Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research
Extracellular histones exacerbate heat stroke-induced liver injury by triggering hepatocyte pyroptosis and liver injury via the TLR9-NLRP3 pathway
CONCLUSIONS: Our findings show that histones are critical mediators of hepatocyte pyroptosis that aggravate liver injury in a heat stroke setting. Therefore, we suggest extracellular histones as potential therapeutic targets to limit heat stroke-induced cell death and liver injury.PMID:38043264 | DOI:10.1016/j.intimp.2023.111305 (Source: International Immunopharmacology)
Source: International Immunopharmacology - December 3, 2023 Category: Allergy & Immunology Authors: Yue Li Huan Li Youqing Tang Yongzhang Rong Source Type: research
Extracellular histones exacerbate heat stroke-induced liver injury by triggering hepatocyte pyroptosis and liver injury via the TLR9-NLRP3 pathway
CONCLUSIONS: Our findings show that histones are critical mediators of hepatocyte pyroptosis that aggravate liver injury in a heat stroke setting. Therefore, we suggest extracellular histones as potential therapeutic targets to limit heat stroke-induced cell death and liver injury.PMID:38043264 | DOI:10.1016/j.intimp.2023.111305 (Source: International Immunopharmacology)
Source: International Immunopharmacology - December 3, 2023 Category: Allergy & Immunology Authors: Yue Li Huan Li Youqing Tang Yongzhang Rong Source Type: research
Molecules, Vol. 28, Pages 7639: Vitexin Regulates Heat Shock Protein Expression by Modulating ROS Levels Thereby Protecting against Heat-Stress-Induced Apoptosis
This study provides a theoretical basis for the prevention and amelioration of heat stress using vitexin. (Source: Molecules)
Source: Molecules - November 17, 2023 Category: Chemistry Authors: Tong Wu Yanan Sheng Yu Tian Changyuan Wang Tags: Article Source Type: research
Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience
CONCLUSIONS: Advanced age, delayed cooling, and higher SOFA scores significantly increase the risk of brain injury post-EHS. These findings underscore the importance of rapid cooling and early assessment of organ failure to improve outcomes in EHS patients.PMID:37973473 | DOI:10.1016/j.cjtee.2023.10.003 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - November 16, 2023 Category: Orthopaedics Authors: Li Zhong Ming Wu Zhe-Ying Liu Yan Liu Zhi-Feng Liu Source Type: research
Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience
CONCLUSIONS: Advanced age, delayed cooling, and higher SOFA scores significantly increase the risk of brain injury post-EHS. These findings underscore the importance of rapid cooling and early assessment of organ failure to improve outcomes in EHS patients.PMID:37973473 | DOI:10.1016/j.cjtee.2023.10.003 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - November 16, 2023 Category: Orthopaedics Authors: Li Zhong Ming Wu Zhe-Ying Liu Yan Liu Zhi-Feng Liu Source Type: research
Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience
CONCLUSIONS: Advanced age, delayed cooling, and higher SOFA scores significantly increase the risk of brain injury post-EHS. These findings underscore the importance of rapid cooling and early assessment of organ failure to improve outcomes in EHS patients.PMID:37973473 | DOI:10.1016/j.cjtee.2023.10.003 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - November 16, 2023 Category: Orthopaedics Authors: Li Zhong Ming Wu Zhe-Ying Liu Yan Liu Zhi-Feng Liu Source Type: research
Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience
CONCLUSIONS: Advanced age, delayed cooling, and higher SOFA scores significantly increase the risk of brain injury post-EHS. These findings underscore the importance of rapid cooling and early assessment of organ failure to improve outcomes in EHS patients.PMID:37973473 | DOI:10.1016/j.cjtee.2023.10.003 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - November 16, 2023 Category: Orthopaedics Authors: Li Zhong Ming Wu Zhe-Ying Liu Yan Liu Zhi-Feng Liu Source Type: research
Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience
CONCLUSIONS: Advanced age, delayed cooling, and higher SOFA scores significantly increase the risk of brain injury post-EHS. These findings underscore the importance of rapid cooling and early assessment of organ failure to improve outcomes in EHS patients.PMID:37973473 | DOI:10.1016/j.cjtee.2023.10.003 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - November 16, 2023 Category: Orthopaedics Authors: Li Zhong Ming Wu Zhe-Ying Liu Yan Liu Zhi-Feng Liu Source Type: research
Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience
CONCLUSIONS: Advanced age, delayed cooling, and higher SOFA scores significantly increase the risk of brain injury post-EHS. These findings underscore the importance of rapid cooling and early assessment of organ failure to improve outcomes in EHS patients.PMID:37973473 | DOI:10.1016/j.cjtee.2023.10.003 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - November 16, 2023 Category: Orthopaedics Authors: Li Zhong Ming Wu Zhe-Ying Liu Yan Liu Zhi-Feng Liu Source Type: research
Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience
CONCLUSIONS: Advanced age, delayed cooling, and higher SOFA scores significantly increase the risk of brain injury post-EHS. These findings underscore the importance of rapid cooling and early assessment of organ failure to improve outcomes in EHS patients.PMID:37973473 | DOI:10.1016/j.cjtee.2023.10.003 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - November 16, 2023 Category: Orthopaedics Authors: Li Zhong Ming Wu Zhe-Ying Liu Yan Liu Zhi-Feng Liu Source Type: research
Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience
CONCLUSIONS: Advanced age, delayed cooling, and higher SOFA scores significantly increase the risk of brain injury post-EHS. These findings underscore the importance of rapid cooling and early assessment of organ failure to improve outcomes in EHS patients.PMID:37973473 | DOI:10.1016/j.cjtee.2023.10.003 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - November 16, 2023 Category: Orthopaedics Authors: Li Zhong Ming Wu Zhe-Ying Liu Yan Liu Zhi-Feng Liu Source Type: research
Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience
CONCLUSIONS: Advanced age, delayed cooling, and higher SOFA scores significantly increase the risk of brain injury post-EHS. These findings underscore the importance of rapid cooling and early assessment of organ failure to improve outcomes in EHS patients.PMID:37973473 | DOI:10.1016/j.cjtee.2023.10.003 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - November 16, 2023 Category: Orthopaedics Authors: Li Zhong Ming Wu Zhe-Ying Liu Yan Liu Zhi-Feng Liu Source Type: research
