A retrospective cohort study of tamoxifen versus surgical treatment for ER-positive gynecomastia
Gynecomastia is a common condition in clinical practice. The present study aimed to review the clinical data of ER-positive gynecomastia patients treated by tamoxifen (TAM) versus surgery and discussed the cli... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 13, 2023 Category: Endocrinology Authors: Weili He, Weidong Wei, Qing Zhang, Rongzhao Lv, Shaohua Qu, Xin Huang, Juan Ma, Ping Zhang, Hening Zhai and Ningxia Wang Tags: Research Source Type: research
Immunohistochemical characterization of a steroid secreting oncocytic adrenal carcinoma responsible for paraneoplastic hyperparathyroidism
We report a unique case of a 44-year-old man with paraneoplastic hyperparathyroidism due to an oncocytic adrenocortical carcinoma (stage pT3N0R0M0, ENSAT 2 with a 4% Ki-67). Paraneoplastic hyperparathyroidism was associated with mild ACTH-independent hypercortisolism and increased estradiol secretion responsible for gynecomastia and hypogonadism. Biological investigations performed in blood samples from peripheral and adrenal veins revealed that the tumor secreted PTH and estradiol. Ectopic PTH secretion was confirmed by abnormally high expression of PTH mRNA and clusters of PTH immunoreactive cells in the tumor tissue. Do...
Source: European Journal of Endocrinology - March 4, 2023 Category: Endocrinology Authors: Haissaguerre Magalie Louiset Estelle Juhlin C Christofer Stenman Adam Laurent Christophe Trouette H élène Lefebvre Herv é Tabarin Antoine Source Type: research
