Adolescent Gynecomastia.
Authors: Guss CE, Divasta AD Abstract Gynecomastia, defined as the presence of glandular breast tissue in men, is a common, typically benign physical exam finding during adolescence. Although the exact pathogenesis of gynecomastia is unknown, it is likely due to a hormonal imbalance between estrogens and androgens. Most cases are idiopathic and do not require further evaluation if the history and physical examination are reassuring. Although the majority of cases will resolve spontaneously, surgical correction may be an option for adolescents with persistent and problematic gynecomastia. Gynecomastia can have signi...
Source: Pediatric Endocrinology Reviews - June 16, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research

Peutz-Jeghers syndrome with early onset of pre-adolescent gynecomastia: a predigree case report and clinical and molecular genetic analysis.
This study reports a case of Peutz-Jeghers syndrome with early onset of gynecomastia, and discusses its clinical characteristics and genetic changes in a family. The clinical characteristics of a child diagnosed with Peutz-Jeghers syndrome in our hospital and his parents were summarized, and related genes were detected in the child and his parents. Furthermore, the therapeutic effect of letrozole was also observed. A five-year-and-three-month-old male patient visited a doctor due to "progressive painless enlargements at bilateral breast for more than two years". The mother of the patient had breast hyperplasia an...
Source: American Journal of Translational Research - June 2, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Gynecomastia: look beyond the obvious
A 29-year-old man was referred to our clinic with a 4-week history of a tender predominant left breast enlargement without nipple discharge. He had been practicing bodybuilding regularly since years, but denied taking anabolic androgenic steroids. His past medical history was unremarkable apart from surgical treatment of undescended testes in childhood. His sexual desire and erectile function were normal. He had no family history of breast or testicular cancer. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - May 18, 2017 Category: General Medicine Authors: Thomas Pusl, Peter Stoemmer Tags: Clinical Communication to the Editor Source Type: research

Kennedy disease (X-linked recessive bulbospinal neuronopathy): A comprehensive review from pathophysiology to therapy.
Authors: Querin G, Sorarù G, Pradat PF Abstract Kennedy's disease, also known as spinal and bulbar muscular atrophy (SBMA), is a rare, adult-onset, X-linked recessive neuromuscular disease caused by expansion of a CAG repeat sequence in exon 1 of the androgen receptor gene (AR) encoding a polyglutamine (polyQ) tract. The polyQ-expanded AR accumulates in nuclei, and initiates degeneration and loss of motor neurons and dorsal root ganglia. While the disease has long been considered a pure lower motor neuron disease, recently, the presence of major hyper-creatine-kinase (CK)-emia and myopathic alterations on mu...
Source: Revue Neurologique - May 8, 2017 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Is the transposition of the nipple-areolar complex necessary in Simon grade 2b gynecomastia operations using suction-assisted liposuction?
Authors: Özalp B, Berköz Ö, Aydınol M Abstract OBJECTIVE: The aim of this study was to assess the efficacy of suction-assisted liposuction (SAL) in Simon grade 2b gynecomastia and its effect on sternal notch to nipple areola (SNN) distance. METHODS: A retrospective analysis was performed on 21 patients with grade 2b gynecomastia who underwent SAL. Preoperative and postoperative SNN distances of the patients were measured, the results were analysed using a Mann-Whitney U test and a p-value
Source: Journal of Plastic Surgery and Hand Surgery - May 6, 2017 Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research

Comparison of laser-assisted liposuction and traditional liposuction combined with endoscopic surgical excision of grade II gynecomastia
ConclusionsEndoscopic surgical excision of grade II gynecomastia combined with traditional or laser-assisted liposuction can achieve satisfactory aesthetic results. Furthermore, the combined use of laser liposuction failed to show superior aesthetic results than traditional liposuction. However, the use of laser-assisted liposuction offers additional advantages such as intraoperative (less bleeding, less operative time) or postoperative either immediately (less pain, indurations, ecchymosis, and edema) or late as improved skin tightness.Level of Evidence: Level III, therapeutic study (Source: European Journal of Plastic Surgery)
Source: European Journal of Plastic Surgery - May 5, 2017 Category: Cosmetic Surgery Source Type: research

