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Cardiogenic shock in pregnancy
BJOG. 2023 Oct 4. doi: 10.1111/1471-0528.17645. Online ahead of print.ABSTRACTCardiac disease complicates 1%-4% of pregnancies globally, with a predominance in low and middle-income countries (LMICs). Increasing maternal age, rates of obesity, cardiovascular comorbidities, pre-eclampsia and gestational diabetes all contribute to acquired cardiovascular disease in pregnancy. Additionally, improved survival in congenital heart disease (CHD) has led to increasing numbers of women with CHD undergoing pregnancy. Implementation of individualised care plans formulated through pre-conception counselling and based on national and i...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - October 5, 2023 Category: OBGYN Authors: Orene Y O Greer Rathai Anandanadesan Nishel M Shah Susanna Price Mark R Johnson Source Type: research

Primary cardiac sarcomas: A clinicopathologic study in a single institution with 25 years of experience with an emphasis on MDM2 expression and adjuvant therapy for prognosis
ConclusionOur study supports the use of adjuvant treatment in primary cardiac sarcoma, as it was associated with a significantly better overall survival rate. Further consideration of tumor histology may be important in determining the optimal use of adjuvant treatment for different types of sarcomas. Therefore, accurate diagnosis by MDM2 test is important condsidering patient's prognosis and treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - September 14, 2023 Category: Cancer & Oncology Authors: Haeyon Cho, In ‐Hye Song, Uiree Jo, Ji‐Seon Jeong, Hyun Jung Koo, Dong Hyun Yang, Sung‐Ho Jung, Joon Seon Song, Kyung‐Ja Cho Tags: RESEARCH ARTICLE Source Type: research

Post-Cardiotomy Shock Syndrome- A Narrative Review of Perioperative Diagnosis and Management.
Post cardiotomy shock (PCS) is generally described as the inability to separate from cardiopulmonary bypass, due to ineffective cardiac output after cardiotomy, caused by a primary cardiac disorder resulting in inadequate tissue perfusion. PCS occurs in 0.5% to 1.5% of contemporary cardiac surgery cases and is accompanied by an in-hospital mortality of approximately 67%. In the last two decades, the incidence of PCS has increased, likely due to the increased age and baseline morbidity of cardiac surgical patients. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - September 11, 2023 Category: Anesthesiology Authors: Andrea Corujo-Rodriguez, Ellen Richter, Stephanie Opunsunju Ibekwe, Tina Shah, Abimbola O. Faloye Tags: Review Article Source Type: research

Postcardiotomy Shock Syndrome: A Narrative Review of Perioperative Diagnosis and Management
Postcardiotomy shock (PCS) is generally described as the inability to separate from cardiopulmonary bypass due to ineffective cardiac output after cardiotomy, which is caused by a primary cardiac disorder, resulting in inadequate tissue perfusion. Postcardiotomy shock occurs in 0.5% to 1.5% of contemporary cardiac surgery cases, and is accompanied by an in-hospital mortality of approximately 67%. In the last 2 decades, the incidence of PCS has increased, likely due to the increased age and baseline morbidity of patients requiring cardiac surgery. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - September 11, 2023 Category: Anesthesiology Authors: Andrea Corujo Rodriguez, Ellen Richter, Stephanie Opunsunju Ibekwe, Tina Shah, Abimbola O. Faloye Tags: Review Article Source Type: research

Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study
CONCLUSION: RBC transfusion in patients on VA ECMO is very common. The sum of RBC transfusions increases rapidly after ECMO initiation, and is dependent on the Hb threshold applied. This study supports the rationale for prospective studies focusing on indications and thresholds for RBC transfusion.PMID:37668074 | DOI:10.1111/trf.17505 (Source: Transfusion)
Source: Transfusion - September 5, 2023 Category: Hematology Authors: Senta Jorinde Raasveld Mina Karami Jimmy Schenk Dinis Dos Reis Miranda Loes Mandigers Dieter F Dauwe Erwin De Troy Federico Pappalardo Evgeny Fominskiy Walter M van den Bergh Annemieke Oude Lansink-Hartgring Franciska van der Velde Jacinta J Maas Pablo va Source Type: research

Multiple cardiac myxofibrosarcomas with complete right pulmonary artery occlusion: a case report
We reported on a 37-year-old female who presented with chest tightness and dyspnea for a month, dry cough, and occasionally having blood streak sputum for half a month. Echocardiography, cardiac computed tomography and cardiac positron emission tomography revealed multiple tumors in the heart. The right ventricle and right pulmonary artery were involved, with occlusion of the right pulmonary artery. Cardiac tumors were surgically resected and were consistent with low-grade MFS. No recurrence or metastasis occurred at 20 months of follow-up. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - September 4, 2023 Category: Cancer & Oncology Source Type: research

Primary Cardiac Fibroblast Cell Culture: Methodological Considerations for Physiologically Relevant Conditions
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00224.2023. Online ahead of print.ABSTRACTPrimary cardiac fibroblast (CF) tissue culture is a necessary tool for interrogating specific signaling mechanisms that dictate the phenotypic heterogeneity observed in vivo in different disease states. Traditional approaches that utilize tissue culture plastic and nutrient rich medium have been shown to induce CF activation and therefore alter CF subpopulation composition. This shift away from in vivo phenotypes complicate interpretation of results through the lens of the animal model. As the field works to identi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Alexandra M Garvin Laxmansa C Katwa Source Type: research