How Significant is First Degree Heart Block?
First degree heart block is an abnormality in the electrical conduction of the heart noted on the ECG, the recording of the electrical activity of the heart. It is not a block in the blood vessels of the heart which we are more familiar with. The waves on an ECG are P, QRS complex and the T wave. Normal interval between the onset of the P wave and the onset of QRS complex is up to one fifth of a second (0.2 seconds). When this interval is increased, it is called first degree heart block or first degree atrioventricular or AV block to be specific. Atria are the upper chambers of the heart and ventricles the lower chambers. ...
Source: Cardiophile MD - April 23, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Types of Ventricular Tachycardia
Three or more ventricular beats in a row at a rate above 100 per minute is termed ventricular tachycardia. Ventricular tachycardia lasting more 30 seconds or requiring termination earlier due to hemodynamic compromise is called sustained ventricular tachycardia. Non sustained ventricular tachycardia is one which lasts less than 30 seconds without hemodynamic compromise. Based on the morphology, ventricular tachycardia can be classifed into monomorphic in which all beats have same morphology on ECG in a given lead and polymorphic in which there is beat to beat variation. Polymorphic ventricular tachycardia with QT interval ...
Source: Cardiophile MD - April 23, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

A Pacemaker quiz and a new concept.
This image comes with courtesy of the Journal of SCAI Jai Parekh, Vikram Sharma, Jared Robl,et al Journal of the Society for Cardiovascular Angiography & Interventions 3 (2024) 101310 What is your diagnosis ? I thought, it was pacemaker extrusion. It was indeed a close answer, still terribly wrong. It is an intentional exterior placement of a permanent pacemaker generator mimicking an extrusion due to pocket infection. Here is a patient, where a permanent pacemaker was kept temporarily for a few weeks or a month in high-risk reversible complete heart block situations. This typically occurs after an inferior post...
Source: Dr.S.Venkatesan MD - April 22, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized chb after tavi chb risk with tavi core valve vs sapien how to use a permanent pacemaker as temporary ? how to use a ppm as tpm? mechansim of chb after tavi TAVR Source Type: blogs

Hippocratic AI Raises $53 Million Series A at a $500 Million Valuation
Company Releases First Product: Generative AI-Powered Staffing Marketplace for Healthcare and will use Funds to Accelerate Further Product Development and Conduct Phase Three Safety Testing for its LLM Hippocratic AI, the company building the first safety-focused Large Language Model (LLM) for healthcare, today announced the close of a $53 million Series A funding round at a $500 million valuation, bringing total funding to $120 million. Today, the company also released its first product for phase three safety testing: a staffing marketplace for healthcare where health systems, payors, and others can “hire” generative ...
Source: EMR and HIPAA - April 22, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT a16z Andreessen Horowitz Bio Health Capsule Cincinnati Children’s ELNA Evernow Fraser Health General Catalyst Guidehealth HarmonyCares Health IT Funding Health IT Fundings Health IT Investmen Source Type: blogs

Difference between pulsed wave and continuous wave Doppler
In pulsed wave Doppler, same piezoelectric crystal is used to transmit and receive the echo from the sample volume. Hence the signals are sent out in pulses and the intervals between the pulses are used to receive the echoes. In continuous wave Doppler, one piezoelectric crystal transmits continuously and another one receives continuously. As the transmission and reception are continuous, it is not possible to find out the depth from which the return signals are received. At the same time continuous wave Doppler can analyze higher velocities while pulsed wave Doppler can analyze only lower velocities. In case of pulsed Dop...
Source: Cardiophile MD - April 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Exercise, Stress, and Cardiovascular Risk
Exercise is well known to correlate with reduced risk of cardiovascular disease in human epidemiological studies. In animal studies, it is possible to demonstrate that increased physical activity does in fact cause a lower incidence of cardiovascular disease. Here researchers argue that stress has a significant effect on cardiovascular outcomes, as demonstrated by the fact that patients with greater degrees of stress, such as those with major depressive disorder, exhibit a larger beneficial correlation of reduced cardiovascular disease with exercise. It is interesting to ask which mechanisms are causing this association; e...
Source: Fight Aging! - April 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