Peripancreatic Mass of Unknown Origin
Question: A 66-year-old man with past medical history of asthma, hypertension, type 2 diabetes mellitus, chronic kidney disease, hypoganadism, and gynecomastia presented with acute abdominal pain that led to an emergency room computed tomography (CT) scan revealing kidney stones. He was then referred to urology for long-term management. Surprisingly, a new mass near his pancreas and stomach was found in the repeat CT scan (Figure A). The homogenous-appearing lesion identified adjacent to the pancreatic body was measured to be about 3.7 cm and demonstrated calcification. (Source: Gastroenterology)
Source: Gastroenterology - May 4, 2017 Category: Gastroenterology Authors: Farnaz Shariati, Hyung Sun Yoo, Virendra Joshi Tags: Electronic Clinical Challenges and Images in GI Source Type: research

Kennedy disease with difficulty in differential diagnosis: A case report
We report a case of a 43-year-old male with progressive limb proximal weakness without family history. Physical examination showed gynecomastia, erectile dysfunction, bilateral tendon reflex and quadriceps weakness, and tongue muscle atrophy. Diagnoses: Laboratory examination found increased creatine kinase, impaired glucose tolerance, and abnormal lactic acid values. There was no mutation or copy number variant in SMN1 gene and related mitochondrion genes tested, even with the use of multiplex ligation probe- dependent amplification technique. Diagnosis was confirmed with genetic analysis which displayed trinucleotide CA...
Source: Medicine - May 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

The Characteristics and Short-Term Surgical Outcomes of Adolescent Gynecomastia
ConclusionsGynecomastia that did not regress spontaneously was mostly the glandular type, so not only liposuction but also surgical removal of glandular tissue is necessary. Surgical treatment, selectively performed in patients who have had gynecomastia for 3  years, and have experienced psychosocial distress, could be an acceptable treatment for adolescent gynecomastia.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the table of contents or the online instructions to authorswww.springer....
Source: Aesthetic Plastic Surgery - April 27, 2017 Category: Cosmetic Surgery Source Type: research

Poems syndrome without "m"- could it be possible ? a case report (p6.119)
Conclusions:Early diagnosis reduces morbidity and enhances survival in POEMS. Sometimes, however, the detection of M-protein could be difficult and a crucial delay in the correct disease management can eventually occur.Disclosure: Dr. Mestrinelli Carrilho has nothing to disclose. Dr. Reck de Oliveira has nothing to disclose. Dr. Bianchi da Silva has nothing to disclose. Dr. Lazzarin Silva has nothing to disclose. Dr. Schran has nothing to disclose. Dr. de Carvalho has nothing to disclose. Dr. Scola has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Carrilho, P. E. M., de Oliveira, B. C. R., da Silva, E. B., Silva, T. A. A. L., da Silva Schran, L., de Carvalho, C. C., Scola, R. H. Tags: Neuromuscular and Clinical Neurophysiology (EMG): Peripheral Neuropathy III Source Type: research

Management of Gynecomastia in Patients With Different Body Types: Considerations on 312 Consecutive Treated Cases
Conclusions: The study demonstrates the importance of the different management of the same disorder according to the different patients' expectations, related to the different body type. Our experience demonstrated that most of the cases did not require extensive skin incisions, reducing the risk of unpleasant scars and that direct excision of glandular tissue ensures stable and satisfactory results. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - April 13, 2017 Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research

Ovotestis in Adolescence: Two Case Reports
We present two patients found to have ovotesticular disorder of sexual differentiation (otDSD) in late adolescence. Two 15-year-old phenotypically male patients presented to a large pediatric hospital with different complaints: one with concern for testicular rupture after a straddle injury; the other with gynecomastia. Further work-up, including imaging and lab tests, was performed before surgical exploration. The first patient had unilateral ovotestis, contralateral testis, and SRY-negative 46,XX karyotype. (Source: Urology)
Source: Urology - April 13, 2017 Category: Urology & Nephrology Authors: Jyoti D. Chouhan, David I. Chu, Antoinette Birs, Louise C. Pyle, Jason P. Van Batavia, Rebecca L. Linn, Susan J. Back, Pierre Russo, Kassa Darge, Thomas F. Kolon, Arun K. Srinivasan Tags: Pediatric Case Reports Source Type: research

