Bis(monoacylglycero)phosphates Accumulate in Aged Tissues
Lipid metabolism is changed and disrupted with advancing age, as is the case for all complex mechanisms in the body. There are a great many different lipids present in the body; even the list of classes of lipid is a long one. Finding specific changes that relate to aging can be interesting, but the challenge lie in better understanding how those changes come about, and whether they causes significant harm to tissues. Many age-related changes in molecular biochemistry are far downstream of the important causes of aging and do not cause much further disruption in and of themselves.
In recent years, laboratory resea...
Source: Fight Aging! - April 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Preventing amputations and saving lives starts with bringing PAD into the 21st century
There’s a condition that is crippling Black and brown communities at a disproportionate rate and causing 400 amputations each day in the U.S. That may sound scary, but the most frightening part? A new consumer survey found that 70 percent of Americans have never heard of the most common vascular disease, peripheral artery disease (PAD)
Read more…
Preventing amputations and saving lives starts with bringing PAD into the 21st century originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 18, 2024 Category: General Medicine Authors: Anahita Dua, MD, MBA Tags: Conditions Cardiology Source Type: blogs
Endothelial Cellular Senescence Contributes to Loss of Capillary Density
The consensus of the research community on senescent cells in old tissues is that (a) their presence causes harm, and (b) treatments based on the selective removal of such cells will be beneficial, reversing many aspects of aging and age-related disease. These cells secrete a pro-inflammatory mix of signal molecules that is disruptive to tissue structure and function when maintained over time. Cells become senescent constantly throughout life, only to be destroyed by programmed cell death or by the immune system. With advancing age, newly created senescent cells are cleared ever more slowly, however, and thus the burden of...
Source: Fight Aging! - April 18, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An Interview with Reason of Repair Biotechnologies on Reversal of Atherosclerosis
As some of you may know, I co-founded Repair Biotechnologies with Bill Cherman. The company is presently on the development of a gene therapy approach now demonstrated to rapidly reverse atherosclerosis in mice, the condition in which fatty plaques grow to narrow blood vessels and weaken blood vessel walls. One of the possible approaches to treating aging as a medical condition is to take the list of causes of human mortality, start at the top, and work down. Atherosclerosis is the single largest cause of death in our species, through the rupture of unstable atherosclerotic plaque leading to heart attack or stroke. The bur...
Source: Fight Aging! - April 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Corvia atrial shunt system: Mean LA pressure reduction device in HFpEF
Lowering the raised LA mean pressure is a major therapeutic goal in any severely symptomatic left heart disease, whether it is valvular or myocardial disease. It is prudent to understand, that even in systolic LV failure; it is the raised LVEDP that causes the symptoms and marks the limits of exercise capacity. Drugs like inotropes, pre-load , afterload modulators like diuretics and vasodilators can take care to a certain extent.
When symptoms are refractory and the underlying condition has no primary correction , we need to intervene with some extreme procedures. We know a small ASD decompresses mitral stenosis, and th...
Source: Dr.S.Venkatesan MD - April 18, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acquired asd in hfpef atrial flow regulator corvia atrial shunt system decompression of left atrium hhpef lutembacher syndrome Source Type: blogs
Who Needs a CT Coronary Angiogram?
CT coronary angiograms are increasing in popularity as a non-invasive screening test for detecting blocks in coronary arteries.
Coronary arteries are blood vessels supplying oxygenated blood to the heart.
Angiograms are images of blood vessels, usually obtained by injecting medications for contrast from body structures.
CT angiograms are reconstructions from multi slice CT scans following injection of contrast material into a forearm veins.
Veins are blood vessels returning deoxygenated blood to the heart.
CT coronary angiogram can be done as an outpatient test, in the X-ray department.
As of now CT angiograms cannot repla...
Source: Cardiophile MD - April 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What are the Cyanotic Congenital Heart Diseases with Increased Pulmonary Blood Flow?
D-Transposition of great arteries
Double outlet right ventricle without pulmonary pulmonary stenosis
Taussig-Bing anomaly
Total anomalous pulmonary venous return
Truncus arteriosus
Single ventricle (double inlet ventricle, univentricular heart) (Source: Cardiophile MD)
Source: Cardiophile MD - April 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What are the Cyanotic Congenital Heart Diseases With Decreased Pulmonary Blood Flow?
Tetralogy of Fallot
TOF with pulmonary atresia
Pulmonary atresia with intact interventricular septum
Tricuspid atresia
Double outlet right ventricle
Transposition of great arteries with ventricular septal defect and pulmonary stenosis
Ebstein’s anomaly of tricuspid valve
In DORV and tricuspid atresia, there are also variants with increased pulmonary blood flow, in the absence of associated pulmonary stenosis. (Source: Cardiophile MD)
Source: Cardiophile MD - April 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Is OMI an ECG Diagnosis?
