Surgically Resected Cardiac Angiosarcoma: Survival Analysis from the National Cancer Database
J Clin Med. 2023 Dec 18;12(24):7764. doi: 10.3390/jcm12247764.ABSTRACTAngiosarcoma is a rare type of soft-tissue sarcoma arising from endothelial cells. It is considered 'high-grade' by definition, reflecting its aggressive behavior. We sought to investigate the role of surgery in cardiac angiosarcoma, identify late mortality predictors, and identify interactions with other modalities in its treatment using a national dataset. The 2004-2017 National Cancer Database was reviewed for patients with primary cardiac angiosarcoma. Late mortality predictors were evaluated with Kaplan-Meier curves and Cox regression analysis. Surg...
Source: Clinical Lung Cancer - December 23, 2023 Category: Cancer & Oncology Authors: Mohamed Rahouma Massimo Baudo Sherif Khairallah Christopher Lau Mario Gaudino Magdy M El-Sayed Ahmed Akshay Kumar Roberto Lorusso Stephanie L Mick Source Type: research
A rare presentation of primary cardiac diffuse large B ‑cell lymphoma: A case report
Oncol Lett. 2023 Dec 4;27(1):40. doi: 10.3892/ol.2023.14174. eCollection 2024 Jan.ABSTRACTPrimary cardiac lymphomas display a low frequency, sudden onset, swift progression of illness and elevated mortality rates. The current study presents a unique instance of primary cardiac diffuse large B-cell lymphoma and examines its clinical manifestations, pathological characteristics and differential diagnosis. A 64-year-old male patient sought medical attention due to cardiac debility and exertional dyspnea persisting for >10 days. Chest enhanced computed tomography revealed a moderately enhancing irregular mass in the ventric...
Source: Oncology Letters - December 18, 2023 Category: Cancer & Oncology Authors: Hongyan Jiang Haijun Liu Linwei Zhao Ling Yang Yunfei Zhao Source Type: research
Review of electrospun microtube array membrane (MTAM) ‐a novel new class of hollow fiber for encapsulated cell therapy (ECT) in clinical applications
AbstractEncapsulated cell therapy (ECT) shows significant potential for treating neurodegenerative disorders including Alzheimer's and Parkinson's, which currently lack curative medicines and must be managed symptomatically. This novel technique encapsulates functional cells with a semi-permeable membrane, providing protection while enabling critical nutrients and therapeutic substances to pass through. Traditional ECT procedures, on the other hand, pose difficulties in terms of cell survival and retrieval. We introduce the Microtube Array Membrane (MTAM), a revolutionary technology that solves these constraints, in this c...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 18, 2023 Category: Materials Science Authors: Chee Ho Chew,
Hsin ‐Lun Lee,
Amanda Lin Chen,
Wan‐Ting Huang,
Shu‐Mei Chen,
Yen‐Lin Liu,
Chien‐Chung Chen Tags: REVIEW ARTICLE Source Type: research
The benign nature and rare occurrence of cardiac myxoma as a possible consequence of the limited cardiac proliferative/ regenerative potential: a systematic review
Cardiac Myxoma is a primary tumor of heart. Its origins, rarity of the occurrence of primary cardiac tumors and how it may be related to limited cardiac regenerative potential, are not yet entirely known. This... (Source: BMC Cancer)
Source: BMC Cancer - December 18, 2023 Category: Cancer & Oncology Authors: Ovais Shafi, Ghazia Siddiqui and Hassam A. Jaffry Tags: Research Source Type: research
Shared and Reciprocal Mechanisms Between Heart Failure and Cancer - An Emerging Concept of Heart-Cancer Axis
Circ J. 2023 Dec 12. doi: 10.1253/circj.CJ-23-0838. Online ahead of print.ABSTRACTEpidemiological evidence of increased risks of cancer in heart failure (HF) patients and HF in cancer patients has suggested close relationships between the pathogenesis of both diseases. Indeed, HF and cancer share common risk factors, including aging and unhealthy lifestyles, and underlying mechanisms, including activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, chronic inflammation, and clonal hematopoiesis of indeterminate potential. Mechanistically, HF accelerates cancer development and progression via...
Source: Circulation Journal - December 13, 2023 Category: Cardiology Authors: Hiroshi Kadowaki Hiroshi Akazawa Akito Shindo Tomomi Ueda Junichi Ishida Issei Komuro Source Type: research
Shared and Reciprocal Mechanisms Between Heart Failure and Cancer - An Emerging Concept of Heart-Cancer Axis
Circ J. 2023 Dec 12. doi: 10.1253/circj.CJ-23-0838. Online ahead of print.ABSTRACTEpidemiological evidence of increased risks of cancer in heart failure (HF) patients and HF in cancer patients has suggested close relationships between the pathogenesis of both diseases. Indeed, HF and cancer share common risk factors, including aging and unhealthy lifestyles, and underlying mechanisms, including activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, chronic inflammation, and clonal hematopoiesis of indeterminate potential. Mechanistically, HF accelerates cancer development and progression via...