Ovotestis in Adolescence: 2 Case Reports
We present 2 patients found to have ovotesticular disorder of sexual development (otDSD) in late adolescence. Two 15-year-old phenotypically male patients presented to a large pediatric hospital with different complaints: 1 with concern for testicular rupture after a straddle injury; 1 with gynecomastia. Further workup, including imaging and laboratory tests, was performed before surgical exploration. The first patient had unilateral ovotestis, contralateral testis, and SRY-negative 46,XX karyotype. (Source: Urology)
Source: Urology - April 13, 2017 Category: Urology & Nephrology Authors: Jyoti D. Chouhan, David I. Chu, Antoinette Birs, Louise C. Pyle, Jason P. Van Batavia, Rebecca L. Linn, Susan J. Back, Pierre Russo, Kassa Darge, Thomas F. Kolon, Arun K. Srinivasan Tags: Pediatric Case Reports Source Type: research

S1 guidelines: Gynecomastia in adults
(Source: JDDG)
Source: JDDG - April 5, 2017 Category: Dermatology Authors: Stefan Schanz, Gerhard Schreiber, Michael Zitzmann, Bj örn Dirk Krapohl, Raymund Horch, Frank‐Michael Köhn Tags: Guideline Source Type: research

Postero-Inferior Pedicle Surgical Technique for the Treatment of Grade III Gynecomastia
(Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - April 3, 2017 Category: Cosmetic Surgery Source Type: research

Multiple symmetric lipomatosis and gynecomastia: a case report and relative literature review
Multiple symmetric lipomatosis (MSL) is a rare disease characterized by a symmetrical accumulation of massive adipose tissue on the neck, the superior part of the trunk and limbs. Here we reported an extremely rare case of MSL in a 46-year-old Chinese man, who has a history of heavy drinking and smoking and presented with diffuse lipomatosis and bilateral breast enlargement. Hyperuricemia and impaired glucose tolerance test were all found in this patient. A brief review of the literature was also made in this paper. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - March 29, 2017 Category: Lipidology Authors: Meimei Tian, Yan Liu, Zhongji Zhi, Yukun Li Source Type: research

Discussion: Surgical Management of Gynecomastia: Subcutaneous Mastectomy and Liposuction
(Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - March 24, 2017 Category: Cosmetic Surgery Source Type: research

Complications and Outcomes After Gynecomastia Surgery: Analysis of 204 Pediatric and 1583 Adult Cases from a National Multi-center Database
ConclusionOperative gynecomastia treatment remains a safe treatment modality across all age groups. Patients with known preoperative medical or surgical comorbidities necessitate more extensive perioperative assessment and monitoring.Level of Evidence IIIThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - March 24, 2017 Category: Cosmetic Surgery Source Type: research

Surgical Masculinization of the Breast: Clinical Classification and Surgical Procedures
ConclusionsAll patients who wish to obtain a masculine breast shape should be treated with only one objective regardless patient ’s gender: to obtain a masculine thorax. We recommend a simple mammary gland classification for determining the best surgical treatment for these patientsLevel of Evidence VThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - March 24, 2017 Category: Cosmetic Surgery Source Type: research

Association of dermatoses with duration and quantum of alcohol intake: A comparative cross-sectional study
Conclusion: Knowledge of cutaneous manifestations of chronic alcoholism could prompt in-depth history taking of alcohol intake, lead to specialist referral and thereby enable timely de-addiction, hopefully before serious adversities in the chronic alcoholics. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - March 9, 2017 Category: Dermatology Authors: Yugal Kishor Sharma Pankaj Shukla Roopa Nayak Preeti Kothari Aayush Gupta Source Type: research

