IGF2BP3 (IMP3) expression in angiosarcoma, epithelioid hemangioendothelioma, and benign vascular lesions
Insulin-like growth factor-2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types, and its expression is often associated with poor prognosis. IGF... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - March 23, 2020 Category: Pathology Authors: Misuzu Okabayshi, Tatsuki R. Kataoka, Marina Oji, Satoko Mibayashi, Kentaro Odani, Atsushi Otsuka and Hironori Haga Tags: Research Source Type: research

Epitheloid hemangioendothelioma of the ulnar artery presenting with neuropathy
We present a rare case of epithelioid hemangioendothelioma arising from the wall of ulnar artery in distal forearm. The presentation was interesting in a 34-year-old man, with progressively worsening symptoms of ulnar neuropathy. A mass was seen arising from the ulnar artery on imaging with ultrasound and magnetic resonance imaging (MRI). Soft tissue epithelioid hemangioendothelioma in extremities almost always arise from the veins. Existing literature do not have elaborated imaging findings of epithelioid hemangioendothelioma arising from the arterial wall. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - March 20, 2020 Category: Surgery Authors: Syed Intakhab Alam, Pankaj Nepal, Sadia Sajid, Issam Al I-Bozo, Mohamed Marshad Salah, Ahmed Muneer Tags: Case Report Source Type: research

Oral and Extraoral Intermediate Tumors: Are MMP-9 and Ki-67 Biomarkers Correlated to Their High Recurrence Rates?
Intermediate tumors of the head and neck fall in the borderline category. They are clinically aggressive tumors with no malignant phenotyping. They are locally infiltrative and have high recurrence rate with less chances to metastasize. The standard care is surgical excision with wide margins. However, surgeons are challenged with the anatomic complexity of the head and neck, increasing the susceptibly of satellite cells being left behind. Ki-67 and MMP-9 are proliferative index and extracellular matrix degradation biomarkers, respectively. They are directly correlated to malignant tumors, whereas less associated with the ...
Source: Applied Immunohistochemistry and Molecular Morphology - March 1, 2020 Category: Chemistry Tags: Research Articles Source Type: research

Outcome of Children Treated for Infantile Hepatic Hemangioendothelioma
Conclusions: Overall, patients with IHHE do well, a significant percentage of whom do not require drug therapy, particularly for those with small focal lesions. In patients with multifocal/diffuse disease, there is a high incidence of low T3 and T4 and while some of these patients did well without additional therapy, those with rapidly progressive lesions during treatment may do poorly. (Source: Journal of Pediatric Hematology Oncology)
Source: Journal of Pediatric Hematology Oncology - February 20, 2020 Category: Hematology Tags: Original Articles Source Type: research

Pseudomyogenic Hemangioendothelioma: Distinctive FDG PET/CT Findings With Numerous Multilayer Lesions in a Single Distal Extremity
Pseudomyogenic hemangioendothelioma is a rare vascular tumor described as a fibroma-like variant of epithelioid sarcoma. There were scant publications about FDG PET/CT findings of pseudomyogenic hemangioendothelioma. A 20-year-old man with biopsy-confirmed pseudomyogenic hemangioendothelioma of the left tibia had FDG PET/CT for evaluation of the lesion extent and metastasis, which demonstrated numerous, multilayer FDG-avid lesions of the left lower extremity below the knee. Although pathologic examination is mandatory for diagnosis, FDG PET/CT of the case showed distinctive image finding of pseudomyogenic hemangioendotheli...
Source: Clinical Nuclear Medicine - February 7, 2020 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Primary pseudomyogenic hemangioendothelioma of right maxilla: a case with immunohistochemistry and FOSB rearrangement study
ConclusionsTo the best of our knowledge, this case represents the first report of PMH arising in the maxilla. The distinct morphologic features, immunophenotypes, and FOSB rearrangement could help achieve precise diagnosis and prevent misdiagnosis of mimics with overlapping features. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 6, 2020 Category: ENT & OMF Source Type: research

Primary pseudomyogenic hemangioendothelioma of right maxilla: a case with immunohistochemistry and FOSB rearrangement study
We present here a case of primary PMH occurring in the maxilla. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - February 5, 2020 Category: ENT & OMF Authors: Rong-Hui Xia, Ling Zhu, Li-Zhen Wang, Zhen Tian, Chun-Ye Zhang, Yu-Hua Hu, Ting Gu, Jiang Li Tags: Original Article Source Type: research

