been classified by the International Society for the Study of Vascular Anomalies into vascular tumors and vascular malformations. Although some vascular tumors, such as tufted angioma and kaposiform hemangioendothelioma, and other vascular malformations can present with coagulation aberrancies, these are not generally m...
Source: Thrombosis and Haemostasis - May 2, 2024 Category: Hematology Authors: Shelley E Crary Joana M Mack Source Type: research
Anticoagulation and vascular anomalies
Res Pract Thromb Haemost. 2024 Apr 3;8(3):102402. doi: 10.1016/j.rpth.2024.102402. eCollection 2024 Mar.ABSTRACTA State of the Art lecture titled "Anticoagulation and Vascular Anomalies" was presented at the International Society on Thrombosis and Haemostasis (ISTH) Congress in 2023. Vascular anomalies have been classified by the International Society for the Study of Vascular Anomalies into vascular tumors and vascular malformations. Although some vascular tumors, such as tufted angioma and kaposiform hemangioendothelioma, and other vascular malformations can present with coagulation aberrancies, these are not generally m...
Source: Thrombosis and Haemostasis - May 2, 2024 Category: Hematology Authors: Shelley E Crary Joana M Mack Source Type: research
Sarcoma of the Lung and Mediastinum
Surg Pathol Clin. 2024 Jun;17(2):243-255. doi: 10.1016/j.path.2023.11.008. Epub 2023 Dec 15.ABSTRACTPrimary sarcoma of the lung and mediastinum is rare. The diagnosis requires careful exclusion of sarcomatoid carcinoma, sarcomatoid mesothelioma, and metastases from extra-thoracic sites. This review summarizes the key morphologic, immunohistochemical, and molecular characteristics of sarcomas that are encountered in the lung and mediastinum. The tumor types discussed are synovial sarcoma, well-differentiated/dedifferentiated liposarcoma, myxoid pleomorphic liposarcoma, intimal sarcoma of the pulmonary artery, inflammatory m...
Source: Clinical Lung Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Ken-Ichi Yoshida Akihiko Yoshida Source Type: research
GSE246235 GDF-15 is a biomarker of aggressiveness and is down-regulated by the mTOR inhibitor sirolimus through ATF4 and ATF5 suppression in epithelioid hemangioendothelioma.
In this study, which used patient-derived xenografts and paired cell lines of epithelioid hemangioendothelioma (EHE), it was found that EHE cells produce and release GDF-15. Furthermore, the mTOR inhibitor sirolimus was observed to inhibit GDF-15 expression and release by down-regulating ATF4 and ATF5 transcription factors. To assess the clinical relevance of GDF-15 in EHE, which can manifest as both relatively indolent and exceptionally aggressive forms, circulating GDF-15 levels were assessed in two independent cohorts of EHE patients, one retrospective and one prospective. The results provided evidence of an association...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE246152 GDF-15 is a biomarker of aggressiveness and is down-regulated by the mTOR inhibitor sirolimus through ATF4 and ATF5 suppression in epithelioid hemangioendothelioma.
In this study, which used patient-derived xenografts and paired cell lines of epithelioid hemangioendothelioma (EHE), it was found that EHE cells produce and release GDF-15. Furthermore, the mTOR inhibitor sirolimus was observed to inhibit GDF-15 expression and release by down-regulating ATF4 and ATF5 transcription factors. To assess the clinical relevance of GDF-15 in EHE, which can manifest as both relatively indolent and exceptionally aggressive forms, circulating GDF-15 levels were assessed in two independent cohorts of EHE patients, one retrospective and one prospective. The results provided evidence of an association...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
PIVKA-II combined with alpha-fetoprotein for the diagnostic value of hepatic tumors in children: a multicenter, prospective observational study
ConclusionsThe serum level of PIVKA-II was significantly higher in children with hepatic tumors, especially those with malignant tumors. The combination of PIVKA-II with AFP further increased the diagnostic performance.Trial registrationClinical Trials, NCT03645655. Registered 20 August 2018,https://www.clinicaltrials.gov/ct2/show/NCT03645655. (Source: Hepatology International)
Source: Hepatology International - April 16, 2024 Category: Infectious Diseases Source Type: research
Evolution of transplant oncology indications: a single-institution experience over 40 years
AbstractLiver transplantation (LT) for uncommon tumoral indications has changed across the decades, with impaired results reported in the first historical series mainly for non-tumoral-related causes. Recently, renewed interest in liver transplant oncology has been reported. The study aims to analyze a mono-center experience exploring the evolution and the impact on patient survival of LT in uncommon tumoral indications. A retrospective analysis of 851 LT performed during 1982 –2023 was investigated. 33/851 (3.9%) uncommon tumoral indications were reported: hepatocellular carcinoma (HCC) on non-cirrhotic liver (n = 1...