Long-Term Follow-up of Recurrence and Patient Satisfaction After Surgical Treatment of Gynecomastia
ConclusionsLong-term follow-up results showed that recurrence rates are significantly higher in patients with lipomatous gynecomastia than in patients with glandular gynecomastia, with BMI increase in patients with glandular and lipomatous gynecomastia showing no statistically significant differences. Furthermore, general patient satisfaction and improvement of self-esteem was higher in younger patient groups than older patient groups.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table o...
Source: Aesthetic Plastic Surgery - March 9, 2017 Category: Cosmetic Surgery Source Type: research

Gynecomastia in Infants, Children, and Adolescents.
CONCLUSION: The majority of cases are physiological and do not require treatment other than reassurance. For pathological cases, the underlying cause should be treated if possible. If gynecomastia persists in spite of the above measures and treatment become necessary, tamoxifen is the treatment of choice. Reduction mammoplasty may be considered for resistant cases. PMID: 28260521 [PubMed - as supplied by publisher] (Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery)
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - March 8, 2017 Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research

Effects of Anabolic Androgenic Steroids on the Reproductive System of Athletes and Recreational Users: A Systematic Review and Meta-Analysis
AbstractBackgroundAnabolic androgenic steroids (AAS) are testosterone derivatives used by athletes and recreational users to improve athletic performance and/or enhance appearance. Anabolic androgenic steroids use may have serious and potentially irreversible adverse effects on different organs and systems, including the reproductive system.ObjectiveThis systematic review and meta-analysis aimed to critically assess the impact of AAS use on the reproductive system of athletes and recreational users.MethodsAn electronic literature search was conducted using the databases MEDLINE, CENTRAL, and Google Scholar. Studies were in...
Source: Sports Medicine - March 4, 2017 Category: Sports Medicine Source Type: research

46 XX karyotype during male fertility evaluation; case series and literature review.
Abstract Forty-six XX disorder of sex development is an uncommon medical condition observed at times during the evaluation of a man's fertility. The following is a case series and literature review of phenotypically normal men diagnosed with this karyotype. Our goal is to comprehend the patients' clinical presentation as well as their laboratory results aiming to explore options available for their management. A formal literature review through PubMed and MEDLINE databases was performed using "46 XX man" as a word search. A total of 55 patients, including those conveyed in this article were diagnosed wit...
Source: Asian Journal of Andrology - March 1, 2017 Category: Urology & Nephrology Authors: Majzoub A, Arafa M, Starks C, Elbardisi H, Al Said S, Sabanegh E Tags: Asian J Androl Source Type: research

Gynecomastia in the Ancient Egypt limestone statue of Hemiunu, the architect of the Great Pyramid of Giza (fl. 2570 BC)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Gynecomastia Classification for Surgical Management: A Systematic Review and Novel Classification System
Conclusions: Based on their review of the current classification systems, the authors believe the ideal classification system should be universal and cater to all causes of gynecomastia; be surgically useful and easy to use; and should include a comprehensive set of clinically appropriate patient-related features, such as breast size, breast ptosis, tissue predominance, and skin redundancy. None of the current classification systems appears to fulfill these criteria. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - February 28, 2017 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Who Gets Severe Gynecomastia Among HIV-infected Children in the United Kingdom and Ireland?
There are few data on gynecomastia in HIV-infected children. Within the UK/Ireland’s national cohort, 56 of 1873 (3%) HIV-infected children had gynecomastia, of which 10 (0.5%) were severe. All 10 had received antiretroviral therapy for a median of 27.5 (21, 42) months; 4 of 10 had received efavirenz, 7 of 10 and 6 of 10 had received stavudine and/or didanosine respectively. Five were nonreversible, despite changing antiretroviral therapy, and required breast reduction surgery. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - February 15, 2017 Category: Infectious Diseases Tags: HIV Reports Source Type: research

Discussion: Surgical Management of Gynecomastia —Subcutaneous Mastectomy and Liposuction
(Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - February 15, 2017 Category: Cosmetic Surgery Source Type: research