Source: Circulation Journal - December 13, 2023 Category: Cardiology Authors: Hiroshi Kadowaki Hiroshi Akazawa Akito Shindo Tomomi Ueda Junichi Ishida Issei Komuro Source Type: research
Shared and Reciprocal Mechanisms Between Heart Failure and Cancer - An Emerging Concept of Heart-Cancer Axis
Circ J. 2023 Dec 12. doi: 10.1253/circj.CJ-23-0838. Online ahead of print.ABSTRACTEpidemiological evidence of increased risks of cancer in heart failure (HF) patients and HF in cancer patients has suggested close relationships between the pathogenesis of both diseases. Indeed, HF and cancer share common risk factors, including aging and unhealthy lifestyles, and underlying mechanisms, including activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, chronic inflammation, and clonal hematopoiesis of indeterminate potential. Mechanistically, HF accelerates cancer development and progression via...
Source: Circulation Journal - December 13, 2023 Category: Cardiology Authors: Hiroshi Kadowaki Hiroshi Akazawa Akito Shindo Tomomi Ueda Junichi Ishida Issei Komuro Source Type: research
Shared and Reciprocal Mechanisms Between Heart Failure and Cancer - An Emerging Concept of Heart-Cancer Axis
Circ J. 2023 Dec 12. doi: 10.1253/circj.CJ-23-0838. Online ahead of print.ABSTRACTEpidemiological evidence of increased risks of cancer in heart failure (HF) patients and HF in cancer patients has suggested close relationships between the pathogenesis of both diseases. Indeed, HF and cancer share common risk factors, including aging and unhealthy lifestyles, and underlying mechanisms, including activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, chronic inflammation, and clonal hematopoiesis of indeterminate potential. Mechanistically, HF accelerates cancer development and progression via...
Source: Circulation Journal - December 13, 2023 Category: Cardiology Authors: Hiroshi Kadowaki Hiroshi Akazawa Akito Shindo Tomomi Ueda Junichi Ishida Issei Komuro Source Type: research
Transcatheter Biopsy of Primary Cardiac Tumors Guided by Echocardiographic and Fluoroscopic Imaging
Circ J. 2023 Nov 25. doi: 10.1253/circj.CJ-23-0819. Online ahead of print.NO ABSTRACTPMID:38008426 | DOI:10.1253/circj.CJ-23-0819 (Source: Circulation Journal)
Source: Circulation Journal - November 26, 2023 Category: Cardiology Authors: Yuki Nishimura Yuya Takahashi Kensuke Yokoi Takanori Yamaguchi Koichi Node Source Type: research
Transcatheter Biopsy of Primary Cardiac Tumors Guided by Echocardiographic and Fluoroscopic Imaging
Circ J. 2023 Nov 25. doi: 10.1253/circj.CJ-23-0819. Online ahead of print.NO ABSTRACTPMID:38008426 | DOI:10.1253/circj.CJ-23-0819 (Source: Circulation Journal)
Source: Circulation Journal - November 26, 2023 Category: Cardiology Authors: Yuki Nishimura Yuya Takahashi Kensuke Yokoi Takanori Yamaguchi Koichi Node Source Type: research
Effects of Doxorubicin on Extracellular Matrix Regulation in Primary Cardiac Fibroblasts from Mice
In this study, we examined the potential effects of DOX on cardiac ECM to further our mechanistic understanding of DOX-induced cardiotoxicity.RESULTS: DOX-induced significant down-regulation of several ECM related genes in primary cardiac fibroblasts, including Adamts1, Adamts5, Col4a1, Col4a2, Col5a1, Fbln1, Lama2, Mmp11, Mmp14, Postn, and TGFβ. Quantitative proteomics analysis revealed significant global changes in the fibroblast proteome following DOX treatment. A pathway analysis using iPathwayGuide of the differentially expressed proteins revealed changes in a list of biological pathways that involve cell adhesion, c...
Source: Cell Research - November 17, 2023 Category: Cytology Authors: Cameron Skaggs Steve Nick Conner Patricelli Laura Bond Kali Woods Luke Woodbury Julia Thom Oxford Xinzhu Pu Source Type: research
Primary cardiac myxofibrosarcoma of the left atrium and pericardium: a case report
Primary cardiac myxofibrosarcoma is rare and commonly occurs in the left atrium. Myxofibrosarcoma is aggressive and has a high mortality rate due to its high rate of recurrence. Complete surgical resection is ... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - November 16, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Ryota Azuma, Kazuyoshi Sato, Hiroki Sunadoi, Yasushi Ishii, Utano Tomaru and Masatoshi Motohashi Tags: Case Report Source Type: research
Effects of Doxorubicin on Extracellular Matrix Regulation in Primary Cardiac Fibroblasts from Mice
Doxorubicin (DOX) is a highly effective chemotherapeutic used to treat many adult and pediatric cancers. However, its use is limited due to a dose-dependent cardiotoxicity, which can lead to lethal cardiomyopa... (Source: BMC Research Notes)
Source: BMC Research Notes - November 16, 2023 Category: Research Authors: Cameron Skaggs, Steve Nick, Conner Patricelli, Laura Bond, Kali Woods, Luke Woodbury, Julia Thom Oxford and Xinzhu Pu Tags: Research Note Source Type: research
Huge Primary Cardiac Undifferentiated Pleomorphic Sarcoma
Intern Med. 2023 Nov 6. doi: 10.2169/internalmedicine.2733-23. Online ahead of print.NO ABSTRACTPMID:37926533 | DOI:10.2169/internalmedicine.2733-23 (Source: Internal Medicine)
Source: Internal Medicine - November 5, 2023 Category: Internal Medicine Authors: Ryo Karasudani Norihiko Nakanishi Masahiro Tabata Hiroyuki Yanai Source Type: research