Kaposiform hemangioendothelioma: current knowledge and future perspectives
Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm with high morbidity and mortality. The initiating mechanism during the pathogenesis of KHE has yet to be discovered. The main pathological feat... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - February 3, 2020 Category: Internal Medicine Authors: Yi Ji, Siyuan Chen, Kaiying Yang, Chunchao Xia and Li Li Tags: Review Source Type: research

Oral Pseudomyogenic Hemangioendothelioma: Case Report and Review of the Literature
AbstractPseduomyogenic hemangioendothelioma (PMH) is a vascular neoplasm of intermediate biological potential first described by Hornick and Fletcher (Am J Surg Pathol 35:190 –201, 2011). Despite its initial categorization as a malignant entity, PMH often demonstrates an indolent behavior profile, and thus was classified as a rarely metastasizing endothelial neoplasm in the 2013 WHO Classification of Tumors of Soft Tissue and Bone. It is a tumor primarily of skin and s oft tissue, with most reported cases involving the trunk or extremities. To date, only one case of PMH involving the oral cavity has been reported. He...
Source: Head and Neck Pathology - February 3, 2020 Category: Pathology Source Type: research

Magnetic Resonance Imaging of Uncommon Hepatic Mesenchymal Tumours: Haemangioendothelioma and Angiosarcoma.
CONCLUSION: The imaging features suggestive of PHA are: Occurrence of metastases (lungs, spleen) at the time of diagnosis, presence of a large dominant mass with smaller satellites, heterogeneity and areas of haemorrhage in a dominant mass, progressive contrast enhancement, slightly elevated ADC values as compared to other malignant liver tumours. PMID: 31989904 [PubMed - in process] (Source: Current Medical Imaging Reviews)
Source: Current Medical Imaging Reviews - January 30, 2020 Category: Radiology Tags: Curr Med Imaging Rev Source Type: research

Mediastinal Epithelioid Hemangioendothelioma Invading Superior Vena Cava: A Case Report and Review of Literature.
CONCLUSION: Mediastinal EHE invading the SVC may present as a homogeneously enhancing mass with punctate calcifications. It should be added to the differential diagnosis of tumors of the mediastinum. Accurate preoperative diagnosis of EHE is critical for surgical planning; therefore, knowledge of the radiologic features of EHE is important. PMID: 31989887 [PubMed - in process] (Source: Current Medical Imaging Reviews)
Source: Current Medical Imaging Reviews - January 30, 2020 Category: Radiology Tags: Curr Med Imaging Rev Source Type: research

Clinical presentation and surgical management of neonatal tumors: Retrospective analysis
Conclusion: NTs have varied presentations. SCT and STS were the most common benign and malignant tumor, respectively. Early diagnosis and complete surgical excision are often curative for all, regardless of the pathology with the minimal role of chemotherapy or radiotherapy. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - January 28, 2020 Category: Surgery Authors: Shailesh Solanki Prema Menon Ram Samujh Kirti Gupta KL N. Rao Source Type: research

The clinicopathological spectrum of pseudomyogenic hemangioendothelioma: report of an additional series with review of the literature
We present here our experience with 24 cases of pseudomyogenic hemangioendothelioma (PMHE) to further delineate its clinicopathological spectrum. There were 18 males and 6 females with a median age of 28  years (range 10~64 years). Most patients presented with erythematous nodules or papules, with or without pain. The majority (63%) occurred in the lower extremities, whereas a minority involved the trunk (25%), upper extremities (8%), and head and neck (4%). Six cases (25%) had a primary bone orig in. With physical and radiological examinations, 16 cases (67%) manifested as multifocal disease, involving multiple ...
Source: Virchows Archiv - January 24, 2020 Category: Pathology Source Type: research

Retiform hemangioendothelioma: An uncommon vascular neoplasm.
We report a case of 35-year-old man with swelling in the postauricular region. He had undergone FNAC which had revealed blood only. Microscopic examination showed narrow, arborizing, vascular channels resembling normal rete testis. Evidence of mitoses or cytological atypia were lacking. Immunohistochemistry showed diffuse and strong staining for CD34 along with CD31 positivity. Immunostains for D240 and GLUT1 were negative. A diagnosis of retiform hemangioendothelioma was made. Histologically, it should be distinguished from Kaposiform hemangioendothelioma, Dabska tumor, epithelioid hemangioendothelioma, and angiosarcoma. ...
Source: Indian Journal of Pathology and Microbiology - January 1, 2020 Category: Pathology Authors: Mondal A, Das M, Chatterjee U, Datta C Tags: Indian J Pathol Microbiol Source Type: research

