Exertional Heat Illness-From Identifying Heat Rash to Treating Heat Stroke
This article will review the epidemiology of exertional heat-related illness and the variations in presentations and pathology, from heat rash and sunburn to heat exhaustion and heat stroke. By the end of this review clinicians should be able to identify and treat different heat-related illnesses in adolescents and potentially save a life. [Pediatr Ann. 2024;53(1):e17-e21.].PMID:38194658 | DOI:10.3928/19382359-20231113-04 (Source: Pediatric Annals)
Source: Pediatric Annals - January 9, 2024 Category: Pediatrics Authors: Rachel M Danzig Jefferey M Raunig Chidimma J Acholonu Source Type: research
Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study
CONCLUSIONS: The volume of NS infusion was associated with a significant increase in the incidence of AKI, admission to the ICU, and length of stay in the ICU and hospital among patients with HS.PMID:38178374 | DOI:10.1080/0886022X.2023.2294151 (Source: Renal Failure)
Source: Renal Failure - January 5, 2024 Category: Urology & Nephrology Authors: Lan Chen Junlu Zhao Liyun Lu Zhumei Gong Shuying Xu Xiaoling Yang Yuping Zhang Xiuqin Feng Source Type: research
Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study
CONCLUSIONS: The volume of NS infusion was associated with a significant increase in the incidence of AKI, admission to the ICU, and length of stay in the ICU and hospital among patients with HS.PMID:38178374 | PMC:PMC10773613 | DOI:10.1080/0886022X.2023.2294151 (Source: Renal Failure)
Source: Renal Failure - January 5, 2024 Category: Urology & Nephrology Authors: Lan Chen Junlu Zhao Liyun Lu Zhumei Gong Shuying Xu Xiaoling Yang Yuping Zhang Xiuqin Feng Source Type: research
Proteomic profiling of serum exosomes reveals acute phase response and promotion of inflammatory and platelet activation pathways in patients with heat stroke
Conclusion: Overall, this study explores the potential role of the serum exosomal proteome in the inflammatory response and platelet activation in HS, suggests the pathological mechanisms underlying HS-induced injuries, and recommends reliable exosomal biomarkers for predicting HS prognosis.PMID:38107577 | PMC:PMC10725172 | DOI:10.7717/peerj.16590 (Source: Cancer Control)
Source: Cancer Control - December 18, 2023 Category: Cancer & Oncology Authors: Yue Li Huan Li Wenjuan Ma Marc Maegele Youqing Tang Zhengtao Gu Source Type: research
Pediatric vehicular heatstroke: An analysis of 296 cases from the National Fatality Review Case Reporting System
CONCLUSIONS: The results align with previous PVH findings and added new information on child race/ethnicity, CPS action, disability/chronic illness, and maltreatment. With the exception of parents being more likely to be the supervisor in incidents occurring at home, which was expected, neither supervisor characteristics nor child race/ethnicity or sex were independently significant in multiple regression, suggesting that PVH is pervasive and that education campaigns should be similarly broad.PMID:38108664 | DOI:10.1080/15389588.2023.2290454 (Source: Traffic Injury Prevention)
Source: Traffic Injury Prevention - December 18, 2023 Category: Accident Prevention Authors: Mark D Chandler Patricia G Schnitzer Heather K Dykstra J Morag MacKay Source Type: research
Pediatric vehicular heatstroke: An analysis of 296 cases from the National Fatality Review Case Reporting System
CONCLUSIONS: The results align with previous PVH findings and added new information on child race/ethnicity, CPS action, disability/chronic illness, and maltreatment. With the exception of parents being more likely to be the supervisor in incidents occurring at home, which was expected, neither supervisor characteristics nor child race/ethnicity or sex were independently significant in multiple regression, suggesting that PVH is pervasive and that education campaigns should be similarly broad.PMID:38108664 | DOI:10.1080/15389588.2023.2290454 (Source: Traffic Injury Prevention)
Source: Traffic Injury Prevention - December 18, 2023 Category: Accident Prevention Authors: Mark D Chandler Patricia G Schnitzer Heather K Dykstra J Morag MacKay Source Type: research
Enhancing exertional heat stroke patient care: where are we now and where do we need to go?
Despite progress in prevention, recognition and treatment, exertional heat stroke (EHS) persists across multiple levels of sport and physical activity, and society remains burdened with preventable deaths. In most EHS-related deaths, an absence of appropriate healthcare, failure to properly recognise and diagnose the condition, and either lack of knowledge or resistance to using best practices are contributing factors responsible for catastrophic outcomes. The purpose of this editorial is to discuss the current landscape related to EHS management, followed by strategies to enhance patient outcomes (box 1). Box 1Key recomme...
Source: British Journal of Sports Medicine - December 15, 2023 Category: Sports Medicine Authors: Adams, W. M., Hosokawa, Y., Scarneo-Miller, S. E., Belval, L. N. Tags: BJSM Editorial Source Type: research
Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
