An investigation into the interest in laser in situ keratomileusis (LASIK) in Canada during the COVID-19 pandemic: Predicting interest and demand in periods of uncertainty
Can J Ophthalmol. 2023 Sep 1:S0008-4182(23)00255-7. doi: 10.1016/j.jcjo.2023.08.007. Online ahead of print.NO ABSTRACTPMID:37666487 | DOI:10.1016/j.jcjo.2023.08.007 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - September 4, 2023 Category: Opthalmology Authors: Sloane Kowal Natalie Mezey Davin Johnson Source Type: research
Comparison of central corneal thickness treated with small incision lenticule extraction, femtosecond laser-assisted in situ keratomileusis, or laser-assisted subepithelial keratomileusis for myopia
AbstractTo compare the central corneal thickness (CCT) treated with small incision lenticule extraction (SMILE), femtosecond laser-assisted in situ keratomileusis (FS-LASIK), or laser-assisted subepithelial keratomileusis (LASEK) for myopia correction. This was a retrospective case series study. Patients who had completed 1-year follow-up after receiving SMILE, FS-LASIK, or LASEK at our hospital from January 2019 to July 2021 were included. Pentacam pachymetry was performed to measure the CCT. The predicted CCT reduction was obtained through laser platform. The measured CCT reduction was defined as the difference between t...
Source: Lasers in Medical Science - September 1, 2023 Category: Laser Surgery Source Type: research
Seven-year corneal densitometry changes after small incision lenticule extraction and femtosecond laser-assisted in situ keratomileusis
This study aims to investigate the 7-year changes in corneal densitometry (CD) after small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK). Forty-two eyes undergoing SMILE and thirty-one undergoing FS-LASIK were included in this retrospective study. CD was measured preoperatively and at 3 and 7 years postoperatively. Three concentric radial zones (0 –2, 2–6, and 6–10 mm) of three different corneal depths (anterior 120 μm, posterior 60 μm, and central layer) were analyzed. In all three zones of the three corneal layers, no significant difference in CD was found ...
Source: Lasers in Medical Science - August 12, 2023 Category: Laser Surgery Source Type: research
Transcriptional dysregulation of cholesterol synthesis underlies hyposensitivity to γ-aminobutyric acid in the ventral tegmental area during acute alcohol withdrawal
The ventral tegmental area (VTA) is a dopaminergic brain area critical in the development and maintenance of addiction. During withdrawal from chronic ethanol exposure, the response of VTA neurons to GABA is reduced through an epigenetically regulated mechanism. A whole genome transcriptomic approach was utilized to investigate the underlying molecular mechanism of GABA hyposensitivity in VTA during withdrawal after chronic ethanol exposure. (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 8, 2023 Category: Psychiatry Authors: Chang You, Harish R. Krishnan, Ying Chen, Huaibo Zhang, Jenny Drnevich, Graziano Pinna, Alessandro Guidotti, Elizabeth J. Glover, Amy W. Lasek, Dennis R. Grayson, Subhash C. Pandey, Mark S. Brodie Tags: Archival Report Source Type: research
Transcriptional Dysregulation of Cholesterol Synthesis Underlies Hyposensitivity to GABA in the Ventral Tegmental Area During Acute Alcohol Withdrawal
The ventral tegmental area (VTA) is a dopaminergic brain area that is critical in the development and maintenance of addiction. During withdrawal from chronic ethanol exposure, the response of VTA neurons to GABA (gamma-aminobutyric acid) is reduced through an epigenetically regulated mechanism. In the current study, a whole-genome transcriptomic approach was used to investigate the underlying molecular mechanism of GABA hyposensitivity in the VTA during withdrawal after chronic ethanol exposure. (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 8, 2023 Category: Psychiatry Authors: Chang You, Harish R. Krishnan, Ying Chen, Huaibo Zhang, Jenny Drnevich, Graziano Pinna, Alessandro Guidotti, Elizabeth J. Glover, Amy W. Lasek, Dennis R. Grayson, Subhash C. Pandey, Mark S. Brodie Tags: Archival Report Source Type: research
De novo designed self-assembling helicomimetic lipooligoureas with antibacterial activity
Eur J Med Chem. 2023 Aug 2;259:115700. doi: 10.1016/j.ejmech.2023.115700. Online ahead of print.ABSTRACTThe overuse of antibiotics has led to a rise in infections caused by multidrug-resistant bacteria, resulting in a need for new antibacterial compounds with different modes of action. In this paper, we describe a new class of compounds called lipooligoureas, which are foldamer-based mimetics of antimicrobial lipopeptides. The lipooligoureas consist of an acyl chain connected to the N-terminus of an oligourea head group that exhibits a well-defined 2.5-helix secondary structure, which is further stabilized by the attachmen...
