A Novel Mutation Causing 17-β-Hydroxysteroid Dehydrogenase Type 3 Deficiency in an Omani Child: First Case Report and Review of Literature.
A Novel Mutation Causing 17-β-Hydroxysteroid Dehydrogenase Type 3 Deficiency in an Omani Child: First Case Report and Review of Literature. Oman Med J. 2015 Mar;30(2):129-34 Authors: Al-Sinani A, Mula-Abed WA, Al-Kindi M, Al-Kusaibi G, Al-Azkawi H, Nahavandi N Abstract This is the first case report in Oman and the Gulf region of a 17-β-hydroxysteroid dehydrogenase type 3 (17-β-HSD3) deficiency with a novel mutation in the HSD17B3 gene that has not been previously described in the medical literature. An Omani child was diagnosed with 17-β-HSD3 deficiency and was followed up for 11 ye...
Source: Oman Medical Journal - December 12, 2015 Category: Middle East Health Tags: Oman Med J Source Type: research

6'6″ United States Marine Seeks Treatment for Gynecomastia Only to Learn It Is All in His Head.
We present an active duty male diagnosed with acromegaly after presenting to his primary care provider with chronic gynecomastia. The most common cause of GH excess is a pituitary somatotroph adenoma; however, it is important to remember that magnetic resonance imaging of the pituitary does not distinguish between functioning and nonfunctioning tumors. Subsequently, the diagnosis of GH excess is based on biochemical studies, not imaging. PMID: 26633678 [PubMed - in process] (Source: Military Medicine)
Source: Military Medicine - December 5, 2015 Category: Global & Universal Tags: Mil Med Source Type: research

Kennedy's Disease Misdiagnosed as polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin Changes (POEMS) Syndrome: A Case Report
Conclusion: This case suggests that clinicians should pay more attention to the differential diagnosis between KD and POEMS syndrome and gene analysis was helpful to detect this rare confusing disease in this patient. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - November 30, 2015 Category: Internal Medicine Source Type: research

Understanding the pathological manifestations of aromatase excess syndrome: lessons for clinical diagnosis.
Authors: Shozu M, Fukami M, Ogata T Abstract CYP19A1: Aromatase excess syndrome is characterized by pre- or peripubertal onset of gynecomastia due to estrogen excess because of a gain-of-function mutation in the aromatase gene (CYP19A1). Subchromosomal recombination events including duplication, deletion, and inversion has been identified. The latter two recombinations recruit novel promoters for CYP19A1 through a unique mechanism. Gynecomastia continues for life, and although the general condition is well preserved, it may cause psychological issues. Minor symptoms (variably advanced bone age and short adult heigh...
Source: Expert Review of Endocrinology and Metabolism - November 18, 2015 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Prepubertal gynecomastia and chronic lavender exposure: report of three cases
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - November 18, 2015 Category: Endocrinology Source Type: research

The effect of tamoxifen on pubertal bone development in adolescents with pubertal gynecomastia
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - November 18, 2015 Category: Endocrinology Source Type: research

Radiologic evaluation of lumps in the male breast.
CONCLUSION: In patients with a classical appearance of gynecomastia on mammography, supplemental ultrasound, FNAC, or biopsy is superfluous and contributes to unnecessary costs. PMID: 26543053 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
Source: Acta Radiologica - November 4, 2015 Category: Radiology Authors: Tangerud Å, Potapenko I, Skjerven HK, Stensrud MJ Tags: Acta Radiol Source Type: research

Beneficial long-term effect of aldosterone antagonist added to a traditional blockade of the renin-angiotensin-aldosterone system among patients with obesity and proteinuria.
This study is a substudy of previously published study on the renoprotective effect of mineralocorticoid receptor blockers in patients with proteinuric nephropathies. Patients with proteinuria levels>1g/24h who were taking spironolactone and were being treated with other RAAS blockers were divided according to body mass index (BMI) into an obesity group (BMI ≥30kg/m2) and a control group. RESULTS: Seventy-one patients were included in the study, with a mean age of 56.7±15.1 years. More than 50% of the patients in both groups had diabetes. Thirty-two patients were included in the obesity group and 39 were i...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - November 2, 2015 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

