Evaluation of a Hapten Conjugate Vaccine Against the “Zombie Drug” Xylazine
Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D4CC00883A, CommunicationMingliang Lin, Lisa M. Eubanks, Bin Zhou, Kim D Janda Xylazine has emerged as a primary adulterant in fentanyl, exacerbating the complexity of the opioid crisis. Yet, there is no approved drug that can reverse xylazine ’s pathophysiology. As a prelude... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 2, 2024 Category: Chemistry Authors: Mingliang Lin Source Type: research
External Oblique Intercostal Plane Block Versus Port-Site Infiltration for Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Study
ConclusionEOI block can be used as a part of multimodal analgesia due to its simplicity and effective postoperative analgesia in LSG.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - April 2, 2024 Category: Surgery Source Type: research
Estradiol Protects Against Pain-Facilitated Fentanyl Use Via Suppression of Opioid-Evoked Dopamine Activity in Males
Pain affects over 50% of US adults. Opioids are potent analgesics used to treat pain symptoms but are highly prone to abuse, creating a major dilemma for public health. Evidence suggests that the risk for opioid misuse under conditions of pain may vary based on gender/sex, but the biological basis of this relationship is unclear. Here, we characterize the effects of pain on fentanyl use and decipher its underlying mechanisms within mesolimbic dopamine reward circuitry, providing evidence for regulation by ovarian hormones. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Jessica Higginbotham, Julian Abt, Rachel Teich, Tania Lintz, Hasan Maqbool, Joanna Dearman, Jose Moron Source Type: research
Opioid Withdrawal and Treatment
This lecture will discuss illicit and prescription opiate use and abuse. As the opioid crisis persists in this country, along with an illicit crisis including fentanyl and iso on the street, it is important for nurses and nurse practitioners to recognize the signs and symptoms of drug withdrawal. Assessment and symptom management will be presented according to current national standards. Proper medication weaning will be explained, utilizing pharmacological agents and non-pharmacological interventions. (Source: Pain Management Nursing)
Source: Pain Management Nursing - April 1, 2024 Category: Nursing Authors: Mary Carter Source Type: research
Updating and encouraging participation in the landscape of federal and state legislation
This session discusses updates to the CDC guidelines, the DEA X waiver change, new and/or proposed legislation, information about (opioid use disorder) OUD and plans to supplement the national and state rulings for issues such as no-RX naloxone, fentanyl and progress towards curtailing its illegal distribution within the US. (Source: Pain Management Nursing)
Source: Pain Management Nursing - April 1, 2024 Category: Nursing Authors: Michael Barnes, Juris Docturate Source Type: research
Fentanyl Pharmacokinetic Paradoxical in Cancer Cachexia
Transdermal fentanyl has a somewhat unpredictable pharmacokinetic profile, which becomes even more unpredictable as patients with cancer become cachectic.1 In a retrospective study involving 30 patients with cachexia and 47 patients without cachexia, a higher morphine equivalent dose (75.5 mg per day) was required for pain control and those with cachexia compared to those who were not cachectic (43.3 mg per day) when rotating to transdermal fentanyl. This increase in morphine dose equivalents correlated with reduced transepidermal water loss. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - March 31, 2024 Category: Palliative Care Authors: Mellar Davis Tags: Letter Source Type: research
Interpectoral and Pectoserratus Plane Block vs. Local Anesthetic Infiltration for Partial Mastectomy: A Prospective Randomized Trial
CONCLUSIONS: Our study showed decreased intraoperative opioid use in the IPP/PSP group and no difference in postoperative pain scores up to 24 hours. Both groups reported low postoperative pain scores. This trial is registered with NCT04824599.PMID:38550709 | PMC:PMC10977337 | DOI:10.1155/2024/9989997 (Source: Pain Research and Management)
Source: Pain Research and Management - March 29, 2024 Category: Anesthesiology Authors: Patryk Eisler Stephan Zimmermann Ragnar Henningsson Source Type: research
Interpectoral and Pectoserratus Plane Block vs. Local Anesthetic Infiltration for Partial Mastectomy: A Prospective Randomized Trial
CONCLUSIONS: Our study showed decreased intraoperative opioid use in the IPP/PSP group and no difference in postoperative pain scores up to 24 hours. Both groups reported low postoperative pain scores. This trial is registered with NCT04824599.PMID:38550709 | PMC:PMC10977337 | DOI:10.1155/2024/9989997 (Source: Pain Research and Management)
Source: Pain Research and Management - March 29, 2024 Category: Anesthesiology Authors: Patryk Eisler Stephan Zimmermann Ragnar Henningsson Source Type: research