Source: Updates in Surgery - April 8, 2024 Category: Surgery Source Type: research
Multifocal lower limb hemangioendothelioma in a young female: a case report and review of the literature
Int J Clin Exp Pathol. 2024 Mar 15;17(3):83-89. doi: 10.62347/YRCF9861. eCollection 2024.ABSTRACTA 26-year-old female presented with pain and swelling of distal thigh and distal leg. She was diagnosed with multifocal epitheloid hemangioendothelioma (EHE) and was successfully treated with wide resection of femoral and tibial lesions followed by their reconstruction using vascularised fibular graft and local bone grafting. One year into follow-up, the patient remained asymptomatic with full Range Of Motion (ROM) and full weight bearing walking. This case illustrates a unique multifocal presentation of hemangioendothelioma an...
Source: International Journal of Clinical and Experimental Pathology - April 5, 2024 Category: Pathology Authors: Sandeep Kumar Yadav Ashraf Jamal Prabodh Kantiwal Abhay Elhence Poonam Elhence Balamurugan Thirunavukkarasu Suvinay Saxena Source Type: research
Multifocal lower limb hemangioendothelioma in a young female: a case report and review of the literature
Int J Clin Exp Pathol. 2024 Mar 15;17(3):83-89. doi: 10.62347/YRCF9861. eCollection 2024.ABSTRACTA 26-year-old female presented with pain and swelling of distal thigh and distal leg. She was diagnosed with multifocal epitheloid hemangioendothelioma (EHE) and was successfully treated with wide resection of femoral and tibial lesions followed by their reconstruction using vascularised fibular graft and local bone grafting. One year into follow-up, the patient remained asymptomatic with full Range Of Motion (ROM) and full weight bearing walking. This case illustrates a unique multifocal presentation of hemangioendothelioma an...
Source: International Journal of Clinical and Experimental Pathology - April 5, 2024 Category: Pathology Authors: Sandeep Kumar Yadav Ashraf Jamal Prabodh Kantiwal Abhay Elhence Poonam Elhence Balamurugan Thirunavukkarasu Suvinay Saxena Source Type: research
Multifocal lower limb hemangioendothelioma in a young female: a case report and review of the literature
Int J Clin Exp Pathol. 2024 Mar 15;17(3):83-89. doi: 10.62347/YRCF9861. eCollection 2024.ABSTRACTA 26-year-old female presented with pain and swelling of distal thigh and distal leg. She was diagnosed with multifocal epitheloid hemangioendothelioma (EHE) and was successfully treated with wide resection of femoral and tibial lesions followed by their reconstruction using vascularised fibular graft and local bone grafting. One year into follow-up, the patient remained asymptomatic with full Range Of Motion (ROM) and full weight bearing walking. This case illustrates a unique multifocal presentation of hemangioendothelioma an...
Source: International Journal of Clinical and Experimental Pathology - April 5, 2024 Category: Pathology Authors: Sandeep Kumar Yadav Ashraf Jamal Prabodh Kantiwal Abhay Elhence Poonam Elhence Balamurugan Thirunavukkarasu Suvinay Saxena Source Type: research
Multifocal lower limb hemangioendothelioma in a young female: a case report and review of the literature
Int J Clin Exp Pathol. 2024 Mar 15;17(3):83-89. doi: 10.62347/YRCF9861. eCollection 2024.ABSTRACTA 26-year-old female presented with pain and swelling of distal thigh and distal leg. She was diagnosed with multifocal epitheloid hemangioendothelioma (EHE) and was successfully treated with wide resection of femoral and tibial lesions followed by their reconstruction using vascularised fibular graft and local bone grafting. One year into follow-up, the patient remained asymptomatic with full Range Of Motion (ROM) and full weight bearing walking. This case illustrates a unique multifocal presentation of hemangioendothelioma an...
