Amino acid solution mitigates hypothermia response and intestinal damage following exertional heat stroke in male mice
Exertional heat stroke (EHS) is a debilitating and potentially fatal condition for which few prevention strategies exist. These results suggest that a 5AAS improves Tc regulation during EHS recovery through maintaining mucosal function and integrity and that protecting the GI tract during EHS may be beneficial in some of the health consequences of EHS exposure. AbstractIncreased gut permeability is implicated in the initiation and extent of the cytokine inflammatory response associated with exertional heat stroke (EHS). The primary objective of this study was to determine if a five amino acid oral rehydration solution (5AA...
Source: Physiological Reports - May 23, 2023 Category: Physiology Authors: Michelle A. King,
Astrid Grosche,
Shauna M. Ward,
Jermaine A. Ward,
Anusree Sasidharan,
Thomas A. Mayer,
Mark L. Plamper,
Xiaodong Xu,
Matthew D. Ward,
Thomas L. Clanton,
Sadasivan Vidyasagar Tags: ORIGINAL ARTICLE Source Type: research
Acquired heat acclimation in rats subjected to physical exercise under environmental heat stress alleviates brain injury caused by exertional heat stroke
Conclusions: This HA model can ameliorate brain injury of EHS by reducing cerebral edema and cell apoptosis, offering experimental evidence for EHS prophylaxis.PMID:37150340 | DOI:10.1016/j.brainres.2023.148393 (Source: Brain Research)
Source: Brain Research - May 7, 2023 Category: Neurology Authors: Xin Li Fan Xv Li-Zhen Ma Ling Xing Jin-Bao Zhao Wei-Jia Zhi Li-Feng Wang Yang Wang Han-Ding Mao Shu-Yuan Liu Ya-Hua Liu Qing Song Source Type: research
Acquired heat acclimation in rats subjected to physical exercise under environmental heat stress alleviates brain injury caused by exertional heat stroke
Conclusions: This HA model can ameliorate brain injury of EHS by reducing cerebral edema and cell apoptosis, offering experimental evidence for EHS prophylaxis.PMID:37150340 | DOI:10.1016/j.brainres.2023.148393 (Source: Cell Research)
Source: Cell Research - May 7, 2023 Category: Cytology Authors: Xin Li Fan Xv Li-Zhen Ma Ling Xing Jin-Bao Zhao Wei-Jia Zhi Li-Feng Wang Yang Wang Han-Ding Mao Shu-Yuan Liu Ya-Hua Liu Qing Song Source Type: research
Acquired heat acclimation in rats subjected to physical exercise under environmental heat stress alleviates brain injury caused by exertional heat stroke
Conclusions: This HA model can ameliorate brain injury of EHS by reducing cerebral edema and cell apoptosis, offering experimental evidence for EHS prophylaxis.PMID:37150340 | DOI:10.1016/j.brainres.2023.148393 (Source: Brain Research)
Source: Brain Research - May 7, 2023 Category: Neurology Authors: Xin Li Fan Xv Li-Zhen Ma Ling Xing Jin-Bao Zhao Wei-Jia Zhi Li-Feng Wang Yang Wang Han-Ding Mao Shu-Yuan Liu Ya-Hua Liu Qing Song Source Type: research
Multiparametric cardiac magnetic resonance reveals persistent myocardial inflammation in patients with exertional heat illness
ConclusionsWith multiparametric CMR, EHI patients demonstrated increased global ECV, T2, and persistent myocardial inflammation at 3-month follow-up after EHI episode. Therefore, multiparametric CMR might be an effective method in evaluating myocardial inflammation in patients with EHI.Clinical relevance statementThis study showed persistent myocardial inflammation after an exertional heat illness (EHI) episode demonstrated by multiparametric CMR, which is a potential promising method to evaluate the severity of myocardial inflammation and guide return to work, play, or duty in EHI patients.Key Points•EHI patients showed...
Source: European Radiology - May 5, 2023 Category: Radiology Source Type: research
Association between cooling temperature and outcomes of patients with heat stroke
This study explored the relationship between body temperature and adverse outcomes in patients with heat stroke to identify the optimal target body temperature within the first 24 h. This retrospective, multicentre study enrolled 143 patients admitted to the emergency department and diagnosed with heat stroke. The primary outcome was the in-hospital mortality rate, while secondary outcomes included the presence and number of damaged organs and neurological sequelae at disch arge. A body temperature curve was built using a generalized additive mixed model, and the association between body temperatures and outcomes was est...