What is the link between thyroid and heart disease?
Heart disease can occur with both increased function of the thyroid gland and decreased function of the thyroid gland. When thyroid function is increased, heart rate increases and the work load of the heart increases. In severe cases heart failure may occur. A peculiarity of heart failure associated with increased thyroid function is that it is a high output failure unlike the usual heart failure in which the pumping function of the heart is reduced, and low output failure occurs. While in low output heart failure the extremities are cold, in high output failure due to increased thyroid function, the extremities of the lim...
Source: Cardiophile MD - April 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Fractional flow reserve for guiding coronary intervention and functional SYNTAX score
Coronary angiography gives a visual impression about the severity of the stenosis. But it need not imply the actual functional significance of the stenosis in terms of flow physiology. It is often difficult to decide which are the flow limiting lesions when there are multiple stenoses in same or different territories. It is here that the fractional flow reserve estimation helps. FFR is estimated using a guide wire with a pressure transducer. FFR wires have properties similar to the floppy guide wires so that they can passed across coronary lesions back and forth easily to assess the pressure drop across the lesions. The f...
Source: Cardiophile MD - April 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Chest pain, resolved. Does it need emergent cath lab activation (some controversy here)? And much much more.
In this study, the major outcomes were the same for both groups, but of 70 patients in the delayed group,4 required emergent intervention for sudden re-occlusion.  You can make your own conclusions.  I think I would want to intervene before there is risk of re-occlusion.However, one could make a reasonable argument for delaying, especially if you would need to awaken your cath team in the middle of the night.  It requires full antiplatelent and antithrombotic therapy, and, in my opinion, if you delay, you should institute continuous 12-lead ECG monitoring.  This is why:1. Why we need cont...
Source: Dr. Smith's ECG Blog - April 22, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs

Sunday Sermonette: Natural History
 Psalm 104 is historically important, because it is among the biblical passages the church used to convict Galileo of heresy. He wrote to the Grand Duchess Christina " Astronomers seem to declare what is contrary to Scripture, for they hold the heavens to be spherical, while the Scripture calls it " stretched out like a tent. " (v. 2) He argued that such passages should not be taken literally as scientific findings might discredit them. In fact, verse 5 was specifically cited at his trial. We know now that God is not the explanation for any of the natural phenomena described here, whether accurately or not. Rel...
Source: Stayin' Alive - April 21, 2024 Category: American Health Source Type: blogs

Relation Between Stroke and Heart Disease
Stroke is often due to sudden loss of blood supply to a region of the brain which usually results in paralysis of a part of the body. Stroke could also be due to bleeding into a part of the brain. Strokes and heart disease are linked together in various ways. In general, risk factors for stroke and some forms of heart disease are similar. Strokes due to blocks in blood vessels, can be seen along with blocks in blood vessels of the heart. Stroke can occur after a heart attack as well. Heart attack damages a part of the heart muscle. This can lead to damage of the inner lining of the heart in that region. A blood clot can fo...
Source: Cardiophile MD - April 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases. « Back to Top A Population Study Correlates Air Pollution with Faster Cognitive Aging https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/ A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

L-type and T-type Calcium Channels
Calcium channels in the heart muscle are of two types: L-type (ICa-L) and T-type (ICa-T). Both these are voltage gated calcium channels. L-type channels are involved in the myocardial contraction while T-type channels are involved in impulse generation and conduction. The calcium channels are located in the plasma membrane and are protein complexes that are voltage gated to regulate entry of calcium ions into the cell. Phase 2 or plateau phase of myocardial action potential is featured by influx of calcium ions through L-type calcium channels (ICa-L). In addition to myocardial cells, L-type calcium channels are important i...
Source: Cardiophile MD - April 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

MCQ on Type 1 Diabetes Mellitus
All of the following are true regarding type 1 diabetes mellitus except: A. Accounts for about 10% of all cases of diabetes mellitus B. First peak of presentation occur at 5 to 7 years of age C. Can occur between 1 and 2 years in high risk groups D. In all populations, females are significantly more affected Correct answer: D. Type 1 diabetes mellitus is slightly more common in boys and men. (https://www.ncbi.nlm.nih.gov/books/NBK441918/) (Source: Cardiophile MD)
Source: Cardiophile MD - April 20, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Potential Risk of Serious Bleeding in Patients With AF Using Diltiazem With Apixaban or Rivaroxaban
A potentially serious drug interaction between diltiazem and apixaban or rivaroxaban has been reported in US Medicare patients taking these drugs together for atrial fibrillation. The study has been published as online ahead of print in the Journal of American Medical Asociation [1]. The study compared serious bleeding risk for new users of apixaban or rivaroxaban with atrial fibrillation treated with diltiazem or metoprolol. It was a retrospective cohort study which included US Medicare benefiaries aged 65 years or more with atrial fibrillation and follow up period was one year. Primary outcome was a composite of bleedi...
Source: Cardiophile MD - April 19, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs