Gynecomastia and drugs: a critical evaluation of the literature
Conclusion Many different medications have been associated with the presence of “gynecomastia.” Generally, it presents as a syndrome characterized by a single painful/tender breast (mastodynia) associated with breast enlargement and is transient. We suggest that these cases be referred to as an acute gynecomastia syndrome. This syndrome also occurs independent of medication use. Thus, in an individual patient, whether it is medication induced often remains uncertain. The pathogenesis remains unknown. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 2, 2015 Category: Drugs & Pharmacology Source Type: research

Adverse Effects of Androgen Deprivation Therapy and Strategies to Mitigate Them
Conclusions ADT is often a necessary component of the treatment of aggressive prostate cancer, yet it has known harms that can impair health and quality of life. Clinicians should be aware of interventions that can help mitigate these adverse effects. Patient summary Androgen deprivation therapy is a critical component of the management of aggressive and advanced prostate cancer, but it causes adverse effects including bone loss, metabolic changes, gynecomastia, muscle loss, hot flashes, and possibly increased cardiovascular events. Clinicians should be aware of interventions that can help mitigate these adverse effects. ...
Source: European Urology - April 2, 2015 Category: Urology & Nephrology Source Type: research

Morphological changes of skeletal muscle in spinal and bulbar muscular atrophy (SBMA), Kennedy's disease: a case report.
Abstract Spinal and bulbar muscular atrophy (SBMA, Kennedy's disease) is an X-linked recessive disease affecting lower motor neurons. In the present case report, we describe morphological changes in a muscle biopsy obtained from a 62-year-old patient with gynecomastia and with the following neurological symptoms: dysphagia, dysarthria, wasting and fasciculation of the tongue, proximal weakness, fasciculations in the limb muscles, and an absence of all tendon reflexes. Neurogenic alternations were predominantly observed using light and electron microscopy. The angulated atrophic muscle fibers formed bundles. The nu...
Source: Clinical Neuropathology - April 1, 2015 Category: Pathology Authors: Acewicz A, Wierzba-Bobrowicz T, Lewandowska E, Sienkiewicz-Jarosz H, Sulek A, Antczak J, Rakowicz M, Ryglewicz D Tags: Clin Neuropathol Source Type: research

Pd45-07 a comparison of estradiol levels and gynecomastia rates in hypogonadal men using clomiphene citrate versus transdermal testosterone
Clomiphene citrate (CC) is recognized as a management strategy in men with hypogonadism (HG). Some concern exists regarding its ability to raise serum estradiol (E2) levels given its mechanism of action. Serum total testosterone (TT) may be converted to E2 by aromatase irrespective of which T replacement therapy (TRT) modality is used. This analysis was undertaken to compare serum E2 levels in men with HG using CC versus transdermal T (TDT). (Source: The Journal of Urology)
Source: The Journal of Urology - April 1, 2015 Category: Urology & Nephrology Authors: Clarisse R. Mazzola, Edoardo Miranda, Joseph Narus, John P. Mulhall Tags: Sexual Function/Dysfunction/Andrology: Medical and Non-Surgical Therapy II Source Type: research

Intratubular Large Cell Hyalinizing Sertoli Cell Tumor of the Testes in a 4-Year-Old Male With Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder that typically displays familial inheritance. Gastrointestinal polyposis and cutaneous pigmentation is a classic presentation of this syndrome. The reported lifetime cumulative cancer risk in PJS patients is>76% when compared with the general public with females affected more often than males. The prepubertal testicular tumor registry found Sertoli cell tumors (SCTs) to compose approximately 1% of all pediatric solid tumors. Prepubertal testicular masses are relatively rare. Only a small number of SCT cases have been reported in the first decade of life....
Source: Journal of Pediatric Hematology Oncology - March 23, 2015 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Overuse of Imaging the Male Breast—Findings in 557 Patients
Abstract Gynecomastia is the most common abnormality of the male breast. However, breast cancer may occur, albeit with a significantly lower incidence than in females. Imaging is often used as part of the diagnosis. The aim of this study was to assess the utilization and outcome of imaging with mammography or ultrasound of the male breast in a university hospital's department of radiology. A retrospective study assessing the imaging of the male breast in 557 patients over a 10‐year period. Referral was done mainly by general surgeons and general practitioners. The most common indication was enlargement of the breast, des...
Source: The Breast Journal - March 13, 2015 Category: Cancer & Oncology Authors: Oren Lapid, Pieter Siebenga, Harmien M Zonderland Tags: Original Article Source Type: research

