Black Americans' Drug Mortality Increases and Local Employment Opportunities, 2010 ‒2021
Conclusions. Increasing employment opportunities can be an important strategy for preventing Black Americans' drug mortality, especially among those living in areas with higher increases in fentanyl seizure rates. (Am J Public Health. Published online ahead of print April 25, 2024:e1-e4. https://doi.org/10.2105/AJPH.2024.307646).PMID:38662973 | DOI:10.2105/AJPH.2024.307646 (Source: American Journal of Public Health)
Source: American Journal of Public Health - April 25, 2024 Category: International Medicine & Public Health Authors: Sehun Oh Manuel Cano Source Type: research
Black Americans' Drug Mortality Increases and Local Employment Opportunities, 2010 ‒2021
Conclusions. Increasing employment opportunities can be an important strategy for preventing Black Americans' drug mortality, especially among those living in areas with higher increases in fentanyl seizure rates. (Am J Public Health. Published online ahead of print April 25, 2024:e1-e4. https://doi.org/10.2105/AJPH.2024.307646).PMID:38662973 | DOI:10.2105/AJPH.2024.307646 (Source: Am J Public Health)
Source: Am J Public Health - April 25, 2024 Category: International Medicine & Public Health Authors: Sehun Oh Manuel Cano Source Type: research
Black Americans' Drug Mortality Increases and Local Employment Opportunities, 2010 ‒2021
Conclusions. Increasing employment opportunities can be an important strategy for preventing Black Americans' drug mortality, especially among those living in areas with higher increases in fentanyl seizure rates. (Am J Public Health. Published online ahead of print April 25, 2024:e1-e4. https://doi.org/10.2105/AJPH.2024.307646).PMID:38662973 | DOI:10.2105/AJPH.2024.307646 (Source: American Journal of Public Health)
Source: American Journal of Public Health - April 25, 2024 Category: International Medicine & Public Health Authors: Sehun Oh Manuel Cano Source Type: research
Black Americans' Drug Mortality Increases and Local Employment Opportunities, 2010 ‒2021
Conclusions. Increasing employment opportunities can be an important strategy for preventing Black Americans' drug mortality, especially among those living in areas with higher increases in fentanyl seizure rates. (Am J Public Health. Published online ahead of print April 25, 2024:e1-e4. https://doi.org/10.2105/AJPH.2024.307646).PMID:38662973 | DOI:10.2105/AJPH.2024.307646 (Source: Am J Public Health)
Source: Am J Public Health - April 25, 2024 Category: International Medicine & Public Health Authors: Sehun Oh Manuel Cano Source Type: research
Black Americans' Drug Mortality Increases and Local Employment Opportunities, 2010 ‒2021
Conclusions. Increasing employment opportunities can be an important strategy for preventing Black Americans' drug mortality, especially among those living in areas with higher increases in fentanyl seizure rates. (Am J Public Health. Published online ahead of print April 25, 2024:e1-e4. https://doi.org/10.2105/AJPH.2024.307646).PMID:38662973 | DOI:10.2105/AJPH.2024.307646 (Source: American Journal of Public Health)
Source: American Journal of Public Health - April 25, 2024 Category: International Medicine & Public Health Authors: Sehun Oh Manuel Cano Source Type: research
Black Americans' Drug Mortality Increases and Local Employment Opportunities, 2010 ‒2021
Conclusions. Increasing employment opportunities can be an important strategy for preventing Black Americans' drug mortality, especially among those living in areas with higher increases in fentanyl seizure rates. (Am J Public Health. Published online ahead of print April 25, 2024:e1-e4. https://doi.org/10.2105/AJPH.2024.307646).PMID:38662973 | DOI:10.2105/AJPH.2024.307646 (Source: Am J Public Health)
Source: Am J Public Health - April 25, 2024 Category: International Medicine & Public Health Authors: Sehun Oh Manuel Cano Source Type: research
Fentanyl Analogs Exert Antinociceptive Effects via Sodium Channel Blockade in Mice
This study investigated whether opioid-related compounds could suppress glutamate- and veratrine-induced nociceptive responses in mice at the same dose. The administration of morphine (3 mg/kg), hydromorphone (0.4 mg/kg), or fentanyl (0.03 mg/kg) suppressed glutamate-induced nociceptive response, but not veratrine-induced nociceptive response at the same doses. However, high doses of morphine (10 mg/kg), hydromorphone (2 mg/kg), or fentanyl (0.1 mg/kg) produced a significant reduction in the veratrine-induced nociceptive response. These results indicate that high doses are required when using morphine, hydromorphone, or fe...
