Palpitations and presyncope in a 40-something
Discussion: Putting all of the information together this patient is most likely suffering from arrhythmogenic cardiomyopathy (AC) better known as ARVC. The medical hx is typical, with sudden onset tachydysrhythmia during physical exertion. It is not uncommon for the initial presentation to be sudden cardiac death (SCD). In fact it is one of the leading causes of SCD in people age less than 40 years. Thus it is very important to identify this disorder. AC is a disease in which myocardium is replaced by fibrofatty tissue. This usually and predominantly affects the RV free wall and apical regions, but it can affect the left v...
Source: Dr. Smith's ECG Blog - March 24, 2024 Category: Cardiology Authors: Magnus Nossen Source Type: blogs
M-Mode Echocardiogram in LV Dysfunction
Transcript of the video: This is a still image of M-Mode Echocardiogram. M-Mode is Time-Motion Mode. The horizontal axis is time. Vertical axis is distance from the transducer. That is M-Mode, one of the older modes, currently used mainly for taking left ventricular measurements. In the inset you can see the two dimensional image. Location of the transducer here, in the parasternal region. This is the parasternal long axis view. Right ventricular outflow tract, left ventricle, left atrium, aorta, aortic valve, mitral valve. These are the things you have seen in that inset image. This is movement of the anterior wall of the...
Source: Cardiophile MD - March 23, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Ret-He: Reticulocyte hemoglobin equivalent – Marker for iron deficiency in ADHF
It is well known that iron deficiency is associated with poor outcome in acute decompensated heart failure. Different criteria like serum ferritin less than 100 ng/mL or 100-299 ng/mL with transferrin saturation less than 20% have been used to define iron deficiency. Inflammation which is common in heart failure may hinder serum ferritin values [1]. Another marker which has been proposed is reticulocyte hemoglobin equivalent (Ret-He) which is thought to reflect the iron content in reticulocytes.
In a study of 225 patients with ADHF from Japan, median left ventricular ejection fraction was 37%. Median hemoglobin level was ...
Source: Cardiophile MD - March 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
M-Mode Echocardiogram in Left Ventricular Dysfunction
Transcript of the video: This is a still image from a colour Doppler echocardiogram, obtained from the apical five chamber view. This is the region where the transducer is placed and the image looks inverted, because it is imaging from apex upwards. Left ventricle, right ventricle, left atrium and part of the aorta. That is why it is called as the five chamber view. This is the region of the right atrium. Here you can see an MR jet. That is, flow away from the transducer is depicted as blue. Flow towards the transducer is depicted as red. Here, this is the forward flow through the mitral valve in diastole in red. This is r...
Source: Cardiophile MD - March 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Mitral and Aortic Regurgitation on Colour Doppler Echo
Transcript of the video: This is a still image from a colour Doppler echocardiogram, obtained from the apical five chamber view. This is the region where the transducer is placed and the image looks inverted, because it is imaging from apex upwards. Left ventricle, right ventricle, left atrium and part of the aorta. That is why it is called as the five chamber view. This is the region of the right atrium. Here you can see an MR jet. That is, flow away from the transducer is depicted as blue. Flow towards the transducer is depicted as red. Here, this is the forward flow through the mitral valve in diastole in red. This is r...
Source: Cardiophile MD - March 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
The Longevity-Associated BPIFB4 Variant is Anti-Inflammatory
A variant in the gene BPIFB4 has been found to correlate with longevity in humans. In these matters it is worth noting that even small effects on mortality risk result in noticeable correlations with sustained over decades, and indeed all of the known human associations between longevity and genetic variation identified in large study populations are thought to have only modest effect sizes. What are the underlying mechanisms for BPIFB4, however? Researchers here make an argument for suppression of the chronic inflammation of aging as the reason for the association between BPIFB4 and longevity. Certainly chronic inflammato...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Aprocitentan the first endothelin receptor antagonist approved for treatment of hypertension
Just now, I read online that aprocitentan has become the first endothelin receptor antagonist to be approved by the USFDA for treatment of hypertension. Edema and anemia are the most common adverse events as per the manufacturer’s prescribing information and aprocitentan is contraindicated in pregnancy. Edema could be managed by adding or uptitrating diuretics.
Macitentan used in the treatment of pulmonary arterial hypertension, metabolizes into the active compound, aprocitentan. Aprocitentan is an orally active, dual endothelin receptor antagonist which inhibits ET‐1 by binding to both ETA and ETB receptors. Aproc...
Source: Cardiophile MD - March 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
A 50-something with chest pain. Is there OMI? And what is the rhythm?