Teaching Video NeuroImages: Hand tremor, tongue and perioral fasciculation in a patient with Kennedy disease
A 54-year-old man presented with a 10-year history of progressive gait difficulty, muscle weakness, and fatigue. Clinical examinations revealed mild nasal speech; postural hand tremor; absence of deep tendon reflexes; atrophy and fasciculation in tongue, facial (perioral), and limb muscles; and gynecomastia (video on the Neurology® Web site at Neurology.org). Nerve conduction studies had normal results; however, needle EMG demonstrated a neurogenic pattern with spontaneous activity (fibrillation, positive sharp wave, and fasciculation) in cranial and limb muscles. Genetic testing confirmed (CAG expansion of the androge...
Source: Neurology - March 9, 2015 Category: Neurology Authors: Rohani, M., Miri, S. Tags: Tremor, Anterior nerve cell disease, Other Education, Trinucleotide repeat diseases RESIDENT AND FELLOW SECTION Source Type: research

Treatment of hyperprolactinemia and gynecomastia with adjunctive aripiprazole in 2 men receiving long-acting injectable antipsychotics.
Authors: Boggs DL, Ranganathan M, Boggs AA, Bihday CM, Peluse BE, D'Souza DC PMID: 24392257 [PubMed] (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - February 7, 2015 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

Correction of Gynecomastia in Body Builders and Patients with Good Physique
Conclusions: This study demonstrates the importance of direct excision of the glandular tissue over any other surgical technique when correcting gynecomastia deformities in body builders. The novice surgeon is advised to proceed with cases that are less challenging, primarily with patients that require excision of small to medium glandular tissue. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - January 30, 2015 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Boomerang Pattern Correction of Gynecomastia
Conclusions: In selected patients, comprehensive body contouring surgery consists of a boomerang correction of gynecomastia. J torsoplasty with an abdominoplasty and oblique excisions of the flanks has proven to be a practical means to achieve aesthetic goals. Gender-specific body lift surgery that goes far beyond the treatment of gynecomastia best serves the muscular male patient after massive weight loss. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - January 30, 2015 Category: Cosmetic Surgery Tags: Cosmetic: Ideas and Innovations Source Type: research

Pathological Findings in Gynecomastia: Analysis of 5113 Breasts
Conclusions: The prevalence of malignancies in GM resection specimens is low; however, it increases with patient age. Unilateral cases have a statistically nonsignificant higher prevalence of pathologies. Level of evidence: Prognostic/risk II. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - January 20, 2015 Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research

Pseudoangiomatous stromal hyperplasia with multinucleated stromal giant cells is neither exceptional in gynecomastia nor characteristic of neurofibromatosis type 1
Abstract Six cases of gynecomastia with pseudoangiomatous stromal hyperplasia (PASH) and multinucleated stromal giant cells (MSGC) associated with neurofibromatosis type 1 (NF1) have been reported, and finding MSGC within PASH in gynecomastia has been suggested as being a characteristic of NF1. The frequency of PASH with MSGC in gynecomastia and its specificity for NF1 have not, however, been systematically studied. A total of 337 gynecomastia specimens from 215 patients, aged from 8 to 78 years (median, 22 years) were reevaluated for the presence of PASH with MSGC. Breast tissue samples of 25 patients w...
Source: Virchows Archiv - January 14, 2015 Category: Pathology Source Type: research

