The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6:S0378-4274(24)00055-9. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their lo...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6;396:1-10. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their low production ...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6;396:1-10. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their low production ...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research
Plasma drug screening using paper spray mass spectrometry with integrated solid phase extraction
AbstractDrug overdoses have risen dramatically in recent years. We developed a simple nontargeted method using a disposable paper spray cartridge with an integrated solid phase extraction column. This method was used to screen for ~160 fentanyl analogs, synthetic cannabinoids, other synthetic drugs, and traditional drugs of abuse in over 300 authentic overdose samples collected at emergency departments in Indianapolis. A solid phase extraction step was implemented on the paper spray cartridge to enable subnanograms per milliliter synthetic drugs screening in plasma. Analysis was performed on a quadrupole orbitrap mass spec...
Source: Drug Testing and Analysis - April 8, 2024 Category: Drugs & Pharmacology Authors: Hannah Zimmerman ‐Federle,
Greta Ren,
Sarah Dowling,
Cassandra Warren,
Daniel Rusyniak,
Robert Avera,
Nicholas E. Manicke Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
Triage-initiated intranasal fentanyl for hip fractures in an Emergency Department - Results from introduction of an analgesic guideline
CONCLUSION: Use of triage-initiated INF significantly decreased time to analgesic administration, time to imaging and overall length of stay in ED.PMID:38579496 | DOI:10.1016/j.ienj.2024.101445 (Source: Pain Physician)
Source: Pain Physician - April 5, 2024 Category: Anesthesiology Authors: Jennifer Smith Danny Soo Antonio Celenza Source Type: research
Triage-initiated intranasal fentanyl for hip fractures in an Emergency Department - Results from introduction of an analgesic guideline
CONCLUSION: Use of triage-initiated INF significantly decreased time to analgesic administration, time to imaging and overall length of stay in ED.PMID:38579496 | DOI:10.1016/j.ienj.2024.101445 (Source: Pain Physician)
Source: Pain Physician - April 5, 2024 Category: Anesthesiology Authors: Jennifer Smith Danny Soo Antonio Celenza Source Type: research
IJERPH, Vol. 21, Pages 442: A Dynamic Model of Opioid Overdose Deaths in Canada during the Co-Occurring Opioid Overdose Crisis and COVID-19 Pandemic
Orpana
With over 40,000 opioid-related overdose deaths between January 2016 and June 2023, the opioid-overdose crisis is a significant public health concern for Canada. The opioid crisis arose from a complex system involving prescription opioid use, the use of prescription opioids not as prescribed, and non-medical opioid use. The increasing presence of fentanyl and its analogues in the illegal drugs supply has been an important driver of the crisis. In response to the overdose crisis, governments at the municipal, provincial/territorial, and federal levels have increased actions to address opioid-related harms. At th...
Source: International Journal of Environmental Research and Public Health - April 4, 2024 Category: Environmental Health Authors: Rifat Zahan Nathaniel D. Osgood Rebecca Plouffe Heather Orpana Tags: Article Source Type: research
Development of fentanyl-specific monoclonal antibody (mAb) to antagonize the pharmacological effects of fentanyl
In conclusion, mAb passive immunization represents a viable strategy for addressing fentanyl addiction and overdose.PMID:38570042 | DOI:10.1016/j.taap.2024.116918 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 3, 2024 Category: Toxicology Authors: Xiao-Yi Chen Li Wang Xiao Ma Fan Yang Xiao Wang Peng Xu Li-Li Xu Bin Di Source Type: research
Development of fentanyl-specific monoclonal antibody (mAb) to antagonize the pharmacological effects of fentanyl
In conclusion, mAb passive immunization represents a viable strategy for addressing fentanyl addiction and overdose.PMID:38570042 | DOI:10.1016/j.taap.2024.116918 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 3, 2024 Category: Toxicology Authors: Xiao-Yi Chen Li Wang Xiao Ma Fan Yang Xiao Wang Peng Xu Li-Li Xu Bin Di Source Type: research
Development of fentanyl-specific monoclonal antibody (mAb) to antagonize the pharmacological effects of fentanyl
In conclusion, mAb passive immunization represents a viable strategy for addressing fentanyl addiction and overdose.PMID:38570042 | DOI:10.1016/j.taap.2024.116918 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 3, 2024 Category: Toxicology Authors: Xiao-Yi Chen Li Wang Xiao Ma Fan Yang Xiao Wang Peng Xu Li-Li Xu Bin Di Source Type: research
Overdose from Unintentional Fentanyl Use when Intending to Use a Non-opioid Substance: An Analysis of Medically Attended Opioid Overdose Events
AbstractFentanyl-mixed and substituted heroin is well-documented, but less is known about unintentional fentanyl use among people using stimulants. To determine the prevalence of and racial and ethnic disparities in unintentional fentanyl use among people experiencing a medically attended opioid overdose, we reviewed 448 suspected non-fatal overdose cases attended by a community paramedic overdose response team in San Francisco from June to September 2022. We applied a case definition for opioid overdose to paramedic records and abstracted data on intended substance use prior to overdose. Among events meeting case criteria...
Source: Journal of Urban Health - April 3, 2024 Category: Health Management Source Type: research
Examining NSDUH's Assessment of Fentanyl Use: A Comparison of Trends in Fentanyl Use and Fentanyl Overdose Deaths from 2015-2020
CONCLUSION: Per NSDUH data, the prevalence of fentanyl misuse did not significantly increase in tandem with synthetic opioid overdose deaths from 2015 to 2020. Scrutiny of NSDUH's approach to assessing fentanyl misuse casts doubt on the utility of NSDUH fentanyl data collection. We acknowledge recent changes to the survey and recommend two further changes to optimize a vital source of data on behaviors related to the opioid overdose crisis.PMID:38563278 | DOI:10.15288/jsad.23-00247 (Source: Journal of Studies on Alcohol and Drugs)
Source: Journal of Studies on Alcohol and Drugs - April 2, 2024 Category: Addiction Authors: James Aluri Ramin Mojtabai Eric C Strain Source Type: research