Onset Manifestations of Spinal and Bulbar Muscular Atrophy (Kennedy’s Disease)
In conclusion, age at onset of SBMA depends on what is regarded as onset manifestation. If non-motor manifestations are additionally considered, age at onset is independent of the CAG-repeat length. Since life expectancy is hardly reduced in SBMA, re-investigation of patients from published studies with regard to their initial disease profiles is recommended. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - October 19, 2015 Category: Neuroscience Source Type: research

A rare case of lateral ovotesticular disorder with Klinefelter syndrome mosaicism 46, XX/47, XXY: An unusual presentation
We report an unusual case of 16-year-old with male habitus who presented with complains of cyclic hematuria. On examination, he had bilateral gynecomastia, unilateral left cryptorchidism, absent facial hair, sparse axillary hair growth, and pubic hair distribution of feminine type. The right testis was of normal size located normally in hemiscrotum and was confirmed by radio imaging. Ultrasonography and magnetic resonance imaging revealed a cystic area behind posterior half of urinary bladder. Chromosomal analysis revealed 46, XX/47, XXY mosaicism of female karyotype and KS. Histopathological report of this left side excis...
Source: Urology Annals - October 14, 2015 Category: Urology & Nephrology Authors: Shyam M TalrejaIndraneel BanerjeeSher Singh YadavVinay Tomar Source Type: research

Signs and Related Mechanisms of Ethanol Hepatotoxicity.
Authors: Dinis-Oliveira RJ, Magalhaes T, Queiros O, Proenca JB, Moreira R, de Lourdes Bastos M, Carvalho F Abstract Ethanol is the most abused psychoactive substance. Accordingly to World Health Organization ethanol ranks among the top five risk factors for disease, disability and death (3.3 million/year) throughout the world. This manuscript highlights and critically analyses clinical and forensic signs related to hepatoxicity of ethanol that may lead to suspected of abuse. Namely, steatosis, jaundice, cirrhosis, hemorrhoids, esophageal varices caput medusae, ascites, petechiae, ecchymoses, splenomegaly, hemochrom...
Source: Current Drug Abuse Reviews - October 13, 2015 Category: Addiction Tags: Curr Drug Abuse Rev Source Type: research

Spinobulbar muscular atrophy (Kennedy's disease): A rare diagnosis in the Greek population
Spinobulbar muscular atrophy (SBMA), best known as Kennedy's disease, is a rare, X-linked disorder, characterized by degeneration of lower motor neurons resulting in progressive muscular weakness affecting the limbs and bulbar musculature. Other clinical features include tremor, cramps, fasciculations, gynecomastia, hypogonadism and sensory symptoms [1]. It is caused by a CAG repeat expansion in exon 1 of the androgen receptor gene (AR) [2]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 12, 2015 Category: Neurology Authors: Georgios Koutsis, Athina Kladi, Marianthi Breza, Georgia Karadima, Marios Panas Tags: Letter to the Editor Source Type: research

Gynecomastia: Simultaneous Subcutaneous Mastectomy and Areolar Reduction with Minimal Inconspicuous Scarring
Abstract Acceptable scar positioning on the anterior male chest is very limited. In Gynecomastia surgery, an obvious areolar incision is the most sensitive indicator of a previous operation; a less apparent scar is indispensable for the patient’s psychological satisfaction. Whenever only areolar diameter reduction is required, the circumareolar incision must be performed in a position leaving the least conspicuous scar. Standard excision of an outer doughnut of areolar skin results in a visible and unnatural peri-areolar scar. The peri-nipple excision of areolar skin leaves the skin–areola junction un...
Source: Aesthetic Plastic Surgery - October 7, 2015 Category: Cosmetic Surgery Source Type: research