The effect of gynecomastia on body image perception and gender roles in adolescents.
Z, Derman O Abstract The aim of our study was to evaluate the effect of gynecomastia on body image perception and gender roles in adolescents. Forty-seven adolescents with gynecomastia and 63 healthy adolescents were enrolled in the study. The Body Image Perception Scale (BIPS) and the Bem Gender Role Inventory (BGRI) were administered to the study group after the first evaluation and also one month later. The percentage of adolescents with a BIPS score lower than the median was higher in the study group than in the control group, although there was no significant difference. Additionally, considering the single i...
Source: The Turkish Journal of Pediatrics - January 1, 2015 Category: Pediatrics Authors: Esenboğa S, Akgül S, Kanbur N, Tüzün Z, Derman O Tags: Turk J Pediatr Source Type: research

Can digit ratio (2D:4D) studies be helpful in explaining the aetiology of idiopathic gynecomastia?
Aetiology of idiopathic form of gynecomastia is unknown and it has not been established if it is related to factors present at the prenatal period or if it is caused by yet unidentified environmental conditions. (Source: Early Human Development)
Source: Early Human Development - December 25, 2014 Category: Perinatology & Neonatology Authors: Anna Kasielska-Trojan, Bogusław Antoszewski Source Type: research

Male breast uptake in rubidium-82 PET due to spironolactone-induced gynecomastia
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - December 24, 2014 Category: Cardiology Source Type: research

46,XX testicular disorder of sexual development with SRY-negative caused by some unidentified mechanisms: a case report and review of the literature
Conclusion: This study adds a new case of SRY-negative 46,XX testicular disorder of sex development and further verifies the view that the absence of major regions from the Y chromosome leads to an incomplete masculine phenotype, abnormal hormone levels and infertility. To date, the mechanisms for induction of testicular tissue in 46,XX SRY-negative patients remain unknown, although other genetic or environmental factors play a significant role in the regulation of sex determination and differentiation. (Source: BioMed Central)
Source: BioMed Central - December 22, 2014 Category: Journals (General) Authors: Tian-Fu LiQiu-Yue WuCui ZhangWei-Wei LiQing ZhouWei-Jun JiangYing-Xia CuiXin-Yi XiaYi-Chao Shi Source Type: research

Review of cases of patient risk associated with ginseng abuse and misuse
Publication date: Available online 6 December 2014 Source:Journal of Ginseng Research Author(s): Doo Jin Paik , Chang Ho Lee Ginseng has long been used as a functional food or therapeutic supplement and it is empirically known to be safe and nontoxic. During recent decades, a number of in vitro and in vivo experiments, as well as human studies have been conducted to prove the safety of various types of ginseng samples and their components. Clinical trials, case reports, and in vitro and in vivo research articles addressing the safety, toxicity, and other adverse events of ginseng application were selected and reviewed. P...
Source: Journal of Ginseng Research - December 19, 2014 Category: Complementary Medicine Source Type: research

GPR30 Gene Polymorphisms Are Associated with Gynecomastia Risk in Adolescents
This study included 109 male adolescents with gynecomastia and 104 controls. Follicle stimulating hormone, luteinizing hormone, total testosterone, estradiol (E2), dehydroepiandrosterone sulfate (DHEAS), and prolactin levels were measured. DNA was extracted from whole blood using a GeneJET Genomic DNA purification kit. The genotypes of the GPR30 gene (rs3808350, rs3808351 and rs11544331) were studied using a tetra-primer ARMS (amplification refractory mutation system) PCR approach. Results: The median E2 (11.80 vs. 16.86 IU/l, p
Source: Hormone Research in Paediatrics - December 18, 2014 Category: Endocrinology Source Type: research

