INV11 Motor neuron and muscle involvement in SBMA: therapeutic implications
Spinal and bulbar muscular atrophy (SBMA, Kennedy's disease) is a neuromuscular disorder caused by expansion of a CAG trinucleotide repeat in the androgen receptor (AR) gene on the X chromosome, resulting in expansion of a polyglutamine tract in the N-terminal transactivation domain of the AR protein. The mutation causes some loss of AR function, leading to gynecomastia and other signs of feminization, but it also causes a toxic gain of function in the mutant protein, leading to progressive bulbar and extremity weakness that is not seen in patients with other mutations in the AR gene. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - October 1, 2023 Category: Neurology Authors: K. Fischbeck Source Type: research
Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs
Conclusion: Clinicians should monitor the adverse events associated with the concomitant use of adaptogens and antidepressant drugs in patients with mental disorders. Aggregation of side effects and pharmacokinetic interactions (inhibition of CYP and p-glycoprotein) between those medicines may result in clinically significant adverse events. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Source Type: research
Non-retroareolar male mucinous breast cancer without gynecomastia development in an elderly man: A case report
CONCLUSION: To the best of our knowledge, this is the first case report of MMBC in the non-retroareolar region of the nipple without gynecomastia development. Mucinous tumors are easily missed during diagnosis, and the incidence of axillary lymph node metastases of chest mucinous tumors has increased.PMID:37727495 | PMC:PMC10506025 | DOI:10.12998/wjcc.v11.i25.5954 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Qiang Sun Xu-Yan Liu Qi Zhang Hai Jiang Source Type: research
Non-retroareolar male mucinous breast cancer without gynecomastia development in an elderly man: A case report
CONCLUSION: To the best of our knowledge, this is the first case report of MMBC in the non-retroareolar region of the nipple without gynecomastia development. Mucinous tumors are easily missed during diagnosis, and the incidence of axillary lymph node metastases of chest mucinous tumors has increased.PMID:37727495 | PMC:PMC10506025 | DOI:10.12998/wjcc.v11.i25.5954 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Qiang Sun Xu-Yan Liu Qi Zhang Hai Jiang Source Type: research
Impact of Surgical Technique on Outcome Measures in Chest Masculinization: A Systemic Review and Meta-analysis
Among plastic surgeons, there are several conventional techniques for performing chest surgery. Research on surgical approaches has focused cis-gender patients with medical conditions, such as breast cancer or gynecomastia, but has never studied transgender populations. The aim of this study is to perform the first systematic review of gender-affirming chest surgery (GAS) in transgender populations, and determine postoperative outcomes differences in relation to surgical technique. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - September 12, 2023 Category: Cosmetic Surgery Authors: Joshua Zhu, Emily Wang, Steven Liu, Jessica Koos, Laurie Shroyer, Aleksandra Krajewski Tags: Review Source Type: research
Invited Editorial on: “Is Breast Magnetic Resonance Imaging Superior to Sonography in Gynecomastia Evaluation and Surgery Planning”
(Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - September 11, 2023 Category: Cosmetic Surgery Source Type: research