Postero-Inferior Pedicle Surgical Technique for the Treatment of Grade III Gynecomastia
ConclusionsWe report a new operative technique using a postero-inferior pedicle. Its main advantage is preservation of neurovascular function, which makes this a promising technique for patients who wish to maintain nipple sensitivity. This surgery is reliable and reproducible. We recommend it as the first line treatment for Grade III gynecomastia because of its low rate of major complications and favorable functional and esthetic results.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Tab...
Source: Aesthetic Plastic Surgery - February 15, 2017 Category: Cosmetic Surgery Source Type: research

Gynecomastia Surgery—Impact on Life Quality: A Prospective Case-Control Study
Objective: To evaluate the results of surgical treatment of gynecomastia in the context of quality of life and satisfaction after the surgery. Methods: Fifty male patients (mean age, 25.1 years [SD = 8 years]) who underwent surgery for gynecomastia and completed both (preoperative and postoperative) stages of the study were included in the analysis. The quality-of-life evaluation instrument was The Short Form-36 Health Survey Questionnaire. Additionally, we used a short questionnaire including 2 questions about patient satisfaction with gynecomastia surgery. Results: The overall change in life satisfaction after gynecoma...
Source: Annals of Plastic Surgery - February 10, 2017 Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research

Risk of gynecomastia and breast cancer associated with the use of 5-alpha reductase inhibitors for benign prostatic hyperplasia
(Source: Clinical Epidemiology)
Source: Clinical Epidemiology - February 10, 2017 Category: Epidemiology Tags: Clinical Epidemiology Source Type: research

The Impact Exerted on Clinical Outcomes of Patients With Chronic Heart Failure by Aldosterone Receptor Antagonists: A Meta-Analysis of Randomized Controlled Trials.
CONCLUSIONS: ARAs reduced the risk of adverse cardiac events in HFREF but not HFpEF. In particular, ARA use in HFpEF patients is questionable, since in this CHF type, no significant improvement in all-cause death and cardiovascular hospitalizations was demonstrated with ARA treatment, in the face of the well-known risks of hyperkalemia and/or gynecomastia that chronic ARA therapy entails. Selective ARAs were equally effective as non-selective ARAs, without the risk of gynecomastia. PMID: 28090229 [PubMed - in process] (Source: Clin Med Res)
Source: Clin Med Res - January 17, 2017 Category: Research Authors: De Vecchis R, Cantatrione C, Mazzei D, Barone A, Maurea N Tags: J Clin Med Res Source Type: research

Sex hormone profile in male patients with hepatitis C virus-related liver cirrhosis and its reflection on clinical presentation
Background and aim Gonadal function is affected significantly in male patients with cirrhosis. The aim of this study was to assess the level of sex hormones in male patients with hepatitis C virus-related liver cirrhosis and its reflection on clinical presentation. Patients and methods This cross-sectional study was carried out on 40 consecutive male patients with hepatitis C virus-related cirrhosis of Child–Pugh class C in addition to 20 age-matched healthy male participants (control group). All were subjected to an assay of serum hormonal levels: total and free testosterone, estradiol (E2), sex hormone-binding...
Source: Egyptian Liver Journal - January 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

No-Drain Single Incision Liposuction Pull-Through Technique for Gynecomastia
ConclusionThe liposuction pull-through technique is an effective treatment for gynecomastia without significant skin redundancy. It combines the benefits of the direct excision of glandular tissues, with the minimally invasive nature of liposuction. Performing the procedure through a single incision without the use of drains and without general anesthesia is a safe alternative.Level of evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorshttp://www....
Source: Aesthetic Plastic Surgery - December 28, 2016 Category: Cosmetic Surgery Source Type: research