Breast ultrasound in the management of gynecomastia in Peutz-Jeghers syndrome in monozygotic twins: two case reports
Conclusions: Breast examination and ultrasound have proved to be a valid approach in the assessment of the treatment of prepubertal gynecomastia because they allow the efficacy of the pharmacological and surgical treatment to be evaluated in a multidisciplinary approach to one of the most frequent endocrine manifestations of Peutz-Jeghers syndrome. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - December 18, 2014 Category: Epidemiology Authors: Graziella Di GreziaTiziana RomanoFrancesco De FrancescoFrancesco SommaGaetano ReaRoberto GrassiGianluca Gatta Source Type: research

Breast ultrasound in the management of gynecomastia in Peutz–Jeghers syndrome in monozygotic twins: two case reports
Conclusions Breast examination and ultrasound have proved to be a valid approach in the assessment of the treatment of prepubertal gynecomastia because they allow the efficacy of the pharmacological and surgical treatment to be evaluated in a multidisciplinary approach to one of the most frequent endocrine manifestations of Peutz–Jeghers syndrome. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 18, 2014 Category: Journals (General) Source Type: research

Bilateral pseudoangiomatous stromal hyperplasia tumors in axillary male gynecomastia: report of a case
We report an unusual case of bilateral axillary tumoral PASH in a 44-year-old man. Awareness of this disease is important when considering the differential diagnosis of axillary masses. To our knowledge, only one other case of unilateral axillary tumoral PASH in a male patient has been described in English and this is the first case of PASH occurring in male bilateral axillary gynecomastia. (Source: Surgery Today)
Source: Surgery Today - December 12, 2014 Category: Surgery Source Type: research

Review on the cases of patient risk associated with ginseng abuse and misuse
Conclusion There is some cases of patient risk associated with ginseng abuse and misuse depending on patients’ conditions although further investigation in more cases is required to clarify these issues. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 7, 2014 Category: Complementary Medicine Source Type: research

An infertile man with gynecomastia caused by a novel mutation of the androgen receptor gene.
PMID: 25532578 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - December 5, 2014 Category: Urology & Nephrology Authors: Xu H, Li C, Tang L, Wang L, Yu X, Gu X, Lin X, Chen B Tags: Asian J Androl Source Type: research

Diethylstilbestrol 1 mg in the Treatment of Acute Urinary Retention due to Prostatic Obstruction in the Elderly: A Preliminary Study.
Diethylstilbestrol 1 mg in the Treatment of Acute Urinary Retention due to Prostatic Obstruction in the Elderly: A Preliminary Study. Adv Urol. 2014;2014:984382 Authors: Reis LO, De Mendonça GB, Carneiro BD, Schneider E, Gewehr EV, Meirelles A, Denardi F, Gugliotta A Abstract Patients who failed a catheter-free trial after acute urinary retention and one week of full dose alpha-blocker and 5-alpha-reductase inhibitor were offered Diethylstilbestrol 1 mg plus Aspirin 100 mg over 4 weeks. Prostate volume, age, serum creatinine, and initial retention drained urine volume were r...
Source: Advances in Urology - December 3, 2014 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Aesthetic Refinements in Body Contouring in the Massive Weight Loss Patient: Trunk
Conclusions: These aesthetic refinements are previously published anecdotal evidence that are presented together as part of the author’s routine clinical experience. They await confirmatory experience or, better yet, rigorous scientific study. Until then, these are practical adaptations routinely used by the author on the trunk that merit the reader’s consideration. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - November 25, 2014 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Clinical and surgical management of unilateral prepubertal gynecomastia
Conclusion The exact mechanism of unilateral gynecomastia formation in our case is unclear. The evaluation of unilateral gynecomastia can therefore be complex. In conclusion, the surgical treatment of unilateral gynecomastia requires an individual approach, based on an appropriate diagnostic algorithm. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - November 18, 2014 Category: Surgery Source Type: research

Preserved Fertility in a Patient with Gynecomastia Associated with the p.Pro695Ser Mutation in the Androgen Receptor
The androgen insensitivity syndrome (AIS) is described as a dysfunction of the androgen receptor (AR) in 46,XY individuals, which can be associated with mutations in the AR gene or can be due to unknown mechanisms. Different mutations in AIS generally cause variable phenotypes that range from a complete hormone resistance to a mild form usually associated with male infertility. The purpose of this study was to search for mutations in the AR gene in a fertile man with gynecomastia and to evaluate the influence of the mutation on the AR transactivation ability. Sequencing of the AR gene revealed the p.Pro695Ser mutation. It ...
Source: Sexual Development - November 15, 2014 Category: Biology Source Type: research

Preserved Fertility in a Patient with Gynecomastia Associated with the p.Pro695Ser Mutation in the Androgen Receptor.
ner R Abstract The androgen insensitivity syndrome (AIS) is described as a dysfunction of the androgen receptor (AR) in 46,XY individuals, which can be associated with mutations in the AR gene or can be due to unknown mechanisms. Different mutations in AIS generally cause variable phenotypes that range from a complete hormone resistance to a mild form usually associated with male infertility. The purpose of this study was to search for mutations in the AR gene in a fertile man with gynecomastia and to evaluate the influence of the mutation on the AR transactivation ability. Sequencing of the AR gene revealed the p...
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - November 15, 2014 Category: Genetics & Stem Cells Authors: Petroli RJ, Hiort O, Struve D, Maciel-Guerra AT, Guerra-Júnior G, Palandi de Mello M, Werner R Tags: Sex Dev Source Type: research

Designer steroids – over‐the‐counter supplements and their androgenic component: review of an increasing problem
Summary Colloquially referred to by various misleading monikers (‘pro‐hormones’, ‘natural steroids’, ‘testosterone boosters’, etc.) designer anabolic steroids have been popular now for over a decade as a way to achieve classic anabolic steroid‐like results from products sold in the legal marketplace. Recent evidence suggests that anabolic steroid use may be the most common cause of hypogonadism in men of reproductive age. Despite recent regulatory efforts that have banned specific compounds, many anabolic‐androgenic steroids (AAS) remain available in over‐the‐counter dietary su...
Source: Andrology - November 1, 2014 Category: Urology & Nephrology Authors: C. D. Rahnema, L. E. Crosnoe, E. D. Kim Tags: Review Article Source Type: research

Risperidone Use and Risk for Gynecomastia in Men
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - October 1, 2014 Category: Psychiatry Tags: Letters to the Editors Source Type: research

Use of Aromatase Inhibitors in Large Cell Calcifying Sertoli Cell Tumors: Effects on Gynecomastia, Growth Velocity, and Bone Age.
Conclusions: Patients with LCCSCT benefit from aromatase inhibitor therapy with reduction and/or elimination of gynecomastia and slowing of linear growth and bone age advancement. Further study of long-term outcomes and safety monitoring are needed but these preliminary data suggest that mammoplasty and/or orchiectomy may be foregone in light of the availability of proper medical therapy. PMID: 25226294 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 16, 2014 Category: Endocrinology Authors: Crocker MK, Gourgari E, Lodish M, Stratakis CA Tags: J Clin Endocrinol Metab Source Type: research

Factors associated with adaptation to Klinefelter syndrome: the experience of adolescents and adults
Klinefelter syndrome (XXY), or 47,XXY, is a common genetic condition caused by the presence of an extra X chromosome in males. It is estimated to occur in one in 650 males, though population-based studies in the UK and Denmark have suggested that 65-75% of individuals with XXY are undiagnosed [1,2]. While the physical and cognitive phenotype associated with XXY is highly variable, common features include tall stature, language-based learning disabilities, disorders of executive function, hypogonadism, gynecomastia, and fertility problems [3]. (Source: Patient Education and Counseling)
Source: Patient Education and Counseling - August 26, 2014 Category: Global & Universal Authors: Amy Turriff, Howard P. Levy, Barbara Biesecker Source Type: research