Upper arm life-saving amputation of a 12 day-old neonate due to extensive vascular tumor of the upper extremity.
ri MM Abstract Vascular tumors in neonates are mostly benign; however, locally aggressive voluminous forms may destabilize the hemodynamics of a neonate. Herein, we present an unusual case of a neonatal giant vascular tumor in the right upper extremity, causing a consumption coagulopathy and acute deterioration of vital signs. The patient required mechanical ventilation, inotropic support, and administration of blood products by the seventh day. Vascular embolization attempts failed to improve the general condition of the patient. Due to the deteriorating and life-threatening general condition of the patient, ampu...
Source: Acta Orthopaedica et Traumatologica Turcica - January 1, 2020 Category: Orthopaedics Authors: Baş CE, Çelik Y, Sayar H, Eskandari MM Tags: Acta Orthop Traumatol Turc Source Type: research

Sirolimus Treatment of an Infant With Intrathoracic Kaposiform Hemangioendothelioma Complicated by Life-threatening Pleural and Pericardial Effusions
We describe a term male who presented as a diagnostic dilemma with life-threatening pleural and pericardial effusions and severe thrombocytopenia. After extensive work-up the etiology for his condition was determined to be KHE with KMP. The patient was commenced on sirolimus and responded well to therapy with resolution of KMP. (Source: Journal of Pediatric Hematology Oncology)
Source: Journal of Pediatric Hematology Oncology - December 19, 2019 Category: Hematology Tags: Clinical and Laboratory Observations Source Type: research

A case report of right atrial epithelioid hemangioendothelioma with multiple pulmonary metastases
We describe herein a patient with hemoptysis, severe anaemia, and diffuse pulmonary nodules with halo signs that represented metastasis of cardiac EHE; these radiologic manifestations are relatively uncommon. During the initial workup for the patient ’s pulmonary nodules, echocardiography missed the cardiac mass. However, positron emission tomography‐computed tomography revealed increased fluorodeoxyglucose intake in the right atrial wall, and cardiac magnetic resonance imaging (MRI) revealed an irregular nodule with normal T1‐weighted sig nal intensity and hyperintense T2‐weighted signal intensity. Enhanced ab...
Source: The Clinical Respiratory Journal - December 17, 2019 Category: Respiratory Medicine Authors: Xiaoming Zhou, Peng Li, Xiu Gu, Fushuang Zheng, Jungang Zhao, Li Zhao Tags: BRIEF REPORT Source Type: research

Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review
Hepatic epithelioid hemangioendothelioma is a rare neoplasm with a variable malignant potential and a high risk of recurrence. No general treatment guidelines have been established. Fortunately, we were able to minimize immunosuppressant after liver transplantation because of a full HLA ‐matched case. There was no recurrence 1 year after treatment. AbstractHepatic epithelioid hemangioendothelioma is a rare neoplasm with a variable malignant potential and a high risk of recurrence. No general treatment guidelines have been established. Fortunately, we were able to minimize immunosuppressant after liver transplantatio...
Source: Clinical Case Reports - December 17, 2019 Category: General Medicine Authors: Sotaro Fukuhara, Hiroyuki Tahara, Yoshito Hirata, Kosuke Ono, Michinori Hamaoka, Seiichi Shimizu, Shinji Hashimoto, Shintaro Kuroda, Masahiro Ohira, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan Tags: CASE REPORT Source Type: research

A retrospective analysis of 597 oral vascular anomalies diagnosed in a brazilian population
ConclusionsThese lesions particularities knowledge is important for a correct diagnosis and adequate treatment decision. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

A case report of right atrial epithelioid hemangioendothelioma with multiple pulmonary and liver metastases
We describe herein a patient with hemoptysis, severe anemia, and diffuse pulmonary nodules with halo signs that represented metastasis of cardiac EHE; these radiologic manifestations are relatively uncommon. During the initial workup for the patient ’s pulmonary nodules, echocardiography missed the cardiac mass. However, positron emission tomography‐computed tomography revealed increased fluorodeoxyglucose intake in the right atrial wall, and cardiac magnetic resonance imaging (MRI) revealed an irregular nodule with normal T1‐weighted sig nal intensity and hyperintense T2‐weighted signal intensity. Enhanced abd...
Source: The Clinical Respiratory Journal - December 3, 2019 Category: Respiratory Medicine Authors: Xiaoming Zhou, Peng Li, Xiu Gu, Fushuang Zheng, Jungang Zhao, Li Zhao Tags: BRIEF REPORT Source Type: research