Long-term Efficacy and Safety of Enzalutamide Monotherapy in Hormone-naïve Prostate Cancer: 1- and 2-Year Open-label Follow-up Results
Conclusions Long-term enzalutamide monotherapy in men with noncastrate HNPC is associated with large sustained reductions in PSA, signals indicating a favorable tumor response, and favorable safety/tolerability profile, with relatively small negative effects on total-body BMD. Patient summary In this long-term follow-up of the efficacy and safety of enzalutamide monotherapy in patients with hormone-naïve prostate cancer, enzalutamide maintained long-term reductions in prostate-specific antigen, with a minimal impact on total-body bone mineral density. Trial registration NCT01302041 Long-term enzalutamide monotherapy...
Source: European Urology - October 5, 2015 Category: Urology & Nephrology Source Type: research

Testis Development and Fertility Potential in Boys with Klinefelter Syndrome
Klinefelter syndrome (KS) is the leading genetic cause of primary hypogonadism and infertility in men. The clinical phenotype has expanded beyond the original description of infertility, small testes, and gynecomastia. Animal models, epidemiologic studies, and clinical research of male subjects with KS throughout the lifespan have allowed the better characterization of the variable phenotype of this condition. This review provides an overview on what is known of the epidemiology, clinical features, and pathophysiology of KS, followed by a more focused discussion of testicular development and the clinical management of hypo...
Source: Endocrinology and Metabolism Clinics of North America - September 29, 2015 Category: Endocrinology Authors: Shanlee M. Davis, Alan D. Rogol, Judith L. Ross Source Type: research

Gynecomastia and psychological functioning: A review of the literature.
Abstract Gynecomastia is defined as excess glandular growth of breast tissue in males. It is a noticeable physical difference that commonly affects males in adolescence and old age. While often transient in nature, gynecomastia persists indefinitely in 10% of cases. Much of the literature on gynecomastia has focused on etiology and management. Little research has been done regarding the impact of gynecomastia on one's mental health and quality of life; however, some studies have suggested various psychosocial and psychological consequences related to gynecomastia. These consequences include but are not limited to ...
Source: Body Image - September 23, 2015 Category: Psychiatry & Psychology Authors: Ordaz DL, Thompson JK Tags: Body Image Source Type: research

Primary cutaneous apocrine gland carcinoma from areolar tissue in a male patient with gynecomastia: a case report
Primary cutaneous apocrine gland carcinoma, which is a type of sweat gland carcinoma, is an extremely rare type of cancer. Clinical courses of this type of cancer usually progress slowly but can, occasionally, be associated with rapid progression. This case report describes a 53-year-old Korean man with primary cutaneous apocrine gland carcinoma that arose from an apocrine gland in the areola tissue. The patient visited our hospital because of a large, painful chest wall mass beneath the right nipple. The mass had been present for more than eight years but had grown rapidly over the past few months. The patient was initial...
Source: Journal of Cardiothoracic Surgery - September 8, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Kyung-Jin SeoJae-Jun Kim Source Type: research

Spinal and Bulbar Muscular Atrophy
Spinal and bulbar muscular atrophy, or Kennedy disease, is a slowly progressive X-linked neuromuscular disease caused by a trinucleotide (CAG) repeat expansion in the androgen receptor gene. Affected males typically develop weakness in their mid-40s as well as evidence of androgen insensitivity with reduced fertility and gynecomastia. Diagnosis is often delayed because of decreased awareness of the disease, although genetic testing allows for direct diagnosis. Therapeutic strategies to block the toxicity of the mutant androgen receptor have been unsuccessful thus far, and evaluation of additional candidate therapies is und...
Source: Neurologic Clinics - September 7, 2015 Category: Neurology Authors: Christopher Grunseich, Kenneth H. Fischbeck Source Type: research

The role of Ad-36 as a risk factor in males with gynecomastia
Gynecomastia is highly prevalent worldwide and Adenovirus-36 (Ad-36), recently implicated in increased adipose tissue deposition due to its affinity for adipose tissue, is a potential etiological agent in the development of obesity and therefore we hypothesized that Ad-36 may also play a role in the development of gynecomastia by possibly accompanying increased regional adiposity.To support our hypothesis, we conducted a study that included 33 adult males with gynecomastia (PG) and 15 adult males as the patient control group (HCG). (Source: Medical Hypotheses)
Source: Medical Hypotheses - September 5, 2015 Category: Biomedical Science Authors: Bekir Kocazeybek, Suat Saribas, Sevgi Ergin Source Type: research

