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Epithelioid hemangioendothelioma as a cause of intestinal intussusception in an adult female patient: case report
CONCLUSIONS: The diagnosis and management process with an appropriate postoperative outcome is described.PMID:37169358 | DOI:10.24875/CIRU.21000708 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - May 11, 2023 Category: Surgery Authors: Osama Bahsas-Zaky Jorge R Guill én-Nieto Leonardo Y P Dugarte-Quintero Carlos E G ómez Eduardo E Marquina-Montilla Estrella Uzc átegui-Paz Source Type: research

Case Report: Pancreatic and hepatic kaposiform hemangioendothelioma presenting as consumptive coagulopathy and right hepatic atrophy
Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor that causes progressive angiogenesis and lymphangiogenesis, which often occurs in the skin or soft tissue, with an acute onset and rapid progression. A 4-year-old girl was admitted to our hospital with a 2-year history of thrombocytopenia, combined with right hepatic atrophy and pancreatic lesion for 3 months. At the age of two, she developed purpura and thrombocytopenia was detected, after treatment with gamma globulin and corticosteroids, the platelet count normalized, but it dropped immediately at lower doses. One year after the cessation of corticosteroids ...
Source: Frontiers in Oncology - May 2, 2023 Category: Cancer & Oncology Source Type: research

Case report: Multiple brain intravascular papillary endothelial hyperplasia: incidence, diagnostic challenges, and management approach
In this study, we describe a case of multiple recurrent brain IPEHs and provide details on the diagnostic phase, therapeutic approaches, and related challenges. A 55-year-old woman presented with a relapsing neurological deficit. Brain magnetic resonance imaging (MRI) revealed a hemorrhagic right frontal-parietal lesion. When new neurological symptoms occurred, subsequent MRI scans detected more bleeding cerebral lesions. She underwent a series of single hemorrhagic lesion debulking. For any samples that underwent histopathological examination, the first results were not informative; the second and the third results reveal...
Source: Frontiers in Neurology - April 20, 2023 Category: Neurology Source Type: research

New Molecular Insights, and the Role of Systemic Therapies and Collaboration for Treatment of Epithelioid Hemangioendothelioma (EHE)
Opinion statementEpithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated vascular sarcoma. EHE can have different clinical presentations from indolent to rapidly evolving cases, behaving as a high-grade sarcoma. Serosal effusion and systemic symptoms such as fever and severe pain are known as adverse prognostic factors; however, outcome prediction at disease onset remains a major challenge. In spite of its rarity, an international collaborative effort is in place with the support of patient advocates to increase the knowledge of EHE biology, develop new treatment options, and improve patient access to new act...
Source: Current Treatment Options in Oncology - April 14, 2023 Category: Cancer & Oncology Source Type: research

CT appearances and classification of hepatic epithelioid hemangioendothelioma
ConclusionCT features variated among HEH patients with different lesion types, and radiological appearances of HEH should be classified into nodular type, locally coalescent type and diffusely coalescent type. (Source: Insights into Imaging)
Source: Insights into Imaging - April 1, 2023 Category: Radiology Source Type: research

Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy
ConclusionThe use of transarterial embolization with spherical embolic agents (TES) has been demonstrated to be a safe, effective, and reliable treatment option for hepatic epithelioid hemangioendothelioma (EHE). Nevertheless, it is crucial to conduct long-term follow-up of this patient in order to assess their clinical outcome. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2023 Category: Cancer & Oncology Source Type: research

A phase 2 study of epacadostat and pembrolizumab in patients with advanced sarcoma
CONCLUSIONS: Combination epacadostat and pembrolizumab was well tolerated and showed limited antitumor activity in sarcoma. Correlative analyses suggested that inadequate IDO1 inhibition was achieved.PMID:36971773 | DOI:10.1158/1078-0432.CCR-22-3911 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 27, 2023 Category: Cancer & Oncology Authors: Ciara M Kelly Li-Xuan Qin Karissa A Whiting Allison L Richards Viswatej Avutu Jason E Chan Ping Chi Mark A Dickson Mrinal M Gounder Mary Louise Keohan Sujana Movva Benjamin A Nacev Evan Rosenbaum Travis Adamson Samuel Singer Edmund K Bartlett Aimee M Crag Source Type: research