Treatment and prognosis of hepatic epithelioid hemangioendothelioma based on SEER data analysis from 1973 to 2014
ConclusionsResection or liver transplantation is worth considering for treatment of patients with HEH. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - November 30, 2019 Category: Gastroenterology Source Type: research

Three cases of histologically proven hepatic epithelioid hemangioendothelioma evaluated using a second-generation microbubble contrast medium in ultrasonography: case reports
Hepatic epithelioid hemangioendothelioma (HEH) is rare; it is reported in (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - November 14, 2019 Category: Gastroenterology Authors: Jun Arai, Yuu Shimozuma, Yumi Otoyama, Ikuya Sugiura, Yoko Nakajima, Eiichi Hayashi, Atsushi Kajiwara, Risa Omori, Shojiro Uozumi, Miyuki Miyashita, Manabu Uchikoshi, Hiroyoshi Doi, Masashi Sakaki, Tianpeng Wang, Junichi Eguchi, Takayoshi Ito & hellip; Tags: Case report Source Type: research

Recurrent upper limb neuropathies secondary to an epithelioid haemangioendothelioma – A rare mimic of nerve tumours
We present a case of left upper limb neurovascular bundle EHE presenting with proximal ulnar nerve neuropathy and subsequent median nerve neuropathy and liver, lungs and bone metastases. The tumour had been identified 20 years prior with a similar presentation of upper limb weakness and sensory disturbance, yet following surgical excision it was misdiagnosed as inflammatory fibrous tissue. Treatment with propranolol has resulted in disease stability and surgical debulking resulted in improved upper limb function. The use of beta-adrenergic receptor antagonists in EHE and other sarcomas have been shown to increase T-cell ...
Source: Journal of Clinical Neuroscience - November 8, 2019 Category: Neuroscience Source Type: research

Selection of treatment for hepatic epithelioid hemangioendothelioma: a single-center experience
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare angiogenic tumor with no recognized effective treatment. Treatment options used worldwide include liver transplantation (LT), liver resection (LR), rad... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - November 7, 2019 Category: Cancer & Oncology Authors: Linping Cao, Jiawei Hong, Lingfeng Zhou, Yufu Ye, Yuanxing Liu, Jun Yu and Shusen Zheng Tags: Research Source Type: research

Acute ST-segment elevation myocardial infarction due to extrinsic compression of left coronary artery from pulmonary epithelioid hemangioendothelioma: A case report
Rationale: Acute myocardial infarction is usually caused by coronary atherosclerotic plaque disruption (rupture or erosion), also including other uncommon etiologies. Pulmonary epithelioid hemangioendothelioma (PEH) is a rare low to intermediate malignant vascular tumor originating from vascular endothelial cells. Here, we report a rare case of acute ST-segment elevation myocardial infarction (STEMI) due to extrinsic compression of left coronary artery from PEH. Patient concerns: A 63-year-old woman with pulmonary nodules received left pulmonary nodulectomy, and the pathological examination indicated PEH. Five months ...
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

CAMTA-1 Expression in 24 Cases of Hepatic Epithelioid Hemangioendothelioma in a Single Institute: Diagnostic Utility for Differential Diagnosis from Hepatic Angiosarcoma
Conclusion: CAMTA1 is a highly sensitive and specific marker for diagnosis of hepatic EHE. It is helpful for differentiation of hepatic EHE and angiosarcoma, especially in small biopsy samples. (Source: In Vivo)
Source: In Vivo - October 29, 2019 Category: Research Authors: JUNG, H., KIM, H.-N., JANG, Y., PARK, C.-K., HA, S.-Y. Tags: Clinical Studies Source Type: research

Epithelioid hemangioendothelioma of the pancreas presented as massive hematemesis
Discussion & conclusionThe treatment strategy should be tailored to the individual patient, the clinical presentation, and the rate of progression of the tumor. The natural history of the disease is still poorly understood and there is no uniform treatment form for such tumors. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - October 20, 2019 Category: Surgery Source Type: research

