Commotio cordis
Sometimes a player drops down dead after being accidentally hit by a ball or another player. This situation which can occur in any contact sports is known as commotio cordis. The sudden hit on the chest causes the heart to stop in ventricular fibrillation. Ventricular fibrillation is a very fast irregular electrical activity of the lower chambers which prevents proper contraction of the heart. The intensity of the blow is not sufficient to cause any damage to the chest wall. No structural damage is noted in the heart as well. If there is a contusion (bruising) of the heart, it will be called contusio cordis. Contusio cordi...
Source: Cardiophile MD - April 17, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Ventricular Tachycardia Management
Ventricular tachycardia is a potentially life threatening cardiac arrhythmia. If the rate is very fast, hemodynamic deterioration can occur rapidly. On the ECG, ventricular tachycardia can be defined as three or more ventricular ectopic beats occurring in a sequence at a rate more than 100 per minute. Ventricular tachycardia which gets spontaneously terminated within 30 seconds is called non sustained ventricular tachycardia (NSVT) . Sustained ventricular tachycardia is one which does not get spontaneously terminated within 30 seconds or needs cardioversion before that due to hemodynamic compromise. Based on the morphology...
Source: Cardiophile MD - April 17, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Difference Between Invasive and Non-Invasive Ventilation
Ventilator is a device used to support breathing. It is used when there is difficulty in breathing or when spontaneous breathing has stopped. Ventilator is an important life supporting device useful in many life threatening conditions. Invasive ventilator is usually used in the intensive care setting or the operating room. An endotracheal tube is introduced under topical anaesthesia with sedation or general anaesthesia. The endotracheal tube is connected to a mechanical ventilator using appropriate connection tubing. In those who do not tolerate the presence of an endotracheal tube deep sedation and neuromuscular blockade ...
Source: Cardiophile MD - April 16, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Difference Between a Biphasic and Monophasic Defibrillators
The direct current shock given can have a monophasic or biphasic waveform. In monophasic shock, the shock is given in only one direction from one electrode to the other. In a biphasic shock, initial direction of shock is reversed by changing the polarity of the electrodes in the latter part of the shock. Usually the initial voltage applied is higher than the reversed polarity shock. Biphasic waveforms were initially developed for use in implantable cardioverter defibrillators (ICD) and later adapted to external defibrillators. Biphasic truncated exponential waveform and rectilinear biphasic waveform are two types of biphas...
Source: Cardiophile MD - April 16, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

From Patent To Product: The Speed Of The Digital Health Evolution
We’re bombarded with mindblowing headlines of new medical miracles every day. BCI helps paralysed patients talk again! Robots in the stomach! Micro-organs on organ-on-chip technologies! But it is almost impossible to see through the hype and know if and when these will yield actual, patient-ready solutions. So let’s get into this maze and decipher how a new, revolutionary medical technology develops from an ingenious idea to a market-ready product with two real-life examples: the artificial pancreas and wireless ECG. In early April, the UK’s NHS rolled out an artificial pancreas (APS) for Type 1 diabetes patients,...
Source: The Medical Futurist - April 16, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF artificial intelligence digital health Innovation patent analysis Medicine Source Type: blogs

Need High Awareness of Symptoms of Heart Attack
High degree of awareness of heart attack symptoms in the community will go a long way in seeking early treatment. For life threatening diseases like heart attack, early recognition of symptoms and prompt reporting to the emergency department is highly desirable. But a study from United States showed that 47% were not able to recognize some heart attack symptoms while 6% were not able to recognize any heart attack symptoms. The main heart attack symptoms assessed by the study were: Chest pain or discomfort Shortness of breath Pain or discomfort in arms or shoulders Feeling weak, lightheaded, or faint Jaw, neck, or back pai...
Source: Cardiophile MD - April 16, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

The current STEMI paradigm: Because STEMI criteria are not met, let's wait until the myocardium is dead!!
This was sent to me by an inpatient nurse who reads this blog but wants to remain anonymous.An inpatient rapid response was called for a patient with hypotension.  The patient was originally admitted for pneumonia and had been transferred out of the ICU a day prior. He had a history of HFrEF, HTN, and AML. " When I arrived his blood pressure was 70s/40s and he was pale and profusely diaphoretic. " " He spoke Spanish but we did deduce that he had 7/10 chest pain radiating to the back. " " We couldn ’t initially get a hold of the primary physician but our hospital allows the rapid response nur...
Source: Dr. Smith's ECG Blog - April 16, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs

Mesenchymal Stem Cell Therapy Produces Thymus Regrowth in Old Non-Human Primates
Thymocytes generated in the bone marrow migrate to the thymus, near the heart, where they mature into T cells of the adaptive immune system. Unfortunately, the thymus atrophies with age. Most people have little active thymus tissue left by the time they are in their 50s. Absent a robust supply of new T cells, the adaptive immune system becomes ever more made up of malfunctioning, senescent, and other problematic cells, lacking the naive T cells needed to respond to new threats. Regeneration of the thymus is thus an important goal. There are some indications that the thymus is more plastic than thought, given that mild calo...
Source: Fight Aging! - April 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Assessment of LV Diastolic Function by Echo in SR and AF
Echocardiographic assessment of left ventricular diastolic function with special reference on diastolic function assessment in atrial fibrillation. Though there are several parameters for evaluation of left ventricular diastolic function by echocardiography, the most commonly used are the pulsed Doppler mitral E/A ratio and tissue Doppler mitral E/e’ ratio. Some of the other useful parameters are mitral E velocity deceleration time, changes in mitral inflow with Valsalva maneuver, mitral L velocity, isovolumic relaxation time, left atrial maximum volume index, pulmonary vein systolic/diastolic velocity ratio, color M-mod...
Source: Cardiophile MD - April 15, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

56 year old male had 5/10 chest pain for several hours, then presented to the ED in the middle of the night with 1/10 pain.
A 56 year old male with PMHx significant for hypertension had chest pain for several hours, then presented to the ED in the middle of the night.He reported chest pain that developed several hours prior to arrival and was 5/10 in intensity. The pain was located in the mid to left chest and developed after riding his bike. There was associated fatigue when symptoms developed and mild shortness of breath at onset of chest pain however that has since resolved.  The patient states he experienced similar 7/10 chest pain 2 days prior when he had to hurry to catch the bus. He states he experience...
Source: Dr. Smith's ECG Blog - April 14, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs

ECG in LMCA Stenosis
ECG in a person with persistent anginal pain for the past several hours showing significant ST segment depression anterolateral leads along with sinus tachycardia. ST segment elevation is noted in aVR. Such a pattern is consistent with significant left main coronary artery stenosis. Clinical evaluation and X-Ray chest showed features of pulmonary edema. Angiography done after initial stabilization showed severe stenosis of distal left main coronary artery. In addition, there were multiple lesions in all three vessels, making a standard indication for an urgent coronary artery bypass grafting. A similar ECG pattern can also...
Source: Cardiophile MD - April 13, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Does non -IRA lesion status confuse you : Try a blind primary PCI !
Primary PCI of IRA is a legally, & globally validated  (of course with lots of ifs & buts) coronary reperfusion strategy. What to do, if  we happen to detect, a significant or borderline lesion in non- IRA territory ? There are too many guidelines scattered across cardiology literature either to “help or confuse” us. They argue for either immediate intervention , defer transiently, postpone or just ignore it , based on clinical ,hemodynamic*, Individual, institutional , or some other non academic factors. (Permanently deferred PCI is other wise called medical management is practiced by s...
Source: Dr.S.Venkatesan MD - April 13, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs

Does the “ Non -IRA ” lesion status confuse you often ?..Try a blind primary PCI !
Primary PCI of IRA , continues to be a clinically & statisticaly validated  (Inspite of some ifs & buts) coronary reperfusion strategy. What to do, if  we happen to detect, a significant or borderline lesion in non- IRA territory ? There are too many guidelines scattered across cardiology literature either to “help or confuse” us. They argue for either immediate intervention , defer transiently, postpone or just ignore it , based on clinical ,hemodynamic*, Individual, institutional , or some other non academic factors. (Permanently deferred PCI is other wise called medical management is prac...
Source: Dr.S.Venkatesan MD - April 13, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs

Delivery of TGF- β1 Following Heart Attack Reduces Reperfusion Injury
A heart attack is triggered by rupture of an atherosclerotic plaque and downstream blockage of an important vessel feeding oxygenated blood to heart tissue. Much of the permanent harm resulting from a heart attack occurs when blood flow is restored to ischemic tissue, however. A cascade of maladaptive reactions, inflammation, and cell death occurs, leading to scarring and loss of function in the heart muscle. This damage to the heart can be reduced to some degree by anti-inflammatory signaling applied soon after the heart attack takes place, as researchers here demonstrate. Despite major improvements using primary...
Source: Fight Aging! - April 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs