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Primary Cardiac Fibroblast Cell Culture: Methodological Considerations for Physiologically Relevant Conditions
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00224.2023. Online ahead of print.ABSTRACTPrimary cardiac fibroblast (CF) tissue culture is a necessary tool for interrogating specific signaling mechanisms that dictate the phenotypic heterogeneity observed in vivo in different disease states. Traditional approaches that utilize tissue culture plastic and nutrient rich medium have been shown to induce CF activation and therefore alter CF subpopulation composition. This shift away from in vivo phenotypes complicate interpretation of results through the lens of the animal model. As the field works to identi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Alexandra M Garvin Laxmansa C Katwa Source Type: research

Clinical presentation, diagnosis, and management of a primary cardiac tumor: A case report
CONCLUSIONS: For patients with malignant tumor, most of them had local invasion or had distant metastasis when the diagnosis was clear, and only conservative management could be done. Moreover, the prognosis of malignant tumor is poor, and the pathological morphology is diverse. The causes of death are due to widespread tumor metastasis, refractory heart failure, and various arrhythmias.PMID:37596232 | DOI:10.1016/j.asjsur.2023.07.099 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - August 18, 2023 Category: Surgery Authors: Jianhua Xie Liang Yuan Yuxue Qin Jianxiong Liu Source Type: research

Multimodality treatment of primary cardiac angiosarcoma: A systematic literature review
Primary cardiac neoplasms are rare entities with an incidence of 1.38 per 100,000 and occur more than 30 times less frequent than metastatic disease of the heart [1,2]. In adults, approximately one fourth of the primary cardiac tumors are malignant, with 75% – 95% of them being sarcomas [3–5]. Angiosarcoma has been recognized as a common primary cardiac sarcoma (PCS) histology arising preferentially in the right atrium between the third and the fifth decade of life [2–8]. The fact that angiosarcomas tend to be bulky, infiltrate the cardiac muscle, and metastasize early (especially to the lungs) in conjunction with no...
Source: Cancer Treatment Reviews - August 15, 2023 Category: Cancer & Oncology Authors: Anastasia Stergioula, Stefania Kokkali, Evaggelos Pantelis Tags: Systematic or Meta-analysis Studies Source Type: research

ATF3 affects myocardial fibrosis remodeling after myocardial infarction by regulating autophagy and its mechanism of action
CONCLUSION: ATF3 can regulate the proliferation of CFs and collagen production by affecting autophagy, thus affecting myocardial fibrosis remodeling after MI.PMID:37572799 | DOI:10.1016/j.gene.2023.147705 (Source: Gene)
Source: Gene - August 12, 2023 Category: Genetics & Stem Cells Authors: Yiwei Huang Haiyue Dai Source Type: research

Maternal and neonatal outcomes in pregnant women with heart disease with single evaluation vs. semi-structured evaluation by a cardio-obstetric team
CONCLUSIONS: In pregnant women with heart disease, an SSF compared with a USF by a cardio-obstetric team did not show statistically significant differences in cardiovascular, obstetric, and neonatal outcomes. However, patients with SSF had a significantly higher risk of adverse outcomes due to the mWHO and CARPREG-II scales. This result suggests that the SSF achieves at least equal outcomes despite the higher risk of adverse events that patients in this group had.PMID:37553104 | DOI:10.24875/ACM.22000057 (Source: Archivos de Cardiologia de Mexico)
Source: Archivos de Cardiologia de Mexico - August 8, 2023 Category: Cardiology Authors: Jes ús Velásquez-Penagos Edison Mu ñoz-Ortiz Catherine Toro-Lugo David A Henao-Parra Maribel Correa-V ásquez Jairo A G ándara-Ricardo Alba M Zapata-Montoya Erica Holgu ín-Gonzalez Natalia Giraldo-Ardila Sandra Milena-Campo Mauricio M únera-García Source Type: research

Maternal and neonatal outcomes in pregnant women with heart disease with single evaluation vs. semi-structured evaluation by a cardio-obstetric team
CONCLUSIONS: In pregnant women with heart disease, an SSF compared with a USF by a cardio-obstetric team did not show statistically significant differences in cardiovascular, obstetric, and neonatal outcomes. However, patients with SSF had a significantly higher risk of adverse outcomes due to the mWHO and CARPREG-II scales. This result suggests that the SSF achieves at least equal outcomes despite the higher risk of adverse events that patients in this group had.PMID:37553104 | PMC:PMC10406487 | DOI:10.24875/ACM.22000057 (Source: Archivos de Cardiologia de Mexico)
Source: Archivos de Cardiologia de Mexico - August 8, 2023 Category: Cardiology Authors: Jes ús Velásquez-Penagos Edison Mu ñoz-Ortiz Catherine Toro-Lugo David A Henao-Parra Maribel Correa-V ásquez Jairo A G ándara-Ricardo Alba M Zapata-Montoya Erica Holgu ín-Gonzalez Natalia Giraldo-Ardila Sandra Milena-Campo Mauricio M únera-García Source Type: research

Surgical treatment of primary cardiac tumors in children
ConclusionsPrimary cardiac tumors in children are mostly benign. Surgery is effective, but the timing of surgery depends on the patient's condition. (Source: General Thoracic and Cardiovascular Surgery)
Source: General Thoracic and Cardiovascular Surgery - July 29, 2023 Category: Cardiovascular & Thoracic Surgery Source Type: research

Arrhythmias in patients with X-linked myotubular myopathy
We report two clinical cases of XLMTM that started with severe sinus bradycardia or auriculoventricular block from the first days of life, with pathologic 24-hours Holter monitoring in both cases. A primary cardiac affection was excluded by electrophysiological studies and normal heart rate was recovered with proper respiratory support.DISCUSSION: These cases with sever bradyarrhythmia in a well know pathology such the XLMTM represents a nuance on the usual differential diagnostics of congenital myopathies.PMID:37466134 | DOI:10.33588/rn.7703.2022222 (Source: Revista de Neurologia)
Source: Revista de Neurologia - July 19, 2023 Category: Neurology Authors: M Pons-Espinal J Clotet-Caba S Cesar-D íaz D Yubero-Siles Source Type: research

Diosmetin-7-O- β-D-glucopyranoside suppresses endothelial-mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis
In this study, molecular docking results showed that diosmetin-7-O-glucoside bound well to ER stress and Src pathway markers. Diosmetin-7-O-glucoside suppressed cardiac fibrosis induced by isoprenaline (ISO) and reduced the levels of EndMT, ER stress in mice heart. Primary cardiac microvascular endothelial cells (CMECs) were induced by transforming growth factor-β1 (TGF-β1) to perform EndMT. Diosmetin-7-O-glucoside could effectively regulate EndMT and diminish the accumulation of collagen I and collagen III. We also showed that the tube formation in CMECs was restored, and the capacity of migration was partially inhibite...
Source: Clinical and Experimental Pharmacology and Physiology - July 11, 2023 Category: Drugs & Pharmacology Authors: Huahua Wang Xiaoyu Zhang Yangyang Liu Yunyun Zhang Yingyu Wang Yunru Peng Yongfang Ding Source Type: research