Population pharmacokinetics of ivermectin after mass drug administration in lymphatic filariasis endemic communities of Tanzania
AbstractIvermectin (IVM) is a drug of choice used with albendazole (ALB) for Mass Drug Administration (MDA) to halt transmission of lymphatic filariasis. We investigated IVM pharmacokinetic (PK) variability for its dose optimization during MDA. PK samples were collected at 0, 2, 4 and 6 hours from individuals weighing> 15 Kg (n=468) receiving IVM (3-, 6-, 9-, or 12 mg) and ALB (400 mg) during MDA campaign in Tanzania. Individual characteristics including demographics, laboratory/clinical parameters and pharmacogenetic variations were assessed. IVM plasma concentrations were quantified by LC-MS/MS and analyzed u sing ...
Source: CPT: Pharmacometrics and Systems Pharmacology - August 28, 2023 Category: Drugs & Pharmacology Authors: Adam M. Fimbo,
Eulambius M. Mlugu,
Eliford Ngaimisi Kitabi,
Gerald S. Kulwa,
Mohammed A. Iwodyah,
Rajabu Hussein Mnkugwe,
Peter P. Kunambi,
Alpha Malishee,
Appolinary A. R. Kamuhabwa,
Omary M. Minzi,
Eleni Aklillu Tags: ARTICLE Source Type: research
An mHealth App (eSkinHealth) for Detecting and Managing Skin Diseases in Resource-Limited Settings: Mixed Methods Pilot Study
CONCLUSIONS: The study provided evidence for the usability and effectiveness of the eSkinHealth app embedded into our surveillance approach to improve the detection and management of skin NTDs and other skin diseases in Côte d'Ivoire and, furthermore, is expected to contribute to knowledge on mobile health approaches in the control of skin diseases in resource-limited settings.TRIAL REGISTRATION: ClinicalTrials.gov NCT05300399; https://clinicaltrials.gov/ct2/show/NCT05300399.PMID:37632977 | DOI:10.2196/46295 (Source: Rural Remote Health)
Source: Rural Remote Health - August 26, 2023 Category: Rural Health Authors: Rie R Yotsu Diabate Almamy Bamba Vagamon Kazuko Ugai Sakiko Itoh Yao Didier Koffi Mamadou Kaloga Ligu é Agui Sylvestre Dizoé Kouam é Kouadio N'guetta Aka Luc Kowaci Gontran Yeboue Koffi Aubin Yao Ronald E Blanton Source Type: research
An mHealth App (eSkinHealth) for Detecting and Managing Skin Diseases in Resource-Limited Settings: Mixed Methods Pilot Study
CONCLUSIONS: The study provided evidence for the usability and effectiveness of the eSkinHealth app embedded into our surveillance approach to improve the detection and management of skin NTDs and other skin diseases in Côte d'Ivoire and, furthermore, is expected to contribute to knowledge on mobile health approaches in the control of skin diseases in resource-limited settings.TRIAL REGISTRATION: ClinicalTrials.gov NCT05300399; https://clinicaltrials.gov/ct2/show/NCT05300399.PMID:37632977 | PMC:PMC10335127 | DOI:10.2196/46295 (Source: Rural Remote Health)
Source: Rural Remote Health - August 26, 2023 Category: Rural Health Authors: Rie R Yotsu Diabate Almamy Bamba Vagamon Kazuko Ugai Sakiko Itoh Yao Didier Koffi Mamadou Kaloga Ligu é Agui Sylvestre Dizoé Kouam é Kouadio N'guetta Aka Luc Kowaci Gontran Yeboue Koffi Aubin Yao Ronald E Blanton Source Type: research
Self-care treatment for lymphoedema of lymphatic filariasis using integrative medicine
CONCLUSION: IM for lower limb lymphoedema successfully reduces limb volume and episodes of cellulitis, BEEPs leading to improved HQoL. It aligns with the WHO's LF treatment goals. It is a low-cost predominantly self-care management protocol. It can potentially change care models and improve lymphoedema patients' lives.PMID:37615507 | DOI:10.1093/bjd/ljad310 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 24, 2023 Category: Dermatology Authors: Saravu R Narahari Madhur G Aggithaya Terence J Ryan Kunnathody Muralidharan Peter J Franks Christine Moffatt Peter S Mortimer Source Type: research
Pharmacokinetics of Moxidectin combined with Albendazole or Albendazole plus Diethylcarbamazine for Bancroftian Filariasis
by Yashpal S. Chhonker, Catherine Bjerum, Veenu Bala, Allassane F. Ouattara, Benjamin G. Koudou, Toki P. Gabo, Abdullah Alshehri, Abdoulaye Me ïté, Peter U. Fischer, Gary J. Weil, Christopher L. King, Philip J. Budge, Daryl J. Murry
Moxidectin (MOX) is a milbemycin endectocide recently approved by the U.S. FDA for the treatment of onchocerciasis in persons at least 12 years of age. MOX has been shown to have a good safety profile in recent clinical trials. The efficacy of MOX for the treatment of lymphatic filariasis (LF) and its potential use in mass drug administration protocols for the elimination of LF is currently ...
