Filariasis Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vitellogenin genes are transcribed in Culex quinquefasciatus ovary
CONCLUSIONS: This is the first time that vitellogenin transcripts are observed in mosquito ovaries. Studies to determine if Vg transcripts are translated into proteins and their contribution to the reproductive success of the mosquito need to be further investigated.PMID:37466532 | PMC:PMC10368008 | DOI:10.1590/0074-02760220143 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - July 19, 2023 Category: Infectious Diseases Authors: Alexandre S Moura Andr é Luis Costa-da-Silva Pedro S Peixoto Ceres Maciel Andr é F Cardoso Source Type: research

Individual longitudinal compliance to neglected tropical disease mass drug administration programmes, a systematic review
by Rosie Maddren, Anna Phillips, Santiago Rayment Gomez, Kathryn Forbes, Benjamin S. Collyer, Klodeta Kura, Roy Anderson Repeated distribution of preventative chemotherapy (PC) by mass drug administration forms the mainstay of transmission control for five of the 20 recognised neglected tropical diseases (NTDs); soil-transmitted helminths, schistosomiasis, lymphatic filariasis, onchocerciasis and trachoma. The efficiency of such programmes is reliant upon participants swallowing the offered treatment consistently at each round. This is measured by compliance, defined as the proportion of eligible participants swallowing t...
Source: PLoS Neglected Tropical Diseases - July 17, 2023 Category: Tropical Medicine Authors: Rosie Maddren Source Type: research

Socio-economic and environmental factors associated with high lymphatic filariasis morbidity prevalence distribution in Bangladesh
by Tijana Williams, Mohammad Jahirul Karim, Shihab Uddin, Sharmin Jahan, Sultan Mahmood ASM, Shaun P. Forbes, Anna Hooper, Mark J. Taylor, Louise A. Kelly-Hope BackgroundLymphatic filariasis (LF) is a vector-borne parasitic disease which affects 70 million people worldwide and causes life-long disabilities. In Bangladesh, there are an estimated 44,000 people suffering from clinical conditions such as lymphoedema and hydrocoele, with the greatest burden in the northern Rangpur division. To better understand the factors associated with this distribution, this study examined socio-economic and environmental factors at divisio...
Source: PLoS Neglected Tropical Diseases - July 11, 2023 Category: Tropical Medicine Authors: Tijana Williams Source Type: research

A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti- < i > Wolbachia < /i > and antifilarial activity
by Negar Alami, David C. Carter, Nisha V. Kwatra, Weihan Zhao, Linda Snodgrass, Ariel R. Porcalla, Cheri E. Klein, Daniel E. Cohen, Loretta Gallenberg, Melina Neenan, Robert A. Carr, Kennan C. Marsh, Dale J. Kempf BackgroundThe parasitic filariae responsible for onchocerciasis and lymphatic filariasis are host to an endosymbiotic bacterium,Wolbachia, which is essential to the fertility and development of the parasites. We performed a Phase-I pharmacokinetic, safety and food-effect study on single and multiple ascending doses of flubentylosin (ABBV-4083), a macrolide antibacterial with activity againstWolbachia, intended to...
Source: PLoS Neglected Tropical Diseases - July 10, 2023 Category: Tropical Medicine Authors: Negar Alami Source Type: research

Global impact of lymphedema on quality of life and society
AbstractLymphedema is a chronic disorder of the lymphatic system characterized by the accumulation of interstitial fluid in tissues. It affects millions of individuals worldwide, resulting in significant disability and morbidity. Despite its prevalence, it is often an underappreciated clinical entity. In this narrative review, we critically examined and synthesized currently available peer-reviewed literature on the global epidemiology, pathophysiology, and societal burden of lymphedema. Most patients have a secondary cause of lymphedema, such as lymphatic filariasis, mostly prevalent in Asia, South America, and Africa. A ...
Source: European Journal of Plastic Surgery - July 10, 2023 Category: Cosmetic Surgery Source Type: research

The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system
This study aimed to investigate the immune system’s role during treatment with OXF and FBZ and explore the potential to boost the treatment efficacy via stimulation of the immune system. Wild type (WT) BALB/c, eosinophil-deficient ΔdblGata1, IL-4r/IL-5−/−, antibody-deficient μMT and B-, T-, NK-cell and ILC-deficient Rag2/IL-2rγ−/− mice were infected with the rodent filaria Litomosoides sigmodontis and treated with an optimal and suboptimal regimen of OXF and FBZ for up to 5 days. In the second part, WT mice were treated for 2–3 days with a combination of OXF and IL-4, IL-5, or IL-33. Treatment of WT mice red...
Source: Frontiers in Microbiology - June 27, 2023 Category: Microbiology Source Type: research

Retraction: Occurrence of L1014F and L1014S mutations in insecticide resistant < i > Culex quinquefasciatus < /i > from filariasis endemic districts of West Bengal, India
by The PLOS Neglected Tropical Diseases Editors (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - June 20, 2023 Category: Tropical Medicine Authors: The PLOS Neglected Tropical Diseases Editors Source Type: research

Assessment of wing geometric morphometrics of urban Culex quinquefasciatus (Diptera: Culicidae) populations
Acta Trop. 2023 Jun 16:106971. doi: 10.1016/j.actatropica.2023.106971. Online ahead of print.ABSTRACTCulex quinquefasciatus is a cosmopolitan species distributed throughout tropical and subtropical areas of the world. The species is of great epidemiological importance as it is responsible for vectoring the causative agent of lymphatic filariasis and several arboviruses, including West Nile virus. Wing geometric morphometrics has been widely used to assess phenotypic variations in mosquito species. Here, we hypothesize that Cx. quinquefasciatus populations in urban parks in the city of São Paulo, Brazil, have been subjecte...
Source: Acta Tropica - June 18, 2023 Category: Infectious Diseases Authors: Rafael Oliveira-Christe Gabriela Cristina de Carvalho Andr é Barretto Bruno Wilke Mauro Toledo Marrelli Source Type: research

Evaluating the availability and quality of services for lymphatic filariasis morbidity in Ghana
Conclusions and significanceThe findings from this study can help the Ghana NTD Program identify areas of improvement as they seek to achieve LF elimination targets and continue to improve access to care for those with LF-related morbidity as part of overall health systems strengthening. Key recommendations include prioritizing refresher and MMDP training for health workers, ensuring reliable patient tracking systems, and integrating lymphatic filariasis morbidity management into the routine healthcare system to ensure medicine and commodity availably. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - June 12, 2023 Category: Tropical Medicine Authors: Melissa Edmiston Source Type: research