Epithelioid Hemangioendothelioma Presenting as Unilateral Vocal Fold Paralysis: A Case Report and Literature Review.
PMID: 31619070 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - October 16, 2019 Category: ENT & OMF Authors: Lui JT, Kang AT, DiFrancesco LM, Warshawski SJ, Randall DR Tags: Ear Nose Throat J Source Type: research

Multifocal and hormone-dependent epithelioid hemangioendothelioma with osteolysis of the second cervical vertebral body: report of an unprecedented surgical approach by using autologous bone graft
. (Source: British Journal of Neurosurgery)
Source: British Journal of Neurosurgery - October 4, 2019 Category: Neurosurgery Authors: Hanno M. Witte Armin Riecke Thomas Mayer Carsten Hackenbroch Konrad Steinestel Niklas Gebauer Dirk Puckhaber Ren é Mathieu Uwe Max Mauer Chris Schulz Source Type: research

1680PA global patient-driven Facebook study in a very rare sarcoma: Health-related quality of life in epithelioid hemangioendothelioma (EHE) patients
AbstractBackgroundEHE is a vascular sarcoma with an incidence of  ≤ 1 per 1 million/year, and an unpredictable clinical course with significant symptom burden. Recruiting EHE patients for studies is difficult and health-related quality of life (HRQoL) in these patients is unknown. We aimed to study the impact of EHE symptom burden on HRQoL.MethodsThe study was initiated after EHE patients ’ foundations approached our research group to study HRQoL. After ethical approval, patients were recruited from the global EHE Facebook group from May-October 2018. Data were collected using the unique, well-establ...
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

1669OIMMUNOSARC: A collaborative Spanish (GEIS) and Italian (ISG) sarcoma groups phase I/II trial of sunitinib plus nivolumab in advanced soft tissue and bone sarcomas: Results of the phase II- soft-tissue sarcoma cohort
ConclusionsThe trial met its primary endpoint. SU-NI is an active combination for the treatment of advanced selected STS patients, with 50% of patients free of progression at 6m. Further exploration of immunomodulatory strategies is warranted in selected sarcoma subtypes.Clinical trial identificationNCT03277924.Legal entity responsible for the studyGrupo Espa ñol de Investigación en Sarcomas (GEIS).FundingPfizer and BMS.DisclosureJ. Martin Broto: Honoraria (self), Speaker Bureau / Expert testimony, Research grant / Funding (institution), Travel / Accommodation / Expenses: PharmaMar; Honoraria (self), Speaker ...
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Rare malignant liver tumors in children
AbstractMalignant hepatic tumors in children are rare, comprising 1.3% of all pediatric malignancies. Following hepatoblastoma, hepatocellular carcinoma is the second most common. Other malignant hepatic tumors seen in childhood include those of mesenchymal origin including undifferentiated embryonal sarcoma, angiosarcoma, rhabdomyosarcoma and epithelioid hemangioendothelioma, as well as biliary tumors such as cholangiocarcinoma. Diagnosis can be challenging because of their rarity, and the recognition of distinctive imaging features for certain tumors such as epithelioid hemangioendothelioma and biliary rhabdomyosarcoma c...
Source: Pediatric Radiology - October 1, 2019 Category: Radiology Source Type: research

Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets
Modern Pathology, Published online: 19 September 2019; doi:10.1038/s41379-019-0368-8Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets (Source: Modern Pathology)
Source: Modern Pathology - September 19, 2019 Category: Pathology Authors: Evan Rosenbaum Bhumika Jadeja Bin Xu Lei Zhang Narasimhan P. Agaram William Travis Samuel Singer William D. Tap Cristina R. Antonescu Source Type: research

Pseudomyogenic hemangioendothelioma of bone treated with denosumab: a case report
Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of p... (Source: BMC Cancer)
Source: BMC Cancer - September 3, 2019 Category: Cancer & Oncology Authors: Shinya Otani, Robert Nakayama, Tetsuya Sekita, Toru Hirozane, Naofumi Asano, Kazumasa Nishimoto, Aya Sasaki, Hajime Okita, Hideo Morioka, Masaya Nakamura and Morio Matsumoto Tags: Case report Source Type: research