Source: Internal and Emergency Medicine - May 3, 2023 Category: Emergency Medicine Source Type: research
Forecasting feels-like temperatures as a strategy to reduce heat illnesses during sport events
Many athletes, amateur and professional alike, compete in and train for outdoor running events every year, and even more participate in outdoor sports in general. Many major sport events such as the Summer Olympic and Paralympic Games and World Championships take place in summer and mostly in the Northern Hemisphere. Therefore, athletes are often at risk of sustaining heat illnesses during heat extremes, which are exacerbated by climate change.1 Heat illnesses describe a group of pathologies ranging from relatively minor to very severe symptoms such as potentially fatal exertional heat stroke.2 3 The risk for heat illnesse...
Source: British Journal of Sports Medicine - May 2, 2023 Category: Sports Medicine Authors: Klöwer, M., Edouard, P., Niess, A. M., Racinais, S., Pitsiladis, Y. P., Pappenberger, F., Hollander, K. Tags: BJSM Editorial Source Type: research
GSE160899 Does heat stroke induces heat intolerance?: What genes tell us
Contributors : Michal Horowitz ; Dani Kopeliovich ; Yoav Smith ; Sharona Elgavish ; Hagai Shermann ; Dani S MoranSeries Type : Expression profiling by arrayOrganism : Homo sapiensRNA samples of each group, extracted from PBMCs (Peripheral blood mononuclear cell) , were hybridized on two dye array. Within groups and between groups analyses to identify canonical pathways and enriched biological annotations were conducted. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
1377 Exploring the factors to regulate sweating by transcriptome analysis for anhidrosis: Novel role of olfactory receptors on sweating via exposing to β-ionone
Sweat maintains systemic homeostasis in humans. Sweat mainly includes certain metabolites, antibiotic peptides, and electrolytes. Sweat contribute to the regulation of body temperature, immune defense, and moisture retention. Acquired idiopathic generalized anhidrosis (AIGA) is an intractable disease, that cause the fatal heatstroke and skin dryness. Although symptoms related to AIGA apparently impairs patients ’ QOLs, there are few promising treatment strategies for AIGA. The etiology of AIGA remains obscure, and the therapy for the disease is not established. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: N. Murayama, T. Miyaki, H. Hayashi, Y. Tanaka, H. Murota Source Type: research
A Small-for-Gestational-Age Infant with MIRAGE Syndrome Who Developed Heat Stroke and Rhabdomyolysis due to Severe Temperature Instability
This report describes heat stroke and rhabdomyolysis caused by anhidrosis as a symptom of MIRAGE syndrome in a small-for-gestational-age (SGA) female neonate born at 32 weeks of gestation (birth weight, 911 g [-3.8 SD]). She developed severe temperature instability with anhidrosis, growth failure, mild developmental delay, hypothyroidism, and intractable enteropathy. On day 156, her temperature reached 42.0°C; her fever persisted for 2 h with prolonged irritability. Her serum creatine kinase level increased to a peak value of 12,716 (normal range, 43-321) IU/L. The clinical feature was diagnosed as rhabdomyolysis caused b...
Source: Neonatology - April 12, 2023 Category: Perinatology & Neonatology Authors: Kana Saito Ryota Nakagawa Satoshi Narumi Hirofumi Ohashi Akiko Ishiguro Kazuhiko Kabe Source Type: research
A Small-for-Gestational-Age Infant with MIRAGE Syndrome Who Developed Heat Stroke and Rhabdomyolysis due to Severe Temperature Instability
This report describes heat stroke and rhabdomyolysis caused by anhidrosis as a symptom of MIRAGE syndrome in a small-for-gestational-age (SGA) female neonate born at 32 weeks of gestation (birth weight, 911 g [ −3.8 SD]). She developed severe temperature instability with anhidrosis, growth failure, mild developmental delay, hypothyroidism, and intractable enteropathy. On day 156, her temperature reached 42.0°C; her fever persisted for 2 h with prolonged irritability. Her serum creatine kinase level incr eased to a peak value of 12,716 (normal range, 43–321) IU/L. The clinical feature was diagnosed as rhabdomyolysis ca...
Source: Neonatology - April 12, 2023 Category: Perinatology & Neonatology Source Type: research
Immersive Cooling in the Prehospital Setting for Heat Stroke: A Case Report
Prehosp Emerg Care. 2023 Apr 11:1-5. doi: 10.1080/10903127.2023.2201515. Online ahead of print.ABSTRACTNon-exertional heat stroke is defined as exposure to high outdoor temperatures, core body temperature >40 °C, and alteration of mentation. Early identification and treatment are imperative to reduce morbidity and mortality in these patients. Cold water immersion therapy is the most efficient and efficacious modality in treating heat stroke, yet it is rarely initiated in the prehospital setting. We outline a case of an 82-year-old man found unconscious outside during a regional heat wave with a temperature >107F. He...
Source: Prehospital Emergency Care - April 11, 2023 Category: Endocrinology Authors: Douglas Young Bryan Everitt Brandon Fine David Miramontes Source Type: research