X chromosome gain in male breast cancer
Male breast cancer (MBC) is an uncommon disease whose molecular profile is not well known. X chromosome gain has been described as a marker of aggressive behavior in female breast cancer. The aim of this study is to investigate the role of the X chromosome in male breast cancer. 20 cases of male breast invasive ductal carcinoma were retrieved and compared with 10 cases of gynecomastia. Cases were tested by fluorescence in situ hybridization (FISH) in order to assess a cytogenetic profile for the X chromosome. (Source: Human Pathology)
Source: Human Pathology - September 3, 2015 Category: Pathology Authors: Enrico Di Oto, Valentina Monti, Maria C. Cucchi, Riccardo Masetti, Zsuzsanna Varga, Maria P. Foschini Tags: Original contribution Source Type: research

The effect of tamoxifen on pubertal bone development in adolescents with pubertal gynecomastia
Journal Name: Journal of Pediatric Endocrinology and MetabolismVolume: 29Issue: 1Pages: 77-83 (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - September 3, 2015 Category: Endocrinology Source Type: research

Prepubertal gynecomastia and chronic lavender exposure: report of three cases
Journal Name: Journal of Pediatric Endocrinology and MetabolismVolume: 29Issue: 1Pages: 103-107 (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - September 3, 2015 Category: Endocrinology Source Type: research

Characterizing POEMS Syndrome with 18F-FDG PET/CT
Conclusion: 18F-FDG PET/CT is a useful tool for the evaluation of patients with suspected POEMS syndrome. 18F-FDG PET/CT may contribute to the diagnosis, evaluation, and follow-up of patients with POEMS syndrome by providing systematic findings of bone lesions, lymphadenopathy, liver or spleen involvement, serous cavity effusion, and the metabolic status of the lesions. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2015 Category: Nuclear Medicine Authors: Pan, Q., Li, J., Li, F., Zhou, D., Zhu, Z. Tags: Clinical Investigations Source Type: research

Gynecomastia in Patients with Prostate Cancer: A Systematic Review
Conclusions Bicalutamide-induced gynecomastia and/or mastodynia can effectively be managed by oral tamoxifen (10–20 mg daily) or radiotherapy without relevant side effects. Prophylaxis or therapeutic treatment with tamoxifen results to be more effective than radiotherapy. (Source: PLoS One)
Source: PLoS One - August 26, 2015 Category: Biomedical Science Authors: Anders Fagerlund et al. Source Type: research

Juvenile Granulosa Cell Tumors of the Testis: A Clinicopathologic Study of 70 Cases With Emphasis on Its Wide Morphologic Spectrum
The clinical and pathologic features of 70 juvenile granulosa cell tumors (JGCTs) of the testis are presented. The patients were from 30 weeks gestational age to 10 years old; 60 of 67 (90%) whose ages are known to us were 6 months old or younger. Sixty-two underwent gonadectomy, 6 wedge excision, and 2 only biopsy. Twenty-six tumors were left sided and 22 right sided. Six occurred in an undescended testis and 2 in dysgenetic gonads. The most common presentation was a testicular mass (65%), followed by an “enlarging testis” (25%). Six of 14 patients in whom it was measured had “elevated” serum &alph...
Source: The American Journal of Surgical Pathology - August 18, 2015 Category: Pathology Tags: Original Articles Source Type: research

Nebivolol-induced gynecomastia
Erkan Köklü, Şakir Arslan, İsa Öner Yüksel, Nermin Bayar, Deniz DemirciJournal of Pharmacology and Pharmacotherapeutics 2015 6(3):166-168Adverse drug reactions play a substantial role in the etiology of gynecomastia. Gynecomastia as an adverse drug reaction, related to some cardiovascular drugs, has been reported in literature. Nebivolol is a third generation beta-blocker, and gynecomastia as an adverse effect on the consumption of this drug has not been reported in any article yet. We herein present the case of a 42-year-old male, who developed bilateral gynecomastia following nebivolol use a...
Source: Journal of Pharmacology and Pharmacotherapeutics - August 4, 2015 Category: Drugs & Pharmacology Authors: Erkan KöklüŞakir Arslanİsa Öner YükselNermin BayarDeniz Demirci Source Type: research