Source: Biological and Pharmaceutical Bulletin - April 24, 2024 Category: Drugs & Pharmacology Authors: Satoka Kasai Natsuki Ogawa Miho Takagi Yukino Takahashi Kosho Makino Hironobu Arita Hideyo Takahashi Kazumi Yoshizawa Source Type: research
Fentanyl Analogs Exert Antinociceptive Effects via Sodium Channel Blockade in Mice
This study investigated whether opioid-related compounds could suppress glutamate- and veratrine-induced nociceptive responses in mice at the same dose. The administration of morphine (3 mg/kg), hydromorphone (0.4 mg/kg), or fentanyl (0.03 mg/kg) suppressed glutamate-induced nociceptive response, but not veratrine-induced nociceptive response at the same doses. However, high doses of morphine (10 mg/kg), hydromorphone (2 mg/kg), or fentanyl (0.1 mg/kg) produced a significant reduction in the veratrine-induced nociceptive response. These results indicate that high doses are required when using morphine, hydromorphone, or fe...
Source: Biological and Pharmaceutical Bulletin - April 24, 2024 Category: Drugs & Pharmacology Authors: Satoka Kasai Natsuki Ogawa Miho Takagi Yukino Takahashi Kosho Makino Hironobu Arita Hideyo Takahashi Kazumi Yoshizawa Source Type: research
Fentanyl Analogs Exert Antinociceptive Effects via Sodium Channel Blockade in Mice
This study investigated whether opioid-related compounds could suppress glutamate- and veratrine-induced nociceptive responses in mice at the same dose. The administration of morphine (3 mg/kg), hydromorphone (0.4 mg/kg), or fentanyl (0.03 mg/kg) suppressed glutamate-induced nociceptive response, but not veratrine-induced nociceptive response at the same doses. However, high doses of morphine (10 mg/kg), hydromorphone (2 mg/kg), or fentanyl (0.1 mg/kg) produced a significant reduction in the veratrine-induced nociceptive response. These results indicate that high doses are required when using morphine, hydromorphone, or fe...
Source: Biological and Pharmaceutical Bulletin - April 24, 2024 Category: Drugs & Pharmacology Authors: Satoka Kasai Natsuki Ogawa Miho Takagi Yukino Takahashi Kosho Makino Hironobu Arita Hideyo Takahashi Kazumi Yoshizawa Source Type: research
Fentanyl Analogs Exert Antinociceptive Effects via Sodium Channel Blockade in Mice
This study investigated whether opioid-related compounds could suppress glutamate- and veratrine-induced nociceptive responses in mice at the same dose. The administration of morphine (3 mg/kg), hydromorphone (0.4 mg/kg), or fentanyl (0.03 mg/kg) suppressed glutamate-induced nociceptive response, but not veratrine-induced nociceptive response at the same doses. However, high doses of morphine (10 mg/kg), hydromorphone (2 mg/kg), or fentanyl (0.1 mg/kg) produced a significant reduction in the veratrine-induced nociceptive response. These results indicate that high doses are required when using morphine, hydromorphone, or fe...
Source: Biological and Pharmaceutical Bulletin - April 24, 2024 Category: Drugs & Pharmacology Authors: Satoka Kasai Natsuki Ogawa Miho Takagi Yukino Takahashi Kosho Makino Hironobu Arita Hideyo Takahashi Kazumi Yoshizawa Source Type: research
Fentanyl Analogs Exert Antinociceptive Effects via Sodium Channel Blockade in Mice
This study investigated whether opioid-related compounds could suppress glutamate- and veratrine-induced nociceptive responses in mice at the same dose. The administration of morphine (3 mg/kg), hydromorphone (0.4 mg/kg), or fentanyl (0.03 mg/kg) suppressed glutamate-induced nociceptive response, but not veratrine-induced nociceptive response at the same doses. However, high doses of morphine (10 mg/kg), hydromorphone (2 mg/kg), or fentanyl (0.1 mg/kg) produced a significant reduction in the veratrine-induced nociceptive response. These results indicate that high doses are required when using morphine, hydromorphone, or fe...
