Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke
Biomed Pharmacother. 2023 Mar 21;161:114565. doi: 10.1016/j.biopha.2023.114565. Online ahead of print.ABSTRACTGlobal warming increases the incidence of heat stroke (HS) and HS causes the reduction of visceral blood flow during hyperthermia, leading to intestinal barrier disruption, microbial translocation, systemic inflammation and multiple organ failure. Cathelicidin LL-37 exhibits antimicrobial activities, helps innate immunity within the gut to maintain intestinal homeostasis, and augments intestinal wound healing and barrier function. Thus, we evaluated the effects and possible mechanisms of cathelicidin LL-37 on HS. W...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2023 Category: Drugs & Pharmacology Authors: Chih-Chin Shih Wei-Chieh Liao Hung-Yen Ke Chia-Wen Kuo Cheng-Ming Tsao Wen-Chiuan Tsai Yi-Lin Chiu Hsieh-Chou Huang Chin-Chen Wu Source Type: research
Whole genome transcriptomic reveals heat stroke molecular signatures in humans
This article is protected by copyright. All rights reserved.PMID:36951421 | DOI:10.1113/JP284031 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 23, 2023 Category: Physiology Authors: Abderrezak Bouchama Mamoon Rashid Shuja Shafi Malik Saeed Almahri Yara Yassin Mashan Abdullah Nour Abdulmalek Fuad Maashi Abdulaziz Mashi Altaf Khan Badriah Alotaibi Cynthia Lehe Sameer Mohammad Haitham Alkadi Deemah Al Waadani Saber Yezli Source Type: research
Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke
Biomed Pharmacother. 2023 Mar 21;161:114565. doi: 10.1016/j.biopha.2023.114565. Online ahead of print.ABSTRACTGlobal warming increases the incidence of heat stroke (HS) and HS causes the reduction of visceral blood flow during hyperthermia, leading to intestinal barrier disruption, microbial translocation, systemic inflammation and multiple organ failure. Cathelicidin LL-37 exhibits antimicrobial activities, helps innate immunity within the gut to maintain intestinal homeostasis, and augments intestinal wound healing and barrier function. Thus, we evaluated the effects and possible mechanisms of cathelicidin LL-37 on HS. W...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2023 Category: Drugs & Pharmacology Authors: Chih-Chin Shih Wei-Chieh Liao Hung-Yen Ke Chia-Wen Kuo Cheng-Ming Tsao Wen-Chiuan Tsai Yi-Lin Chiu Hsieh-Chou Huang Chin-Chen Wu Source Type: research
Whole genome transcriptomic reveals heat stroke molecular signatures in humans
This article is protected by copyright. All rights reserved.PMID:36951421 | DOI:10.1113/JP284031 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 23, 2023 Category: Physiology Authors: Abderrezak Bouchama Mamoon Rashid Shuja Shafi Malik Saeed Almahri Yara Yassin Mashan Abdullah Nour Abdulmalek Fuad Maashi Abdulaziz Mashi Altaf Khan Badriah Alotaibi Cynthia Lehe Sameer Mohammad Haitham Alkadi Deemah Al Waadani Saber Yezli Source Type: research
Infographic. Prehospital management of exertional heat stroke at sports competitions for Paralympic athletes
This infographic presents a summary of the prehospital management of exertional heat stroke (EHS) at sports competitions for Para athletes.1 Our original article was designed to provide Para athlete-specific modifications to the original EHS algorithm that was developed and implemented at the Tokyo 2020 Olympic Games.2 Both the Olympic and Paralympic algorithms were successfully rolled out during educational workshops leading into the games, and implemented with support of the organising committee medical volunteers in Tokyo. It is the authors’ intention that these algorithms can be used at other events where Para at...
Source: British Journal of Sports Medicine - March 23, 2023 Category: Sports Medicine Authors: Goosey-Tolfrey, V. L., Hosokawa, Y., Webborn, N., Blauwet, C., Adami, P. E. Tags: BJSM Infographic Source Type: research