Quality of Life and Hormonal, Biochemical, and Anthropometric Profile Between Olanzapine and Risperidone Users
Abstract This cross-sectional study compared quality of life and side effects in 108 users of olanzapine or risperidone suffering schizophrenia and being attended at psychiatric ambulatory services in Rio Grande do Norte, Brazil. Economic, socio-demographic, anthropometric, biochemical, and hormonal variables were compared. The EuroQoL Five-Dimension Scale (EQ-5D) was used to evaluate quality of life, and side effects were assessed using the Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale and the Simpson–Angus Scale. Data were analysed using the χ2 test and Student’s t t...
Source: Psychiatric Quarterly - July 29, 2015 Category: Psychiatry Source Type: research

Spinal and bulbar muscular atrophy and Charcot–Marie–Tooth type 1A: Co-existence of two rare neuromuscular genetic diseases in the same patient
Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy disease, is a rare X-linked neurodegenerative disorder caused by the expansion of a CAG repeat in the first exon of the androgen receptor (AR) gene. It has an estimated prevalence of 1:50,000 males and is characterized by progressive weakness predominantly affecting proximal limb and bulbar muscles, with atrophy and fasciculations; extra-neurological signs include gynecomastia, hypogonadism and reduced fertility, all signs of androgen insensitivity [1,2]. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - July 29, 2015 Category: Neurology Authors: Anna Sagnelli, Vidmer Scaioli, Giuseppe Piscosquito, Ettore Salsano, Eleonora Dalla Bella, Cinzia Gellera, Davide Pareyson Tags: Case report Source Type: research

Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease
Abnormal estrogen metabolism in liver disease has been long recognized in the clinic. Concomitants of liver diseases are clinical signs and symptoms like palmar erythema, spider nevus, gynecomastia, and infertility due to disturbed homeostasis of steroid hormones, especially the estrogens. Studies have reported increased estrogen levels and signs of endocrine disturbance in patients with chronic liver diseases [1]. The hormone levels are positively correlated to the severity of the liver disease [2], whereas treating patients towards improved liver function resulted in regression of endocrine disturbance [3]. (Source: Journal of Hepatology)
Source: Journal of Hepatology - July 25, 2015 Category: Gastroenterology Authors: Mengxi Jiang, Marcus Klein, Ulrich M. Zanger, Mohammad K. Mohammad, Matthew C. Cave, Nilesh W. Gaikwad, Natasha J. Dias, Kyle W. Selcer, Yan Guo, Jinhan He, Xiuhui Zhang, Qiujin Shen, Wenxin Qin, Jiang Li, Song Li, Wen Xie Tags: Research Article Source Type: research

Bitropic D3 Dopamine Receptor Selective Compounds s Potential Antipsychotics.
Abstract Neuropsychiatric disorders represents a substantial social and health care issue. The National Institutes of Health estimates that greater than 2 million adults suffer from neuropsychiatric disorders in the USA. These individuals experience symptoms that can include auditory hallucinations, delusions, unrealistic beliefs and cognitive dysfunction. Although antipsychotic medications are available, suboptimal therapeutic responses are observed for approximately one-third of patients. Therefore, there is still a need to explore new pharmacotherapeutic strategies for the treatment of neuropsychiatric disorder...
Source: Current Pharmaceutical Design - July 23, 2015 Category: Drugs & Pharmacology Authors: Luedtke RR, Rangel-Barajas C, Malik M, Reichert DE, Mach RH Tags: Curr Pharm Des Source Type: research

A systematic review of literature on psychosocial aspects of gynecomastia in adolescents and young men
Publication date: August 2015 Source:Journal of Adolescence, Volume 43 Author(s): Lynn Rew, Cara Young, Tracie Harrison, Robert Caridi Gynecomastia represents a serious psychosocial challenge for many adolescent and young adult males, but short of surgery, little attention has been given to this concern. The purpose of this paper is to report findings from a systematic review of the literature about psychosocial correlates, psychosocial interventions, and quality of research evidence about young males with gynecomastia. From an initial 233 published papers, 10 studies were identified and reviewed. Five were descripti...
Source: Journal of Adolescence - July 17, 2015 Category: Child Development Source Type: research