Metastatic epithelioid haemangioendothelioma masquerading as periodontal pathosis: a case report
We present a non-healing lesion on the gingivae attached to the mandible that mimicked periodontal disease, and was refractory to local debridement and oral hygiene measures. Biopsy examination showed a metastatic epithelioid haemangioendothelioma. This rare vascular tumour is considered to be malignant and management is controversial, owing to the paucity of published data. Treatment was provided in a multi-disciplinary setting as a result of established pulmonary and musculoskeletal metastases. The patient opted for conservative management and close surveillance of the lesion, which continues to remain stable at the time...
Source: British Journal of Oral and Maxillofacial Surgery - August 30, 2019 Category: ENT & OMF Source Type: research

Fusion of the Genes PHF1 and TFE3 in Malignant Chondroid Syringoma
Conclusion: Malignant chondroid syringoma is genetically related to tumors with PHF1 rearrangements such as low-grade endometrial sarcoma and ossifying fibromyxoid tumor, but also with tumors having TFE3 rearrangements such as renal cell carcinoma, alveolar soft part sarcoma, PEComa, and epithelioid hemangioendothelioma. Further investigations on malignant chondroid syringomas are needed in order to determine whether genetic heterogeneity exists among them and the clinical impact of the PHF1-TFE3 fusion. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 29, 2019 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., LUND-IVERSEN, M., BASSAROVA, A., HEIM, S. Tags: Article Source Type: research

Successful excision of epithelioid hemangioendothelioma of the superior vena cava
We report a case of a radically resected mediastinal EHE originating from the superior vena cava. A 79-year-old woman was referred to our hospital for colon cancer surgery. Computed tomography showed a 50-mm middle mediastinal tumor in direct contact with the left and right brachiocephalic veins, aortic arch, and right brachiocephalic artery. Right lateral thoracotomy was performed, and the tumor was resected en bloc with the right brachiocephalic vein and vagal nerve. Recurrence was not observed at 7 years after surgery, even without adjuvant therapy. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 28, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

What is new in endothelial neoplasia?
AbstractThe classification of vascular neoplasms continues to evolve as we accumulate more genetic and clinical data, particularly for rare tumor types. Because of tumor rarity, changes to classification schema, overlapping histologic features, and in some cases, lack of morphologic evidence of vasoformation, vascular neoplasms present a diagnostic challenge. Here, we discuss recent developments in our understanding of vascular tumors, with a detailed discussion of epithelioid hemangioma, tufted angioma, kaposiform hemangioendothelioma, composite hemangioendothelioma, pseudomyogenic hemangioendothelioma, epithelioid hemang...
Source: Virchows Archiv - August 28, 2019 Category: Pathology Source Type: research

Metastatic epithelioid haemangioendothelioma masquerading as periodontal pathosis: a case report
We present a non-healing lesion on the gingivae attached to the mandible that mimicked periodontal disease, and was refractory to local debridement and oral hygiene measures. Biopsy examination showed a metastatic epithelioid haemangioendothelioma. This rare vascular tumour is considered to be malignant and management is controversial, owing to the paucity of published data. Treatment was provided in a multi-disciplinary setting as a result of established pulmonary and musculoskeletal metastases. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - August 28, 2019 Category: ENT & OMF Authors: J.B. Olsen, D. Gebauer, A. Frydrych Tags: Short communication Source Type: research

FDG PET/CT of Mediastinal Epithelioid Hemangioendothelioma
We present a case of a 65-year-old woman diagnosed as having mediastinal epithelioid hemangioendothelioma, a location which is very exceptional. FDG PET/CT was more sensitive than CT for staging, revealing intense FDG uptake in the primary tumor and in the metastatic disease. Despite high FDG uptake, the disease was stable with no further specific treatment. Only few reports utilizing FDG PET/CT are available; review of the literature on this subject is included. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - August 8, 2019 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Epithelioid hemangioendothelioma arising from the kidney: A rare case report
We reported a 30-year-old woman who had a 3-month history of gross hematuria and aggravated for half a month. The imaging examination showed a cystic lesion in the mid pole of the left kidney pelvicaliceal. Diagnoses: The diagnosis was confirmed according to the specific anatomical location and pathological examination which was proved as EH. Interventions: The patient underwent ureteroscopy and partial left nephrectomy. Outcomes: Her postoperative condition was good without complications. No clinical evidence of local recurrence or metastatic disease was found during 6 months of follow-up clinical and ultrasound ...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Tips and Tricks in Contrast-Enhanced Ultrasound (CEUS) for the Characterization and Detection of Liver Malignancies.
Abstract Contrast-enhanced ultrasound (CEUS) has a high diagnostic accuracy in the assessment of focal liver lesions. Clinical context (presence of liver cirrhosis, history of other malignancy versus incidental finding) is crucial for the correct interpretation of CEUS findings. CEUS has to be preceded by structured anamnesis and clinical examination as well as accurate B-mode sonography. Metastases are the most common malignant liver lesions in a non-cirrhotic liver. According to their contrast enhancement in the arterial phase, metastases are categorized as hyper- and hypo-vascular metastases. A common feature o...
Source: Ultraschall in der Medizin - August 1, 2019 Category: Radiology Authors: Schellhaas B, Strobel D Tags: Ultraschall Med Source Type: research