A rapidly progressive defective spermatogenesis in a Mexican family affected by spino-bulbar muscular atrophy.
In this report we describe a Mexican family with three affected brothers with primary infertility caused by a progressive impairment of spermatogenesis leading to azoospermia before 40 years of age. They presented common features associated to patients affected by SMBA, such as gynecomastia, high level of CPK, muscle cramps, fasciculations, muscle wastage, and impaired swallowing. Two intracytoplasmic sperm injection (ICSI) cycles were performed in one of the patients resulting in fertilization failure. Molecular analysis of AR gene exon 1 revealed 54 CAG repeats in DNA extracted from leukocytes in affected patients and 22...
Source: Reproductive Biology - December 16, 2016 Category: Reproduction Medicine Authors: Piña-Aguilar RE, Regalado-Hernández MÁ, Moreno-García JD, Buentello-Volante B, Chacón-Camacho OF, Gallegos-Rivas MC, Kazakova E, Santillán-Hernández Y, Zenteno JC Tags: Syst Biol Reprod Med Source Type: research

Aldosterone receptor antagonists decrease mortality and cardiovascular hospitalizations in chronic heart failure (CHF) with reduced left ventricular ejection fraction(LVEF), but not in CHF with preserved LVEF. A meta-analysis of randomized controlled trials.
CONCLUSIONS: Our meta-analysis provides further evidence that ARAs should be systematically used in patients with HFREF , in whom these drugs improve some hard clinical endpoints, such as all-cause mortality and hospitalizations from cardiac cause. Conversely, based on the present meta-analysis, ARA usage in HFpEF patients is questionable since in this CHF setting no significant improvement in clinical endpoints has been demonstrated so far, in the face of the well-known risks of hyperkalemia and/or gynecomastia that chronic ARA therapy entails. Furthermore, new selective ARAs are not burdened by significant risk of gyneco...
Source: Minerva Cardioangiologica - December 15, 2016 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research

Surgical Management of Gynecomastia: Subcutaneous Mastectomy and Liposuction
ConclusionOur study shows that combination treatment with liposuction and subcutaneous mastectomy results in satisfactory outcomes, including the extent of scarring. We conclude that this combination treatment should be recommended as the standard surgical treatment for gynecomastia and can provide excellent results in cases where glandular tissue needs to be removed.Level of Evidence VThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266...
Source: Aesthetic Plastic Surgery - December 1, 2016 Category: Cosmetic Surgery Source Type: research

Response to the anastrozole treatment in a case with peutz-jeghers syndrome who was detected to have large cell calcifying sertoli cell tumor and developed pre-pubertal gynecomastia.
RESPONSE TO THE ANASTROZOLE TREATMENT IN A CASE WITH PEUTZ-JEGHERS SYNDROME WHO WAS DETECTED TO HAVE LARGE CELL CALCIFYING SERTOLI CELL TUMOR AND DEVELOPED PRE-PUBERTAL GYNECOMASTIA. J Clin Res Pediatr Endocrinol. 2016 Nov 22;: Authors: Koç Yekedüz M, Şıklar Z, Burgu B, Kuloğlu Z, Kocaay P, Çamtosun E, İsakoca M, Kansu A, Soygür T, Berberoğlu M Abstract Peutz-Jeghers Syndrome (PJS) is inherited as an autosomal dominant trait which is characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of neoplasm. Large Cell Cal...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - November 24, 2016 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings.
Authors: Hatano M, Takenaka Y, Inoue I, Homma K, Hasegawa T, Sasano H, Awata T, Katayama S Abstract We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological d...
Source: Internal Medicine - November 18, 2016 Category: Internal Medicine Tags: Intern Med Source Type: research

Orange Peel Excision of Gland: A Novel Surgical Technique for Treatment of Gynecomastia
Conclusion: The technique has reduced operative time and avoids residual gland and hematoma with excellent aesthetic outcome. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - November 11, 2016 Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research

Atypical Leydig Cell Tumor in Children: Report of 2 Cases
We report 2 cases of LCT in prepubertal boys presenting with advanced unilateral pubarche and testicular volume asymmetry. Both subjects had normal penis size for age; no axillary hair or other signs of puberty were present. Height velocity was normal, and bone age was coincident with chronological age. Androgen levels were normal, as well as estrogen, corticotropin, and cortisol concentration. Testicular ultrasound demonstrated a testicular mass. Histology examination revealed a well-differentiated LCT. This is the first report of 2 pediatric patients with LCT presenting with advanced pubarche in absence of systemic hyper...
Source: PEDIATRICS - November 1, 2016 Category: Pediatrics Authors: Mameli, C., Selvaggio, G., Cerini, C., Bulfamante, G., Madia, C., Riccipetitoni, G., Zuccotti, G. V. Tags: Endocrinology, Puberty Case Report Source Type: research