Laser-Assisted Liposuction Using the Novel 1,444-nm Nd:YAG Laser for the Treatment of Gynecomastia: A Pilot Study
In this study, we investigated the efficacy of 1,444-nm Nd:YAG LAL for the treatment of gynecomastia. Patients and Methods: Thirteen Korean male patients (20-28 years, mean age 23 years) diagnosed with gynecomastia were enrolled in this study. All patients were treated by LAL with 1,444-nm Nd:YAG laser (100 µs pulse width, 40 Hz frequency, 300 mJ pulse energy and 12 W power with continuous emission) after tumescent anesthetic infiltration and were then evaluated. Outcome was assessed using the following 4 methods: (1) clinical assessment with photographs obtained before and 12 weeks after LAL treatment, (2) compariso...
Source: Dermatology - July 15, 2015 Category: Dermatology Source Type: research

Ultrasound of pediatric breast masses: what to do with lumps and bumps
Abstract The approach to breast masses in children differs from that in adults in many ways, including the differential diagnostic considerations, imaging algorithm and appropriateness of biopsy as a means of further characterization. Most pediatric breast masses are benign, either related to breast development or benign neoplastic processes. Biopsy is rarely needed and can damage the developing breast; thus radiologists must be familiar with the imaging appearance of common entities so that biopsies are judiciously recommended. The purpose of this article is to describe the imaging appearances of the normally dev...
Source: Pediatric Radiology - July 12, 2015 Category: Radiology Source Type: research

Derivation of integration-free iPSCs from a Klinefelter syndrome patient
Conclusions KS patient-derived iPS cells that could differentiate into cardiomyocyte-like cells were established. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - July 2, 2015 Category: OBGYN Source Type: research

Efficacy of ultrasound-guided testicle-sparing surgery for small testicular masses
Conclusion The OS, the low rate of local recurrence, and absence of complications, tend to demonstrate the safety of the procedure. The benefits to testicular-sparing surgery include improving the patient’s overall quality of life, fertility, endocrine function and negative cosmetic effects of radical orchiectomy. (Source: Journal of Ultrasound)
Source: Journal of Ultrasound - June 23, 2015 Category: Radiology Source Type: research

ACR Appropriateness Criteria Evaluation of the Symptomatic Male Breast
Publication date: Available online 19 May 2015 Source:Journal of the American College of Radiology Author(s): Martha B. Mainiero , Ana P. Lourenco , Lora D. Barke , Amy D. Argus , Lisa Bailey , Selin Carkaci , Carl D’Orsi , Edward D. Green , Susan O. Holley , Peter M. Jokich , Su-Ju Lee , Mary C. Mahoney , Linda Moy , Priscilla J. Slanetz , Sunita Trikha , Monica M. Yepes , Mary S. Newell Most male breast problems are benign, and men with typical symptoms of gynecomastia or pseudogynecomastia do not usually need imaging. When a differentiation between benign disease and breast cancer cannot be made on the basis of ...
Source: Journal of the American College of Radiology - June 19, 2015 Category: Radiology Source Type: research

A 46,XX Male Adolescent Presenting with a Chief Complaint of Gynecomastia
Publication date: Available online 7 May 2015 Source:Pediatrics & Neonatology Author(s): Min Sun Kim , Pyoung Han Hwang , Dae-Yeol Lee (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 13, 2015 Category: Perinatology & Neonatology Source Type: research

Gynecomastia: A systematic review
Journal of Plastic Surgery and Hand Surgery, Ahead of Print. (Source: Journal of Plastic Surgery and Hand Surgery)
Source: Journal of Plastic Surgery and Hand Surgery - June 8, 2015 Category: Surgery Tags: article Source Type: research