Factors associated with adaptation to Klinefelter syndrome: The experience of adolescents and adults
Klinefelter syndrome (XXY), or 47,XXY, is a common genetic condition caused by the presence of an extra X chromosome in males. It is estimated to occur in one in 650 males, though population-based studies in the UK and Denmark have suggested that 65–75% of individuals with XXY are undiagnosed [1,2]. While the physical and cognitive phenotype associated with XXY is highly variable, common features include tall stature, language-based learning disabilities, disorders of executive function, hypogonadism, gynecomastia, and fertility problems [3]. (Source: Patient Education and Counseling)
Source: Patient Education and Counseling - August 26, 2014 Category: Global & Universal Authors: Amy Turriff, Howard P. Levy, Barbara Biesecker Tags: Patient Perception, Preference and Participation Source Type: research

Testosterone in Men with Advanced Liver Disease: Abnormalities and Implications
Abstract Serum testosterone is reduced in up to 90% of men with cirrhosis, with levels falling as liver disease advances. Testosterone is an important anabolic hormone, with effects on muscle, bone, and haematopoiesis. Many of the features of advanced liver disease are similar to those seen in hypogonadal men, including sarcopenia, osteoporosis, gynecomastia and low libido. However the relative contribution of testosterone deficiency to the symptomatology of advanced liver disease has not been well established. More recently it has been demonstrated that low testosterone in men with cirrhosis is associated with increased m...
Source: Journal of Gastroenterology and Hepatology - August 4, 2014 Category: Gastroenterology Authors: Marie Sinclair, Mathis Grossmann, Paul J Gow, Peter W Angus Tags: Review Article Source Type: research

Elucidating encounters of atypical ductal hyperplasia arising in gynecomastia
ConclusionsADH in gynecomastia can be distinguished from UDH by morphologic and immunhistochemical features. We also identified a subset of young patients (
Source: Histopathology - August 1, 2014 Category: Pathology Authors: Justin M. Wells, Yifang Liu, Paula S. Ginter, Michaela T. Nguyen, Sandra J. Shin Tags: Original Article Source Type: research

Pseudomembranous trigonitis in a male with Klinefelter syndrome: a case report and evidence of a hormonal etiology.
We report a 16 year old boy with Klinefelter syndrome presenting to our institution with gross hematuria. Cystoscopy and biopsy revealed the diagnosis of pseudomembranous trigonitis. Immunohistochemical stains showed an increase in estrogen and progesterone receptors in the trigone area but not in the rest of the bladder. In view of the patient's mildly raised estrogen levels and the histological findings, we postulate that estrogen is the driver of the development of pseudomembranous trigonitis. This is the first reported case of pseudomembranous trigonitis seen in association with Klinefelter syndrome, and also the first...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Lian DW, Li FX, Ong CC, Kuick Ch, Chang KT Tags: Int J Clin Exp Pathol Source Type: research

Early onset and novel features in a spinal and bulbar muscular atrophy patient with a 68 CAG repeat
Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy’s disease [1], is an X-linked neuromuscular disease caused by a CAG repeat expansion in the androgen receptor gene. Affected males develop weakness, atrophy, and fasciculations in the limb and bulbar muscles during adulthood. In addition to the motor effects, degeneration of the dorsal root ganglia can result in a loss of sensory function in the distal extremities. Patients also often show evidence of androgen insensitivity, such as gynecomastia, oligospermia, and erectile dysfunction. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - July 3, 2014 Category: Neurology Authors: Christopher Grunseich, Ilona R. Kats, Laura C. Bott, Carlo Rinaldi, Angela Kokkinis, Derrick Fox, Ke-lian Chen, Alice B. Schindler, Ami K. Mankodi, Joseph A. Shrader, Daniel P. Schwartz, Tanya J. Lehky, Chia-Ying Liu, Kenneth H. Fischbeck Tags: Case report Source Type: research

