Chlormethiazole as a hypnotic in elderly patients: A systematic review and meta-analysis
In conclusion, chlormethiazole showed significant effects on the duration and the quality of sleep with better tolerability if compared with other drugs in older adults with insomnia.PMID:37658716 | DOI:10.1111/jsr.14018 (Source: Journal of Sleep Research)
Source: Journal of Sleep Research - September 2, 2023 Category: Sleep Medicine Authors: Marwa Al Juburi Holger Cramer Martin Schaefer Source Type: research
A study of new labor market entrants’ job satisfaction trajectories during a series of consecutive job changes.
This study distinguishes adaptation to a single job change in the short term from adaptation to the process of job change in the long term. Drawing on two large-scale, long-running panel data sets from Britain and Australia, it examined how job satisfaction trajectory evolved as individuals made a series of consecutive job changes since they first entered the labor market. Our fixed effect analyses show that in both countries, individuals experienced a stronger honeymoon effect with each successive job change, before gradually reverting to their baseline job satisfaction. In short, the amplitude of the honeymoon–hangover...
Source: Journal of Applied Psychology - August 24, 2023 Category: Psychiatry & Psychology Source Type: research
T-cell-derived TNF- α and a cluster of immunological parameters from plasma allow a separation between SARS-CoV-2 convalescent versus vaccinated elite athletes
Guidelines for medical clearing after SARS-CoV-2 infection in elite athletes do not include T-cell immunity aspects despite its relevance in the course of COVID-19 disease. Therefore, we aimed to analyze T-cell-related cytokines before and after in-vitro activation of CD4+ T-cells. We sampled professional indoor sports athletes at medical clearing after SARS-CoV-2 infection obtaining clinical, fitness data, and serological data including CD4+ T-cell cytokines. All data were analyzed by principal component analysis and 2 × 2 repeated measures ANOVA. CD4+ T-cells were sampled for cell culture activation with anti-CD3/anti-C...
Source: Frontiers in Physiology - June 22, 2023 Category: Physiology Source Type: research
Molecules, Vol. 28, Pages 4878: Chemical Constituents from the Fruits of Amomum kravanh and Their Role in Activating Alcohol Dehydrogenase
In this study, ten new (amomumols A-J, 1–10) and thirty-five known (11–45) compounds were isolated from the fruits of Amomum kravanh by an activity-guided separation. Ten novel compounds were identified as four sesquiterpenoids (1–4), three monoterpene derivatives (5–7), two neolignans (8, 9), and a novel norsesquiterpenoid (10) with a new C14 nor-bisabolane skeleton. Their structures were determined by the comprehensive analysis of high-resolution electrospray ionization mass spectrometry (HRESIMS), nuclear magnetic resonance (NMR), and electronic circular dichroism ...
Source: Molecules - June 20, 2023 Category: Chemistry Authors: Hao-Ming Xiong Hui-Ying Li Zhi-Rong Lin Xiao-Mei Liu Li-Ping Bai Wei Zhang Zhi-Hong Jiang Guo-Yuan Zhu Tags: Article Source Type: research
An evening of alcohol consumption negatively impacts next-day immune fitness in both hangover-sensitive drinkers and hangover-resistant drinkers
CONCLUSIONS: Whereas hangover-sensitive drinkers reported a hangover following an alcohol day and hangover-resistant drinkers did not, both groups reported significantly reduced immune fitness throughout the day. However, the reduction in immune fitness among hangover-sensitive drinkers was significantly more pronounced in comparison to the hangover-resistant group.PMID:37331135 | DOI:10.1016/j.addbeh.2023.107776 (Source: Addictive Behaviors)
Source: Addictive Behaviors - June 18, 2023 Category: Addiction Authors: Agnese Merlo Marlou Mackus Aurora J A E van de Loo Renier H P van Neer Sterre A Vermeulen Suzan S Thijssen Karen Knipping Gillian Bruce Johan Garssen Joris C Verster Source Type: research
An evening of alcohol consumption negatively impacts next-day immune fitness in both hangover-sensitive drinkers and hangover-resistant drinkers
CONCLUSIONS: Whereas hangover-sensitive drinkers reported a hangover following an alcohol day and hangover-resistant drinkers did not, both groups reported significantly reduced immune fitness throughout the day. However, the reduction in immune fitness among hangover-sensitive drinkers was significantly more pronounced in comparison to the hangover-resistant group.PMID:37331135 | DOI:10.1016/j.addbeh.2023.107776 (Source: Addictive Behaviors)
Source: Addictive Behaviors - June 18, 2023 Category: Addiction Authors: Agnese Merlo Marlou Mackus Aurora J A E van de Loo Renier H P van Neer Sterre A Vermeulen Suzan S Thijssen Karen Knipping Gillian Bruce Johan Garssen Joris C Verster Source Type: research
Probiotic properties and proteomics analysis of ethanol-induced Lactococcus lactis subsp. lactis IL1403
AbstractOur previous study indicated that ethanol-induced intracellular extracts (E-IEs) ofLactococcus lactis subsp.Lactis IL1403 (L. lactis IL1403) alleviated hangovers more effectively in mice than untreated intracellular extracts (U-IEs), but the material basis was unclear. Considering that stress-related proteins might play a significant role, the effects of ethanol induction on probiotic properties ofL. lactis IL1403 and the associated stress response mechanism were initially explored in this study. E-IEs ofL. lactis IL1403 showed better biological activities, significantly increased bacteria survival rates in oxidati...
Source: World Journal of Microbiology and Biotechnology - May 15, 2023 Category: Microbiology Source Type: research
Acute Consequences Associated with Co-use of Alcohol and Cannabis: A Daily Survey Analysis
CONCLUSION: Days with different types of substance use differed in specific consequences. Most of the negative co-use consequences investigated here appear to be driven by alcohol consumption rather than cannabis use. Results also indicated that young adults are more likely to endorse driving under the influence of cannabis than alcohol. Interventions for co-use should target alcohol consumption to reduce negative consequences such as blackout, injury, rude/aggressive behavior, and unwanted sex and highlight the dangers of driving under the influence of cannabis.PMID:36971729 | DOI:10.15288/jsad.22-00062 (Source: Journal o...
Source: Journal of Studies on Alcohol and Drugs - March 27, 2023 Category: Addiction Authors: Megan M Drohan Angela K Stevens Rachel L Gunn Alexander W Sokolovsky Helene R White Kristina M Jackson Source Type: research
The role of effortful control in mitigating negative consequences associated with emerging adult drinking
CONCLUSIONS: The results provide some evidence that very high levels of attentional and activation control protect against alcohol-related negative consequences associated with drinking. Emerging adults who are very high in attentional and activation control are likely better able to control their attention and engage in goal-directed behavior, like leaving a party at a reasonable hour, or attending school and/or work when experiencing the punishing effects of a hangover. Results emphasize the importance of distinguishing facets of self-regulation when testing self-regulation models.PMID:36811151 | DOI:10.1111/acer.15016 (...
Source: Alcoholism, Clinical and Experimental Research - February 22, 2023 Category: Addiction Authors: Katie J Paige Rachael J Shaw Craig R Colder Source Type: research
Investigating the effects of emotion dysregulation and repetitive negative thinking on alcohol hangover anxiety and depression
CONCLUSION: Results provide preliminary support for the role of emotion dysregulation and RNT in hangover depression severity.PMID:36689889 | DOI:10.1016/j.addbeh.2023.107619 (Source: Addictive Behaviors)
Source: Addictive Behaviors - January 23, 2023 Category: Addiction Authors: Kristin Tellez-Monnery Christopher R Berghoff Michael J McDermott Source Type: research