Written by Willy FrickA man in his 50s with history of hypertension, hyperlipidemia, and a 30 pack-year smoking history presented to the ER with 1 hour of acute onset, severe chest pain and diaphoresis. His ECG is shown:What do you think?The history thus far is highly suggestive of OMI, so we must study the ECG very closely to see if we can confirm this. Looking at the rhythm strip, we see there is more going on than simple sinus rhythm, and in fact there are two different morphologies of QRS complexes. Take a closer look at the rhythm by itself and see if you can figure out what ' s going on before scrolling further....
Source: Dr. Smith's ECG Blog - March 22, 2024 Category: Cardiology Authors: Willy Frick Source Type: blogs
Biatrial Enlargement on Chest X-Ray PA View
Transcript of the video: Chest X-ray PA view. You can see that there is straightening of left border. Normally, the main pulmonary artery segment will be concave and left atrial appendage region also will be not prominent. Here both have enlarged slightly, but not enough to produce gross bulges. So that is why we see straightening of left border, typically heard of in mitral stenosis with left atrial enlargement and mild pulmonary hypertension. When there is gross pulmonary hypertension, instead of these being straight over here, it will form a bulge over here. And when there is gross enlargement of left atrial appendage, ...
Source: Cardiophile MD - March 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
TIMI Thrombus Grade
Transcript of the video: TIMI Thrombus Grade is useful for quantification of thrombus which is detected angiographically, mainly for study purposes, but also for day to day use. There are six grades, starting from grade 0 to grade 5. Grade 0 is no thrombus, while grade 5 is total occlusion of the vessel due to thrombus formation.
These are the grade, TIMI grades, named after the landmark Thrombolysis In Myocardial Infarction trial. Grade 0, no angiographic evidence of thrombus. Grade 1, possible thrombus present, grade 2, small thrombus, grade 3, moderate thrombus, grade 4, large sized thrombus and grade 5, total occlusion...
Source: Cardiophile MD - March 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
TREM2 Influences the Formation of Unstable Atherosclerotic Plaque
The growth of atherosclerotic plaques in blood vessels is harmful, not least because it restricts blood flow, even blocking entire vessels in the worst cases. The vast majority of cardiovascular mortality results from the rupture of fatty, unstable plaques, however, leading to stroke and heart attack when the fragments block downstream vessels. If the development of plaque instability could be slowed or reversed, this would have a sizable impact on cardiovascular mortality - even given that this goal is a step down from reversal of plaque in general. Thus researchers are interested in finding the mechanisms that determine ...
Source: Fight Aging! - March 21, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Excimer Laser Coronary Angioplasty
Transcript of the video: Conventional balloon angioplasty enlarges the vessel a bit as well as plasters the plaque on to the vessel wall, while laser angioplasty is a new technique, also known as laser atherectomy, in which excimer laser, which is a monochromatic source of light, is used to vaporize the plaque or thrombus by producing heat and shock waves. The most important advantage of laser angioplasty or excimer laser angioplasty, is that you need only a standard guidwire, 0.014 inch standard guide wire, unlike the other atherectomy devices which require a bulkier guidewire.
Diagrammatic representation of laser angiopl...
Source: Cardiophile MD - March 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Evaluation of JVP
Transcript of the video: Now we will discuss the basic principles of evaluation of jugular venous pressure and jugular venous pulse. These are assessed in the internal jugular vein and not in the external jugular vein. To revise the anatomy lessons, this is the external jugular vein and this is the internal jugular vein. Now, why we should not be looking at external jugual vein, though it is much easier to find out is that, in lower portion, it may be kinked so that it may not reflect the true right atrial pressure. The whole purpose of assessing the jugular venous pressure and pulse is that it reflects the right atrial pr...
Source: Cardiophile MD - March 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Wednesday Bible Study: QAnon
Psalms 81 and 82 are pretty standard fare. 81 is written for a specific observance, and it reminds the Israelites that they are God ' s chosen people and to be faithful. 82 calls on God to punish the wicked and reward the righteous -- as if he wouldn ' t do it unless we asked. Psalm 83, however, is getting a whole lot of attention right now, from people who probably don ' t read this blog and who you probably are barely aware of. It describes a broad alliance against Israel, bent on its destruction, and calls on God to exterminate them, referring to the massacres of the Midianites in Numbers 31, and the massacre of th...
Source: Stayin' Alive - March 20, 2024 Category: American Health Source Type: blogs
The 12 Best Be Kind to Yourself Quotes (and Helpful Tips on Self-Love)
When you fall or stumble then the default for many is to be hard on yourself.
To push yourself forward again. Or to not make the same mistake in the future.
Being tough on oneself is a common strategy in many situations but I have over the years found that being kind to yourself works even better.
Why?
Well, for one, I find it makes it easier to get back on the right track and move forward (being hard on yourself can lead to feeling disappointed and discouraged from even trying again).
And in today’s post I want to share 12 of my favorite be kind to yourself quotes plus my own thoughts and tips related to each of these ...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - March 20, 2024 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Self Esteem Source Type: blogs