Teaching Video NeuroImages: Muscle cramps and a raised creatine kinase
A 40-year-old man presented with a 25-year history of cramps affecting the abdomen, neck, and limbs. Examination revealed fasciculation in the forearms, abdomen, and chin (video on the Neurology® Web site at Neurology.org). There was shoulder girdle wasting with bilateral mastectomy scars (figure, B and C). Creatine kinase (CK) was 1,650 U/L (normal
Source: Neurology - June 16, 2014 Category: Neurology Authors: Whittaker, R. G., Chinnery, P. F., Miller, J. A. L. Tags: All Clinical Neurology, Anterior nerve cell disease, EMG RESIDENT AND FELLOW SECTION Source Type: research

Testicular Seminoma Presenting as Unilateral Gynecomastia
(Source: The Breast Journal)
Source: The Breast Journal - June 2, 2014 Category: Cancer & Oncology Authors: Sarantos Kaptanis, Laila Parvanta, Luis Beltran Tags: Breast Images Source Type: research

[Bariatric and plastic surgery in obese adolescents: An alternative treatment.]
Abstract The increased frequency of extreme forms of obesity in adolescents and the disappointing results of conventional treatments are now leading pediatricians to consider bariatric or cosmetic surgery as the only real long-term effective therapeutic alternative. The two main techniques currently used for bariatric surgery in adolescents are gastric bypass and adjustable gastric banding. Whatever the technique, weight loss is significant with improvement of comorbidities and quality of life. In addition, the complications are identical to those in adults and equally frequent. However, because of the particulari...
Source: Archives de Pediatrie - May 8, 2014 Category: Pediatrics Authors: Dubern B, Tounian P Tags: Arch Pediatr Source Type: research

Digital breast tomosynthesis of gynecomastia and associated findings—a pictorial review
Men referred for breast imaging most frequently present with a unilateral palpated breast lump or breast enlargement. In the vast majority of these cases, the cause is benign and the most common etiology is gynecomastia. This pictorial review illustrates the appearance by full field digital mammography and digital breast tomosynthesis of gynecomastia as well as additional findings in the male breast including sternalis muscle and hypertrophied pectoralis muscle, lipoma, intramammary lymph node, fat necrosis, breast cancer, and atypical ductal hyperplasia. (Source: Clinical Imaging)
Source: Clinical Imaging - April 23, 2014 Category: Radiology Authors: Emily B. Sonnenblick, Laurie R. Margolies, Janet R. Szabo, Lauren M. Jacobs, Neesha Patel, Karen A. Lee Tags: Review Articles Source Type: research

Digital breast tomosynthesis of gynecomastia and associated findings—a pictorial review
(Source: Clinical Imaging)
Source: Clinical Imaging - April 21, 2014 Category: Radiology Authors: Emily B. Sonnenblick, Laurie R. Margolies, Janet R. Szabo, Lauren M. Jacobs, Neesha Patel, Karen A. Lee Source Type: research

Anthropometric and Hormonal Risk Factors for Male Breast Cancer: Male Breast Cancer Pooling Project Results
Conclusions Consistent findings across case–control and cohort investigations, complemented by pooled analyses, indicated important roles for anthropometric and hormonal risk factors in the etiology of male breast cancer. Further investigation should focus on potential roles of endogenous hormones. (Source: JNCI)
Source: JNCI - March 26, 2014 Category: Cancer & Oncology Authors: Brinton, L. A., Cook, M. B., McCormack, V., Johnson, K. C., Olsson, H., Casagrande, J. T., Cooke, R., Falk, R. T., Gapstur, S. M., Gaudet, M. M., Gaziano, J. M., Gkiokas, G., Guenel, P., Henderson, B. E., Hollenbeck, A., Hsing, A. W., Kolonel, L. N., Isaa Tags: Article Source Type: research

[Unilateral gynecomastia in young male due to tea tree oil.]
PMID: 24529892 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - February 13, 2014 Category: Pediatrics Authors: Lopez-Rodriguez JA, Duelo Marcos M Tags: An Pediatr (Barc) Source Type: research