Written by Jesse McLaren A 70 year old with prior MIs and stents to LAD and RCA presented to the emergency
department with 2 weeks of increasing exertional chest pain radiating to the
left arm, associated with nausea. The pain recurred at rest 90 minutes prior to
presentation, felt like the patient ’s prior MIs, and was not relieved by 6
sprays of nitro. Paramedics provided another 3 sprays of nitro, and 6mg of
morphine, which reduced but did not resolve the pain. What do you think of the ECG, and does it
matter?There ’s normal sinus rhythm, LAFB, old anterior Q waves,
and no diagnostic sign of OMI. I sent th...
Source: Dr. Smith's ECG Blog - April 18, 2024 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
What are the acyanotic congenital heart diseases with left to right shunt lesions?
Atrial septal defect – Ostium Primum, Ostium Secundum, Sinus Venosus
Partial anomalous pulmonary venous return
Atrioventricular septal defect
Ventricular septal defect – inlet, outlet, perimembranous, muscular
Patent ductus arteriosus
Aortopulmonary window
Coronary artery fistula draining to right heart
Ruptured sinus of Valsalva aneurysm to right heart (Source: Cardiophile MD)
Source: Cardiophile MD - April 17, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Wednesday Bible Study: The Return of the King
You may recall that an earlier psalm purported to be the last Psalm of David, but as we know, the current Book of Psalms is actually a compilation and the editors just didn ' t delete that. There are more psalms attributed to David and we ' ve come to two of them today. Psalm 101, attributed to David, is a sort of oath of office. Psalm 103 is a song of praise, which gives God several attributes that he clearly doesn ' t have. No, he doesn ' t heal all diseases (v. 3), doesn ' t renew youth (v. 5), doesn ' t work vindication and justice for all who are oppressed (v. 6) and most certainly is not merciful and...
Source: Stayin' Alive - April 17, 2024 Category: American Health Source Type: blogs
This Week ’ s Health IT Jobs – April 17, 2024
It can be very overwhelming scrolling though job board after job board in search of a position that fits your wants and needs. Let us take that stress away by finding a mix of great health IT jobs for you! We hope you enjoy this look at some of the health IT jobs we saw healthcare organizations trying to fill this week.
Here’s a quick look at some of the health IT jobs we found:
Oracle Health Analysts – Ellit Groups
Patient Access Manager – Generis Tek Inc
EPIC Ambulatory Analyst – Odyssey Information Services
Quality Improvement Director – Saint Vincent Hospital
Application Developer (Oracle...
Source: EMR and HIPAA - April 17, 2024 Category: Information Technology Authors: Grayson Miller Tags: Career and Jobs Health IT Company Healthcare IT Hospital - Health System AG Globe Services Cardiovascular Institute of the South Catawba Valley Health System Catholic Relief Services CIOX Health Community Health Systems ECU Health El Source Type: blogs
Commotio cordis
Sometimes a player drops down dead after being accidentally hit by a ball or another player. This situation which can occur in any contact sports is known as commotio cordis. The sudden hit on the chest causes the heart to stop in ventricular fibrillation. Ventricular fibrillation is a very fast irregular electrical activity of the lower chambers which prevents proper contraction of the heart.
The intensity of the blow is not sufficient to cause any damage to the chest wall. No structural damage is noted in the heart as well. If there is a contusion (bruising) of the heart, it will be called contusio cordis. Contusio cordi...
Source: Cardiophile MD - April 17, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Ventricular Tachycardia Management
Ventricular tachycardia is a potentially life threatening cardiac arrhythmia. If the rate is very fast, hemodynamic deterioration can occur rapidly. On the ECG, ventricular tachycardia can be defined as three or more ventricular ectopic beats occurring in a sequence at a rate more than 100 per minute.
Ventricular tachycardia which gets spontaneously terminated within 30 seconds is called non sustained ventricular tachycardia (NSVT) . Sustained ventricular tachycardia is one which does not get spontaneously terminated within 30 seconds or needs cardioversion before that due to hemodynamic compromise.
Based on the morphology...
Source: Cardiophile MD - April 17, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Difference Between Invasive and Non-Invasive Ventilation
Ventilator is a device used to support breathing. It is used when there is difficulty in breathing or when spontaneous breathing has stopped. Ventilator is an important life supporting device useful in many life threatening conditions.
Invasive ventilator is usually used in the intensive care setting or the operating room. An endotracheal tube is introduced under topical anaesthesia with sedation or general anaesthesia. The endotracheal tube is connected to a mechanical ventilator using appropriate connection tubing. In those who do not tolerate the presence of an endotracheal tube deep sedation and neuromuscular blockade ...
Source: Cardiophile MD - April 16, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
