Yet More Development of Proteomic Signatures of Longevity
The cost of obtaining transcriptomic and proteomic data, and then using machine learning techniques to develop insights based on that data, has fallen dramatically over the past decade. As a result there is a proliferation of signatures of aging and longevity, as many different research groups analyze many different large transcriptomic and proteomic databases. The example here is one of a number of such signatures created with the idea of finding potential targets for therapy. It is far from clear that one can alter any of the various protein levels related to aging and longevity and obtain meaningful benefits, however. A...
Source: Fight Aging! - March 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Assessment of Right Atrial Pressure From IVC Dimensions by Echocardiography
Assessment of inferior vena caval dimensions by echocardiography is very useful in knowing the volume status of the individual and indirectly assessing the right atrial pressure. When the IVC is collapsed, that means right atrial pressure is low and person is likely to be hypovolemic. Especially in a person with hypotension this is very important in guiding fluid management. On the other way round, when the IVC is enlarged, or rather plethoric, then you know right atrial pressure is high and even if there is hypotension, you cannot give much fluid to such a case. So this is the importance of assessing IVC, which we will se...
Source: Cardiophile MD - March 19, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
An anxious approach to a benign arrhythmia in Holter recording
A 32-year-old high-profile businessman was advised Holter monitoring for a few ectopic beats during routine screening ECG. The 72-hour extended Holter monitoring picked up a single short pause with a blocked P wave and reported as doubtful Mobitz type 2 AV block.
The cardiologist in-charge, told the patient that findings are significant, and he would need further investigation. He was referred to their associate center for an EP study. After hearing about the procedure ,the patient was freighted about inserting multiple catheters inside his heart.
This was the time he consulted me with Holter report. It was i...
Source: Dr.S.Venkatesan MD - March 19, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized 2:1 av block a pilot with av block approach to av block in holter asymptomatic mobitz type 2 block ep study esc pacemaker guideline europace heart rhythm society holter monitoring hv interval mobitz type 2 av block we Source Type: blogs
Microplastics, Major Problem
By KIM BELLARD
It’s been almost four years since I first wrote about microplastics; long story short, they’re everywhere. In the ground, in the oceans (even at the very bottom), in the atmosphere. More to the point, they’re in the air you breathe and in the food you eat. They’re in you, and no one thinks that is a good thing. But we’re only starting to understand the harm they cause.
The Washington Post recently reported:
Scientists have found microplastics — or their tinier cousins, nanoplastics — embedded in the human placenta, in blood, in the heart and in the liver and bowels. In one re...
Source: The Health Care Blog - March 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Kim Bellard Microplastics Source Type: blogs
An 80 year old woman with Left Bundle Branch Block (LBBB) and pleuritic chest pain
This case was sent by Amandeep (Deep) Singh at Highland Hospital, part of Alameda Health System.The patient presented to an outside hospitalAn 80yo female per triage “patient presents with chest pain, also hurts to breathe”PMH: CAD, s/p stent placement, CHF, atrial fibrillation, pacemaker (placed 1 month earlier), LBBB.HPI:
Abrupt onset of substernal chest pain associated with nausea/vomiting
30 min PTA. She reports associated SOB but no dizziness or LOC. She
was given NTG
at home before coming to the hospital. This was the ECG obtained at triage.This ECG was recorded and was reviewed remotely by a...
Source: Dr. Smith's ECG Blog - March 19, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs
Single Frame Echo Quiz
Transcript of the video: Interpreting an echo quiz just from a single frame has a lot of limitations. But, still for an academic exercise, we will try. Unlike the ECG, where a single image may be more informative, echo usually requires moving images. And moreover, even ECG requires a knowledge of the clinical background before interpretation, to avoid errors. Similarly, for echocardiogram, what we would do usually is, first we do a clinical history evaluation, then physical examination, and after that only we proceed with echocardiography in our routine work. But for an academic curiosity, we will just try to interpret an...
Source: Cardiophile MD - March 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
X-Ray Chest PA View in Severe PAH
Transcript of the video: Here is an X-ray chest PA view. The striking finding is the huge enlargement of the right pulmonary artery, almost aneurysmal dilatation of right pulmonary artery. Main pulmonary artery is also grossly dilated. And you can see left pulmonary artery shadow and rest of it is not seen here. It will be behind the main pulmonary artery shadow, because left pulmonary artery descends behind the main pulmonary artery and it will be a retrocardiac shadow. It is not visible here. This is the aortic knuckle. And you are seeing some end on views probably. This could be an end on view. This also could be, but y...