Source: PLoS Neglected Tropical Diseases - August 24, 2023 Category: Tropical Medicine Authors: Yashpal S. Chhonker Source Type: research
Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings
J Cell Mol Med. 2023 Aug 22. doi: 10.1111/jcmm.17913. Online ahead of print.ABSTRACTMore than half a century has passed since the introduction of the National Filariasis Control Program; however, as of 2023, lymphatic filariasis (LF) still prevails globally, particularly in the tropical and subtropical regions, posing a substantial challenge to the objective of worldwide elimination. LF is affecting human beings and its economically important livestock leading to a crucial contributor to morbidities and disabilities. The current scenario has been blowing up alarms of attention to develop potent therapeutics and strategies ...
Source: J Cell Mol Med - August 22, 2023 Category: Molecular Biology Authors: Nabarun Chandra Das Pritha Chakraborty Samapika Nandy Abhijit Dey Tabarak Malik Suprabhat Mukherjee Source Type: research
Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings
J Cell Mol Med. 2023 Aug 22. doi: 10.1111/jcmm.17913. Online ahead of print.ABSTRACTMore than half a century has passed since the introduction of the National Filariasis Control Program; however, as of 2023, lymphatic filariasis (LF) still prevails globally, particularly in the tropical and subtropical regions, posing a substantial challenge to the objective of worldwide elimination. LF is affecting human beings and its economically important livestock leading to a crucial contributor to morbidities and disabilities. The current scenario has been blowing up alarms of attention to develop potent therapeutics and strategies ...
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: Nabarun Chandra Das Pritha Chakraborty Samapika Nandy Abhijit Dey Tabarak Malik Suprabhat Mukherjee Source Type: research
Scientific literature on neglected tropical diseases: a bibliometric analysis
Pathog Glob Health. 2023 Aug 22:1-8. doi: 10.1080/20477724.2023.2250619. Online ahead of print.ABSTRACTNeglected tropical diseases (NTDs) are a group of diseases mainly affecting people in low- and middle-income Countries. The aim of this study was to perform a bibliometric analysis of the scientific literature on NTDs. Using the MeSH database, we quantified the number of publications on MEDLINE targeting each NTD, which were published from 1 January 1999 to 31 January 2019. In order to weight the number of publications targeting a given NTD according to the total number of publications/year, we calculated a Yearly Publica...
Source: Pathogens and Global Health - August 22, 2023 Category: International Medicine & Public Health Authors: Gianpiero Tebano Elisa Vanino Paolo Muratori Francesco Cristini Source Type: research
Scabies prevalence after ivermectin-based mass drug administration for lymphatic filariasis, Samoa 2018 –2019
ConclusionsWe found moderate prevalence of scabies in two population-representative surveys conducted within 8 months of the 2018 MDA for lymphatic filariasis. Prevalence appeared to increase between the surveys, and ongoing surveillance is recommended, particularly in young children. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - August 22, 2023 Category: Tropical Medicine Authors: Gabriela A. Willis Source Type: research
Understanding gender and its intersection with social stratifiers on prevention and care seeking behavior of lymphatic filariasis in Nepal
ConclusionsOverall, the findings emphasized how access to resources, division of work, norms and values and decision-making power alone and its interaction with various social stratifiers shaped peoples ’ vulnerability to disease, ability to prevent exposure and response to illness.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - August 22, 2023 Category: Infectious Diseases Source Type: research
