Diosmetin-7-O- β-D-glucopyranoside suppresses endothelial-mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis
In this study, molecular docking results showed that diosmetin-7-O-glucoside bound well to ER stress and Src pathway markers. Diosmetin-7-O-glucoside suppressed cardiac fibrosis induced by isoprenaline (ISO) and reduced the levels of EndMT, ER stress in mice heart. Primary cardiac microvascular endothelial cells (CMECs) were induced by transforming growth factor-β1 (TGF-β1) to perform EndMT. Diosmetin-7-O-glucoside could effectively regulate EndMT and diminish the accumulation of collagen I and collagen III. We also showed that the tube formation in CMECs was restored, and the capacity of migration was partially inhibite...
Source: Clinical and Experimental Pharmacology and Physiology - July 11, 2023 Category: Drugs & Pharmacology Authors: Huahua Wang Xiaoyu Zhang Yangyang Liu Yunyun Zhang Yingyu Wang Yunru Peng Yongfang Ding Source Type: research
Case of left atrial myxoid sarcoma with lung metastases presented as a cardiogenic shock: a case report and literature review
CONCLUSIONS: Primary cardiac tumors should be suspected in adult patients with progressive dyspnea, and a biopsy should also be done to determine the histopathological pattern of the mass and estimate the overall prognosis and outcomes.PMID:37427231 | PMC:PMC10328677 | DOI:10.1097/MS9.0000000000000898 (Source: Annals of Medicine)
Source: Annals of Medicine - July 10, 2023 Category: Internal Medicine Authors: Omar R S Khalil Belal M M Omar Lamees Khalil Doaa Tarabieh Layth Al-Karaja Hasan Alkhatib Diya Asad Source Type: research
Siblings with Gorlin –Goltz syndrome associated with cardiac tumors: a case report and review of literature
Primary cardiac tumors in children are very rare and may be associated with severe arrhythmias and sudden infant death syndrome. These cardiac arrhythmias vary depending on the location and size of the tumor. ... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - July 5, 2023 Category: Internal Medicine Authors: Paula I. Wilke, Daniel Biermann, Maria Grafmann, Rainer Kozlik-Feldmann, Dzhoy Papingi, J örg S. Sachweh, Fridrike Stute and Jakob Olfe Tags: Review Source Type: research
Postoperative radiotherapy for high-grade primary cardiac spindle cell sarcoma: a rare entity
BMJ Case Rep. 2023 Jun 30;16(6):e255438. doi: 10.1136/bcr-2023-255438.ABSTRACTA patient in her early 20s presented with blood-stained sputum and shortness of breath. Initially, she was treated for pneumonia. Later, upon exacerbation of symptoms, further investigations were done which exhibited a left atrial mass causing compression of contralateral atrium. She underwent surgical resection of the mass, which was initially mistaken as myxoma. However, histopathological correlation revealed spindle cell sarcoma with focal myogenic differentiation. This case report highlights the role of Radiation Therapy in adjuvant setting w...
Source: Cancer Control - July 3, 2023 Category: Cancer & Oncology Authors: Tooba Ali Nasir Ali Laraib Khan Khurram Minhas Source Type: research
Management of primary cardiac leiomyosarcoma
CONCLUSION: The nonspecific symptoms presented in the reported case demonstrate that the cardiac tumour can mimic other cardiac disorders, such as coronary artery disease or pericarditis, rarely representing the first manifestation of a previously unknown malignancy.PMID:37396103 | PMC:PMC10310325 | DOI:10.3332/ecancer.2023.1562 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - July 3, 2023 Category: Cancer & Oncology Authors: Lucrecia Aline Cabral Formigosa Luciana Ferreira Dos Santos Jaqueline Dantas Neres Martins Bianca Silva de Brito Hemilly Vasconcelos de Miranda Silva Ricardo Luiz Saldanha da Silva Josinete da Concei ção Barros do Carmo Samara Machado Castilho Source Type: research
Cardiac rhabdomyomas: clinical progression, efficacy and safety of everolimus treatment
CONCLUSIONS: According to our results, everolimus accelerates tumor mass reduction, but not amount of mass regression in the long term. Everolimus may be considered for treatment of rhabdomyomas which cause hemodynamic compromise or life-threatening arrhythmias before surgical intervention.PMID:37395967 | DOI:10.24953/turkjped.2022.922 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - July 3, 2023 Category: Pediatrics Authors: Sayg ın Yıldırım Ebru Aypar Bur ça Aydın Canan Aky üz Hayrettin Hakan Aykan İlker Ertuğrul Tevfik Karag öz Dursun Alehan Source Type: research
Postoperative radiotherapy for high-grade primary cardiac spindle cell sarcoma: a rare entity
BMJ Case Rep. 2023 Jun 30;16(6):e255438. doi: 10.1136/bcr-2023-255438.ABSTRACTA patient in her early 20s presented with blood-stained sputum and shortness of breath. Initially, she was treated for pneumonia. Later, upon exacerbation of symptoms, further investigations were done which exhibited a left atrial mass causing compression of contralateral atrium. She underwent surgical resection of the mass, which was initially mistaken as myxoma. However, histopathological correlation revealed spindle cell sarcoma with focal myogenic differentiation. This case report highlights the role of Radiation Therapy in adjuvant setting w...