Euprolactinemic gynecomastia and galactorrhea with risperidone-fluvoxamine combination.
We report a case of gynecomastia and galactorrhea in an adolescent male while on a combination of risperidone and fluvoxamine, although the serum prolactin was within normal range. PMID: 22506441 [PubMed - indexed for MEDLINE] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - June 5, 2015 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Kennedy's disease and partial androgen insensitivity syndrome. Report of 4 cases and literature review
We report 4 cases with the typical neurological presentation, consisting of slowly progressing generalized muscle weakness with atrophy and bulbar muscle involvement; these patients also had several endocrine manifestations; the most common non-neurological manifestation was gynecomastia. In all cases reported, molecular analysis showed an abnormal cytosine-adenine-guanine triplet repeat expansion in the androgen receptor gene. (Source: Endocrinologia y Nutricion)
Source: Endocrinologia y Nutricion - June 5, 2015 Category: Endocrinology Source Type: research

Digoxin use after diagnosis of breast cancer and survival: a population-based cohort study
Abstract Digoxin has been shown to have an estrogenic effect and is associated with increased risk of gynecomastia and estrogen-sensitive cancers such as breast and uterus cancer. These findings, particularly recent observations of increased breast cancer risk, raise questions about the safety of digoxin use in breast cancer patients. Therefore, we investigated whether digoxin use after breast cancer diagnosis increased the risk of breast cancer-specific mortality in breast cancer patients. A cohort of 17,842 breast cancer patients newly diagnosed from 1998 to 2009 was identified from English cancer registrie...
Source: Breast Cancer Research and Treatment - June 1, 2015 Category: Cancer & Oncology Source Type: research

[Specificities of sex-cord stromal tumors in children and adolescents].
Abstract Sex-cord stromal tumors (SCT) are rare pediatric tumors accounting for less than 5% of gonadal tumors in children and adolescents. They differ from those diagnosed in adults by their presentation, histology, evolution and treatment modalities. Testicular SCT occur mostly in infants less than 6 months. Testicular swelling is often the only symptom, but signs of hormonal secretion with gynecomastia may be present. Juvenile granulosa SCT is the main histologic subtype. Sertoli SCTs are much less frequent while Leydig tumors occurred in older children and adolescents. Prognosis is excellent after inguinal orc...
Source: Bulletin du Cancer - May 28, 2015 Category: Cancer & Oncology Authors: Thebaud E, Orbach D, Faure-Conter C, Patte C, Hameury F, Kalfa N, Dijoud F, Martelli H, Fresneau B Tags: Bull Cancer Source Type: research

The debate on the link between subclinical hypothyroidism and childhood migraine: is initial endocrinological evaluation necessary for children with migraine?
In this study, the presence of subclinical hypothyroidism and associated endocrinological abnormalities in children with migraine naïve to treatment was investigated. Children with migraine who were diagnosed in Pediatric Neurology Clinic based on the second edition of the International Classification of Headache Disorders and who did not receive any medication were recruited in this cross-sectional study. All patients were examined by the same pediatric endocrinologist and anthropometric measurements, systemic blood pressure, pubertal stages were recorded. Fasting serum levels of thyroid function tests, lipids, gluco...
Source: Acta Neurologica Belgica - May 20, 2015 Category: Neurology Source Type: research

ACR Appropriateness Criteria Evaluation of the Symptomatic Male Breast
Most male breast problems are benign, and men with typical symptoms of gynecomastia or pseudogynecomastia do not usually need imaging. When a differentiation between benign disease and breast cancer cannot be made on the basis of clinical findings or when the clinical findings are suspicious for breast cancer, imaging is indicated. Mammography is useful in both identifying cancer and obviating the need for biopsy in patients for whom a benign mammographic impression confirms the clinical impression. (Source: Journal of the American College of Radiology : JACR)
Source: Journal of the American College of Radiology : JACR - May 19, 2015 Category: Radiology Authors: Martha B. Mainiero, Ana P. Lourenco, Lora D. Barke, Amy D. Argus, Lisa Bailey, Selin Carkaci, Carl D’Orsi, Edward D. Green, Susan O. Holley, Peter M. Jokich, Su-Ju Lee, Mary C. Mahoney, Linda Moy, Priscilla J. Slanetz, Sunita Trikha, Monica M. Yepes, Ma Tags: Original article Source Type: research

A 46,XX male adolescent presenting with a chief complaint of gynecomastia
This report describes a case of gynecomastia in a boy aged 17 years and 6 months who had shown progressive breast budding for 1 year before presenting to our hospital. His only symptom was symmetrical nipple pain. Biochemical testing revealed higher than normal luteinizing hormone, follicle-stimulating hormone, and estradiol levels, and decreased testosterone levels, which led to a diagnosis of hypergonadotropic hypogonadism. A multiplex polymerase chain reaction analysis and chromosomal analysis determined that the patient had the sex-determining region of the Y chromosome (SRY) gene -positive 46,XX karyotype. The present...
Source: Pediatrics and Neonatology - May 7, 2015 Category: Perinatology & Neonatology Source Type: research

Surgical Correction of Gynecomastia: A Geometric Approach
Summary: Many techniques are available for surgical correction of gynecomastia. In this article, we describe a technique based on geometrical principles that is simple to execute, effective, highly reproducible, and relies less on intuition of the surgeon. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - April 30, 2015 Category: Cosmetic Surgery Tags: Cosmetic: Ideas and Innovations Source Type: research

Adverse reactions among patients being treated for multi-drug resistant tuberculosis at Abbassia Chest Hospital
Conclusions There is a relation between both tobacco smoking and drug addiction, and MDR TB. The most common type of resistance is acquired resistance because of lack of adherence to treatment or inappropriate treatment. The most common co-morbidities associated with MDR TB are diabetes and chronic obstructive lung diseases. The most important predictors of patients’ outcome are sputum conversion, number of previous TB treatment and presence of co-morbidities. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 30, 2015 Category: Respiratory Medicine Source Type: research

Trends in the Surgical Correction of Gynecomastia
Seminars in Plastic Surgery 2015; 29: 122-130DOI: 10.1055/s-0035-1549053Gynecomastia refers to the enlargement of the male breast due to a proliferation of ductal, stromal, and/or fatty tissue. Although it is a common condition affecting up to 65% of men, not all cases require surgical intervention. Contemporary surgical techniques in the treatment of gynecomastia have become increasingly less invasive with the advent of liposuction and its variants, including power-assisted and ultrasound-assisted liposuction. These techniques, however, have been largely limited in their inability to address significant skin excess and pt...
Source: Seminars in Plastic Surgery - April 16, 2015 Category: Cosmetic Surgery Authors: Brown, Rodger H.Chang, Daniel K.Siy, RichardFriedman, Jeffrey Source Type: research

Surgical Strategies in the Treatment of Gynecomastia Grade I-II: The Combination of Liposuction and Subcutaneous Mastectomy Provides Excellent Patient Outcome and Satisfaction
Conclusions: This analysis demonstrates that treatment of GM grade I-II can easily be performed by liposuction combined with subcutaneous resection of the glandular tissue as a minimally invasive and low-impact surgical treatment with a low rate of complications and excellent patient satisfaction. Preoperative workup is important to rule out specific diseases or malignancy causing the GM.Breast Care (Source: Breast Care)
Source: Breast Care - April 11, 2015 Category: Cancer & Oncology Source Type: research

Co-occurrence of Klinefelter Syndrome and Tourettism: a case report (P3.029)
We describe a case of patient with a concomitant diagnosis of Klinefelter Syndrome (KS) and Tourettism. Case description A 20-year old male with genetic diagnosis of Klinefelter syndrome was referred for evaluation of tics. His motor tics began at 4-years-old with repetitive eye fluttering, progressing over the years to a constellation of uncontrollable movements including painful head jerking, limb flailing, kicking, and vocalizations including humming, nose clearing, shouts, and specific words. The tics were preceded by an urge, were temporarily suppressible, and demonstrated rebound if suppressed (video). He also suffer...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Brito De Almeida, L., Okun, M., Malaty, I. Tags: Movement Disorders: Tics, Dyskinesias, and Chorea Source Type: research