A Single Arm Phase 2 Trial of Trametinib in Patients With Locally Advanced or Metastatic Epithelioid Hemangioendothelioma
CONCLUSIONS: Trametinib was associated with reduction in EHE-related pain and median PFS of more than 6 months providing palliative benefit in patients with advanced EHE, but the trial did not meet the ORR goal.PMID:38446990 | DOI:10.1158/1078-0432.CCR-23-3817 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 6, 2024 Category: Cancer & Oncology Authors: Scott M Schuetze Karla V Ballman Rachel Heise Kristen N Ganjoo Elizabeth J Davis Suzanne George Melissa A Burgess Edwin Choy Dale R Shepard Gabriel Tinoco Angela Hirbe Ciara M Kelly Steven Attia Hari A Deshpande Gary K Schwartz Brittany L Siontis Richard Source Type: research
A Uncommon Case: Kasabach-Merritt syndrome with VACTERL Association
We present a case of a mature male neonate with Kasabach-Merritt- Syndrome as well as VACTERL association. The VACTERL association describes a group of malformations. Our patient presented with anal atresia combined with tethered cord, and left renal agenesis. The VACTERL association as well as Kasabach-Merritt syndrome were found to be independent pathologies within this patient. A common occurrence or an association with each other has not been described in the literature so far. The challenging coagulation setting due to severe thrombocytopenia complicated the surgical management so far. Finally, mTOR-inhibitor sirolimu...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - March 1, 2024 Category: Perinatology & Neonatology Authors: Melanie Le Katharina Wenke Jochen Herrmann Dominique Singer Mario Lange Source Type: research
A Uncommon Case: Kasabach-Merritt syndrome with VACTERL Association
We present a case of a mature male neonate with Kasabach-Merritt- Syndrome as well as VACTERL association. The VACTERL association describes a group of malformations. Our patient presented with anal atresia combined with tethered cord, and left renal agenesis. The VACTERL association as well as Kasabach-Merritt syndrome were found to be independent pathologies within this patient. A common occurrence or an association with each other has not been described in the literature so far. The challenging coagulation setting due to severe thrombocytopenia complicated the surgical management so far. Finally, mTOR-inhibitor sirolimu...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - March 1, 2024 Category: Perinatology & Neonatology Authors: Melanie Le Katharina Wenke Jochen Herrmann Dominique Singer Mario Lange Source Type: research
A Uncommon Case: Kasabach-Merritt syndrome with VACTERL Association
We present a case of a mature male neonate with Kasabach-Merritt- Syndrome as well as VACTERL association. The VACTERL association describes a group of malformations. Our patient presented with anal atresia combined with tethered cord, and left renal agenesis. The VACTERL association as well as Kasabach-Merritt syndrome were found to be independent pathologies within this patient. A common occurrence or an association with each other has not been described in the literature so far. The challenging coagulation setting due to severe thrombocytopenia complicated the surgical management so far. Finally, mTOR-inhibitor sirolimu...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - March 1, 2024 Category: Perinatology & Neonatology Authors: Melanie Le Katharina Wenke Jochen Herrmann Dominique Singer Mario Lange Source Type: research
A Uncommon Case: Kasabach-Merritt syndrome with VACTERL Association
We present a case of a mature male neonate with Kasabach-Merritt- Syndrome as well as VACTERL association. The VACTERL association describes a group of malformations. Our patient presented with anal atresia combined with tethered cord, and left renal agenesis. The VACTERL association as well as Kasabach-Merritt syndrome were found to be independent pathologies within this patient. A common occurrence or an association with each other has not been described in the literature so far. The challenging coagulation setting due to severe thrombocytopenia complicated the surgical management so far. Finally, mTOR-inhibitor sirolimu...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - March 1, 2024 Category: Perinatology & Neonatology Authors: Melanie Le Katharina Wenke Jochen Herrmann Dominique Singer Mario Lange Source Type: research
A Uncommon Case: Kasabach-Merritt syndrome with VACTERL Association
We present a case of a mature male neonate with Kasabach-Merritt- Syndrome as well as VACTERL association. The VACTERL association describes a group of malformations. Our patient presented with anal atresia combined with tethered cord, and left renal agenesis. The VACTERL association as well as Kasabach-Merritt syndrome were found to be independent pathologies within this patient. A common occurrence or an association with each other has not been described in the literature so far. The challenging coagulation setting due to severe thrombocytopenia complicated the surgical management so far. Finally, mTOR-inhibitor sirolimu...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - March 1, 2024 Category: Perinatology & Neonatology Authors: Melanie Le Katharina Wenke Jochen Herrmann Dominique Singer Mario Lange Source Type: research