Source: Cancer Control - July 3, 2023 Category: Cancer & Oncology Authors: Tooba Ali Nasir Ali Laraib Khan Khurram Minhas Source Type: research
Management of primary cardiac leiomyosarcoma
CONCLUSION: The nonspecific symptoms presented in the reported case demonstrate that the cardiac tumour can mimic other cardiac disorders, such as coronary artery disease or pericarditis, rarely representing the first manifestation of a previously unknown malignancy.PMID:37396103 | PMC:PMC10310325 | DOI:10.3332/ecancer.2023.1562 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - July 3, 2023 Category: Cancer & Oncology Authors: Lucrecia Aline Cabral Formigosa Luciana Ferreira Dos Santos Jaqueline Dantas Neres Martins Bianca Silva de Brito Hemilly Vasconcelos de Miranda Silva Ricardo Luiz Saldanha da Silva Josinete da Concei ção Barros do Carmo Samara Machado Castilho Source Type: research
Cardiac rhabdomyomas: clinical progression, efficacy and safety of everolimus treatment
CONCLUSIONS: According to our results, everolimus accelerates tumor mass reduction, but not amount of mass regression in the long term. Everolimus may be considered for treatment of rhabdomyomas which cause hemodynamic compromise or life-threatening arrhythmias before surgical intervention.PMID:37395967 | DOI:10.24953/turkjped.2022.922 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - July 3, 2023 Category: Pediatrics Authors: Sayg ın Yıldırım Ebru Aypar Bur ça Aydın Canan Aky üz Hayrettin Hakan Aykan İlker Ertuğrul Tevfik Karag öz Dursun Alehan Source Type: research
Management of primary cardiac leiomyosarcoma
CONCLUSION: The nonspecific symptoms presented in the reported case demonstrate that the cardiac tumour can mimic other cardiac disorders, such as coronary artery disease or pericarditis, rarely representing the first manifestation of a previously unknown malignancy.PMID:37396103 | PMC:PMC10310325 | DOI:10.3332/ecancer.2023.1562 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - July 3, 2023 Category: Cancer & Oncology Authors: Lucrecia Aline Cabral Formigosa Luciana Ferreira Dos Santos Jaqueline Dantas Neres Martins Bianca Silva de Brito Hemilly Vasconcelos de Miranda Silva Ricardo Luiz Saldanha da Silva Josinete da Concei ção Barros do Carmo Samara Machado Castilho Source Type: research
Cardiac rhabdomyomas: clinical progression, efficacy and safety of everolimus treatment
CONCLUSIONS: According to our results, everolimus accelerates tumor mass reduction, but not amount of mass regression in the long term. Everolimus may be considered for treatment of rhabdomyomas which cause hemodynamic compromise or life-threatening arrhythmias before surgical intervention.PMID:37395967 | DOI:10.24953/turkjped.2022.922 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - July 3, 2023 Category: Pediatrics Authors: Sayg ın Yıldırım Ebru Aypar Bur ça Aydın Canan Aky üz Hayrettin Hakan Aykan İlker Ertuğrul Tevfik Karag öz Dursun Alehan Source Type: research
Management of primary cardiac leiomyosarcoma
CONCLUSION: The nonspecific symptoms presented in the reported case demonstrate that the cardiac tumour can mimic other cardiac disorders, such as coronary artery disease or pericarditis, rarely representing the first manifestation of a previously unknown malignancy.PMID:37396103 | PMC:PMC10310325 | DOI:10.3332/ecancer.2023.1562 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - July 3, 2023 Category: Cancer & Oncology Authors: Lucrecia Aline Cabral Formigosa Luciana Ferreira Dos Santos Jaqueline Dantas Neres Martins Bianca Silva de Brito Hemilly Vasconcelos de Miranda Silva Ricardo Luiz Saldanha da Silva Josinete da Concei ção Barros do Carmo Samara Machado Castilho Source Type: research
Cardiac rhabdomyomas: clinical progression, efficacy and safety of everolimus treatment
CONCLUSIONS: According to our results, everolimus accelerates tumor mass reduction, but not amount of mass regression in the long term. Everolimus may be considered for treatment of rhabdomyomas which cause hemodynamic compromise or life-threatening arrhythmias before surgical intervention.PMID:37395967 | DOI:10.24953/turkjped.2022.922 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - July 3, 2023 Category: Pediatrics Authors: Sayg ın Yıldırım Ebru Aypar Bur ça Aydın Canan Aky üz Hayrettin Hakan Aykan İlker Ertuğrul Tevfik Karag öz Dursun Alehan Source Type: research
Management of primary cardiac leiomyosarcoma
CONCLUSION: The nonspecific symptoms presented in the reported case demonstrate that the cardiac tumour can mimic other cardiac disorders, such as coronary artery disease or pericarditis, rarely representing the first manifestation of a previously unknown malignancy.PMID:37396103 | PMC:PMC10310325 | DOI:10.3332/ecancer.2023.1562 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - July 3, 2023 Category: Cancer & Oncology Authors: Lucrecia Aline Cabral Formigosa Luciana Ferreira Dos Santos Jaqueline Dantas Neres Martins Bianca Silva de Brito Hemilly Vasconcelos de Miranda Silva Ricardo Luiz Saldanha da Silva Josinete da Concei ção Barros do Carmo Samara Machado Castilho Source Type: research
