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Transmucosal fentanyl-related opioid use disorder in a cancer survivor
Therapie. 2024 Feb 24:S0040-5957(24)00031-3. doi: 10.1016/j.therap.2024.02.002. Online ahead of print.NO ABSTRACTPMID:38494374 | DOI:10.1016/j.therap.2024.02.002 (Source: Therapie)
Source: Therapie - March 17, 2024 Category: Psychiatry & Psychology Authors: Salim Mezaache Christophe Cutarella Elisabeth Frauger Jo ëlle Micallef Source Type: research

Impact of Replacing Fentanyl With Hydromorphone as the First-Line Postoperative Opioid Among Patients Undergoing Outpatient Cancer Surgery
In response to a nationwide fentanyl shortage, our institution assessed whether changing our first-line postoperative intravenous opioid from fentanyl to hydromorphone impacted patient outcomes. The primary research aim was to evaluate the association between first-line opioid and rapidity of recovery. (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - March 16, 2024 Category: Nursing Authors: Jennifer R. Majumdar, John Grbic, Sigrid Carlsson, Donna Barreiro, Marie Marte, Vincent Laudone, Melissa J. Assel, Geema Masson Tags: Research Source Type: research

A confirmed case of xylazine-induced skin ulcers in a person who injects drugs in Miami, Florida, USA
Xylazine is an alpha-2 adrenergic receptor agonist that has emerged as a contaminant in the illicit drug supply of fentanyl. Xylazine use may be suspected in naloxone-resistant overdoses and atypical, chronic ... (Source: Harm Reduction Journal)
Source: Harm Reduction Journal - March 15, 2024 Category: Drugs & Pharmacology Authors: Peyton V. Warp, Maia Hauschild, David P. Serota, Katrina Ciraldo, Irasema Cruz, Tyler S. Bartholomew and Hansel E. Tookes Tags: Case Study Source Type: research

Beyond a spec: assessing heterogeneity in the unregulated opioid supply
Drug checking services aim to provide compositional information for the illicit drug supply and are being employed in public health responses to extreme rates of overdose associated with fentanyl within street... (Source: Harm Reduction Journal)
Source: Harm Reduction Journal - March 15, 2024 Category: Drugs & Pharmacology Authors: Lea Gozdzialski, Rebecca Louw, Collin Kielty, Ava Margolese, Eric Poarch, Miriam Sherman, Fred Cameron, Chris Gill, Bruce Wallace and Dennis Hore Tags: Research Source Type: research

Evaluating the rate of reversal of fentanyl-induced respiratory depression using a novel long-acting naloxone nanoparticle, cNLX-NP
DiscussionWhile cNLX-NP alone may not sufficiently reverse F/FA overdose in a timely manner, mixing free NLX with cNLX-NP can provide a mechanism to both rapidly reverse fentanyl-related effects and maintain extended protection against synthetic opioid toxicity. These data support further development of cNLX-NP as a fast-acting and long-lasting antidote to treat F/FA-induced respiratory depression and overdose, and potentially prevent renarcotization in humans. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - March 14, 2024 Category: Psychiatry Source Type: research

Clinical Pharmacokinetics and Pharmacodynamics of Naloxone
AbstractNaloxone is a World Health Organization (WHO)-listed essential medicine and is the first choice for treating the respiratory depression of opioids, also by lay-people witnessing an opioid overdose. Naloxone acts by competitive displacement of opioid agonists at the μ-opioid receptor (MOR). Its effect depends on pharmacological characteristics of the opioid agonist, such as dissociation rate from the MOR receptor and constitution of the victim. Aim of treatment is a balancing act between restoration of respiration (not consciousness) and avoidance of withdrawa l, achieved by titration to response after initial dose...
Source: Clinical Pharmacokinetics - March 14, 2024 Category: Drugs & Pharmacology Source Type: research