Multiple Schwannomas in a Patient with Gynecomastia
(Source: The Breast Journal)
Source: The Breast Journal - November 1, 2016 Category: Cancer & Oncology Authors: Utsav M. Patwardhan, Megan T. Vu, Peter W. Soballe Tags: Breast Images Source Type: research

Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome
Postfinasteride syndrome (PFS) is a term recently coined to characterize a constellation of reported undesirable side effects described in postmarketing reports and small uncontrolled studies that developed during or after stopping finasteride treatment, and persisted after drug discontinuation. Symptoms included decreased libido, erectile dysfunction, sexual anhedonia, decreased sperm count, gynecomastia, skin changes, cognitive impairment, fatigue, anxiety, depression, and suicidal ideation. The aim of this study is to review the existing medical literature for evidence-based research of permanent sexual dysfunction and ...
Source: Skin Appendage Disorders - September 22, 2016 Category: Dermatology Source Type: research

Gynecomastia as a Paraneoplastic Symptom of Choriocarcinoma.
Authors: Yamane H, Ochi N, Honda Y, Takigawa N PMID: 27629979 [PubMed - in process] (Source: Internal Medicine)
Source: Internal Medicine - September 18, 2016 Category: Internal Medicine Tags: Intern Med Source Type: research

Incidental unilateral and bilateral ductal carcinoma in situ encountered in the surgical management of young male gynecomastia.
CONCLUSION: We conclude that gynecomastia is a benign breast disease but recent reports had described malignant variants, mostly DCIS, including 5 young males in our series. Therefore, regardless of the age group, histopathological examination of the resected gynecomastia tissue should be carefully done in all patients. Further evidence-based studies are needed to investigate the optimum management of incidental DCIS in gynecomastia specimens. PMID: 27612041 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - September 10, 2016 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia.
CONCLUSION: Dutasteride 0.5 mg is to be well-tolerated in 18 to 41 years old AGA patients in a clinical practice environment. PMID: 27489426 [PubMed] (Source: Annals of Dermatology)
Source: Annals of Dermatology - August 5, 2016 Category: Dermatology Tags: Ann Dermatol Source Type: research

EP 40. Gynecomastia – A sign of a neuromuscular disease?
The aim of a neurological examination is to narrow down by signs and symptoms which components of the neurological system are affected. In neuromuscular diseases non-neurological signs such as gynecomastia can be a valuable hint. Gynecomastia is defined as excess glandular growth of breast tissue in males, pathologically associated e.g. with testicular neoplasms or gonadal dysfunction [1,2]. However there are also neuromuscular diseases such as spinal and bulbar muscular atrophy, myofibrillar myopathies and thyrotoxic hypokalemic periodic paralysispresenting with gynecomastia, we herby want to summarize. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: E. Widmann, J. Sche ßl, B. Schoser Source Type: research

Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report
10.1080/17843286.2016.1215869 Hale Tuhan (Source: Acta Clinica Belgica)
Source: Acta Clinica Belgica - August 4, 2016 Category: Journals (General) Authors: Hale Tuhan Ayhan Abaci Banu Sars ık T ülay Öztürk Mustafa Olguner Gonul Catli Ahmet Anik Nur Olgun Ece Bober Source Type: research

Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report
. (Source: Acta Clinica Belgica)
Source: Acta Clinica Belgica - August 4, 2016 Category: Journals (General) Authors: Hale Tuhan Ayhan Abaci Banu Sars ık T ülay Öztürk Mustafa Olguner Gonul Catli Ahmet Anik Nur Olgun Ece Bober Source Type: research

Anatomy of the Gynecomastia Tissue and Its Clinical Significance
Source: Plastic and Reconstructive Surgery Global Open - August 1, 2016 Category: Cosmetic Surgery Tags: Original Article Source Type: research