Survival Analysis of Patients with Osseous Malignant Vascular Tumors: Results of the Surveillance, Epidemiology, and End Results (SEER) Database from 1973 to 2015.
CONCLUSIONS This study is the largest population-based study to show the demographic characteristics and analyze the prognosis of OMVT patients. Independent predictors of OS for patients with AS included old age, distant tumor stage, low tumor grade, and surgery. Old age, surgery, and low tumor grade were also predictors of CSS for patients with OAS. Independent predictors of CSS and OS for patients with OHE included old age and surgery. PMID: 31344019 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A not so harmless mass: Kaposiform hemangioendothelioma complicated by a Kasabach-Merritt phenomenon.
Abstract A vascular mass localized in the face and the neck was displayed by ultrasonography in a 38-week-old male fetus. At birth, the mass was bulky and purplish. The newborn breathed spontaneously but with severe desaturation. During laryngoscopy, we observed an obstruction of the larynx with a left-shift caused by the hemorrhagic mass. Blood analysis revealed anemia, severe thrombocytopenia, and coagulation disorders. The diagnosis of kaposiform hemangioendothelioma (KHE) complicated by a Kasabach-Merritt phenomenon (KMP) was put forward and treatment with propranolol, corticoids, and vincristine was initiated...
Source: Archives de Pediatrie - July 25, 2019 Category: Pediatrics Authors: Tribolet S, Hoyoux C, Boon LM, Cheruy C, Demarche M, Jamblin P, Roberti A, Willemaers V, Viellevoye R, Rigo V, Broux I Tags: Arch Pediatr Source Type: research

Research Progress of Pulmonary Epithelioid Hemangioendothelioma
This article tries to present the etiopathogenesis, clinical manifestations, diagnosis, treatment and prognosis of P-EHE. 
 DOI: 10.3779/j.issn.1009-3419.2019.07.10 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

A rare case of pseudomyogenic hemangioendothelioma (PHE)/epithelioid sarcoma-like hemangioendothelioma (ES-H) of the breast first misdiagnosed as metaplastic carcinoma by FNAB and review of the literature
Pseudomyogenic hemangioendothelioma (PHE)/epithelioid sarcoma-like hemangioendothelioma (ES-H) is a rare vascular tumor of intermediate malignancy that commonly occurs in soft tissue of distal extremities of y... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 17, 2019 Category: Pathology Authors: Yan Ge, Xingtao Lin, Fen Zhang, Fangping Xu, Luqiao Luo, Weiye Huang, Zhihua Liu, Yanhui Liu and Zhi Li Tags: Case Report Source Type: research

Epithelioid Haemangioendothelioma of the tongue – A Case Report and Review
This article is protected by copyright. All rights reserved. (Source: Oral Surgery)
Source: Oral Surgery - July 10, 2019 Category: ENT & OMF Authors: Ross Leader, Adair Stephen Tags: Case Report Source Type: research

Kaposiform lymphangiomatosis and kaposiform hemangioendothelioma: similarities and differences
Kaposiform lymphangiomatosis (KLA) and kaposiform hemangioendothelioma (KHE) are rare and aggressive vascular disorders. The aim of this study was to examine the clinical features and prognosis of KLA and KHE ... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - July 5, 2019 Category: Internal Medicine Authors: Yi Ji, Siyuan Chen, Suhua Peng, Chunchao Xia and Li Li Tags: Research Source Type: research

Intraosseous epithelioid haemangioendothelioma of the mandible: A case report and literature review
Conclusions: Intraosseous EHE of the mandible is an unpredictable lesion with a relatively benign course; however, the few reported cases of this disease do not highlight any factors that can predict the risk of locoregional recurrence or metastasis. There is also no consensus regarding the optimal treatment for intraosseous EHE; however, we recommend extensive local excision with close clinical follow-up. (Source: Medicine)
Source: Medicine - July 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research