Source: International Journal of Clinical and Experimental Pathology - April 5, 2024 Category: Pathology Authors: Sandeep Kumar Yadav Ashraf Jamal Prabodh Kantiwal Abhay Elhence Poonam Elhence Balamurugan Thirunavukkarasu Suvinay Saxena Source Type: research
Multifocal lower limb hemangioendothelioma in a young female: a case report and review of the literature
Int J Clin Exp Pathol. 2024 Mar 15;17(3):83-89. doi: 10.62347/YRCF9861. eCollection 2024.ABSTRACTA 26-year-old female presented with pain and swelling of distal thigh and distal leg. She was diagnosed with multifocal epitheloid hemangioendothelioma (EHE) and was successfully treated with wide resection of femoral and tibial lesions followed by their reconstruction using vascularised fibular graft and local bone grafting. One year into follow-up, the patient remained asymptomatic with full Range Of Motion (ROM) and full weight bearing walking. This case illustrates a unique multifocal presentation of hemangioendothelioma an...
Source: International Journal of Clinical and Experimental Pathology - April 5, 2024 Category: Pathology Authors: Sandeep Kumar Yadav Ashraf Jamal Prabodh Kantiwal Abhay Elhence Poonam Elhence Balamurugan Thirunavukkarasu Suvinay Saxena Source Type: research
Multifocal lower limb hemangioendothelioma in a young female: a case report and review of the literature
Int J Clin Exp Pathol. 2024 Mar 15;17(3):83-89. doi: 10.62347/YRCF9861. eCollection 2024.ABSTRACTA 26-year-old female presented with pain and swelling of distal thigh and distal leg. She was diagnosed with multifocal epitheloid hemangioendothelioma (EHE) and was successfully treated with wide resection of femoral and tibial lesions followed by their reconstruction using vascularised fibular graft and local bone grafting. One year into follow-up, the patient remained asymptomatic with full Range Of Motion (ROM) and full weight bearing walking. This case illustrates a unique multifocal presentation of hemangioendothelioma an...
Source: International Journal of Clinical and Experimental Pathology - April 5, 2024 Category: Pathology Authors: Sandeep Kumar Yadav Ashraf Jamal Prabodh Kantiwal Abhay Elhence Poonam Elhence Balamurugan Thirunavukkarasu Suvinay Saxena Source Type: research
Multifocal lower limb hemangioendothelioma in a young female: a case report and review of the literature
Int J Clin Exp Pathol. 2024 Mar 15;17(3):83-89. doi: 10.62347/YRCF9861. eCollection 2024.ABSTRACTA 26-year-old female presented with pain and swelling of distal thigh and distal leg. She was diagnosed with multifocal epitheloid hemangioendothelioma (EHE) and was successfully treated with wide resection of femoral and tibial lesions followed by their reconstruction using vascularised fibular graft and local bone grafting. One year into follow-up, the patient remained asymptomatic with full Range Of Motion (ROM) and full weight bearing walking. This case illustrates a unique multifocal presentation of hemangioendothelioma an...
Source: International Journal of Clinical and Experimental Pathology - April 5, 2024 Category: Pathology Authors: Sandeep Kumar Yadav Ashraf Jamal Prabodh Kantiwal Abhay Elhence Poonam Elhence Balamurugan Thirunavukkarasu Suvinay Saxena Source Type: research
Multifocal lower limb hemangioendothelioma in a young female: a case report and review of the literature
Int J Clin Exp Pathol. 2024 Mar 15;17(3):83-89. doi: 10.62347/YRCF9861. eCollection 2024.ABSTRACTA 26-year-old female presented with pain and swelling of distal thigh and distal leg. She was diagnosed with multifocal epitheloid hemangioendothelioma (EHE) and was successfully treated with wide resection of femoral and tibial lesions followed by their reconstruction using vascularised fibular graft and local bone grafting. One year into follow-up, the patient remained asymptomatic with full Range Of Motion (ROM) and full weight bearing walking. This case illustrates a unique multifocal presentation of hemangioendothelioma an...
Source: International Journal of Clinical and Experimental Pathology - April 5, 2024 Category: Pathology Authors: Sandeep Kumar Yadav Ashraf Jamal Prabodh Kantiwal Abhay Elhence Poonam Elhence Balamurugan Thirunavukkarasu Suvinay Saxena Source Type: research