Spironolactone Reduces Cardiovascular and Cerebrovascular Morbidity and Mortality in Hemodialysis Patients
ConclusionsAldosterone receptor blockade using spironolactone may substantially reduce the risk of both CCV morbidity and death among HD patients; however, larger-scale studies are recommended to further confirm its efficacy. (Effects of Spironolactone on Cardio- and Cerebrovascular Morbidity and Mortality in Hemodialysis Patients; NCT01687699) (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - February 10, 2014 Category: Cardiology Source Type: research

Aromatase excess syndrome presenting with prepubertal gynecomastia in an Egyptian child with type 1 neurofibromatosis
Kotb Abbass Metwalley, Hekma Saad FarghalyIndian Journal of Human Genetics 2013 19(4):472-474A romatase excess syndrome (AEXS) is a rare autosomal dominant disorder characterized by prepubertal gynecomastia, it responds well to medical treatment. In the absence of prompt suspicion, it can expose the patient to the risk of unnecessary surgical intervention. Up to our best knowledge, the association between AEXS and neurofibromatosis type 1 (NF1) was not reported before. Here, we describe a AEXS presenting with prepubertal gynecomastia in an Egyptian child with NF1 that improved with aromatase inhibitors. (Source: Indian Jou...
Source: Indian Journal of Human Genetics - January 4, 2014 Category: Genetics & Stem Cells Authors: Kotb Abbass MetwalleyHekma Saad Farghaly Source Type: research

Surgical Management of Gynecomastia: 20 Years' Experience.
CONCLUSION: These results most probably represent differences in the population and pathologies treated. This is possibly due to a bias in the referrals by primary care physicians. PMID: 24345981 [PubMed - as supplied by publisher] (Source: Hand Surgery)
Source: Hand Surgery - December 17, 2013 Category: Surgery Authors: Lapid O, Jolink F Tags: Scand J Surg Source Type: research

Rapidly growing histologically confirmed female breast in a genotypically confirmed male
Asymptomatic gynecomastia is a very common finding with a trimodal age distribution: the prevalence may approximate 90% in neonates, 60% in adolescents and 70% in men aged between 50 and 69 years. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - November 18, 2013 Category: Cosmetic Surgery Authors: D. Schmauss, Y. Harder, H.G. Machens, J.A. Lohmeyer Tags: Correspondence and Communications - E-Only Publication Source Type: research

Spironolactone Reduces Cardiovascular and Cerebrovascular Morbidity and Mortality in Hemodialysis Patients
Conclusions: Aldosterone receptor blockade using spironolactone may substantially reduce the risk of both CCV morbidity and death among HD patients; however, larger-scale studies are recommended to further confirm its efficacy. (Effects of Spironolactone on Cardio- and Cerebrovascular Morbidity and Mortality in Hemodialysis Patients; NCT01687699) (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 1, 2013 Category: Cardiology Authors: Yoshihiro Matsumoto, Yasuo Mori, Shinji Kageyama, Kazuo Arihara, Toshikazu Sugiyama, Hiromichi Ohmura, Toru Yakushigawa, Hatsumi Sugiyama, Yasushi Shimada, Youichi Nojima, Nobuo Shio Tags: Cardiometabolic Risk Source Type: research

Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for prepubertal gynecomastia in boys with Peutz Jeghers Syndrome.
Conclusions:LOH of the STK11 gene leads to an increase in aromatase expression associated with an increase in CRTC nuclear localization, thereby providing a mechanism whereby PJS results in increased endogenous estrogens in affected males. PMID: 24037887 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 13, 2013 Category: Endocrinology Authors: Ham S, Meachem SJ, Choong CS, Charles AK, Baynam GS, Jones TW, Samarajeewa NU, Simpson ER, Brown KA Tags: J Clin Endocrinol Metab Source Type: research