Source: European Journal of Medicinal Chemistry - August 5, 2023 Category: Chemistry Authors: Paulina Bachurska-Szpala Kinga Burdach Robert Lasek Dagmara Tymecka Joanna Juhaniewicz-D ębińska Dariusz Bartosik Karolina Pu łka-Ziach S ławomir Sęk Source Type: research
De novo designed self-assembling helicomimetic lipooligoureas with antibacterial activity
Eur J Med Chem. 2023 Aug 2;259:115700. doi: 10.1016/j.ejmech.2023.115700. Online ahead of print.ABSTRACTThe overuse of antibiotics has led to a rise in infections caused by multidrug-resistant bacteria, resulting in a need for new antibacterial compounds with different modes of action. In this paper, we describe a new class of compounds called lipooligoureas, which are foldamer-based mimetics of antimicrobial lipopeptides. The lipooligoureas consist of an acyl chain connected to the N-terminus of an oligourea head group that exhibits a well-defined 2.5-helix secondary structure, which is further stabilized by the attachmen...
Source: European Journal of Medicinal Chemistry - August 5, 2023 Category: Chemistry Authors: Paulina Bachurska-Szpala Kinga Burdach Robert Lasek Dagmara Tymecka Joanna Juhaniewicz-D ębińska Dariusz Bartosik Karolina Pu łka-Ziach S ławomir Sęk Source Type: research
Conserved role for PCBP1 in altered RNA splicing in the hippocampus after chronic alcohol exposure
Molecular Psychiatry, Published online: 03 August 2023; doi:10.1038/s41380-023-02184-yConserved role for PCBP1 in altered RNA splicing in the hippocampus after chronic alcohol exposure (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - August 3, 2023 Category: Psychiatry Authors: Luana Carvalho Hu Chen Mark Maienschein-Cline Elizabeth J. Glover Subhash C. Pandey Amy W. Lasek Source Type: research
A Novel Role for Corneal Pachymetry in Planning Cataract Surgery by Determining Changes in Spherical Equivalent Resulting from a Previous LASIK Treatment
CONCLUSIONS: CPT ratio cutoffs can correctly classify if a cornea previously had a hyperopic versus myopic LASIK surgery and estimate the ablation spherical equivalent of such treatment. This could prove useful for increased accuracy of intraocular lens (IOL) calculations for patients with no historical data of their prior LVC surgery at the time of cataract surgery planning.PMID:37483313 | PMC:PMC10362985 | DOI:10.1155/2023/2261831 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 24, 2023 Category: Opthalmology Authors: Arthur Hammer Tjebo F C Heeren Romesh Angunawela John Marshall Kamran Saha Source Type: research
The tolerance of refractive errors of extended depth of focus intraocular lens in patients with previous corneal refractive surgery
ConclusionThe EDOF IOL have a certain tolerance for refractive errors and corneal astigmatism, and it ’s recommended for patients with prior myopia excimer laser surgery to achieve satisfactory visual performance. (Source: International Ophthalmology)
Source: International Ophthalmology - July 17, 2023 Category: Opthalmology Source Type: research