Source: Biological and Pharmaceutical Bulletin - April 24, 2024 Category: Drugs & Pharmacology Authors: Satoka Kasai Natsuki Ogawa Miho Takagi Yukino Takahashi Kosho Makino Hironobu Arita Hideyo Takahashi Kazumi Yoshizawa Source Type: research
Fentanyl Analogs Exert Antinociceptive Effects via Sodium Channel Blockade in Mice
This study investigated whether opioid-related compounds could suppress glutamate- and veratrine-induced nociceptive responses in mice at the same dose. The administration of morphine (3 mg/kg), hydromorphone (0.4 mg/kg), or fentanyl (0.03 mg/kg) suppressed glutamate-induced nociceptive response, but not veratrine-induced nociceptive response at the same doses. However, high doses of morphine (10 mg/kg), hydromorphone (2 mg/kg), or fentanyl (0.1 mg/kg) produced a significant reduction in the veratrine-induced nociceptive response. These results indicate that high doses are required when using morphine, hydromorphone, or fe...
Source: Biological and Pharmaceutical Bulletin - April 24, 2024 Category: Drugs & Pharmacology Authors: Satoka Kasai Natsuki Ogawa Miho Takagi Yukino Takahashi Kosho Makino Hironobu Arita Hideyo Takahashi Kazumi Yoshizawa Source Type: research
The 90% effective dose of intrathecal hyperbaric bupivacaine for Cesarean delivery under combined spinal –epidural anesthesia in parturients with super obesity: an up-down sequential allocation study
ConclusionThe estimated ED90 of hyperbaric bupivacaine with fentanyl and morphine in parturients with super obesity undergoing Cesarean delivery under CSE was approximately 11.5 mg.Study registrationClinicalTrials.gov (NCT03781388); first submitted 18 December 2018. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - April 23, 2024 Category: Anesthesiology Source Type: research
mRNA Expression Levels of Cytochrome P450 CYP1A2, CYP3A4, and CYP3A5 in the Epidermis: A Focus on Individual Differences Among Japanese Individuals
Xenobiotica. 2024 Apr 22:1-28. doi: 10.1080/00498254.2024.2344664. Online ahead of print.ABSTRACTVarious cytochrome P450 enzymes (CYPs) that contribute to drug metabolism are expressed in the skin. However, variation among individuals in CYP expression profiles is not well-understood.To investigate CYPs related to the metabolism of transdermal preparations in Japan, multiple skin tissue specimens of individuals of Japanese descent were prepared, and the mRNA expression levels of CYP1A2, CYP3A4, and CYP3A5 were measured. Associations between the expression patterns of these CYPs and body mass index (BMI) were also investiga...
Source: Xenobiotica - April 22, 2024 Category: Research Authors: Hiroko Makihara Mika Maezawa Kazusa Kaiga Toshihiko Satake Mayu Muto Yui Tsunoda Tsutomu Shimada Tomoko Akase Source Type: research
Evaluation of in-house drug evidence testing by King County Medical Examiner's Office in "real-time" fatal overdose surveillance
J Forensic Sci. 2024 Apr 22. doi: 10.1111/1556-4029.15526. Online ahead of print.ABSTRACTWith the escalating overdose epidemic, many surveillance efforts have appeared. In 2018, King County Medical Examiner's Office (KCMEO) initiated a fatal overdose surveillance project aimed at expediting death certification and disseminating timely information. In this project, KCMEO investigators collected items of evidence of drug use from overdose death scenes, which were tested by five in-house methods, four using handheld devices: TruNarc Raman spectrometer, with and without the manufacture's H-Kit, Rigaku ResQ Raman spectrometer, ...
Source: Journal of Forensic Sciences - April 22, 2024 Category: Forensic Medicine Authors: Richard C Harruff William L Barbour Nicole A Yarid Source Type: research