Source: Cardiophile MD - March 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What is the meaning of 10% gradient on treadmill?
Transcript of the video: A question that is often asked is, what is the meaning of 10% gradient in a treadmill test? Usually, in the first stage of Bruce protocol, of treadmill test, there is a 10% gradient in stage 1. That means, if the treadmill length is 150 centimeters, the front end is elevated, about 15 cm from the ground, so that this produces a slope. So 15 cm elevation for a 150 cm treadmill will give a 10% gradient. This is what happens in stage 1 of standard Bruce protocol. In modified Bruce protocol, there is no gradient in stage 1, so that the treadmill will be horizontal. In stage 2, 5% gradient is given and ...
Source: Cardiophile MD - March 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Reaching the cutting edge of medical practice, and losing it
Where I stand today regarding my forty years in clinical medical practice forces me to say things that every physician can personally relate to. After all, we old guys frequently languish in dispensing medical advice to our peers. Most of it comes from the heart. We all adhere to the presumption that the “best doctors”
Read more…
Reaching the cutting edge of medical practice, and losing it originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 18, 2024 Category: General Medicine Authors: Curtis G. Graham, MD Tags: Finance Practice Management Source Type: blogs
Calorie Restriction Induces Plasminogen Production to Protect Muscle Tissue
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
Link: https://doi.org/10.1016/j.celrep.2024.113881 (Source: Fight Aging!)
Source: Fight Aging! - March 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Electrophysiology Catheters and EP Tracing in Ventricular Pacing
Transcript of the video: Just before discussing about an electrophysiology tracing in ventricular pacing, we will have a look at how the electrodes are placed. This is the left anterior oblique view and right anterior oblique view on fluoroscopy. Multiple catheters can be seen here. Those marked by yellow arrows are not catheters, they are the surface electrodes on the chest, pasted over the chest using usual dot snappers. And, intracardiac electrodes this one is coming from above. It is introduced through the jugular vein, into the coronary sinus. It is a decapolar catheter, meaning 10 poles are there. The poles are numbe...
Source: Cardiophile MD - March 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
ECG Quiz, Focusing Mainly on Rhythm
Here is the transcript of the video: Now we will have an ECG, focusing mainly on the rhythm analysis. That is what we are going to see. Clinical history is currently not available, let us see, what we can make out from the ECG.
If you have a look at this ECG, sometimes, in this region, you may pass off it as just a low normal heart rate with nothing else. But careful analysis in this region will easily tell you that, this is one P wave with a fairly normal PR interval. But you have another P wave here, which is not conducted. So, for two P waves, you have one QRS. You might be tempted to think that this is 2:1 AV block. Th...
Source: Cardiophile MD - March 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Why is an Implantable Defibrillator NOT Useful Soon After Myocardial Infarction?
Here is the transcript of the video: Implantable defibrillator is an important life saving device. It can automatically detect life threatening ventricular arrhythmias and treat them, either with a shock or, sometimes by overdrive pacing. Then, why is it mentioned that, implanting a defibrillator soon after an acute myocardial infarction, in those with left ventricular dysfunction and prone for ventricular arrhythmias and sudden cardiac death, is not useful?
This a representative image, showing the implanted defibrillator, and two shock coils, one in the superior vena cava and another in the right ventricle. These are high...
Source: Cardiophile MD - March 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
This Plant-Based Diet Reduces Heart Disease Risk 50%
A nutritionally rich diet containing beneficially rated foods can lower the risk of heart disease by 52 percent. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 17, 2024 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Heart Disease Source Type: blogs
Bonus Features – March 17, 2024 – 65% of nurses think AI will negatively impact healthcare, 14% of EHRs have known cybersecurity vulnerabilities, plus 24 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
CHIME provided some clarity on the Smart Hospital Maturity Model initiative, noting it’s meant to “complement and enhance” the existing Digital Health Most Wired Program. The organization also announced C...
Source: EMR and HIPAA - March 17, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Akasa Apixio Availity Avalon Healthcare Solutions CenTrak CharmHealth CHIME Christina Rassi Claim.MD Claroty ECRI Institute Encoda Epic Research Evry Health Healthcare IT Today Bonus Features HealtheLink HIM Source Type: blogs
